Synthesis of Best-Seller Drugs

1st Edition - January 7, 2016
Authors: Ruben Vardanyan, Victor Hruby
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 4 1 1 4 9 2 - 0
eBook ISBN:
9 7 8 - 0 - 1 2 - 4 1 1 5 2 4 - 8

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book… Read more

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Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type.

Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field.

Dedication
Preface
Chapter 1. General Anesthetics
- 1.1. Noninhalation Components for General Anesthesia
- 1.2. Inhalation Anesthetics
Chapter 2. Local Anesthetics
- 2.1. Aminoester Anesthetics
- 2.2. Aminoamide Anesthetics
Chapter 3. Analgesics
- 3.1. Nonsteroidal Antiinflammatory Drugs
- 3.2. Opioid Analgesics
- 3.3. Adjunctive Agents in the Management of Pain, or “Nonanalgesic” Pain Killers
Chapter 4. Soporific Agents (Hypnotics and Sedative Drugs)
- 4.1. Barbiturates
- 4.2. Histamine H1 Receptor Antagonists
- 4.3. Benzodiazepines
- 4.4. Z-Drugs
- 4.5. New Gaba Receptor Agonists
- 4.6. Melatonergic (MT1/MT2) Agonists
- 4.7. 5-HT Antagonists and Antagonists/Inverse Agonists
- 4.8. NK1-Receptor Antagonists
- 4.9. Orexin Receptor (OX1/OX2) Antagonists
- 4.10. Sodium Oxybate
Chapter 5. Anxiolytics (Tranquilizers)
- 5.1. Benzodiazepines
- 5.2. Anxiolytic Drugs Acting on Serotonin Receptors
- 5.3. Anxiolytic Drugs Acting on Adrenoreceptors
- 5.4. Anxiolytic Drugs Acting on Glutamate Receptors
- 5.5. Anxiolytic Compounds Acting on Other Receptors
Chapter 6. Antipsychotics
- 6.1. First-Generation Antipsychotics
- 6.2. Second-Generation Antipsychotics
- 6.3. Third-Generation Antipsychotics
Chapter 7. Antidepressants
- 7.1. Tricyclic Antidepressants
- 7.2. Monoamine Oxidase Inhibitors
- 7.3. Selective Serotonin Reuptake Inhibitors
- 7.4. Selective Norepinephrine (Noradrenaline) Reuptake Inhibitors
- 7.5. Dual Uptake Inhibitors (SSRI/SNRI)
- 7.6. Dual Uptake Inhibitors (SNRI/SDARI)
- 7.7. Triple Uptake Inhibitors (SSRI/SNRI/SDARI)
Chapter 8. Central Nervous System Stimulants
Chapter 9. Antiepileptic Drugs
Chapter 10. Antiparkinsonian Drugs
- 10.1. Levodopa (Levodopa–Carbidopa)
- 10.2. Dopamine Agonists
- 10.3. Anticholinergics
- 10.4. MAO Inhibitors
- 10.5. Catechol-O-Methyltransferase Inhibitors
- 10.6. Amantadine
- 10.7. New Drugs in Development for Parkinson Disease
Chapter 11. Adrenergic (Sympathomimetic) Drugs
- 11.1. α1-Receptor Activating Drugs
- 11.2. α2-Receptor Activating Drugs
- 11.3. β1-Receptor Activating Drugs
- 11.4. β2-Receptor Activating Drugs
- 11.5. Dopamine-Receptor Activating Drugs
- 11.6. Multiple Adrenoreceptor Activation
- 11.7. Dopamine-Receptor Agonist Bestseller Drugs
Chapter 12. Adrenoblockers
- 12.1. α Adrenoblockers
- 12.2. β Adrenoblockers
Chapter 13. Cholinomimetics
- 13.1. Direct-Acting Cholinomimetics
- 13.2. Cholinesterase Inhibitors (Indirect-Acting Cholinomimetics)
Chapter 14. Anticholinergic Drugs
- 14.1. Antinicotinic Agents (Neuromuscular Blocking Drugs)
- 14.2. Ganglionic Blockers
- 14.3. Antimuscarinic Agents
Chapter 15. Centrally Acting Skeletal Muscle Relaxants
Chapter 16. Antihistamine Drugs
- 16.1. H1 Antihistamines
- 16.2. H2 Antihistamines
- 16.3. H3 Antihistamines
- 16.4. H4 Antihistamines
Chapter 17. Cardiotonic Inotropic Drugs
- 17.1. Class I Cardiotonic Inotropic Agents (Drugs That Increase the Cyclic Adenosine Monophosphate Level)
- 17.2. Class II Cardiotonic Inotropic Agents (Drugs that Regulate ION Channels or Pumps in the Myocardial Cell Membrane)
- 17.3. Class III Cardiotonic Inotropic Agents (Drugs that Modulate Intracellular Calcium Regulation)
- 17.4. Class IV Drugs That Modulate Intracellular Calcium Regulation Agents (Drugs that Augment Contractility Through Various Mechanisms)
Chapter 18. Antiarrhythmic Drugs
- 18.1. Class I
- 18.2. Class II
- 18.3. Class III
- 18.4. Class IV
- 18.5. Class V
Chapter 19. Antianginal Drugs
- 19.1. Nitrates
- 19.2. Calcium-Channel Blockers
- 19.3. β-Adrenergic Blockers
- 19.4. Novel Antianginal Drugs
Chapter 20. Hypolipidemic and Antihyperlipidemic Drugs
- 20.1. Statins
- 20.2. Fibrates
- 20.3. Bile Acid Sequestrants
- 20.4. Ezetimibe–Vytorin
- 20.5. Niacin
- 20.6. Omega-3 Fatty Acids (Fish Oils)
- 20.7. New Agents for the Pharmacotherapy of Dyslipidemia
Chapter 21. Diuretics
- 21.1. Carbonic Anhydrase Inhibitors
- 21.2. Loop Diuretics (High-Ceiling Diuretics)
- 21.3. Diuretics Acting at the Distal Convoluted Tubule
- 21.4. Diuretics Acting at the Collecting Duct System
- 21.5. Osmotic Diuretics
- 21.6. Novel Diuretic Targets
Chapter 22. Antihypertensive Drugs
- 22.1. Diuretics
- 22.2. β Blockers
- 22.3. Calcium-Channel Blockers
- 22.4. Renin–Angiotensin System Blockers
- 22.5. Miscellaneous
Chapter 23. Drugs for Treating Respiratory System Diseases
- 23.1. Bronchodilators
- 23.2. Corticosteroids
- 23.3. Combination Agents
- 23.4. Mucoactive Drugs
- 23.5. Development of New Drugs for Chronic Obstructive Pulmonary Disease
Chapter 24. Antithrombotic Drugs (Anticoagulants, Antiplatelets, and Thrombolytics)
- 24.1. Anticoagulant Drugs
- 24.2. Antiplatelet Drugs
- 24.3. Fibrinolytic Drugs
Chapter 25. Thyroid and Antithyroid Drugs
- 25.1. Drugs for Treatment of Hyperthyroidism
- 25.2. Drugs for Treatment of Hypothyroidism
Chapter 26. Hyperglycemic and Hypoglycemic Drugs
- 26.1. Insulin and Insulin Preparations
- 26.2. Oral Antidiabetic Drugs
Chapter 27. Steroid Hormones
- 27.1. Glucocorticoids
- 27.2. Mineralocorticoids
- 27.3. Estrogens
- 27.4. Progestins
- 27.5. Androgens
Chapter 28. Antineoplastic Agents
- 28.1. Chemotherapeutic Agents
- 28.2. Targeted Cancer Therapy Agents
- 28.3. Immunotherapeutic Agents
- 28.4. Hormonal Anticancer Drugs
Chapter 29. Immunopharmacological Drugs
- 29.1. Immunosuppressants
- 29.2. Immunostimulants
Chapter 30. Antibiotics
- 30.1. β-Lactam Antibiotics—Penicillins, Cephalosporins, Carbapenems, Monobactams
- 30.2. Tetracyclines
- 30.3. Macrolide Antibiotics
- 30.4. Aminoglycosides
- 30.5. Peptide Antibiotics
- 30.6. Miscellaneous Antibiotics
Chapter 31. Antibacterial Drugs
- 31.1. Sulfonamides
- 31.2. Antimicrobial Quinolones
- 31.3. Antimicrobial Nitrofurans
Chapter 32. Antimicobacterial Drugs
- 32.1. Antituberculosis Drugs
- 32.2. Antileprosy Drugs
Chapter 33. Antifungal Drugs
- 33.1. Polyenes
- 33.2. Azoles
- 33.3. Echinocandins
- 33.4. Allylamines
- 33.5. Antimetabolites
- 33.6. Miscellaneous Antifungal Agents
Chapter 34. Antiviral Drugs
- 34.1. Direct Virus-Targeting Antiviral Drugs
- 34.2. Indirect virus-targeting antivirals
Chapter 35. Drugs for Treating Protozoan Infections
- 35.1. Antimalarials
- 35.2. Amebiasis
- 35.3. Leishmaniasis
- 35.4. Trypanosomiasis
- 35.5. Balantidiasis and Cystoisosporiasis
Chapter 36. Anthelmintics
- 36.1. Piperazines
- 36.2. Phenothiazines
- 36.3. Benzimidazoles
- 36.4. Imidazothiazoles
- 36.5. Tetrahydropyrimidines
- 36.6. Isoquinolines
- 36.7. Salicylanilides
- 36.8. Arylisothiocyanates
- 36.9. Amino Acetonitrile Derivatives
- 36.10. Spiroindoles
- 36.11. Macrocyclic Lactones
- 36.12. Melaminylthioarsenates
- 36.13. Peptides (Cyclooctadepsipeptide)
- 36.14. Quarternary/Tertiary Amines
- 36.15. Pyridines
- 36.16. Benzene-Sulphonamides
- 36.17. Halogenated Phenols
Chapter 37. Proton Pump Inhibitors
- Esomeprazole–Nexium
- Lansoprazole–Prevacid
- Dexlansoprazole–Kapidex, Dexilant
- Pantoprazole–Protonix
- Rabeprazole–Aciphex
Chapter 38. Drugs for Treatment of Erectile Dysfunction
- 38.1. Drugs for Intracavernosal Administration
- 38.2. Drugs for Nonintracavernosal Administration
- 38.3. PDE-5 Inhibitors
Drugs Index
Subject Index

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Synthesis of Best-Seller Drugs

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Ruben Vardanyan

Victor Hruby