Dihydropyrimidinones as Potent Anticancer Agents

Medicinal Chemistry Perspective

1st Edition - August 15, 2023
Editors: Mashooq Ahmad Bhat, Muneeb U Rehman, Amita Verma
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 0 9 4 - 0
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 3 0 4 - 4

Dihydropyrimidinones as Potent Anticancer Agents gives readers a unique update on scientific knowledge, accomplishments and recent advances in the medicinal chemistry of dihydropy… Read more

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Dihydropyrimidinones as Potent Anticancer Agents gives readers a unique update on scientific knowledge, accomplishments and recent advances in the medicinal chemistry of dihydropyrimidinones in cancer treatment. Dihydropyrimidinones are known to be active scaffold and have been reported to show some exceptional results with regards to malignancies. With ever increasing knowledge and information about synthesis, pharmacology and other aspects of dihydropyrimidinones, there is need to document such information in one place. Since the field of medicinal chemistry is dynamic, with new emerging trends, it provides readily available updated information on chemistry and pharmacology aspects of dihydropyrimidinones in cancer.

This book covers everything about dihydropyrimidinones from synthesis, derivatives, mode of action and potential therapeutic targets. It will also provide insights about the clinical trials and way forward in cancer research of dihydropyrimidinones.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. Introduction of dihydropyrimidinones: a medicinal chemistry perspective
Abstract
Abbreviations
1.1 Introduction
1.2 History
1.3 Separation of isomers
1.4 Synthesis
1.5 Future perspective
1.6 Conclusion
References
Chapter 2. Synthetic strategies of dihydropyrimidinones
Abstract
2.1 Introduction
2.2 Synthetic strategies for dihydropyrimidinones
2.3 Conclusion
References
Chapter 3. Biological activities of dihydropyrimidinones
Abstract
3.1 Introduction
3.2 Antitubercular activity
3.3 Anticancer activity
3.4 Antihypertensive activity
3.5 Antiparasitic activity
3.6 Mitotic kinesin inhibitors
3.7 HIV-1 replication inhibitors
3.8 Antifungal activity
3.9 Antidiabetic activity
3.10 α1A-Receptor antagonist
3.11 Antimicrobial activity
3.12 Antioxidant activity
3.13 Antiulcer activity
3.14 Antimalarial activity
3.15 Conclusion
References
Chapter 4. Dihydropyrimidinone scaffold and potential therapeutic targets
Abstract
4.1 Introduction
4.2 Synthetic strategies
4.3 Pharmacological potential of dihydropyrimidinones
4.4 Conclusion
Acknowledgment
Conflict of interest
Funding
References
Chapter 5. Dihydropyrimidinones scaffold and potential anticancer targets
Abstract
5.1 Introduction
5.2 Biological activities
References
Chapter 6. Recent advances of dihydropyrimidinone derivatives in cancer research
Abstract
6.1 Introduction
6.2 Chemistry of dihydropyrimidinone
6.3 General methods of synthesis of dihydropyrimidinone
6.4 Conclusion
References
Chapter 7. Applications of dihydropyrimidinone derivatives on blood cancer and colon cancer
Abstract
7.1 Introduction
7.2 Current insights into blood and colon cancer treatment
7.3 Conclusion
References
Chapter 8. Novel dihydropyrimidine as potential cytotoxic agents in hepatic and blood cancers
Abstract
8.1 Introduction
8.2 Cytotoxic compounds of synthetic pyrimidines
8.3 Synthesis of Dihydropyrimidinones
8.4 Dihydropyrimidinone derivatives of pyridine as antitumor Agents
8.5 Cytotoxic synthetic pyridine derivatives of dihydropyrimidinones
8.6 Targets in biology for pyrimidine derivatives of dihydropyrimidinones
8.7 Dihydropyrimidinone pyrimidine derivatives categorized according to biological effects
8.8 Unreliable study on hepatocellular cancer
8.9 Conclusion
References
Chapter 9. REMOVED: Advances in the discovery of DHPMs as Eg5 inhibitors for the management of breast cancer
Chapter 10. Dihydropyrimidinones inhibit proliferation and tumor growth
Abstract
10.1 Introduction
10.2 Dihydropyrimidinones
10.3 Biginelli reaction—synthetic route of DHPMs
10.4 Dihydropyrimidinones as antiproliferative and antitumorogenic agents (a mechanistic approach)
10.5 Scope of molecular hybridization for yielding potent DHPM hybrids
10.6 Mitochondrial ROS: a novel approach for the antiproliferative activity of DHPM hybrids
10.7 Conclusion
Acknowledgments
References
Index

Mashooq Ahmad Bhat

Mashooq Ahmad Bhat (Ph.D.) is a faculty member and Professor of Pharmaceutical chemistry at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Pharmaceutical Chemistry from Jamia Hamdard, New Delhi, India. Dr. Bhat has more than 18 years of research and teaching experience in the field of Pharmaceutical and Medicinal Chemistry. He is the recipient of several national and international fellowships and awards. He has published more than 90 research papers in peer-reviewed, international journals of Medicinal Chemistry. He has been granted 07 patens from United states patents office. He is also an expert reviewer of various international journals and funding organizations. Currently, Dr. Bhat is engaged in studying the breast cancer especially triple negative breast cancer and its possible treatment through drug design and synthesis of small molecules.

Affiliations and expertise

Faculty Member and Professor of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Muneeb U Rehman

Muneeb U Rehman (Ph.D.) is a Faculty member at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product research) from Jamia Hamdard, New Delhi, India. Dr. Rehman has more than 10 years of research and teaching experience in the field of toxicology, cancer biology, natural product pharmacology and pharmacogenomics. He is the recipient of several national and international fellowships and awards. He has published more than 100 research papers in peer-reviewed, international journals, and has 5 edited books and 30 book chapters. Dr. Rehman is on the editorial boards and is a reviewer of several high-impact, international scientific journals. He is also a life member of various international societies and organizations. Currently, Dr. Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs.

Affiliations and expertise

College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Amita Verma

Amita Verma (Ph.D.) is a Principal Investigator, Bioorganic and Medicinal Chemistry Research Laboratory and Professor, Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India. She has more than 15 years’ experience in teaching and research. Her area of research is to develop newer therapeutics against cancer, diabetes and other disorders by synthesizing compounds and isolating natural products from medicinal plants. She is also developing nanotherapeutics by using natural products. She has authored more than 100 publications.

Affiliations and expertise

Principal Investigator, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, India

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Dihydropyrimidinones as Potent Anticancer Agents

Medicinal Chemistry Perspective

Purchase options

Institutional subscription on ScienceDirect

Mashooq Ahmad Bhat

Muneeb U Rehman

Amita Verma