Basic to Modern Strategies of Synthetic Organic Chemistry
- 1st Edition - January 20, 2025
- Imprint: Elsevier
- Author: Hyun-Joon Ha
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 3 1 2 6 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 3 1 2 7 - 5
Basic to Modern Strategies of Synthetic Organic Chemistry offers fresh perspectives and interests to professionals engaged in organic synthesis in various fields. The book starts… Read more
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Request a sales quoteBasic to Modern Strategies of Synthetic Organic Chemistry offers fresh perspectives and interests to professionals engaged in organic synthesis in various fields. The book starts with sections for review and understanding of reactions and proceeds with more in-depth knowledge in organic synthesis, including examples of total synthesis. Sections provide a systematic learning of organic reactions, with a focus on the relatively simple yet somewhat complex approach to compound synthesis. Furthermore, this reference will serve as a useful resource for graduate students to enhance their understanding and review of organic chemistry and synthesis.
It includes examples of total synthesis that helps pursuing further studies. Additionally, the book provides an introduction to environmental and economic considerations in synthesis, which has become an important issue in recent years, especially for those working in fine chemicals and the pharmaceutical industry. The book also introduces flow chemistry, along with an overview of the processes and equipment used.
It includes examples of total synthesis that helps pursuing further studies. Additionally, the book provides an introduction to environmental and economic considerations in synthesis, which has become an important issue in recent years, especially for those working in fine chemicals and the pharmaceutical industry. The book also introduces flow chemistry, along with an overview of the processes and equipment used.
- Covers a broad area of organic chemistry, reaction selectivity, stereochemistry, asymmetric synthesis, green chemistry, and total synthesis
- Provides practical handles and guidelines, along with tips and tricks to avoid frequently encountered problems and obstacles
- Written by a highly experienced author and teacher
Students in organic chemistry; Researchers in natural product chemistry, biopharmaceutics, organic and medicinal chemistry
- Basic to Modern Strategies of Synthetic Organic Chemistry
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Chapter One Overview of organic synthesis
- Abstract
- Keywords
- Chapter Two Fundamentals of organic chemistry reactions and synthesis
- Abstract
- Keywords
- Carbon cation (carbocation or carbenium ion)
- Carbon anion (carbanion)
- Radical
- Carbene
- Overview of substitution and elimination reactions
- Overview of alkene reactions
- Overview of alkyne reactions
- Overview of aldehyde and ketone reactions
- Overview of carboxylic acid and derivative reactions
- Formation and reactions of enolates
- Knoevenagel condensation reaction
- Alkylation
- Aldol reaction
- Claisen condensation
- Dieckmann condensation (cyclization with Claisen condensation)
- Umpolung
- 1,4-Addition reaction (Michael-type reaction)
- Robinson annulation
- Organometallic compounds
- Organolithium compounds
- Organomagnesium compounds
- Organocopper compounds
- Organozinc compounds
- Organic transition metal-mediated reactions
- Metathesis reactions
- Heck reaction
- Suzuki, Stille, and Negishi reactions
- Kumada coupling
- Sonogashira coupling
- Hiyama coupling
- Buchwald-Hartwig coupling reaction
- Tsuji-Trost coupling reaction
- Obtaining alkenes from alkyne
- Obtaining alkenes via carbonyl reactions
- Wittig reaction
- Peterson reaction
- Julia olefination
- The Shapiro reaction
- Obtaining alkenes from alkynes
- Amine synthesis
- Mannich reaction
- Aromatic substitution reactions
- Problems
- Chapter Three Oxidation and reduction
- Abstract
- Keywords
- Oxidation
- Reduction
- Metal-catalyzed hydrogenation
- Problems
- Chapter Four Pericyclic reactions, cyclizations, and sigmatropic rearrangement
- Abstract
- Keywords
- Ene reaction
- Cope rearrangement
- Claisen rearrangement
- Carroll Claisen rearrangement
- Johnson-Claisen rearrangement
- Eschenmoser-modified Claisen rearrangement
- Ireland-Claisen rearrangement
- Cyclization reactions
- Six-membered rings
- Diels-Alder reaction
- Five-membered rings
- Five-membered rings by Nazarov cyclization reaction
- Five-membered rings by 1,3-dipole cycloaddition
- Four-membered rings
- Three-membered rings
- Three-membered rings with dimethylsulfoxonium ylide
- Acyloin condensation
- 1,2-Shift rearrangement reactions
- Pinacol coupling and pinacol rearrangement
- Cation π-cyclization
- Grob fragmentation
- Problems
- Chapter Five Reaction selectivity and protecting groups
- Abstract
- Keywords
- Chemoselectivity: Distinguishing reactivity of chemically similar functional groups
- Protection and deprotection
- Protecting groups for the specific functional group
- Regioselectivity: The differentiation of possible reaction sites within the same framework
- Problems
- Regarding the problems
- Chapter Six Stereoselectivity and stereoselective reactions
- Abstract
- Keywords
- Stereoselectivity: Diastereoselectivity and enantioselectivity
- Stereospecific reactions
- Stereoselective reactions
- Asymmetric alkylation reaction with chiral auxiliary
- Chiral pool synthesis
- Chiral base for asymmetric deprotonation
- Problems
- Chapter Seven Synthetic strategy and retrosynthesis
- Abstract
- Keywords
- Achmatowicz reaction
- Problems
- Chapter Eight Green organic synthesis
- Abstract
- Keywords
- Atom Economy
- E Factor
- One-pot multicomponent reaction
- Protecting-group-free synthesis
- Problems
- Chapter Nine Catalytic organic synthesis
- Abstract
- Keywords
- Biotransformation
- Biological (enzymatic) oxidation and reduction
- Other biotransformation
- Organocatalysis
- Chapter Ten Flow chemistry (applications) in organic synthesis
- Abstract
- Keywords
- Chapter Eleven Examples of total synthesis
- Abstract
- Keywords
- Answers to problems
- Chapter 2
- Chapter 3
- Chapter 4
- Chapter 5
- Chapter 6
- Chapter 7
- Chapter 8
- Index
- Edition: 1
- Published: January 20, 2025
- Imprint: Elsevier
- No. of pages: 252
- Language: English
- Paperback ISBN: 9780443331268
- eBook ISBN: 9780443331275
HH
Hyun-Joon Ha
Hyun-Joon Ha is presently Professor at the Department of Chemistry, Hankuk University of Foreign Studies, in South Korea. He obtained a PhD from Brown University, USA. His research interests include heterocyclic chemistry, stereoselective synthesis, enzyme and medicinal chemistry. He published over 160 peer reviewed original research papers and holds 28 patents. He published three books including a recent one “Synthesis of 4- to 7-membered Heterocycles by Ring Expansion: Aza-, oxa-and thiaheterocyclic small-ring systems” in 2016. He was awarded the 2011 ACP Lectureship Award, (ICCEOCA-6), Asian Core Program (ACP), the 2012 Sigma-Aldrich (Korea) Award, and the 2015 Award of Researches in Organic Chemistry, Division of Organic Chemistry, KCS.
Affiliations and expertise
Professor, Department of Chemistry, Hankuk University of Foreign Studies, in South KoreaRead Basic to Modern Strategies of Synthetic Organic Chemistry on ScienceDirect