Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition
An Applied Approach
- 1st Edition - November 1, 2025
- Imprint: Academic Press
- Author: Claudio Trombini
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 6 5 4 2 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 6 5 4 3 - 0
Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach provides an exhaustive introduction to retrosynthetic analysis, based upon a stra… Read more
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Request a sales quoteStrategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach provides an exhaustive introduction to retrosynthetic analysis, based upon a strategic disconnection approach. It presents a sequence of prioritized disconnections of general structures, each characterized by either a specific functionalization pattern (such as 1,4-dicarbonyl compounds), or a structural motif like the presence of stereogenic centers, bicyclic frameworks, etc. The book provides numerous examples which follow each strategic disconnection of functional or structural motifs. The examples, coming from a careful selection of literature, are organized in the following hierarchical order: i) functional or structural pattern, ii) selected disconnection, iii) polar, radical, or concerted reaction pathway. Unravelling the chemistry behind each example offers excellent training for developing 3D visualization skills, refining critical reasoning in proposing alternative approaches to the synthetic choices found in the literature, and cultivating one’s own expertise. In addition to providing an overview through the analysis of various advancements made in organic synthesis over the last 50 years, each strategic disconnection is illustrated with several cases of varying complexity sourced from curated literature. Whilst numerous examples are provided, it is not necessary to examine them all; just a few can be sufficient at first glance to understand a synthetic strategy. Readers can then focus on the most interesting ones from their perspectives or those most akin to their own problems in their lab work. Each case comes with its original reference, enabling readers interested in delving into specific examples to easily find primary information. Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach is written primarily for graduate and postdoc students levels studying organic chemistry and organic synthesis, as well as researchers in industry involved in synthetic chemistry. The general disconnection schemes may also be useful to advanced undergraduate students with a solid foundation in general organic chemistry.
- Provides clear schematizations and organized teaching materials in well-structured chapters, designed to aid students in the retention of information and its application to specific problems
- Collects over a thousand examples drawn from the literature, explaining each single concept
- Encourages students to handle molecules from a 3D stereochemical perspective and observe structural patterns that are often overlooked, suggesting alternative synthetic strategies
Graduate and postdoc students levels studying organic chemistry and organic synthesis, as well as researchers in industry involved in synthetic chemistry. Some of the general disconnection schemes may be understood by advanced undergraduate students pursuing their bachelor’s degree if they have a good foundation in general organic chemistry
1. Chemical synthesis as design and construction of molecular architectures: A brief history.
2. Organic Synthesis: Basic concepts, definitions, and classification of synthetic steps
3. Retrosynthetic Analysis, Glossary, and Operating Instructions directed to the synthesis of alkanes and of ether-type linkages
4. One-Group Disconnections: Target molecules containing one carbon-heteroatom bond
5. One-group disconnections: Target molecules containing one carbon-carbon multiple bond
6. Two-group disconnections: 1,3-Bifunctional compounds containing two carbon-heteroatom bonds (diones, aldols, etc.). FS = 3
7. Two-group disconnections: Bifunctional compounds containing two carbon-heteroatom bonds (diones, ketols, etc.) with FS = 2, 4, and 5
8. Two-group disconnections: Bifunctional compounds containing two carbon-carbon double or triple bonds (dienes, diynes, enynes)
9. Two-group disconnections: Target molecules containing one carbon-heteratom bond and one carbon-carbon multiple bond
10. Topology-guided retrosynthetic analysis
11. Ring-guided retrosynthetic analysis of cyclic compounds
12. Chirality-guided retrosynthetic analysis
13. One-pot multistep reactions
14. Organic Synthesis in the 21st Century: The new environment in which organic synthesis is expanding its reach
2. Organic Synthesis: Basic concepts, definitions, and classification of synthetic steps
3. Retrosynthetic Analysis, Glossary, and Operating Instructions directed to the synthesis of alkanes and of ether-type linkages
4. One-Group Disconnections: Target molecules containing one carbon-heteroatom bond
5. One-group disconnections: Target molecules containing one carbon-carbon multiple bond
6. Two-group disconnections: 1,3-Bifunctional compounds containing two carbon-heteroatom bonds (diones, aldols, etc.). FS = 3
7. Two-group disconnections: Bifunctional compounds containing two carbon-heteroatom bonds (diones, ketols, etc.) with FS = 2, 4, and 5
8. Two-group disconnections: Bifunctional compounds containing two carbon-carbon double or triple bonds (dienes, diynes, enynes)
9. Two-group disconnections: Target molecules containing one carbon-heteratom bond and one carbon-carbon multiple bond
10. Topology-guided retrosynthetic analysis
11. Ring-guided retrosynthetic analysis of cyclic compounds
12. Chirality-guided retrosynthetic analysis
13. One-pot multistep reactions
14. Organic Synthesis in the 21st Century: The new environment in which organic synthesis is expanding its reach
- Edition: 1
- Published: November 1, 2025
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443365423
- eBook ISBN: 9780443365430
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Claudio Trombini
Claudio Trombini was appointed a full professor at the University of Bologna in 1994; he currently serves as an Alma Mater Adjunct Professor at the University of Bologna, Italy and is a faculty member of the Erasmus Mundus MSc program in Chemical Innovation and Regulation. He is a fellow of the Academy of Sciences of the Institute of Bologna. He taught Organic Synthesis at the same University from 1979 to 2020, without interruption.
His scientific work has received awards from the Italian Chemical Society, including the Pino Medal (2013), and the GICO Senior Prize on organometallic chemistry (2012). He served on the Scientific Committees of the “A. Corbella Summer School on Organic Synthesis” (1996-1998), and the prestigious “Ischia Advanced School of Organic Chemistry” (2009-2018). Among various meetings, workshops, etc., he chaired the “III Italian-German Symposium on Organic Chemistry” in Ravenna in 2001”, the workshop “Perspective and Future Research in Malaria in 2015, and the “XXXVI National Meeting of the Division of Organic Chemistry of the Italian Chemical Society” in 2015.
In the last 15 years, he has been member of the International Advisory Board of CHEMCATCHEM, member of the management committee of COST Action CM905-Organocatalysis (ORCA), coordinator of a "great relevance bilateral project" with India and funded by the Italian Foreign Office entitled: Design and Synthesis of new antimalarial molecules. From 2010 he has been visiting professor at the Universities of Pune (India), Algarve (P), Freiburg (CH), and Barcelona (E).
His primary scientific interests are centred around methodology-oriented organic synthesis, exploiting organometallic catalysis and organocatalysis to develop new stereoselective transformations. He was actively engaged in function-oriented synthesis, wherein he designed and synthesized new biologically active molecules against the parasites causing malaria and Leishmaniasis. He has also developed new sensors for metals in environmental or biological contexts. Notable examples include studies of mercury speciation in environmental and biological samples, the synthesis of fluorescent ligands for detecting magnesium in cell compartments, and the development of thermochemiluminescent compounds that can be employed as nanoprobes in biosensors and binding bioassays.
Affiliations and expertise
Alma Mater Adjunct Professor, University of Bologna, Italy, and Faculty Member, Erasmus Mundus MSc Program, Chemical Innovation and Regulation