Bioorganic & Medicinal Chemistry Letters

BMCL (Bioorganic & Medicinal Chemistry Letters) publishes research communications of outstanding significance and timeliness on topics at the interface of chemistry and biology, together with concise review articles and perspectives. BMCL publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging advances and concepts in these fields. The aim of BMCL is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. BMCL continues to be a major forum for the first publication of new chemical entities prior to them entering clinical trials.

BMCL welcomes papers on:

• the medicinal chemistry and associated biology (including target identification and validation) of established or new disease targets

• The reporting of the discovery, design or optimization of potent new compounds or biological agents

• the analysis and discussion of structure-activity relationships and pharmacological issues relevant to drug design and action using in vitro and in vivo models, including the use of computational techniques when closely linked to experimental data

• the reporting of "first-in-class" new therapeutic compounds

• the chemical biology or bioorganic/bioinorganic chemistry that significantly advances knowledge of a biological mechanism

• methodological advances that are chemistry-based and which significantly impact on medicine or biology

• the preparation and examination of biotherapeutics for the treatment of pathophysiological disease states

• the development of materials for specific therapeutic targeting

Manuscripts on phytochemistry, theoretical molecular dynamics and exclusively computational papers are out of scope. All manuscripts will be rigorously peer-reviewed by independent experts following an initial assessment by the Editors. Please note that BMCL is not suitable for straightforward reports of incremental advances. Above all the presentation of a rational basis and a sound underlying hypothesis for the work is of particular importance, whatever its exact field.