Oxetane Synthesis
- 1st Edition - March 22, 2023
- Latest edition
- Author: Navjeet Kaur
- Language: English
Oxetane Synthesis rings play an important role as versatile motifs both in the overall formation of natural products and in synthetic organic chemistry. Oxetanes are important… Read more
Oxetane Synthesis rings play an important role as versatile motifs both in the overall formation of natural products and in synthetic organic chemistry. Oxetanes are important motifs in pharmaceutical chemistry that can confer improved metabolic and physicochemical properties. These developments continue to enhance the use of oxetanes in medicinal chemistry. Thanks to the growing commercial accessibility of oxetane possessing building blocks, together with improved approaches for the formation, oxetanes are likely to be progressively utilized in medicinal chemistry programs. Oxetanes are becoming valuable as a result of their vast diversity of uses in medicinal chemistry and varying applications.
Several procedures have been developed for the formation and ring-opening of oxetanes to give important compounds in agrochemical, medicinal and material sciences. Novel approaches have been developed for the synthesis of oxetanes. These methods depend on both established synthetic approaches and development of many novel approaches for the formation of oxetanes.
- Highlights methods for the synthesis of oxetanes
- Includes new developments that enhance the use of oxetanes in medicinal chemistry
- Covers new approaches recently developed for the synthesis of oxetanes
1.1 Introduction
1.2 Synthesis of oxetanes from epoxides
1.3 Metal-catalyzed synthesis of oxetanes from epoxides
1.4 Methylsulfonium methylide-assisted synthesis of oxetanes from epoxides
1.5 Base-assisted synthesis of oxetanes from epoxides
1.6 Lithium reagent-assisted synthesis of oxetanes from epoxides
References
2. Synthesis of oxetanes from ketenes
2.1 Introduction
2.2 Synthesis of oxetanes from ketenes
2.3 Synthesis of oxetanes from ketene carbonyls
2.4 Synthesis of oxetanes from ketenes and carbonyl compounds
2.5 N-Heterocyclic carbene-assisted synthesis of oxetanes from ketenes and carbonyl compounds
2.6 Metal-assisted synthesis of oxetanes from ketenes and carbonyl compounds
2.7 KHMDS-assisted synthesis of oxetanes from ketenes and carbonyl compounds
References
3. Synthesis of oxetanes from carbonyl compounds
3.1 Introduction
3.2 Synthesis of oxetanes from carbonyl compounds
3.3 Synthesis of oxetanes from two carbonyl compounds
3.4 Synthesis of oxetanes by addition of alkenes to carbonyl compounds
3.5 Synthesis of oxetanes by addition of allenes to carbonyl compounds
3.6 Synthesis of oxetanes by addition of alkynes to carbonyl compounds
3.7 Synthesis of oxetanes from other heterocycles
References
4. Synthesis of oxetanes from acid, alcohol, and carbonyl moiety containing compounds
4.1 Introduction
4.2 Synthesis of oxetanes from acid moiety containing compounds
4.3 Synthesis of oxetanes from acid and alcohol moieties containing compounds
4.4 Synthesis of oxetanes from acid and carbonyl moieties containing compounds
References
5. Synthesis of oxetanes from alcohols
5.1 Introduction
5.2 Synthesis of oxetanes from alcohols
5.3 Synthesis of oxetanes from diols
5.4 Synthesis of oxetanes by addition of alkenes to alcohols
5.5 Synthesis of oxetanes by addition of alkynes to alcohols
References
6. Synthesis of oxetanes from diols and halo alcohols
6.1 Introduction
6.2 Synthesis of oxetanes from diols
6.3 Synthesis of oxetanes from halo alcohols
References
7. Synthesis of oxetanes under photochemical irradiation
7.1 Introduction
7.2 Photochemical synthesis of oxetanes
7.3 Photochemical synthesis of oxetanes from alkenes and aldehydes
7.4 Photochemical synthesis of oxetanes from alkenes and ketones
7.5 Photochemical synthesis of oxetanes from alkenes and diones
7.6 Photochemical synthesis of oxetanes fused with four-membered rings
References
8. Synthesis of fused oxetanes under photochemical irradiation
8.1 Introduction
8.2 Photochemical synthesis of oxetanes fused with five-membered carbocycles
8.3 Photochemical synthesis of oxetanes fused with five-membered heterocycles
8.4 Photochemical synthesis of oxetanes fused with six-membered carbocycles
8.5 Photochemical synthesis of oxetanes fused with six-membered heterocycles
8.6 Photochemical synthesis of oxetanes fused with seven-membered carbocycles
References
- Edition: 1
- Latest edition
- Published: March 22, 2023
- Language: English
NK
Navjeet Kaur
Dr. Navjeet Kaur, Ph.D. (Chemistry, Banasthali Vidyapith, 2014) is currently an Associate Professor in the Department of Chemistry and Division of Research & Development at Lovely Professional University, Punjab. She specializes in organic synthetic and medicinal chemistry, with a focus on heterocyclic compound synthesis. With 14 years of teaching and research experience, she has guided five Ph.D. scholars and numerous MSc students, and has published over 200 research papers, reviews, books, and chapters. She is the author of nineteen books with leading publishers including CRC Press, Elsevier, and Springer Nature.
Dr. Kaur has consistently ranked among the World’s Top 2% Scientists in subject-wise analyses by Stanford University (2018–2025). She has received awards such as the Prof. G. L. Telesara Award and Best Paper Presentation Award, and has served as Editor-in-Chief of Advanced Chemicobiology Research. Beyond academia, she has contributed to rural development initiatives through NSS and UBA, and holds a Sikh Missionary certification.
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