Recent Frontiers of Phytochemicals
- 1st Edition - April 26, 2023
- Editors: Siddhartha Pati, Tanmay Sarkar, Dibyajit Lahiri
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 4 3 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 8 0 8 - 7
Phytochemicals have been present in human diet and life since the birth of mankind, including the consuming of plant foods and the application of herbal treatments. This co… Read more
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Request a sales quotePhytochemicals have been present in human diet and life since the birth of mankind, including the consuming of plant foods and the application of herbal treatments. This coevolutionary interaction of plants and people has resulted in humans' reliance on food and medicinal plants as sources of macronutrients, micronutrients, and bioactive phytochemicals. Phytochemicals can be used as adjuvant agents and sensitizers in traditional antibiotic and anticancer therapy, reducing the potential of selecting resistant microbial strains and cancer cells. Recent Frontiers of Phytochemicals addresses the many processes of potential phytochemical evaluation of known sources, with a focus on phytochemical and pharmacological evaluations, and computational research into the structures and pharmacological mechanisms of natural products and their applications in medicine, food and biotech.
- Novel extraction, characterization, and application method for phytochemicals in food, pharmacology, and biotechnology
- Colour illustrations and extensive tables with state-of-art information
- Covers potential sources of phytochemicals, their extraction and characterization techniques
Researchers and post graduate students in Chemistry, Biotechnology, Biochemistry, Photochemistry. Medical practitioners and clinicians. Researchers in Food Sciences and Pharmacology
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Preface
- Acknowledgment
- Chapter 1. Extraction, isolation, and characterization of phytochemicals, the bioactive compounds of plants
- Abstract
- 1.1 Introduction
- 1.2 Extraction of phytochemicals
- 1.3 Isolation and purification of phytoconstituents
- 1.4 Identification of phytochemicals
- 1.5 Conclusion
- Acknowledgments
- References
- Chapter 2. Importance and extraction techniques of functional components
- Abstract
- 2.1 Introduction
- 2.2 Current techniques for extraction of phytochemicals
- 2.3 Characterization of phytochemicals
- 2.4 Conclusion
- 2.5 Future considerations for effective extraction of phytochemicals
- References
- Chapter 3. Novel extraction conditions for phytochemicals
- Abstract
- 3.1 Introduction
- 3.2 Pre-extraction conditions
- 3.3 Selecting a pre-extracting sample preparation
- 3.4 Extraction conditions
- 3.5 Selection approach for a suitable extraction method
- 3.6 Conclusion
- References
- Chapter 4. Novel extraction and characterization methods for phytochemicals
- Abstract
- 4.1 Introduction
- 4.2 Extraction methods
- 4.3 Separation techniques
- 4.4 Applications of chromatography techniques
- 4.5 Characterization methods
- 4.6 Conclusions and future directions
- References
- Chapter 5. Phytochemicals: recent trends in food, pharmacy, and biotechnology
- Abstract
- 5.1 Introduction
- 5.2 Bioactive phytochemicals
- 5.3 Antioxidant and antimicrobial properties of phytochemicals
- 5.4 Phytochemicals from the agri-food by-products
- 5.5 Pharmacological aspects of phytochemicals
- 5.6 Nanodrug delivery of the phytochemicals in treating cancer
- 5.7 Current limitations and future of phytochemicals
- 5.8 Conclusion and future prospect
- References
- Chapter 6. Phytochemicals as bioactive ingredients for functional foods
- Abstract
- 6.1 Introduction
- 6.2 Phytonutrients
- 6.3 Health-promoting ability of phytochemicals
- 6.4 Biological activities of phytochemicals
- 6.5 Phytochemicals-based functional foods
- 6.6 Future perspective
- 6.7 Conclusion
- References
- Chapter 7. Exploring the role of Mahua as a functional food and its future perspectives
- Abstract
- 7.1 Introduction
- 7.2 Traditional uses
- 7.3 Nutritional and phytochemical profiling
- 7.4 Pharmaceutical uses and pharmacological importance
- 7.5 Mahua as a functional food
- 7.6 Current trends and future perspectives
- Acknowledgment
- References
- Chapter 8. Functional beverages: an emerging trend in beverage world
- Abstract
- 8.1 Introduction
- 8.2 Market of nutraceutical or functional beverages
- 8.3 Soft drinks
- 8.4 Nonalcoholic beverages
- 8.5 Probiotics beverages
- 8.6 Fruits-based beverages
- 8.7 Fermented beverages
- 8.8 Whey-based beverages
- 8.9 Micronutrient-fortified beverage
- 8.10 Beverages rich in antioxidants and herbs
- 8.11 Prebiotic beverages
- 8.12 Sports or energy drinks
- 8.13 Storage study of beverages
- 8.14 Health safety of drinks
- 8.15 Consumer demand for beverages
- References
- Chapter 9. Recent targeted discovery of phytomedicines to manage endocrine disorder develops due to adapting sedentary lifestyle
- Abstract
- 9.1 Introduction
- 9.2 Concept of herbal targeted drug delivery
- 9.3 List of most effective phytochemicals/phytomedicinal herbs
- 9.4 List of novel phytomedicinal formulations in pharmacy to target the endocrine glands and hormone for the treatment of various major endocrine disorders
- 9.5 Application of phytomedicine in modern drug development in pharmacy
- 9.6 Advantages of herbal phytomedicines in modern system
- 9.7 Conclusion
- References
- Chapter 10. Current updates on phytopharmaceuticals for cancer treatment
- Abstract
- 10.1 Introduction
- 10.2 Phytochemicals unexplored
- 10.3 Molecular mechanism of phytochemicals in preventing cancer
- 10.4 Strategies to improve phytochemical drugability
- 10.5 Drug delivery approach to improve phytochemical drugability
- 10.6 Phytochemicals in clinical and preclinical stages for preventing cancer
- 10.7 Insights on phytochemicals as dietary recommendation in cancer
- 10.8 Conclusion and future perspectives
- References
- Chapter 11. Phytochemicals in prostate cancer
- Abstract
- 11.1 Introduction
- 11.2 Types of prostate cancer
- 11.3 Causes of prostate cancer
- 11.4 Symptoms of prostate cancer
- 11.5 Test to identify prostate cancer
- 11.6 Prostate cancer treatments
- 11.7 Prevention of prostate cancer
- 11.8 Phytochemicals in prostate cancer
- 11.9 Phytochemicals and conventional medical practice
- 11.10 Effects of specific plant families extracts on human prostate cancer cells
- 11.11 Prostate cancer risk factors
- 11.12 Conclusion
- References
- Further reading
- Chapter 12. Therapeutic phytochemicals from Plumbago auriculata: a drug discovery paradigm
- Abstract
- 12.1 Introduction
- 12.2 Traditional uses
- 12.3 Phytochemistry
- 12.4 Plumbagin
- 12.5 Medicinal uses
- 12.6 Nano-biotechnology
- 12.7 Other properties
- 12.8 Future perspectives
- 12.9 Conclusion
- Acknowledgments
- References
- Chapter 13. Alkaloids as potential anticancer agent
- Abstract
- 13.1 Introduction
- 13.2 Theoretical relevance
- 13.3 Biological source, mechanism of action, and applications of indole alkaloids
- 13.4 Biological source, mechanism of action, and applications of isoquinoline alkaloids
- 13.5 Biological source, mechanism of action, and applications of Taxus alkaloid
- 13.6 Aporphinoid alkaloids
- 13.7 Emetine and related alkaloids
- 13.8 Biological source, mechanism of action, and applications of Cephalotaxus alkaloids
- 13.9 Biological source, mechanism of action, and applications of pyrrolizidine alkaloids
- 13.10 Anticancer alkaloids with future perspective
- References
- Chapter 14. Potential phytochemicals as microtubule-disrupting agents in cancer prevention
- Abstract
- 14.1 Introduction
- 14.2 Molecular basis of microtubule dynamics
- 14.3 Factors affecting microtubule dynamics in cancer cells
- 14.4 Intracellular stress in cancer
- 14.5 Targeting microtubules in cancer
- 14.6 Alkaloids as microtubulin-disrupting agents
- 14.7 Taxol as a therapeutic agent disrupting cell polymerization
- 14.8 Colchicine as a microtubule-disrupting agent
- 14.9 Curcumin, a phenolic compound, disrupts microtubule function
- 14.10 Noscapine therapeutic agents disrupting microtubule dynamics
- 14.11 Coumarin’s background and therapeutic activities
- 14.12 Discussion
- 14.13 Conclusion
- Acknowledgment
- References
- Chapter 15. Therapeutic effectiveness of phytochemicals targeting specific cancer cells: a review of the evidence
- Abstract
- 15.1 Introduction
- 15.2 Strategies for identification of phytochemicals with pharmaceutical potential
- 15.3 Perceptions of phytochemicals as anticancer agents in the history
- 15.4 Synthetic analogs for plant-derived compounds: enhancement and application
- 15.5 Classification of phytochemicals
- 15.6 Plant-derived phytochemicals currently in use for various cancer treatments
- 15.7 Curcumin
- 15.8 Quercetin
- 15.9 Vinca alkaloids
- 15.10 Camptothecin
- 15.11 Cervical cancer and phytochemicals
- 15.12 Current scenario and future perspective
- Competing interests
- References
- Chapter 16. Understanding the role of the natural warriors: phytochemicals in breast cancer chemoprevention
- Abstract
- 16.1 Introduction
- 16.2 Breast cancer: definition, subtypes, and conventional therapies
- 16.3 Perils of conventional BC therapies
- 16.4 Role of complementary and alternative medicine (CAM) in breast cancer treatment
- 16.5 Phytochemicals: traversing a new window in breast cancer therapy
- 16.6 Phytochemicals and ER(+) breast cancer
- 16.7 Phytochemicals and HER(2) breast cancer
- 16.8 Phytochemicals used for triple-negative breast cancer (TNBC)
- 16.9 Role of phytochemicals in modulating noncoding RNA expression in BC cells
- 16.10 Phytochemical interventions in healing cancer-associated MDR
- 16.11 Diet and dietary phytochemicals in chemosensitization
- 16.12 Challenges and perspectives: into the future of BC phytochemical interventions
- 16.13 Conclusion
- References
- Chapter 17. Phytochemicals and cancer
- Abstract
- 17.1 Introduction
- 17.2 Role of phytochemicals in various diseases
- 17.3 Phytochemicals in cancer
- References
- Chapter 18. Phytochemicals as a complementary alternative medicine in cancer treatment
- Abstract
- 18.1 Introduction
- 18.2 Role of oxidative stress in carcinogenesis
- 18.3 Mode of action of phytochemicals for cancer prevention by targeting cellular signaling transduction pathways
- 18.4 A historical perspective of plant-derived drugs used popularly in cancer
- 18.5 Phytochemicals induce cancer cell apoptosis and autophagy
- 18.6 Gut microbiota in gastrointestinal malignancy—a potential target for phytotherapy
- 18.7 Plant-derived drugs
- 18.8 Conclusion
- 18.9 Challenges
- References
- Chapter 19. Applications of phytochemicals in cancer therapy and anticancer drug development
- Abstract
- 19.1 Introduction
- 19.2 Conclusion
- References
- Chapter 20. Bioactivity, medicinal applications, and chemical compositions of essential oils: detailed perspectives
- Abstract
- 20.1 Introduction
- 20.2 Chemistry of essential oils
- 20.3 Biological activity of essential oils
- 20.4 Medicinal applications of essential oils
- 20.5 Conclusion
- References
- Chapter 21. Biological potential of essential oils in pharmaceutical industries
- Abstract
- 21.1 Introduction
- 21.2 Bioactive components of essential oils
- 21.3 Biological activities of EO
- 21.4 Cancer-preventing function
- 21.5 Antioxidant and anti-inflammatory properties
- 21.6 Role in cardiovascular diseases
- 21.7 Antidiabetic agents
- 21.8 Other important properties
- 21.9 Application of EO in pharmaceutical industry
- 21.10 Future perspective and conclusion
- References
- Chapter 22. A review on marine-based phytochemicals and their application in biomedical research
- Abstract
- 22.1 Introduction
- 22.2 Phytochemicals from marine resources
- 22.3 Metabolic process to form marine phytochemicals
- 22.4 Bioactive potential of marine phytochemical
- 22.5 Biomedical applications of marine phytochemicals
- 22.6 Conclusion
- References
- Chapter 23. Phytochemicals in biofilm inhibition
- Abstract
- 23.1 Introduction
- 23.2 Biofilm formation
- 23.3 Inactivation mechanism of biofilm
- 23.4 Role of phytochemicals in biofilm inhibition
- 23.5 Phenolics
- 23.6 Terpenoids
- 23.7 Organic acids
- 23.8 Other phytochemicals
- 23.9 Sulfur- and nitrogen-containing phytochemicals
- 23.10 Future perspective and conclusion
- References
- Chapter 24. New perspectives and role of phytochemicals in biofilm inhibition
- Abstract
- 24.1 Introduction
- 24.2 Biofilm development and its health hazards
- 24.3 Occurrence of biofilms
- 24.4 Phytochemicals in biofilm inhibition
- 24.5 Conclusion
- References
- Chapter 25. Novel perspectives on phytochemicals-based approaches for mitigation of biofilms in ESKAPE pathogens: recent trends and future avenues
- Abstract
- 25.1 Introduction
- 25.2 Biofilm-mediated drug resistance in ESKAPE pathogens
- 25.3 Mitigation of biofilm architecture: current therapeutic trends
- 25.4 Phytochemicals-based mitigation strategies against biofilm formation
- 25.5 Current trends in biofilm inhibition
- 25.6 Future perspectives
- Key points
- Acknowledgment
- References
- Chapter 26. Phytochemicals in downregulation of quorum sensing
- Abstract
- 26.1 Introduction
- 26.2 Biofilm formation and quorum sensing
- 26.3 Mechanism of quorum sensing in bacteria
- 26.4 Phytochemicals as quorum-sensing inhibitors
- 26.5 Clinical studies
- 26.6 Mechanism of phytochemicals involved in quorum-sensing inhibition
- 26.7 Conclusion
- Acknowledgment
- References
- Chapter 27. Phytoconstituents-based nanoformulations for neurodegenerative disorders
- Abstract
- 27.1 Introduction
- 27.2 Key issues associated with neurodegenerative diseases
- 27.3 Significance of nanotechnology in neurodegenerative disorders: incapacitating the blood–brain barrier
- 27.4 Phytoconstituents and their general mechanism of actions pertaining to neuroprotection
- 27.5 Phyto-nanomedicine in the management of neurodegenerative disorders
- 27.6 Nanoformulations in tackling neurodegeneration: preclinical proofs
- 27.7 Limitations of nanotechnology-based approaches for management of neurodegenerative disorders
- 27.8 Future outlook and conclusion
- References
- Chapter 28. Oxidative stress and its management through phytoconstituents
- Abstract
- 28.1 Introduction
- 28.2 Oxidative stress and free radicals
- 28.3 Antioxidants
- 28.4 Antioxidative effect of phytoconstituents
- 28.5 Conclusion
- References
- Chapter 29. Phytochemicals: an immune booster against the pathogens
- Abstract
- 29.1 Introduction
- 29.2 Secondary metabolites
- 29.3 Phytotherapy
- 29.4 Phytomedicine
- 29.5 SARS-CoV-2
- References
- Chapter 30. Phytochemicals: recent trends and future prospective in COVID-19
- Abstract
- 30.1 Introduction
- 30.2 Virus-based targets
- 30.3 Host-based targets
- 30.4 Conclusion and future prospective
- References
- Chapter 31. Phytochemicals—a safe fortification agent in the fermented food industry
- Abstract
- 31.1 Introduction
- 31.2 Types of phytochemicals
- 31.3 Health benefits of phytochemicals
- 31.4 Fortification in the fermentation industry
- 31.5 Effect of fermentation on phytochemicals
- 31.6 Use of phytochemicals as a safe fortifying agent
- 31.7 Limitations
- 31.8 Conclusion
- References
- Chapter 32. Molecular docking study of bioactive phytochemicals against infectious diseases
- Abstract
- 32.1 Introduction
- 32.2 Molecular docking studies of plant products as anti-coronal agents
- 32.3 Molecular docking studies of plant products as anti-leishmanial agents
- 32.4 Molecular docking studies of plant products as antitubercular agents
- 32.5 Conclusion
- References
- Chapter 33. Phytochemicals in structure-based drug discovery
- Abstract
- 33.1 Introduction
- 33.2 Phytochemicals screening of plant extracts
- 33.3 Phytochemicals from Phytolacca dioica L. seeds extracts—case study I
- 33.4 Phytochemicals composition and biological properties of seed extracts from Washingtonia filifera—case study II
- 33.5 Phytochemicals—opportunities and challenges
- References
- Chapter 34. Modulation of drug resistance in leukemia using phytochemicals: an in-silico, in-vitro, and in-vivo approach
- Abstract
- 34.1 Introduction
- 34.2 Drug resistance: therapeutic failure in leukemia
- 34.3 Combination index method and synergism
- 34.4 Phytochemicals as chemosensitizer and modulators
- 34.5 Conclusions and future prospects
- Acknowledgment
- References
- Chapter 35. Phytochemical and bioactive potentialities of Melastoma malabathricum
- Abstract
- 35.1 Introduction
- 35.2 Ethno-medicinal practices
- 35.3 Phytochemical constituents
- 35.4 Pharmacological potentialities
- 35.5 Conclusion and future perspective
- References
- Chapter 36. Bioactivity of essential oils and its medicinal applications
- Abstract
- 36.1 Introduction
- 36.2 Chemical structure of flavonoids
- 36.3 Flavonoids activity against multidrug-resistant microbes
- 36.4 Conclusion
- Ethics declarations
- References
- Chapter 37. Essential oils as anticancer agents
- Abstract
- 37.1 Introduction
- 37.2 Anticancer potential of essential oils
- 37.3 Conclusion and future perspective
- Abbreviations
- References
- Chapter 38. Molecular docking study of bioactive phytochemicals against cancer
- Abstract
- 38.1 Introduction
- 38.2 Molecular docking of bioactive phytochemicals with anticancer properties
- 38.3 Conclusion
- References
- Index
- No. of pages: 704
- Language: English
- Edition: 1
- Published: April 26, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780443191435
- eBook ISBN: 9780443158087
SP
Siddhartha Pati
TS
Tanmay Sarkar
DL