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Studies in Natural Products Chemistry
- 1st Edition, Volume 78 - August 1, 2023
- Editor: Atta-ur Rahman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 2 5 3 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 2 5 5 - 6
Studies in Natural Products Chemistry, Volume 78 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts… Read more
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Request a sales quoteStudies in Natural Products Chemistry, Volume 78 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects.
With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.
- Focuses on the chemistry of bioactive natural products
- Contains contributions by leading authorities in the field
- Presents sources of new pharmacophores
Natural product chemists working in academia and industry, Medicinal chemists and pharmacologists in academia and industry
- Cover image
- Title page
- Table of Contents
- Studies in Natural Products Chemistry
- Copyright
- Preface
- Chapter 1. Structure defines bioactivity of avocado-derived acetogenins
- Introduction
- Acute myeloid leukemia
- Diet-induced obesity
- Dengue virus
- Prostate cancer
- Oral cancer
- Breast cancer
- Gram-positive microbes
- Antithrombotic activity
- Acetyl-CoA carboxylase inhibition
- Nitrogen oxidative stress
- Liver injury
- Conclusion
- Chapter 2. Phytochemicals in synucleinopathies: targeting mitochondrial dysfunction and α-synuclein toxicity
- Introduction
- Phytochemicals: classification, chemical structure and functions
- α-synuclein: Pathogenic fibril pathway to toxic oligomers
- Phytochemicals intervene α-synuclein oligomer formation and modulate the toxicity
- Phytochemicals ameliorate α-synuclein-induced mitochondrial dysfunction
- Phytochemicals modulate the autophagy-lysosome pathway
- Discussion
- Conclusion and future prospect
- Abbreviations
- Chapter 3. Extraction, isolation, and Biological activity of natural cyclic dipeptides
- Synthesis and metabolism
- Nonenzymatic synthesis and byproducts
- Modification enzymes
- Bacterial cyclic dipeptides
- Cyclic dipeptide isolation techniques from bacteria
- Fungal cyclic dipeptides
- Cyclic dipeptide isolation techniques from fungi
- Plant and animal cyclic dipeptides
- Roles of cyclic dipeptides in neurodegenerative diseases
- Future outlook
- Chapter 4. Sesquiterpenoid oligomers from chloranthaceae plants: Structural diversity, biological activities and total syntheses
- Introduction
- Classifications, biogenetic pathways, and distributions
- Biological activities
- Syntheses of sesquiterpenoid oligomers
- Conclusion
- Abbreviations
- Chapter 5. Synthesis of naturally occurring seven-membered nitrogen heterocycles and related bioactive compounds
- Introduction
- Formation of C–N bonds
- Formation of C–C bonds
- Formation of C–S and C–O bonds
- Formation of more than one bond
- Ring expansions
- Conclusions and perspectives
- Chapter 6. American mistletoes as a promising source of bioactive compounds
- Introduction
- Functional biology and ethno-ecological perceptions
- Phytochemistry
- Conclusion
- Chapter 7. The Chemistry and biology of the plant poisons and their forensic significance
- Introduction
- Historical background
- Classification of poisonous plants
- The chemistry of the formation of poisons in plants
- Pathophysiological actions (signs and symptoms) and treatment of the poisonous plant
- Detection techniques of poisonous plants
- Forensic significance of poisonous plants
- Concluding remarks
- Future perspective
- Abbreviations
- Chapter 8. Surfacing hybrid medicines of bioactive molecules: a solid states formulation approach
- Introduction
- Identification and characterization
- Preformulation and formulation
- Case studies
- Conclusion
- Chapter 9. Immobilization of essential oils in biopolymeric matrices: recent approaches for controlled delivery systems
- Introduction
- Essential oils: sources, chemical composition, and properties
- Immobilization methods for essential oils
- Biopolymer-based matrices
- Derivatives systems: chemical modification of biopolymers
- Applications
- Conclusion and future trends
- Chapter 10. Secondary metabolites in wound healing: a review of their mechanisms of action
- Introduction
- Physiopathology of the healing process
- Secondary metabolites in wound healing
- Conclusions
- List of abbreviations
- Chapter 11. Fungal coumarins: biotechnological and pharmaceutical aspects
- Introduction
- Coumarin derivatives place among natural products
- Endophytic producents of herbal compounds
- Natural products from host plants
- Fungal-derived biological activities
- Concluding remarks
- Abbreviations
- Chapter 12. Innovative and Eco-friendly methods and pretreatments for essential oil extraction: an update
- Introduction
- Emergent and eco-friendly extraction techniques and pretreatments
- Conclusion
- Abbreviations
- Index
- No. of pages: 544
- Language: English
- Edition: 1
- Volume: 78
- Published: August 1, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780323912532
- eBook ISBN: 9780323912556
AR
Atta-ur Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, PakistanRead Studies in Natural Products Chemistry on ScienceDirect