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Comprehensive Organic Synthesis
- 3rd Edition - August 1, 2025
- Editors: Paul Knochel, Gary A Molander
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 6 0 2 5 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 6 0 2 4 - 3
Comprehensive Organic Synthesis, Third Edition, Eleven Volume Set will build upon the highly respected previous editions - the 2nd edition won the 2015 PROSE Award for Multivolu… Read more
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Request a sales quoteComprehensive Organic Synthesis, Third Edition, Eleven Volume Set will build upon the highly respected previous editions - the 2nd edition won the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers - in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline.
Fully revised and updated, comprising of around 200 advanced chapters, this new edition will continue to constitute an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Third Edition an invaluable source, providing an authoritative overview of core concepts
- A completely revised and expanded new edition of the renowned Comprehensive Organic Synthesis (winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers) which once again authoritatively and comprehensively covers this ever-growing field in more than 9,000 pages across 11 volumes
- Around 200 advanced chapters, each written by distinguished chemists from across the globe each offering an in-depth and detailed analysis of core topics such as bonds, oxidation, and reduction as well as new important growing areas such as: asymmetric synthesis, photocatalysis, electrochemistry, and many more
- Includes more than 10,000 schemes and images
- Chapters follow a consistent structure and feature elements such as key objective boxes, summaries, figures, references, cross-references etc. which not only help learning and research but can also be used as teaching aids
Advanced undergraduate and graduate chemistry students, as well as researchers both from academia and industry in the organic chemistry domain. The work will also be of interest for institutions and companies researching pharmaceuticals, medicine, agrochemicals, electronics and materials (polymers)
1. Additions to C–X π-Bonds: comprehensive coverage of reactions involving carbon-bond formation with various substituents
2. Carbon–Carbon Bond Formation: fundamental methods for forming carbon-carbon bonds, essential for synthetic organic chemistry
3. Heteroatom Manipulation: techniques for introducing and modifying heteroatoms in organic molecules
4. Oxidation: various methodologies for oxidizing organic compounds, a cornerstone of synthetic transformations
5. Reduction: detailed approaches for reducing functional groups, providing essential strategies for chemists
6. Asymmetric Synthesis: methods for producing enantiomerically enriched compounds, increasingly important in pharmaceuticals
7. Photocatalysis: utilization of light to drive chemical reactions, highlighting innovative and sustainable synthetic strategies
8. Electrochemistry: emerging techniques for organic synthesis using electrochemical methods, signifying advancements in green chemistry
New Areas of Coverage in the 3rd Edition:
1. C-H Activation: new strategies for activating C-H bonds, enabling direct functionalization of hydrocarbons
2. Flow Chemistry: Innovative techniques for continuous flow synthesis, enhancing efficiency and scalability in organic synthesis
3. Dual Catalysis: recent developments in using two catalysts simultaneously for complex transformations
4. Biosynthesis: exploration of natural product synthesis through biological pathways, bridging organic chemistry and biochemistry
5. Catalytic Oxidation: Advanced methodologies for oxidation processes using modern catalytic systems
6. Photocatalysis: expanded focus on light-driven reactions, reflecting growing interest in sustainable and energy-efficient methods
7. Metal Catalysis: new approaches involving transition metals in catalysis, emphasizing their role in modern synthetic strategies
8. Asymmetric Synthesis: enhanced coverage of methods to achieve enantioselectivity in synthetic routes
2. Carbon–Carbon Bond Formation: fundamental methods for forming carbon-carbon bonds, essential for synthetic organic chemistry
3. Heteroatom Manipulation: techniques for introducing and modifying heteroatoms in organic molecules
4. Oxidation: various methodologies for oxidizing organic compounds, a cornerstone of synthetic transformations
5. Reduction: detailed approaches for reducing functional groups, providing essential strategies for chemists
6. Asymmetric Synthesis: methods for producing enantiomerically enriched compounds, increasingly important in pharmaceuticals
7. Photocatalysis: utilization of light to drive chemical reactions, highlighting innovative and sustainable synthetic strategies
8. Electrochemistry: emerging techniques for organic synthesis using electrochemical methods, signifying advancements in green chemistry
New Areas of Coverage in the 3rd Edition:
1. C-H Activation: new strategies for activating C-H bonds, enabling direct functionalization of hydrocarbons
2. Flow Chemistry: Innovative techniques for continuous flow synthesis, enhancing efficiency and scalability in organic synthesis
3. Dual Catalysis: recent developments in using two catalysts simultaneously for complex transformations
4. Biosynthesis: exploration of natural product synthesis through biological pathways, bridging organic chemistry and biochemistry
5. Catalytic Oxidation: Advanced methodologies for oxidation processes using modern catalytic systems
6. Photocatalysis: expanded focus on light-driven reactions, reflecting growing interest in sustainable and energy-efficient methods
7. Metal Catalysis: new approaches involving transition metals in catalysis, emphasizing their role in modern synthetic strategies
8. Asymmetric Synthesis: enhanced coverage of methods to achieve enantioselectivity in synthetic routes
- No. of pages: 9500
- Language: English
- Edition: 3
- Published: August 1, 2025
- Imprint: Elsevier
- Hardback ISBN: 9780323960250
- eBook ISBN: 9780323960243
PK
Paul Knochel
Paul Knochel works at Ludwig-Maximilians-Universitat, Munich, Germany.
Affiliations and expertise
Ludwig-Maximilians-Universitat, Munich, GermanyGM
Gary A Molander
Professor Gary A Molander works in the Department of Chemistry at University of Pennsylvania, USA.
Affiliations and expertise
Professor, Department of Chemistry, University of Pennsylvania, USA