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Elsevier

Books in Pharmaceutical chemistry

  • Quantitative Gas Chromatography-Mass Spectrometry in Clinical and Pharmacological Analysis

    Principles and Applications in Lipids and Biomarkers
    • 1st Edition
    • Dimitrios Tsikas
    • English
    Quantitative Gas Chromatography-Mass Spectrometry in Clinical and Pharmacological Analysis: Principles and Applications in Lipids and Biomarkers is an essential resource for researchers, clinicians, and analytical scientists involved in clinical and pharmacological analysis. It provides practical guidance on using gas chromatography-mass spectrometry (GC-MS) and tandem mass spectrometry (GC-MS/MS) for the accurate quantification of physiological substances such as lipids, fatty acids, bile acids, eicosanoids, and biomarkers of oxidative stress like malondialdehyde and isoprostanes. Emphasizing the use of stable isotope-labelled internal standards and chemical ionization techniques, the book enables sensitive and precise measurement of analytes in complex biological samples like blood and urine, supporting disease diagnosis, therapy monitoring, and biomedical research. Designed with a focus on real-world application, it offers step-by-step procedures, troubleshooting tips, and illustrative diagrams to aid understanding. The content covers sample preparation, method validation, and quality control, making it a practical reference for laboratory scientists. Additionally, it highlights recent developments and biomedical applications, providing current knowledge and innovative approaches in the field. Overall, this comprehensive manual bridge analytical techniques with clinical and pharmacological needs, facilitating accurate biomarker analysis to improve health outcomes and scientific understanding.

  • Sonochemical Synthesis of Natural Products and Heterocycles of Pharmaceutical Importance

    Strategy Towards a Sustainable Society
    • 1st Edition
    • Sasadhar Majhi + 1 more
    • English
    Sonochemical Synthesis of Natural Products and Heterocycles of Pharmaceutical Importance: Strategy Towards a Sustainable Society comprehensively summarizes sonochemistry and ultrasound and their applicability to synthetic organic chemistry. Chapters demonstrate the application of sonochemistry to synthesizing molecules of natural origin, organic compounds containing N-heterocycles, O-heterocycles, and S-heterocycles, and the total synthesis and semisynthesis of bioactive compounds under ultrasonication through case studies and detailed illustrations and methodologies. Other sections explore sonochemical organic synthesis under solvent- and catalyst-free conditions, and in an aqueous medium as a green solvent, use of nanoparticles as efficient catalysts, and much more. This is a valuable resource for organic synthesis experts, specialists in natural products, advocates for sustainable chemistry, and researchers and professionals working in total synthesis, semisynthesis, organic synthesis, medicinal chemistry, and the pharmaceutical industries.

  • Specification of Drug Substances and Products

    Development and Validation of Analytical Methods
    • 2nd Edition
    • Christopher M. Riley + 2 more
    • English
    Specification of Drug Substances and Products: Development and Validation of Analytical Methods, Second Edition, presents a comprehensive and critical analysis of the requirements and approaches to setting specifications for new pharmaceutical products, with an emphasis on phase-appropriate development, validation of analytical methods, and their application in practice. This thoroughly revised second edition covers topics not covered or not substantially covered in the first edition, including method development and validation in the clinical phase, method transfer, process analytical technology, analytical life cycle management, special challenges with generic drugs, genotoxic impurities, topical products, nasal sprays and inhalation products, and biotechnology products.The book's authors have been carefully selected as former members of the ICH Expert Working Groups charged with developing the ICH guidelines, and/or subject-matter experts in the industry, academia and in government laboratories.

  • Validamycin and Its Derivatives

    Discovery, Chemical Synthesis, and Biological Activity
    • 1st Edition
    • Xiaolong Chen + 3 more
    • English
    Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.

  • Synthesis of Best-Seller Drugs

    • 1st Edition
    • Ruben Vardanyan + 1 more
    • English
    Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field.

  • The Practice of Medicinal Chemistry

    • 4th Edition
    • Camille Georges Wermuth + 3 more
    • English
    The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 54
    • English
    Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.

  • Organofluorine Compounds in Biology and Medicine

    • 1st Edition
    • V Prakash Reddy
    • English
    Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area.

  • Fusarium

    Mycotoxins, Taxonomy, Pathogenicity
    • 1st Edition
    • Volume 2
    • J. Chelkowski
    • English
    Specialists from a number of different disciplines have contributed to this book which presents actual basic and applied findings on Fusarium species, on their metabolites and taxonomy, in connection with pathogenicity to cereal plants and potato tubers. Over 100 metabolites produced by Fusaria are described together with results of studies on their occurrence in agricultural products, their metabolism in farm animals, and possibilities of elmination and detoxification during technological processes. Pathogenic Fusarium species are described from the point of view of their taxonomy, profiles of produced metabolites, ecology, pathogenicity and interaction with cereal tissues. Finally, some actual solutions to avoid cereal grain contamination are discussed, mainly in connection with agricultural practices and breeding programmes.The interdisciplinary and comprehensive nature of the book makes it particularly useful to all who are studying or teaching plant pathology, plant breeding, animal nutrition and any other area in which Fusaria and their metabolites play an important role.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 53
    • English
    Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems, including g-secretase modulators, P2X7 antagonists as therapeutic agents for CNS disorders, N-type calcium channel modulators for the treatment of pain, and more.

  • Key Chiral Auxiliary Applications

    • 2nd Edition
    • Gregory Roos
    • English
    Key Chiral Auxiliary Applications, Second Edition is a detailed compilation of chiral auxiliary applications organized by type of transformation. Continuing from the most important and relevant auxiliaries described in its predecessor, the three-volume set Compendium of Chiral Auxiliary Applications (2001), as well as advances in the field, the book provides a vital and timely resource for chemists in the field. Each reaction class includes a series of tables and graphical abstracts of real reactions from the literature and patents to enable easy review and comparison of results. This anticipated edition is based on a screening of nearly 40,000 auxiliary reaction applications, with details supplied for the more than 13,000 selected representative entries: synthetic route, reagents, yields, diastereomeric/enant... excesses, and characterization data. Updated and streamlined with more than 60% new material, Key Chiral Auxiliary Applications provides valuable guidance and reliable content for selecting the best auxiliary for a specific asymmetric synthetic transformation.

  • Specification of Drug Substances and Products

    Development and Validation of Analytical Methods
    • 1st Edition
    • Christopher M. Riley + 1 more
    • English
    Specification of Drug Substances and Products: Development and Validation of Analytical Methods is a comprehensive and critical analysis of the requirements and approaches to setting specifications for new pharmaceutical products, with an emphasis on phase-appropriate development and validation of analytical methods. This book is intended as more than a review of new regional guidelines, existing regulatory guidance, and industry practices. It provides a hands-on guide to understanding and applying these in practice. The authors discuss critical issues, novel approaches, and future directions while also providing insight into how International Guidelines were developed and the rationale behind them.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 52
    • English
    Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 48
    • English
    Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

  • The Practice of Medicinal Chemistry

    • 3rd Edition
    • Camille Georges Wermuth
    • English
    The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.

  • Profiles of Drug Substances, Excipients and Related Methodology

    Critical Compilation of pKa Values for Pharmaceutical Substances
    • 1st Edition
    • Volume 33
    • Harry G. Brittain
    • English
    Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions will now also be augmented by publication of critical review chapters that summarize information related to the characterization of drug substances and excipients. This change is required to better meet the needs of the pharmaceutical communtiy and to allow the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series will encompass review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

  • Significant Pharmaceuticals Reported in US Patents

    • 1st Edition
    • Thomas F. DeRosa
    • English
    Significant Pharmaceuticals Reported in US Patents identifies the next generation of pharmaceuticals reported in US Patents. This "hands-on" title provides explicit laboratory methods for preparing the most recent and effective medications. Each entry documents the biological testing protocols used to evaluate a drug and the significance of the current treatment agent over previous methods. Pharmaceuticals are included in this review only if at least two of the following criteria were met: Effectiveness in treating an illness, Innovative, ease of preparation, synergy with existing Medications. Pharmaceuticals are reported for 27 separate classes of illness, including: AIDS, Alzheimer's Disease, Cardiovascular Disorders, Diabetes, Epilepsy, Hepatitis C, Osteoporosis, Obesity and Sleep Disorders. Significant Pharmaceuticals Reported in US Patents has been designed to be used as both a reference and synthetic guide for pharmaceutical, medicinal and organic chemists and graduate students. Researchers working in other areas will also find the information valuable as in many instances intermediates or the next generation pharmaceutical are readily convertible into other industrial products including: anti-oxidants, chemical additives, herbicides, polymer precursors, water purification agents. Clear structural depictions of reagents and chemical transformations have been supplied to permit the identification of other future applications.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 45
    • F.D. King + 1 more
    • English
    The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a ‘quality lead’, where these ‘quality leads’ come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.

  • Surface Activity in Drug Action

    • 1st Edition
    • Volume 21
    • English
    Surface activity is present in living systems; for example in body fluid or cell soup and molecules of surface-active nature are crucial to living matter and its organization. Surface Activity in Drug Action proposes "a liquid membrane hypothesis of drug action" for surface-active drugs. Chapters 1-7 contains an account of the hypothesis and chapter 8 contains a general account of the application of surface activity in therapeutics. The methodology and presentation of the information makes Surface Activity in Drug Action valuable reading for students and researchers interested in surface activity.

  • Designer Drugs Directory

    • 1st Edition
    • K. Valter + 1 more
    • J-C. Landry
    • English
    This book is intended to serve as quick reference handbook on so-called designer drugs. These new, mainly synthetic compounds are also often referred to as analogues of controlled substances. This new work provides a unique directory of 104 designer drugs. This class of drugs is rapidly growing in variety and number of compounds. Although identification, toxicology and other properties have been thoroughly investigated, their analogues and derivatives remain poorly documented. This book fills the gap.Data which is available is often contradictory and confused. This directory provides a critical treatment of the subject which is thoroughly indexed including both the subject index and an index listing more that 230 street names of the described designer drugs.Divided into two parts; the first section describes aspects of designer drug manufacture, new abuse trends, sources of information and terminology. The second, descriptive part, classifies the drugs into ten main categories according to their chemical structure and prevalent pharmacological action. A separate chapter is devoted to each category, followed by a set of corresponding data sheets, street names and eventual synonyms, Toxicological data, short notes on the history of drugs as well as the most pertinent bibliographic references are included.

  • Chemistry and Pharmacology

    • 1st Edition
    • Volume 49
    • English
    Internationally acclaimed for more than 40 years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all naturalproduct chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • Chemistry and Pharmacology

    • 1st Edition
    • Volume 45
    • English
    Internationally acclaimed for more than 40 years, this serial, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine origins, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids, Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 21
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 19
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 18
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 17
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 16
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 15
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 14
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 13
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 12
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 11
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 9
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 8
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 7
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 6
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 5
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 4
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 3
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 2
    • English

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 1
    • English