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Elsevier

Books in Organic synthesis

  • Comprehensive Organic Synthesis

    • 3rd Edition
    • Paul Knochel + 1 more
    • English
    Comprehensive Organic Synthesis, Third Edition, Eleven Volume Set builds upon the highly respected previous editions, including the 2nd edition which won the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers. This new edition continues to draw together the common themes that underlie the many disparate areas of organic chemistry, supporting effective and efficient synthetic strategies. With around 200 advanced chapters, it offers a comprehensive overview of this important discipline, making it essential for both experienced practitioners and those new to organic synthesis.This fully revised and updated edition provides an authoritative overview of core concepts, serving as a valuable resource for synthetic chemists requiring essential facts in new areas and students completely new to the field. The work remains an invaluable source for anyone seeking information on solving synthetic problems, ensuring it continues to be an essential reference work for all in the field of organic chemistry.

  • Organic Syntheses Based on Name Reactions

    A Practical Encyclopedic Guide to Nearly 800 Transformations
    • 4th Edition
    • Alfred Hassner + 2 more
    • English
    Organic Syntheses Based on Name Reactions is an invaluable reference book for organic chemists in academia and industry. In continuation of Hassner and Namboothiri’s popular 3rd Edition, this new edition with full colored graphics covers nearly 800 reactions, with numerous chemo-, regio- and stereoselective reactions. A diligently prepared summary of important information for each entry allows a chemist to grasp and apply these seminal reactions in their studies and research work. A general scheme, a brief introduction and a representative reaction from the literature with mechanistic outline, a brief procedure, and selected literature references to assist further reading are included in each entry. Besides various indexes (name, reagent, reaction and functional group transformation), a unique overview (in alphabetic order and in terms of reaction category) enable readers to look through the vast repertoire of key organic reactions and an appendix enriched with general information that is extremely useful to students and organic chemistry practitioners are part of this book. Additionally, an online companion site offers preface to previous editions and extensive reference materials. This new edition is very special with its exhaustive coverage, excellent organization and high-quality presentation and is an indispensable resource for every organic chemist.

  • Basic to Modern Strategies of Synthetic Organic Chemistry

    • 1st Edition
    • Hyun-Joon Ha
    • English
    Basic to Modern Strategies of Synthetic Organic Chemistry offers fresh perspectives and interests to professionals engaged in organic synthesis in various fields. The book starts with sections for review and understanding of reactions and proceeds with more in-depth knowledge in organic synthesis, including examples of total synthesis. Sections provide a systematic learning of organic reactions, with a focus on the relatively simple yet somewhat complex approach to compound synthesis. Furthermore, this reference will serve as a useful resource for graduate students to enhance their understanding and review of organic chemistry and synthesis.It includes examples of total synthesis that helps pursuing further studies. Additionally, the book provides an introduction to environmental and economic considerations in synthesis, which has become an important issue in recent years, especially for those working in fine chemicals and the pharmaceutical industry. The book also introduces flow chemistry, along with an overview of the processes and equipment used.

  • Synthesis of Epoxides

    • 1st Edition
    • Navjeet Kaur
    • English
    Synthesis of Epoxides explores different techniques for making epoxides, both old and new, and delves into the growing field of heterocyclic chemistry. The book presents a variety of methods that will help readers figure out which one best suits their specific needs. Diazo compounds are important synthetic intermediates in organic synthesis, but because of their unpredictable, explosive nature and toxicity their unique reactivity has not been fully exploited and their use at large scale has been avoided. Readers, including students in chemistry, will learn about different methods and important information, allowing them to evaluate which method is most suitable in particular cases.The synthetic usefulness of diazo compounds cannot be overlooked despite their danger. Because of their ylide and 1,3-dipole nature, the diazo compounds have a unique reactivity. The diazo compounds can be utilized for various different conversions including S-ylide-assisted epoxidation, cyclopropanation, or aziridination reactions. This book describes the new and classic methods for the synthesis of epoxides and covers an important and rapidly growing branch of heterocyclic chemistry.

  • Visible Light-Driven Organic Synthesis

    • 1st Edition
    • Goutam Brahmachari
    • English
    Visible Light-Driven Organic Synthesis covers the recent cutting-edge investigations in the field of visible light– driven organic synthesis in a single comprehensive volume. It provides information on rigorously selected reaction schemes and covers new reactions and new methods under visible light photocatalysis. It enlists more than 100 important synthetic strategies/methodolo... with particular emphasis on useful reactions for organic synthesis under the mild reaction conditions reported in recent times involving carbon–carbon (C–C) and carbon–heteroatom bond–forming reactions, resulting in a wide spectrum of chemical compounds, providing an outstanding source of information concerning industrial applications.The chapters are classified based on various photocatalysts that have found direct applications in organic synthesis by carrying out different kinds of organic reactions. Each chapter is dedicated to a particular photocatalyst, and each selected reaction is dealt with in a compact manner through point-wise discussion under distinct subheadings covering the reaction type, reaction conditions, bond-forming information, reaction strategy involved, general reaction scheme, examples of representative entries with chemical structures and physical properties, a suggested plausible mechanism, critical views, and literature. In addition, visible light–mediated self-sensitized organic transformations that took place without any external photocatalysts have also been covered.This book is immensely helpful to chemistry students, teachers, researchers, academicians, and chemical/ agrochemical industry people to access the latest information and advances on visible light–driven organic synthesis developments.

  • Synthesis of Aziridines and Oxaziridines from Imines

    • 1st Edition
    • Navjeet Kaur
    • English
    Synthesis of Aziridines and Oxaziridines from Imines describes both new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine.The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures.

  • Handbook of Organic Name Reactions

    Reagents, Mechanism and Applications
    • 1st Edition
    • Dakeshwar Kumar Verma + 2 more
    • English
    Handbook of Organic Named Reactions: Reagents, Mechanisms and Applications discusses the reactions used in organic synthesis, showing the value and scope of these reactions and how they are used in the synthesis of organic molecules. Presenting an accounting of the traditional methods used, as well as the latest details on the advances made in synthetic chemistry research, the named reactions of carbonyl compounds, alcohols, amines, heterocyclic molecules, rearrangements and coupling reactions are all included. Explaining the established research and including detailed mechanism information, step-by-step descriptions, problems and the applications of named reactions in industry, this book also discusses emerging aspects. Additional sections cover present and future research directions, making it an invaluable resource for all those needing to familiarize themselves with the concepts and applications of designated reactions.

  • Oxetane Synthesis

    • 1st Edition
    • Navjeet Kaur
    • English
    Oxetane Synthesis rings play an important role as versatile motifs both in the overall formation of natural products and in synthetic organic chemistry. Oxetanes are important motifs in pharmaceutical chemistry that can confer improved metabolic and physicochemical properties. These developments continue to enhance the use of oxetanes in medicinal chemistry. Thanks to the growing commercial accessibility of oxetane possessing building blocks, together with improved approaches for the formation, oxetanes are likely to be progressively utilized in medicinal chemistry programs. Oxetanes are becoming valuable as a result of their vast diversity of uses in medicinal chemistry and varying applications. Several procedures have been developed for the formation and ring-opening of oxetanes to give important compounds in agrochemical, medicinal and material sciences. Novel approaches have been developed for the synthesis of oxetanes. These methods depend on both established synthetic approaches and development of many novel approaches for the formation of oxetanes.

  • Nanoparticles in Green Organic Synthesis

    Strategy towards Sustainability
    • 1st Edition
    • Sabyasachi Bhunia + 4 more
    • English
    Nanoparticles in Green Organic Synthesis: Strategy towards Sustainability presents the fundamental and latest practical uses of metal nanoparticles (MNPs) in organic synthesis, as well as their promising multidimensional applications. The book examines the latest emerging research on MNP synthesis and their applications—from organic transformation to energy and the environment—allowing readers to critically analyze the role of different MNPs in seeking ideas for widespread application. The book covers the fundamentals while also providing a comprehensive account of MNPs and their modification for a variety of green platform-based derivatives, focusing on the multifunctional technological evolution. The book covers a wide range of applications in organic synthesis using a variety of transition-metal-bas... nanoparticles in both homo- and heterogeneous media. The text details the concept of catalyst design and recent developments in the preparation and characterization of nanomaterials, followed by several chapters on the design of catalysts for specific applications. This volume is a valuable resource for those working in green chemistry, sustainability, material science and engineering, nanotechnology, energy, and the environment.

  • 5-Membered Heterocycle Synthesis Using Iodine

    • 1st Edition
    • Navjeet Kaur
    • English
    5-Membered Heterocycle Synthesis Using Iodine presents both old and new methods for the synthesis of various five-membered heterocycles using iodine, providing information for making specific compounds using particular reagents. Heterocyclic frameworks represent the main structural subunits of many biologically active compounds and natural products, and the ability of heterocycles to act both as reactive pharmacophores and biomimetics has greatly contributed to their unique value as traditional key elements of various drugs. Contemporary developments in process chemistry and discovery emphasize novel sustainable synthetic pathways as fast and ecologically acceptable alternatives to the traditional protocols. This book serves as a guide for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals to obtain easy access to synthetic protocols for different five-membered heterocycles using iodine.

  • Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles

    • 1st Edition
    • Navjeet Kaur
    • English
    Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles provides a useful guide to key approaches being explored in this area. The volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Drawing on the experience of its expert author, the book is a useful guide on the key approaches being explored in this area. Following a user-friendly structure based on specific six-membered heterocycle ring groups, this volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates.

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 14
    • Michael Harmata
    • English
    Strategies and Tactics in Organic Synthesis, Volume 14, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world.

  • The Wolff-Kishner Reduction and Related Reactions

    Discovery and Development
    • 1st Edition
    • David E. Lewis
    • English
    The Wolff-Kishner Reduction and Related Reactions: Discovery and Development offers a detailed discussion of this reaction, its discoverers, and its development since its discovery. Derivative name reactions—including the Wharton and Shapiro reactions—are also discussed. The book is illustrated with examples from literature and corresponding references to the primary literature to aid further reading. It provides a comprehensive review of the century of chemistry that allows the reader to follow the development of this important synthetic reaction. In addition, it provides biographical details on the chemists who discovered and developed the reaction, thus adding a human dimension to the discussion.

  • Strategies and Solutions to Advanced Organic Reaction Mechanisms

    A New Perspective on McKillop's Problems
    • 1st Edition
    • Andrei Hent + 1 more
    • English
    Strategies and Solutions to Advanced Organic Reaction Mechanisms: A New Perspective on McKillop's Problems builds upon Alexander (Sandy) McKillop’s popular text, Solutions to McKillop’s Advanced Problems in Organic Reaction Mechanisms, providing a unified methodological approach to dealing with problems of organic reaction mechanism. This unique book outlines the logic, experimental insight and problem-solving strategy approaches available when dealing with problems of organic reaction mechanism. These valuable methods emphasize a structured and widely applicable approach relevant for both students and experts in the field. By using the methods described, advanced students and researchers alike will be able to tackle problems in organic reaction mechanism, from the simple and straight forward to the advanced.

  • Phosphines as Reagents and Catalysts in Organic Synthesis

    • 1st Edition
    • Hongchao Guo + 1 more
    • English
    Phosphines as Reagents and Catalysts in Organic Synthesis provides comprehensive coverage of metal-free organic reactions with phosphines as reagents or catalysts, as well as their synthetic uses. The work begins with a historical overview of the use of phosphines in metal-free organic reactions, followed by details of their physical properties and the source and preparation methods for representative phosphines and chiral variants. The applications of phosphines as reagents and catalysts in organic synthesis are discussed, along with case studies organized according to reaction type. Researchers, graduate students and undergraduates working in organic synthesis will find this work an invaluable resource.These reactions include halogenation under Appel conditions, Wittig reaction, Staudinger reaction, Mitsunobu reaction, alcohol acylation and kinetic resolution, Rauhut-Currier reaction, Morita-Baylis-Hillma... reaction, conjugate addition, umpolung additions, annulation reactions, allylic substitution, allylic amination, and isomerization reactions. For each reaction an overview of the state-of-the-art is presented along with the reaction data, enantioselective version using chiral phosphine, and its application in the synthesis of biologically active compounds and total synthesis of natural products. The work concludes with a summary that highlights the most promising reactions for future development in this field of research.

  • Anionic Annulations in Organic Synthesis

    A Versatile and Prolific Class of Ring-Forming Reactions
    • 1st Edition
    • Dipakranjan Mal
    • English
    Anionic Annulations in Organic Synthesis: A Versatile and Prolific Class of Ring-Forming Reactions is a comprehensive review of the main annulations for the construction of cyclic structures and their use in the total synthesis of functional molecules. The book explores in detail the Hauser, Robinson, Sammes, and Myers annulations, all of which are beneficial to constructing substrates with complex molecular structures suitable for pharmaceutical purposes. This volume begins with an in-depth introduction on the history and perspectives of annulations. It then covers different categories of annulation in each chapter, examining their application to drug synthesis for a range of different medicinal compounds. Anionic Annulations in Organic Synthesis delivers a thorough analysis of the topic and provides the tools necessary to master anionic organic chemistry. It is a valuable resource for chemists, researchers, and students seeking a complete and detailed understanding of anionic annulations.

  • Fluorine

    A Paradoxical Element
    • 1st Edition
    • Volume 5
    • Alain Tressaud
    • English
    Fluorine: A Paradoxical Element, Volume Five, deals with the link between fluorine, humanity and the environment. It is divided into three main sections, including i) The history and developmental stages of fluorinated products, ii) Awareness of its importance in our environment, and iii) Recent contributions of fluoride products in medicine, pharmacy and our daily lives. Made engaging through interesting figures and accessible language, and written by a leading expert, Professor Tressaud, the book supports the work of scientists working in materials, toxicology and environmental science. It complements the author’s edited series, Progress in Fluorine Science, covering recent advances.

  • Advances in Transition-Metal Mediated Heterocyclic Synthesis

    • 1st Edition
    • Daniel Sole + 1 more
    • English
    Advances in Transition-Metal Mediated Heterocyclic Synthesis provides an overview of recent catalytic reactions involving transition metals to produce heterocyclic compounds. The book is organized according to the type of transformation used to achieve the synthesis of the heterocyclic systems (mainly aza- and oxa-heterocycles). As such, it covers recent applications on the synthesis of heterocycles, also describing the details of the novel transformations in a didactic manner to motivate readers in search of new catalytic processes. The editors have included state-of-the-art strategies, including transition-metal reactions involving unsaturated systems (reactions of allenes, new gold(I)-catalyzed reactions, and Prins reaction). Chapters highlight the versatility of organopalladium chemistry dealing with carbonylative transformations, C-H activation reactions, coupling processes, and the control of the ambiphilic character of organopalladium species. Finally, the book discusses new reactions leading to heterocycles based on C-H activation processes catalyzed by other metals (Rh, Ru, Co). Written by an outstanding team of authors who are leading experts in organometallic chemistry and organic synthesis, this book is a valuable resource not only for chemists mainly focused on synthesis, but also for those interested in reaction mechanisms involving transition metals.

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 13
    • Michael Harmata
    • English
    Strategies and Tactics in Organic Synthesis, Volume 13, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world.

  • Reactivity of P-H Group of Phosphorus Based Compounds

    • 1st Edition
    • Kolio D. Troev
    • English
    Reactivity of P-H Group of Phosphorus Based Compounds bridges the gap between inorganic and organic phosphorus compounds, providing a basis to explore the myriad possibilities for synthesis of novel low and high molecular phosphorus-containin... compounds. It covers well-documented reactions in detail, including: tautomerization, oxidation, reduction, alkylation, oxidation coupling, addition reaction to: carbon-carbon multiple bonds, Schiff base, isocyanates, nitriles, epoxides; addition to carbonyl group, Kabachnik- Fields reaction, cross-coupling reaction and more. In an accessible style complete with synthetic routes and figures, the resource then covers the reactivity of multiple P-H group members: phosphines, phosphine oxides, hypophosphorus acid, H-phosphinic acids and polys(alkylene H-phosphonate). This valuable coverage supports the advancement of research and applications in this area for scientists solving a scientific problem or starting a variety of new projects, such as a new reaction for the synthesis of biologically active compounds, new methods of polymer synthesis or a new methodology for polymer modification.

  • Strategies for Palladium-Catalyzed Non-directed and Directed C bond H Bond Functionalization

    • 1st Edition
    • Anant R. Kapdi + 1 more
    • English
    Strategies for Palladium-Catalyzed Non-directed and Directed C-H Bond Functionalization portrays the complete scope of these two aspects of C-H bond functionalization in a single volume for the first time. Featured topics include the influence of palladacyclic systems in C-H bond functionalization (need for newer catalytic systems for better efficiency), mechanistic aspect of the functionalization strategies leading to better systems, and applications of these methodologies to natural product synthesis and material synthesis.

  • Advances in Asymmetric Autocatalysis and Related Topics

    • 1st Edition
    • Gyula Palyi + 2 more
    • English
    Advances in Asymmetric Autocatalysis and Related Topics provides various viewpoints on the important developments in asymmetric autocatalysis that have occurred in the past few years, also including brand new information in the field. Asymmetric autocatalysis is a chemical reaction which leads from achiral starting materials to chiral products, and in which the product accelerates its own formation reaction (conventional catalysis) and promotes the prevalence of its own chiral configuration (asymmetric induction). The combination of these two effects in the same reaction was unprecedented before 1995 when it was first described by Kenso SOAI at the Tokyo University of Science. Since then, several new combinations of this effect have been found, most intriguingly the possibility of absolute asymmetric synthesis, which is the spontaneous formation of the excess of one of the enantiomers of the product, a dream of organic chemists for more than a century. The book contains expert-contributed chapters that describe the most exciting recent developments in the field of the Soai reaction and in related topics, ranging from mechanistic studies and theoretical research, to very practical problems in chiral syntheses and products.

  • Validamycin and Its Derivatives

    Discovery, Chemical Synthesis, and Biological Activity
    • 1st Edition
    • Xiaolong Chen + 3 more
    • English
    Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.

  • Transition Metal-Catalyzed Benzofuran Synthesis

    Transition Metal-Catalyzed Heterocycle Synthesis Series
    • 1st Edition
    • Xiao-Feng Wu + 1 more
    • English
    Transition Metal-Catalyzed Benzofuran Synthesis: Transition Metal-Catalyzed Heterocycle Synthesis Series provides an overview of benzofuran, describing properties of these heterocycle compounds and the traditional synthetic procedures used for them. The book then explores catalyzed procedures for benzofuran synthesis in greater detail and depth than is currently available in published review articles. This volume is part of the short series authored by Xiao-Feng Wu that summarizes recent achievements on heterocycle synthesis with transition metals as catalysts, with each volume dedicated to one heterocycle compound.

  • Organic Synthesis

    • 4th Edition
    • Michael Smith
    • English
    Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching.

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 12
    • English
    Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done. Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world.

  • Studies in Natural Products Chemistry

    Bioactive Natural Products (Part XIII)
    • 1st Edition
    • Volume 50
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry: Bioactive Natural Products (Part XIII) is the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.

  • Handbook of Synthetic Organic Chemistry

    • 2nd Edition
    • Michael C. Pirrung
    • English
    Handbook of Synthetic Organic Chemistry, Second Edition updates and expands the author’s popular 2007 work, Synthetic Organic Chemist’s Companion. This new handbook provides valuable, practical guidance; incorporates corrections, and includes coverage on important topics, such as lyophylization, crystallization, precipitation, HPLC detectors, gases, and microwave reactions. The book maintains the useful organization of the author’s earlier work, beginning with a basic overview and walking through every practical step of the process of organic synthesis, from reagents, solvents, and temperature control, to documentation, implementation, purification, and analytical methods for the product. From planning and setting up reactions, to recording them, the book provides insight and valuable guidance into every step of the process.

  • Studies in Natural Products Chemistry

    Bioactive Natural Products (Part XI)
    • 1st Edition
    • Volume 48
    • English
    Studies in Natural Products Chemistry, Volume 48, provides the latest on the use of natural products from the plant and animal kingdom and the ways in which they can offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development. The series covers all aspects of the science, along with the synthesis, testing, and recording of the medicinal properties of natural products. With articles written by leading authorities in their respective fields of research, the book presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable resource for all those working in natural product and medicinal chemistry.

  • Mechanochemical Organic Synthesis

    • 1st Edition
    • Davor Margetic + 1 more
    • English
    Mechanochemical Organic Synthesis is a comprehensive reference that not only synthesizes the current literature but also offers practical protocols that industrial and academic scientists can immediately put to use in their daily work. Increasing interest in green chemistry has led to the development of numerous environmentally-frie... methodologies for the synthesis of organic molecules of interest. Amongst the green methodologies drawing attention, mechanochemistry is emerging as a promising method to circumvent the use of toxic solvents and reagents as well as to increase energy efficiency. The development of synthetic strategies that require less, or the minimal, amount of energy to carry out a specific reaction with optimum productivity is of vital importance for large-scale industrial production. Experimental procedures at room temperature are the mildest reaction conditions (essentially required for many temperature-sensitiv... organic substrates as a key step in multi-step sequence reactions) and are the core of mechanochemical organic synthesis. This green synthetic method is now emerging in a very progressive manner and until now, there is no book that reviews the recent developments in this area.

  • The Alkaloids

    • 1st Edition
    • Volume 76
    • English
    The Alkaloids, a series that has covered the topic for more than 60 years, is the leading book series in the field of alkaloid chemistry. In more than 70 volumes, all aspects of alkaloids, including chemistry, biology and pharmacology, are covered in high-quality, timeless reviews written by renowned experts in the field.

  • Organic Synthesis Using Biocatalysis

    • 1st Edition
    • Animesh Goswami + 1 more
    • English
    Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules.

  • Hybrid Retrosynthesis

    Organic Synthesis using Reaxys and SciFinder
    • 1st Edition
    • Michael B. Smith + 1 more
    • English
    Designed to supplement existing organic textbooks, Hybrid Retrosynthesis presents a relatively simple approach to solving synthesis problems, using a small library of basic reactions along with the computer searching capabilities of Reaxys and SciFinder. This clear, concise guide reviews the essential skills needed for organic synthesis and retrosynthesis, expanding reader knowledge of the foundational principles of these techniques, whilst supporting their use via practical methodologies. Perfect for both graduate and post-graduate students, Hybrid Retrosynthesis provides new applied skills and tools to help during their organic synthesis courses and future careers, whilst simultaneously acting as useful resource for those setting tutorial and group problems, and as a helpful go-to guide for organic chemists involved in either industry or academia.

  • Room Temperature Organic Synthesis

    • 1st Edition
    • Goutam Brahmachari
    • English
    Filling a gap in the scientific literature, Room Temperature Organic Synthesis is unique in its authoritative, thorough, and applied coverage of a wide variety of "green" organic synthetic methodologies. The book describes practical, feasible protocols for room temperature reactions to produce carbon-carbon and carbon-heteroatom bond formations including aliphatic, aromatic, alicyclic, heterocycles, and more. Consistently organized for easy access, each selected reaction is discussed in a very compact and structured manner including: reaction type, reaction condition, reaction strategy, catalyst, keywords, general reaction scheme, mechanism (in selected cases), representative entries, experimental procedure, characterization data of representative entries, and references. This book will be a valuable resource for synthetic organic, natural products, medicinal, and biochemists as well as those working in the pharmaceutical and agrochemical industry.

  • Organofluorine Compounds in Biology and Medicine

    • 1st Edition
    • V Prakash Reddy
    • English
    Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area.

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 10
    • Michael Harmata
    • English
    A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done, and we are educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

  • Writing Reaction Mechanisms in Organic Chemistry

    • 3rd Edition
    • Kenneth A. Savin
    • English
    Writing Reaction Mechanisms in Organic Chemistry, Third Edition, is a guide to understanding the movements of atoms and electrons in the reactions of organic molecules. Expanding on the successful book by Miller and Solomon, this new edition further enhances your understanding of reaction mechanisms in organic chemistry and shows that writing mechanisms is a practical method of applying knowledge of previously encountered reactions and reaction conditions to new reactions. The book has been extensively revised with new material including a completely new chapter on oxidation and reduction reactions including stereochemical reactions. It is also now illustrated with hundreds of colorful chemical structures to help you understand reaction processes more easily. The book also features new and extended problem sets and answers to help you understand the general principles and how to apply these to real applications. In addition, there are new information boxes throughout the text to provide useful background to reactions and the people behind the discovery of a reaction. This new edition will be of interest to students and research chemists who want to learn how to organize what may seem an overwhelming quantity of information into a set of simple general principles and guidelines for determining and describing organic reaction mechanisms.

  • Synthesis of Optically Active Alpha-Amino Acids

    • 1st Edition
    • Volume 7
    • R. M. Williams
    • Patrick Perlmutter
    • English
    The purpose of this book is to review and critically evaluate the best new methods to synthesize alpha-amino acids in optically active form. There is so much new literature on amino acid synthesis that the experimentalist will undoubtedly have difficulty in selecting the most appropriate methodology for constructing the amino acid of immediate interest. This book is a guide for steering the scientist through the maze of existing reports on the subject and contains the most up-to-date critical reviews of methods of asymmetric synthesis of amino acids. In areas that are relatively new conceptually and less studied experimentally, an effort has been made to review the most salient works with an eye towards future development. Over 330 schemes and figures are presented with references for rapid visual retrieval of information. The book will be of great value to academic and industrial organic research chemists, especially those concerned with medicinal and agricultural chemistry, as well as to graduate and post graduate students, biochemists and biologists.

  • Conjugate Addition Reactions in Organic Synthesis

    • 1st Edition
    • Volume 9
    • P. Perlmutter
    • Patrick Perlmutter
    • English
    This book provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organised in terms of the major classes of conjugate acceptors. Within each of these classes, the chemistry and applications of conjugate additions with several different categories of nucleophiles have been examined. Where several different nucleophiles achieve the same synthetic transformation, they are cross-referenced within the book and qualitative comparisons offered where appropriate. Examples of the use of conjugate additions in total synthesis of important molecules are included, with a special emphasis throughout the book on stereoselectivity. This will be a useful main text for graduate and postgraduate courses on conjugate addition reactions or the Michael reaction. It could also serve as a supplementary text for courses on topics such as the chemistry of organocopper reagents, enamines and carbanion chemistry.

  • Annual Reports in Organic Synthesis 1992

    1992
    • 1st Edition
    • Volume 1992
    • Philip M. Weintraub
    • English
    The Journal of the American Chemical Society has aptly described this publication as an "aid to the harassed organic chemist who cannot keep up with the never-diminishing stream of new primary literature" and hails it "an outstandingly good buy."

  • Sulfur Reagents in Organic Synthesis

    • 1st Edition
    • Patrick Metzner + 1 more
    • A. R. Katritzky
    • English
    Designed for the practising organic chemist, this book details over a hundred experimental procedures using sulfer compounds in organic synthesis. Many of these methods are new to the literature, having been published since 1991, and illustrate the striking versatility of the use of sulfur reagents. Examples are simple to perform and extremely useful, and as such this book will be an invaluable aid to all involved in synthetic organic chemistry, whether in academic or industrial laboratories.

  • Selenium Reagents & Intermediates in Organic Synthesis

    • 1st Edition
    • Volume 4
    • C. Paulmier
    • Patrick Perlmutter
    • English
    The explosive growth of organoselenium chemistry over the past 12 years can be attributed to the specific properties of organic selenium molecules, which fit the requirements of modern organic synthesis. Most of them are well adapted to chemo-, regio- and stereo-selectivities... In addition, they can be used in mild experimental conditions which are compatible with the stability of both substrates and products in the preparation of unsaturated and functional complex molecules, especially in the field of natural products. This book describes and illustrates different synthetic routes to organic structures using selenium reagents or intermediates. The approach emphasizes that such transformations are simple, efficient and often carried out at room temperature. The scope ranges from the preparation of both inorganic and organic selenium reagents, through descriptions of structure, toxicity, biological aspects and nuclear magnetic resonance, to applications of specific selenium compounds in various syntheses including natural products and biologically active compounds.

  • Chemistry and Analysis of Hop and Beer Bitter Acids

    • 1st Edition
    • Volume 27
    • M. Verzele + 1 more
    • English
    Largely based on laboratory work, the volume opens with a review on hops in general, while the bulk of the book covers the chemistry of the bitter acids of hop and beer. Practical, fully detailed procedures on the preparation and/or the separation of many of the compounds discussed are included. There is a chapter included on the complicated issue of bitter acid analysis, and several on the high-efficiency liquid chromatography of hop bitter acids.Bearing in mind the lack of literature produced recently in this field, the book is an excellent review of the present state of knowledge, and gives a large list of topics pointing to worthwhile studies for the future. The indexes provided will serve as a reference library-dictionary to hops, hop and beer bitter acids chemistry and analysis.

  • Organic Syntheses Based on Name Reactions and Unnamed Reactions

    • 1st Edition
    • Volume 11
    • Alfred Hassner + 1 more
    • Patrick Perlmutter
    • English
    Synthetically useful organic reactions or reagents are often referred to by the name of the discoverer(s) or developer(s). Older name reactions are described in text books, but more recently developed synthetically useful reactions that may have been associated occasionally with a name are not always well known. For neither of the above are experimental procedures or references easy to find.In this monograph approximately 500 name reactions are included, of which over 200 represent newer name reactions and modern reagents. Each of these reactions are extremely useful for the contemporary organic chemistry researcher in industry or academic institutions. This book provides the information in an easily accessible form.In addition to seminal references and reviews, one or more examples for each name reaction are provided and a complete typical experimental procedure is included, to enable the student or researcher to immediately evaluate reaction conditions.Besides an alphabetical listing of reactions and reagents, cross references permit the organic practitioner to find those name reactions or reagents that enable specific transformations, such as, conversion of amines to nitriles, stereoselective reduction, fluoroalkylation, phenol alkynylation, asymmetric syntheses, allylic alkylation, nucleoside synthesis, cyclopentanation, hydrozirconation, to name a few. Emphasis has been placed on stereoselective and regioselective transformations as well as on enantioselective processes. The listing of reactions and reagents is supported by four indexes.

  • Sulphones in Organic Synthesis

    • 1st Edition
    • Volume 10
    • N S. Simpkins
    • Patrick Perlmutter
    • English
    Over the last twenty years the use of sulphones in organic synthesis has increased dramatically, the synthetic repertoire of sulphones having been developed to such an extent as to rival the carbonyl functionality for versatility. Not only have sulphones been employed in a great many synthetic methodologies, enabling the preparation of a vast array of functionalised products, but the sulphone group has also proved to be of enormous value in many of the most demanding and sophisticated total syntheses carried out in recent years. This book describes in detail all of the important sulphone chemistry employed in organic synthesis, ranging from the well-established sulphone-mediated methods to less familiar sulphone reactions and very recent discoveries of synthetic potential.

  • Nitration of Hydrocarbons and Other Organic Compounds

    • 1st Edition
    • A. V. Topchiev
    • English
    Nitration of Hydrocarbons and Other Organic Compounds tackles various concerns in the process of substituting hydrogen atoms in the aromatic or heterocyclic nucleus, or in saturated hydrocarbon, by nitro groups. The title first covers the nitration of aromatic and heterocyclic compounds with nitric acid and nitrating mixture, and then proceeds to discussing the mechanism of the nitration of aromatic compounds with nitric acid and nitrating mixture. Next, the selection deals with the nitration of saturated, aromatic-aliphatic and unsaturated hydrocarbons with nitric acid. The text also talks about the nitration with nitrogen oxides, along with the nitration of amines. The last chapter details the nitration of organic compounds with organic and inorganic nitrates and nitroxyl. The book will be of great interest to students, researchers, and practitioners of organic chemistry.

  • Advances in the Use of Synthons in Organic Chemistry

    A Research Annual
    • 1st Edition
    • Alessandro Dondoni
    • English
    Advances in the Use of Synthons in Organic Chemistry: A Research Annual, Volume 1 provides information pertinent to a useful reagent that can perform a certain chemical operation that is otherwise impossible or difficult to carry out. This book presents the developments on established synthons. Organized into four chapters, this volume begins with an overview of the significant role of the formyl group in synthetic methodologies, which has stimulated the search for other reagents. This text then describes trimethysilyldiazome... as a stable and safe substitute for hazardous diazomethane. Other chapters consider the usefulness of trimethysilyldiazome... in organic syntheses. This book discusses as well that malonic amides, silylenol ethers, malonic esters, and tetra-donor-substitu... allenes serve as synthetic equivalents for the dianions of malonic esters, ketones, and malonic amides. The final chapter deals with the synthesis of biologically-active compounds, which has been one of the major challenges for organic chemists. This book is a valuable resource for practicing synthetic chemists.

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 9
    • Michael Harmata
    • English
    A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done, and we are educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

  • Pyridines: From Lab to Production

    • 1st Edition
    • Eric F.V. Scriven
    • English
    Pyridines: From Lab to Production provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more.

  • Advanced Organic Synthesis

    Methods and Techniques
    • 1st Edition
    • Richard Monson
    • English
    Advanced Organic Synthesis: Methods and Techniques presents a survey and systematic introduction to the modern techniques of organic synthesis. The book attempts to acquaint the reader with a variety of laboratory techniques as well as introduce chemical reagents that require deftness and care in handling. Chapters are devoted that discuss the techniques of organic synthesis; apparatus and terminology used in the description of synthetic procedures; the scope and mechanism of chemical reactions; and technical procedures on how to perform chemical experiments. The text will be of vital importance to advanced undergraduate student or beginning graduate student of chemistry.