Progress in Medicinal Chemistry
- 1st Edition, Volume 54 - February 2, 2015
- Latest edition
- Editors: G. Lawton, David R. Witty
- Language: English
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeut… Read more
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.
- Extended timely reviews of topics in medicinal chemistry
- Targets and technologies relevant to the discovery of tomorrow’s drugs
- Analyses of successful drug discovery programmes
Everyone interested in the strategy and practice of the preclinical phases of the creation of new medicines. Those wishing to understand the drivers of drug design or expand their knowledge of therapeutic target classes
Chapter One: Recent Advances in Cancer Therapeutics
- Abstract
- 1 Introduction
- 2 Chaperone Inhibitors
- 3 Kinase Inhibitors
- 4 HDAC Inhibitors
- 5 Inhibitors of Protein-Protein Interactions (PPIs)
Chapter Two: Fluorine in Medicinal Chemistry
- Abstract
- 1 Introduction
- 2 Survey of Fluorine Chemotypes in Marketed Drugs
- 3 Impact of Fluorine on Lipophilicity
- 4 Impact of Fluorine on pKa
- 5 Impact of Fluorine on Metabolism
- 6 Metabolism to Toxic Metabolites
- 7 Fluorine Interactions in Proteins
- 8 Conformational Influences of Fluorine
- 9 Marketed Drug Case Studies
- 10 Summary and Future Outlook
Chapter Three: A Perspective on the Next Generation of Antibacterial Agents Derived by Manipulation of Natural Products
- Abstract
- 1 Introduction
- 2 Glycopeptides
- 3 Tetracyclines
- 4 Aminoglycosides
- 5 Ketolides
- 6 Thiazolyl Peptides
- 7 Pleuromutilins
- 8 Polymyxins
- 9 Conclusion
Chapter Four: A New Era for Chagas Disease Drug Discovery?
- Abstract
- 1 Introduction
- 2 Benznidazole as Historic Anti-Chagasic Chemotherapy
- 3 CYP51 as a Drug Target for T. cruzi Growth Inhibition
- 4 Clinical Trials
- 5 Evolution of Screening Cascades
- 6 Compound Landscape for Chagas Disease Chemotherapies
- 7 Summary
Chapter Five: Imaging in Drug Development
- Abstract
- 1 Introduction
- 2 Magnetic Resonance Imaging
- 3 Nuclear Medicine Imaging
- 4 Summary and Future Prospects
- Edition: 1
- Latest edition
- Volume: 54
- Published: February 2, 2015
- Language: English
GL
G. Lawton
From 2003 to 2007 he was founding Research Director with Lectus Therapeutics building from start-up a drug discovery organisation; generating the team, facilities and project portfolio targeting the next generation of ion channel modulating medicines.
Since 2001 Geoff has provided scientific and strategic evaluation and advice on drug discovery as an independent consultant for a number small and medium sized biotech companies, CROs, VCs, academic groups and medical research charities.
Geoff serves on the Board of Antabio, a French biotech company developing tomorrow’s antibacterial drugs.
He is a founder of INMedD, a new medicines discovery social enterprise.
DW
David R. Witty
In 2010 David and several colleagues successfully raised $35M in venture funding to found Convergence Pharmaceuticals, a specialist ion channel company focused on the development of novel treatments for pain, based in Cambridge UK. David presently leads their discovery programme and manages scientific operations within the business.
David is chairman of the Fine Chemicals Group of the Society of Chemical Industry, with responsibility for the delivery of conferences, seminars and training courses for chemists throughout the UK and Europe, and advising parliamentary bodies on matters of relevance to the UK chemical industry.
Since 2008 David has been a STEM ambassador for SETPOINT, introducing school students at both primary and secondary level to the excitement and possibilities of pursuing scientific careers, through workshops, lectures and competitions.