Synthesis of Aziridines and Oxaziridines from Imines
- 1st Edition - January 13, 2024
- Imprint: Elsevier
- Author: Navjeet Kaur
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 2 0 5 9 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 2 0 6 0 - 9
Synthesis of Aziridines and Oxaziridines from Imines describes both new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing b… Read more
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Synthesis of Aziridines and Oxaziridines from Imines describes both new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine.
The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures.
- Focuses on the biological importance of different heterocycles
- Describes traditional and innovative methods for the synthesis of aziridines from imines
- Includes comparison amongst different methods, reagents, reaction conditions in tabulated forms, advantages, disadvantages, and critical analysis of different methodologies with respect to their comparison with green technique
Postgraduate students and researchers in Organic, Synthetic and Medicinal Chemistry Chemists working in industry
Chapter-1: Aziridine synthesis from imines-I
1.1 Introduction
1.2 Synthesis of aziridines from imines
1.3 Synthesis of aziridines from two imines
References
Chapter-2: Aziridine synthesis from imines-II
2.1 Introduction
2.2 Synthesis of aziridines from imines and carbonyl compounds
2.3 Synthesis of aziridines from imines and halomethane compounds
2.4 Synthesis of aziridines from imines and sulfur-containing compounds
References
Chapter-3: Aziridine synthesis by condensation of phenylimines with ethyl diazoacetate
3.1 Introduction
3.2 Synthesis of aziridines from phenylimines and ethyl diazoacetate
3.3 Synthesis of aziridines from phenylimines and ethyl diazoacetate using boron trifluoride
3.4 Synthesis of aziridines from phenylimines and ethyl diazoacetate using imidazolium ionic liquids
3.5 Synthesis of aziridines from phenylimines and ethyl diazoacetate using pyridinium salts
3.6 Synthesis of aziridines from phenylimines and ethyl diazoacetate using VAPOL or VANOL
References
Chapter-4: Aziridine synthesis by metal-catalyzed condensation of phenylimines with ethyl diazoacetate
4.1 Introduction
4.2 Metal-catalyzed synthesis of aziridines from phenylimines and ethyl diazoacetate
4.3 Copper-catalyzed synthesis of aziridines from phenylimines and ethyl diazoacetate
4.4 Iron-catalyzed synthesis of aziridines from phenylimines and ethyl diazoacetate
References
Chapter-5: Aziridine synthesis by addition of biphenyl imines to ethyl diazoacetate
5.1 Introduction
5.2 Synthesis of aziridines from biphenyl imines and ethyl diazoacetate
5.3 Synthesis of aziridines from biphenyl imines and ethyl diazoacetate using vaulted chiral ligands binaphthol (VANOL) and biphenanthrol (VAPOL)
References
Chapter-6: Aziridine synthesis by metal-catalyzed addition of biphenyl imines to ethyl diazoacetate
6.1 Introduction
6.2 Metal-catalyzed synthesis of aziridines from biphenyl imines and ethyl diazoacetate
6.3 Ruthenium-catalyzed synthesis of aziridines from biphenyl imines and ethyl diazoacetate
References
Chapter-7: Aziridine synthesis by condensation of imines with diazo compounds
7.1 Introduction
7.2 Synthesis of aziridines from diazoimines
7.3 Synthesis of aziridines from imines and diazo compounds
7.4 Synthesis of aziridines from imines and diazoacetamides
7.5 Synthesis of aziridines from imines and t-butyl diazoacetates
References
Chapter-8: Aziridine synthesis by condensation of imines with diazomethane
8.1 Introduction
8.2 Synthesis of aziridines from imines and diazomethane
8.3 Synthesis of aziridines from imines and trimethylsilyldiazomethane
8.4 Synthesis of aziridines from imines and phenyldiazomethane
References
Chapter-9: Aziridine synthesis by ring-closure of haloimines
9.1 Introduction
9.2 Synthesis of aziridines from haloimines
References
Chapter-10: Aziridine synthesis by ring-closure of imines and halo compounds
10.1 Introduction
10.2 Synthesis of aziridines from imines and halo compounds
References
Chapter-11: Aziridine synthesis by alkene-imine and alkyne-imine reactions
11.1 Introduction
11.2 Synthesis of aziridines from alkenes and imines
11.3 Synthesis of aziridines from alkynes and imines
References
Chapter-12: Oxaziridine synthesis from imines
12.1 Introduction
12.2 Synthesis of oxaziridines from imines
12.3 Synthesis of oxaziridines from imines using hydrogen peroxide
12.4 Synthesis of oxaziridines from imines using Oxone
12.5 Synthesis of oxaziridines from imines using peroxy acids
References
Chapter-13: Oxaziridine synthesis from imines using m-CPBA
13.1 Introduction
13.2 Synthesis of oxaziridines from imines using m-chloroperoxybenzoic acid
References
- Edition: 1
- Published: January 13, 2024
- Imprint: Elsevier
- Language: English
NK
Navjeet Kaur
Dr. Navjeet Kaur received her BSc from Panjab University Chandigarh (Panjab, India) in 2008. In 2010, she completed her MSc in Chemistry from Banasthali Vidyapith. She was awarded with PhD in 2014 by the same university. With 11 years of teaching experience, she has published over 160 scientific research papers, review articles, book chapters, and monographs in the field of organic synthesis in national and international reputed journals. She has published five authored books: with Elsevier. She secured her place amongst top 2% scientists of the world in 2017 (single year ranking), 2018 (full career wise ranking), 2019 [full career wise ranking with 424 world rank (04 in India) and single year ranking with 03 world rank (01 in India)] and 2020 (full career wise ranking with 372 world rank and single year ranking with 126 world rank). In 2021, Dr. Kaur was chosen as a candidate for membership by Royal Society of Research, London, England, UK with full waiver of application fees. She is serving as an Editor-in-Chief of the “Advanced Chemicobiology Research” journal.
Affiliations and expertise
Lovely Professional University, IndiaRead Synthesis of Aziridines and Oxaziridines from Imines on ScienceDirect