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Books in Pharmaceutical chemistry

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    • Sonochemical Synthesis of Natural Products and Heterocycles of Pharmaceutical Importance

      • 1st Edition
      • March 1, 2026
      • Sasadhar Majhi + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 7 4 8 2 4
      • eBook
        9 7 8 0 4 4 3 2 7 4 8 3 1
      Sonochemical Synthesis of Natural Products and Heterocycles of Pharmaceutical Importance: Strategy Towards a Sustainable Society comprehensively summarizes of sonochemistry and ultrasound and their applicability to synthetic organic chemistry. Ultrasound has emerged as a potent activation technique for the development of low cost, efficient, and sustainable methodologies for the synthesis of natural products and heterocycles. Chapters demonstrate the application of sonochemistry to synthesizing molecules of natural origin, organic compounds containing N-heterocycles, O-heterocycles, and S-heterocycles, and the total synthesis and semisynthesis of bioactive compounds under ultrasonication through case studies, and detailed illustrations and methodologies. Sonochemical organic synthesis under solvent- and catalyst-free conditions and in an aqueous medium as a green solvent, use of nanoparticles as efficient catalysts, and green routes for drug design and synthesis using ultrasound, and their application in pharmaceutical and environmental chemistry are also explored. Sonochemical Synthesis of Natural Products and Heterocycles of Pharmaceutical Importance: Strategy Towards a Sustainable Society is a valuable resource for organic synthesis experts, specialists in natural products, advocates for sustainable chemistry and researchers and professionals working in total synthesis, semisynthesis, organic synthesis, and medicinal chemistry and pharmaceutical industries.

    • Azetidine Synthesis

      • 1st Edition
      • June 20, 2025
      • Navjeet Kaur
      • English
      • Paperback
        9 7 8 0 4 4 3 4 0 3 5 0 7
      • eBook
        9 7 8 0 4 4 3 4 0 3 5 1 4
      Azetidine Synthesis offers a comprehensive exploration of various methods for the synthesis of azetidines, a class of heterocyclic compounds with diverse applications. The significance of azetidine synthesis has grown largely due to the importance of these molecules as constituents of antibiotics. Chapters cover different synthetic pathways, starting with the general synthesis of azetidines and progressing to specific methods using various starting materials. From the copper-catalyzed synthesis of azetidines from nitrones to the synthesis from isoxazoles, oxazines, and diazo compounds, each chapter delves into the unique strategies and mechanisms involved.Rhodium-cat... approaches, cycloaddition reactions of imines to carbonyl compounds, and the use of isocyanides and isocyanates for azetidine synthesis are discussed in detail. The book also explores photochemical methods for azetidine synthesis, including the photochemical synthesis of fused azetidines. By providing a comprehensive overview of diverse synthetic routes to azetidines, this book serves as a valuable resource for researchers and practitioners in the field of organic chemistry, offering insights into the versatility and potential applications of these important heterocyclic compounds.

    • Chemometrics

      • 1st Edition
      • June 26, 2024
      • Fabiano André Narciso Fernandes + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 1 4 9 3 6
      • eBook
        9 7 8 0 4 4 3 2 1 5 0 3 2
      Chemometrics: Data Treatment and Applications demonstrates best practices for treating real-world analytical instrument data and how to apply chemometrics to this data. Rather than focusing on the mathematical theory involved in chemometrics, the book is meant for the industrial chemist, academics, and advanced students that want to use chemometrics in practice. Case studies on several applications are presented. Unlike existing literature, this book focuses on best practices, practical realities, and challenges when treating data, rather than on the mathematical theory. It also provides basic information on chemometrics and the best practices used to treat data from different analytical instruments.The book is written primarily for analytic chemists as practitioners in analytical laboratories and other industries. It will also be useful to academics and graduate, masters and postdoc students chiefly working in analytical chemistry who want to improve the practical aspects of their research activities.

    • Phytochemistry, Computational Tools, and Databases in Drug Discovery

      • 1st Edition
      • November 30, 2022
      • Chukwuebuka Egbuna + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 5 9 3 0
      • eBook
        9 7 8 0 3 2 3 9 0 7 1 6 3
      Phytochemistry, Computational Tools and Databases in Drug Discovery presents the state-of-the-art in computational methods and techniques for drug discovery studies from medicinal plants. Various tools and databases for virtual screening and characterization of plant bioactive compounds and their subsequent predictions on biological targets for the discovery of new drugs against specific diseases are presented, along with computational tools for the prediction of the toxic effects of phytochemicals on living systems. The book also provides in-depth insight on the applications of these computational tools as well as the databases that describe the interactions of phytochemicals with diseases along with predictions for druggable bioactive compounds. Useful for drug developers, medicinal chemists, toxicologists, phytochemists, plant biochemists and analytical chemists, this book clearly presents the various computational techniques, tools and databases for phytochemical research.

    • Specification of Drug Substances and Products

      • 2nd Edition
      • July 23, 2020
      • Christopher M. Riley + 2 more
      • English
      • Paperback
        9 7 8 0 0 8 1 0 2 8 2 4 7
      • eBook
        9 7 8 0 0 8 1 0 2 8 2 5 4
      Specification of Drug Substances and Products: Development and Validation of Analytical Methods, Second Edition, presents a comprehensive and critical analysis of the requirements and approaches to setting specifications for new pharmaceutical products, with an emphasis on phase-appropriate development, validation of analytical methods, and their application in practice. This thoroughly revised second edition covers topics not covered or not substantially covered in the first edition, including method development and validation in the clinical phase, method transfer, process analytical technology, analytical life cycle management, special challenges with generic drugs, genotoxic impurities, topical products, nasal sprays and inhalation products, and biotechnology products.The book's authors have been carefully selected as former members of the ICH Expert Working Groups charged with developing the ICH guidelines, and/or subject-matter experts in the industry, academia and in government laboratories.

    • Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals

      • 1st Edition
      • September 19, 2018
      • Gunter Haufe + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 2 7 3 3 9
      • eBook
        9 7 8 0 1 2 8 1 2 7 3 4 6
      Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics and Agrochemicals, volume four in Alain Tressaud’s Progress in Fluorine Science series, presents a critical, multidisciplinary overview of the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques and agriculture. Edited by recognized experts, this book provides unique coverage of the wide-ranging uses and implications of fluorine and fluorinated compounds. Topics include medicinal monitoring and diagnosis, 19F MRI in medicine and in vivo cell tracking, 18F-labeled radiopharmaceuticals... brain imaging and neurology, risk assessment of reactive metabolites in drug discovery, and more. Edited by Alain Tressaud, past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry who bring valuable and varied content to this active field.

    • Design of Hybrid Molecules for Drug Development

      • 1st Edition
      • April 5, 2017
      • Michael Decker
      • English
      • Paperback
        9 7 8 0 0 8 1 0 1 0 1 1 2
      • eBook
        9 7 8 0 0 8 1 0 1 1 1 8 8
      Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.

    • Validamycin and Its Derivatives

      • 1st Edition
      • March 31, 2017
      • Xiaolong Chen + 3 more
      • English
      • Paperback
        9 7 8 0 0 8 1 0 0 9 9 9 4
      • eBook
        9 7 8 0 0 8 1 0 1 1 1 3 3
      Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.

    • Synthesis of Best-Seller Drugs

      • 1st Edition
      • January 7, 2016
      • Ruben Vardanyan + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 4 1 1 4 9 2 0
      • eBook
        9 7 8 0 1 2 4 1 1 5 2 4 8
      Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field.

    • Chinmedomics

      • 1st Edition
      • July 15, 2015
      • Xijun Wang + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 3 1 1 7 9
      • eBook
        9 7 8 0 1 2 8 0 3 1 1 8 6
      Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future.