Books in Organic synthesis

Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition

1st Edition
November 1, 2025
Claudio Trombini
English

Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach provides an exhaustive introduction to retrosynthetic analysis, based upon a strategic disconnection approach. It presents a sequence of prioritized disconnections of general structures, each characterized by either a specific functionalization pattern (such as 1,4-dicarbonyl compounds), or a structural motif like the presence of stereogenic centers, bicyclic frameworks, etc. The book provides numerous examples which follow each strategic disconnection of functional or structural motifs. The examples, coming from a careful selection of literature, are organized in the following hierarchical order: i) functional or structural pattern, ii) selected disconnection, iii) polar, radical, or concerted reaction pathway. Unravelling the chemistry behind each example offers excellent training for developing 3D visualization skills, refining critical reasoning in proposing alternative approaches to the synthetic choices found in the literature, and cultivating one’s own expertise. In addition to providing an overview through the analysis of various advancements made in organic synthesis over the last 50 years, each strategic disconnection is illustrated with several cases of varying complexity sourced from curated literature. Whilst numerous examples are provided, it is not necessary to examine them all; just a few can be sufficient at first glance to understand a synthetic strategy. Readers can then focus on the most interesting ones from their perspectives or those most akin to their own problems in their lab work. Each case comes with its original reference, enabling readers interested in delving into specific examples to easily find primary information. Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach is written primarily for graduate and postdoc students levels studying organic chemistry and organic synthesis, as well as researchers in industry involved in synthetic chemistry. The general disconnection schemes may also be useful to advanced undergraduate students with a solid foundation in general organic chemistry.

Comprehensive Organic Synthesis

3rd Edition
August 1, 2025
Paul Knochel + 1 more
English
Hardback
9 7 8 0 3 2 3 9 6 0 2 5 0
eBook
9 7 8 0 3 2 3 9 6 0 2 4 3

Comprehensive Organic Synthesis, Third Edition, Eleven Volume Set builds upon the highly respected previous editions, including the 2nd edition which won the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers. This new edition continues to draw together the common themes that underlie the many disparate areas of organic chemistry, supporting effective and efficient synthetic strategies. With around 200 advanced chapters, it offers a comprehensive overview of this important discipline, making it essential for both experienced practitioners and those new to organic synthesis.This fully revised and updated edition provides an authoritative overview of core concepts, serving as a valuable resource for synthetic chemists requiring essential facts in new areas and students completely new to the field. The work remains an invaluable source for anyone seeking information on solving synthetic problems, ensuring it continues to be an essential reference work for all in the field of organic chemistry.

Organic Syntheses Based on Name Reactions

4th Edition
March 17, 2025
Alfred Hassner + 2 more
English
eBook
9 7 8 0 0 8 1 0 2 9 6 2 6

Organic Syntheses Based on Named Reactions: A Practical Encyclopedic Guide to Over 800 Transformations, Fourth Edition is an indispensable reference companion for chemistry students and researchers. The book provides an overview of name reactions based on reaction types and products formed and presents schemes, procedures and references in a simple, one-page format that offers a brief, representative procedure for each name reaction. The book is illustrated with real synthetic examples from literature, with about 3,400 references to primary literature that direct users to additional information. Extensive indexes (name, reagent, reaction) and a very useful functional group transformation index help the reader fully navigate this extensive collection of important reactions.With its comprehensive coverage, superb organization and quality of presentation, this new edition belongs on the shelf of every organic chemist.

Synthesis of Epoxides

1st Edition
November 14, 2024
Navjeet Kaur
English
Paperback
9 7 8 0 4 4 3 3 1 6 0 0 5
eBook
9 7 8 0 4 4 3 3 1 6 0 1 2

Synthesis of Epoxides explores different techniques for making epoxides, both old and new, and delves into the growing field of heterocyclic chemistry. The book presents a variety of methods that will help readers figure out which one best suits their specific needs. Diazo compounds are important synthetic intermediates in organic synthesis, but because of their unpredictable, explosive nature and toxicity their unique reactivity has not been fully exploited and their use at large scale has been avoided. Readers, including students in chemistry, will learn about different methods and important information, allowing them to evaluate which method is most suitable in particular cases.The synthetic usefulness of diazo compounds cannot be overlooked despite their danger. Because of their ylide and 1,3-dipole nature, the diazo compounds have a unique reactivity. The diazo compounds can be utilized for various different conversions including S-ylide-assisted epoxidation, cyclopropanation, or aziridination reactions. This book describes the new and classic methods for the synthesis of epoxides and covers an important and rapidly growing branch of heterocyclic chemistry.

Organic Synthesis

5th Edition
August 13, 2024
Michael Smith
English
Paperback
9 7 8 0 4 4 3 1 5 8 6 7 4
eBook
9 7 8 0 4 4 3 1 5 8 6 8 1

**2025 Textbook and Academic Authors Association (TAA) Textbook Excellence "Texty" Award Winner**Organic Synthesis, Fifth Edition provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, providing them with critical working knowledge of basic reactions, stereochemistry, and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature.There have been advancements in organic reactions, particularly organometallic reactions, and there is a need to show how these advancements have influenced current organic synthesis. The goal is to revise and update the reaction examples taken from the synthesis literature from 2017 to 2023. The reactions illustrate those used most often in modern organic synthesis, but these new examples will show their current relevance. Where new approaches and reactions have been developed for organic synthesis, examples have been added as new material.

Visible Light-Driven Organic Synthesis

1st Edition
August 9, 2024
Goutam Brahmachari
English
Paperback
9 7 8 0 3 2 3 9 5 8 9 3 6
eBook
9 7 8 0 3 2 3 9 5 8 9 4 3

Visible Light-Driven Organic Synthesis covers the recent cutting-edge investigations in the field of visible light– driven organic synthesis in a single comprehensive volume. It provides information on rigorously selected reaction schemes and covers new reactions and new methods under visible light photocatalysis. It enlists more than 100 important synthetic strategies/methodologies with particular emphasis on useful reactions for organic synthesis under the mild reaction conditions reported in recent times involving carbon–carbon (C–C) and carbon–heteroatom bond–forming reactions, resulting in a wide spectrum of chemical compounds, providing an outstanding source of information concerning industrial applications.The chapters are classified based on various photocatalysts that have found direct applications in organic synthesis by carrying out different kinds of organic reactions. Each chapter is dedicated to a particular photocatalyst, and each selected reaction is dealt with in a compact manner through point-wise discussion under distinct subheadings covering the reaction type, reaction conditions, bond-forming information, reaction strategy involved, general reaction scheme, examples of representative entries with chemical structures and physical properties, a suggested plausible mechanism, critical views, and literature. In addition, visible light–mediated self-sensitized organic transformations that took place without any external photocatalysts have also been covered.This book is immensely helpful to chemistry students, teachers, researchers, academicians, and chemical/ agrochemical industry people to access the latest information and advances on visible light–driven organic synthesis developments.

Synthesis of Aziridines and Oxaziridines from Imines

1st Edition
January 13, 2024
Navjeet Kaur
English
Paperback
9 7 8 0 4 4 3 2 2 0 5 9 3
eBook
9 7 8 0 4 4 3 2 2 0 6 0 9

Synthesis of Aziridines and Oxaziridines from Imines describes both new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine.The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures.

Handbook of Organic Name Reactions

1st Edition
August 14, 2023
Dakeshwar Kumar Verma + 2 more
English
Paperback
9 7 8 0 3 2 3 9 5 9 4 8 3
eBook
9 7 8 0 3 2 3 9 5 9 4 7 6

Handbook of Organic Named Reactions: Reagents, Mechanisms and Applications discusses the reactions used in organic synthesis, showing the value and scope of these reactions and how they are used in the synthesis of organic molecules. Presenting an accounting of the traditional methods used, as well as the latest details on the advances made in synthetic chemistry research, the named reactions of carbonyl compounds, alcohols, amines, heterocyclic molecules, rearrangements and coupling reactions are all included. Explaining the established research and including detailed mechanism information, step-by-step descriptions, problems and the applications of named reactions in industry, this book also discusses emerging aspects. Additional sections cover present and future research directions, making it an invaluable resource for all those needing to familiarize themselves with the concepts and applications of designated reactions.

Oxetane Synthesis

1st Edition
March 22, 2023
Navjeet Kaur
English
Paperback
9 7 8 0 4 4 3 1 8 9 4 7 0
eBook
9 7 8 0 4 4 3 1 8 9 4 8 7

Oxetane Synthesis rings play an important role as versatile motifs both in the overall formation of natural products and in synthetic organic chemistry. Oxetanes are important motifs in pharmaceutical chemistry that can confer improved metabolic and physicochemical properties. These developments continue to enhance the use of oxetanes in medicinal chemistry. Thanks to the growing commercial accessibility of oxetane possessing building blocks, together with improved approaches for the formation, oxetanes are likely to be progressively utilized in medicinal chemistry programs. Oxetanes are becoming valuable as a result of their vast diversity of uses in medicinal chemistry and varying applications. Several procedures have been developed for the formation and ring-opening of oxetanes to give important compounds in agrochemical, medicinal and material sciences. Novel approaches have been developed for the synthesis of oxetanes. These methods depend on both established synthetic approaches and development of many novel approaches for the formation of oxetanes.

Nanoparticles in Green Organic Synthesis

1st Edition
February 23, 2023
Sabyasachi Bhunia + 4 more
English
Paperback
9 7 8 0 3 2 3 9 5 9 2 1 6
eBook
9 7 8 0 3 2 3 9 5 9 2 2 3

Nanoparticles in Green Organic Synthesis: Strategy towards Sustainability presents the fundamental and latest practical uses of metal nanoparticles (MNPs) in organic synthesis, as well as their promising multidimensional applications. The book examines the latest emerging research on MNP synthesis and their applications—from organic transformation to energy and the environment—allowing readers to critically analyze the role of different MNPs in seeking ideas for widespread application. The book covers the fundamentals while also providing a comprehensive account of MNPs and their modification for a variety of green platform-based derivatives, focusing on the multifunctional technological evolution. The book covers a wide range of applications in organic synthesis using a variety of transition-metal-based nanoparticles in both homo- and heterogeneous media. The text details the concept of catalyst design and recent developments in the preparation and characterization of nanomaterials, followed by several chapters on the design of catalysts for specific applications. This volume is a valuable resource for those working in green chemistry, sustainability, material science and engineering, nanotechnology, energy, and the environment.

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