Studies in Natural Product Chemistry
- 1st Edition, Volume 76 - May 8, 2023
- Editor: Atta-ur Rahman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 2 9 6 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 3 0 1 - 0
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the mi… Read more
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Request a sales quoteNatural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.
Studies in Natural Products Chemistry
covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.- Focuses on the chemistry of bioactive natural products
- Contains contributions by leading authorities in the field
- Presents sources of new pharmacophores
Natural product chemists working in academia and industry, Medicinal chemists and pharmacologists in academia and industry
- Cover image
- Title page
- Table of Contents
- Studies in Natural Products Chemistry
- Copyright
- Chapter 1. Uses of natural biopolymers in food and biomedical applications
- Introduction
- Molecular structure and versatile functionalization of natural polysaccharides
- Development of new encapsulation systems from natural products
- Polysaccharide-based nanomaterials for application in food and pharmaceuticals
- Concluding remarks
- List of abbreviations
- Chapter 2. Prophylactic and therapeutic alternatives for respiratory diseases: technological innovations obtained in natural products
- Introduction
- Methodology
- Results and discussion
- Conclusion
- Chapter 3. Essential oils as potential skin antiinflammatory agent and their mechanisms of action
- Introduction
- Extraction of essential oils
- Biosynthesis of EO
- Skin inflammation
- Antiinflammatory effect of EOs in various skin inflammation models
- Imiquimod-induced psoriasis-like skin inflammation model
- Human dermal fibroblast model
- Human keratinocyte cell model
- Mechanism of action of EOs against skin inflammation
- Inhibition of myeloperoxidase activity
- Inhibition of proinflammatory molecule and growth factor production
- Conclusion and future perspectives
- Chapter 4. Medicinal mushrooms as potential sources of anticancer polysaccharides and polysaccharide–protein complexes
- Introduction
- Polysaccharides and polysaccharide–protein complexes
- Anticancer activity of polysaccharides and polysaccharide–protein complexes
- Structural and biological function relationship of mushroom polysaccharides
- Anticancer activity of mushroom polysaccharides: mechanism of action
- Future perspectives
- Conclusions
- Chapter 5. Polyphenol-mediated epigenetic regulation of human cancer breast
- Introduction
- Breast cancer
- Polyphenols-based treatment
- Conclusion
- List of abbreviations
- Chapter 6. Recent patents based on natural products
- Introduction
- Properties and identification of natural compounds
- Synthesis and biosynthesis of natural products
- Future outlooks
- List of abbreviations
- Chapter 7. Hybrid alkaloids: an approach toward development of better antimalarial therapeutics
- Introduction
- Alkaloids and their role in antimalarial activity
- Hybrid alkaloids and their role in antimalarial drug discovery
- Conclusions
- List of abbreviations
- Chapter 8. Medicinally important natural bioactive compounds for leishmaniasis treatment: efficient alternate of toxic drugs
- Introduction
- Taxonomy and life cycle of leishmania
- Classification and drug treatment of clinical forms of leishmania
- Potential drug targets of leishmaniasis
- Sterol biosynthetic pathway
- Glycolytic pathways
- Purine salvage pathway
- GPI biosynthetic pathway as a drug target
- Folate biosynthesis
- Glyoxalase system
- Trypanothione pathway
- Bioactive natural products for the treatment of leishmaniasis
- Challenges faced by natural products in leishmaniasis treatment
- Future considerations
- Chapter 9. Metabolites in Moringa oleifera and their associated health potentials
- Introduction
- Traditional medicinal uses of Moringa
- Plant metabolites and their functions in the plants
- Metabolites found in Moringa oleifera
- Study trends from Moringa medicinal properties
- Clinical studies with metabolites found in Moringa
- Mechanisms of action of the bioactive compounds in Moringa
- Possible consequences on excessive consumption of Moringa
- Concluding remarks
- Abbreviations
- Chapter 10. Transformations of pentacyclic triterpenoids as a route to the future medicines
- Introduction
- Native triterpenoids and their derivatives as scaffolds
- Transformations of triterpenoids by the functional groups
- Skeletal and oxidative transformations of triterpenoids
- Synthesis and transformations of other type triterpenoids based on betulin
- Synthesis of new triterpene hybrid molecules
- The biological activities and pharmacological properties of triterpenoids
- Conclusion
- List of abbreviations
- Chapter 11. Recent developments on the chemical and biological activity studies of dihydro-β-agarofuran sesquiterpenoids
- Introduction
- Classification and structures of naturally occurring dihydro-β-agarofuran sesquiterpenoids
- Isolation and structure elucidation
- Biological activities
- Conclusion
- List of abbreviations
- Index
- No. of pages: 510
- Language: English
- Edition: 1
- Volume: 76
- Published: May 8, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780323912969
- eBook ISBN: 9780323913010
AR
Atta-ur Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, PakistanRead Studies in Natural Product Chemistry on ScienceDirect