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Books in Stereochemistry

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C-Furanosides

  • 1st Edition
  • November 30, 2017
  • Peter Goekjian + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 3 7 3 9 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 3 7 8 9 - 8
Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon. While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems.

Organic Synthesis

  • 4th Edition
  • November 22, 2016
  • Michael Smith
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 0 8 0 7 - 2
Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching.

Enantioselective Chemical Synthesis

  • 1st Edition
  • October 23, 2013
  • Elias J. Corey + 1 more
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 0 1 5 1 - 6
Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field’s progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules

Stereochemical and Stereophysical Behaviour of Macrocycles

  • 1st Edition
  • Volume 2
  • December 2, 2012
  • Bozzano G Luisa
  • English
  • eBook
    9 7 8 - 0 - 4 4 4 - 5 9 7 0 0 - 7
Stereochemical and Stereophysical Behavior of Macrocycles deals with the stereochemical and stereophysical properties of macrocyclic ligands and their coordination compounds. More specifically, the stereochemistry of metallic macrocyclics is discussed, along with the relationship between the thermodynamics and stereochemistry of macrocyclics and cryptates. The stereochemical aspects of the macrocycles of second and third row transition elements are also examined. Comprised of three chapters, this volume begins with an introduction to the stereochemistry of metallic macrocyclics as well as their structure, together with the conformation of their chemical rings and the steric effects of their coordination geometry. The next chapter considers the relationship between the thermodynamics and stereochemistry of macrocyclics and cryptates, with particular reference to the macrocyclic and cryptate effect. Cation-ligand interactions and solvent effects upon complex formation are described, along with macrocyclic and macrobicyclic ligands having different donor atoms. The final chapter is devoted to the stereochemical aspects of the macrocycles of transition metal ions, with additional comments on the stereochemistry of copper and nickel in unusual oxidation states. This book will be of interest to inorganic chemists.

Structural Chemistry of Inorganic Actinide Compounds

  • 1st Edition
  • December 8, 2006
  • Sergey Krivovichev + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 6 7 9 1 - 7
Structural Chemistry of Inorganic Actinide Compounds is a collection of 13 reviews on structural and coordination chemistry of actinide compounds. Within the last decade, these compounds have attracted considerable attention because of their importance for radioactive waste management, catalysis, ion-exchange and absorption applications, etc. Synthetic and natural actinide compounds are also of great environmental concern as they form as a result of alteration of spent nuclear fuel and radioactive waste under Earth surface conditions, during burn-up of nuclear fuel in reactors, represent oxidation products of uranium miles and mine tailings, etc. The actinide compounds are also of considerable interest to material scientists due to the unique electronic properties of actinides that give rise to interesting physical properties controlled by the structural architecture of respective compounds. The book provides both general overview and review of recent developments in the field, including such emergent topics as nanomaterials and nanoparticles and their relevance to the transfer of actinides under environmental conditions.

Progress in Biological Chirality

  • 1st Edition
  • September 21, 2004
  • Gyula Palyi + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 0 8 - 0 4 4 3 9 6 - 6
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 7 4 0 3 - 8
Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality.

Advances in BioChirality

  • 1st Edition
  • September 8, 1999
  • C. Zucchi + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 2 6 6 2 - 1
Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

Studies in Natural Products Chemistry

  • 1st Edition
  • Volume 18
  • May 1, 1996
  • Atta-ur Rahman
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 8 2 4 5 8 - 5
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 4 1 7 7 - 8
In Volume 18 of this well-established series, Professor Atta-ur-Rahman again brings together the work of several of the world's leading authorities in organic chemistry. Their contributions demonstrate the rapid, ongoing development of this field by illustrating many of the latest advances in synthetic methods, total synthesis, structure determination, biosynthetic pathways, and biological activity.The opening chapter presents an overview of strategies for the synthesis of several classes of natural products with an emphasis on complex polycyclic systems. Subsequent chapters discuss the synthesis of specific classes of compounds, including morphine, polyketides, acetogenins, nonactic acid derivatives, complex spirocyclic ethers, ä-lactam and pyridone derivatives, inositol phosphates, sphingolipids, brassinosteroids, Hernandia lignans, and dimeric steroidal pyrazine alkaloids. Finally, the ever stronger links between chemistry and biology are reinforced by chapters on the origin and function of secondary metabolites, bioactive conformations of gastrin hormones, and immunochemistry.