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Elsevier

Books in Life sciences

  • Aging

    How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases
    • 1st Edition
    • Michael Fossel
    • English
    Aging: How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases explains the process of aging beyond mere entropy, exposing it as a complicated and dynamic process that undercuts maintenance and permits age-related disease. With a deeper understanding of the aging process, intervention becomes both easy to understand and clinically feasible.With a solid academic approach, this proposed book builds upon the substantial work published over the past 20 years, citing the newest data, up-to-date models based upon that data, and the implications for improved clinical intervention, including recent developments in gene and cell therapy. Coverage of age-related diseases includes neurodegenerative, cardiovascular, bone and joint, immune system, renal, pulmonary, and skin aging. Future directions of the field focus on interventions, including a summary of previous attempts to intervene in aging and age-related disease, the status of current research, and proposed biotech interventions, as well as their potential obstacles, risks, and benefits. This is the perfect reference for scientists, clinicians, and researchers interested in the translational research opportunities such as drug discovery, pharmacogenetics, and experimental therapeutics, not only summarizing where the field stands, but giving a clear and cogent view of where clinical medicine is going in the next decade.

  • Strigolactones

    Synthesis, Application and Role in Plants
    • 1st Edition
    • Gausiya Bashri + 2 more
    • English
    Strigolactones: Synthesis, Application and Role in Plants presents the current state of the science for this recently discovered class of plant hormones, offering foundational insights. The book covers the structure of natural and synthetic SLs, synthesis, transport, signaling, and their application, role in the growth and development of plants like seed germination, root growth, and stem branching plant architecture. Further, the crosstalk of SLs with other plant hormones and signaling molecules are discussed. Finally, the role of SLs in plant defense systems, particularly in biotic and abiotic stresses, heavy metals, salt, temperature, radiation, pesticide drought, and flood stress on plants.Concluding with the latest discoveries, future perspectives, and challenges in plant biology, this book will be a valuable reference for those in plant and agricultural sciences.

  • Profiles of Drug Substances, Excipients, and Related Methodology

    • 1st Edition
    • Volume 49
    • English
    Profiles of Drug Substances, Excipients, and Related Methodology, Volume 49 provides timely and pertinent information on a variety of timely topics, including Physical Profiles of Drug Substances and Excipients; Analytical Profiles of Drug Substances and Excipients; ADME Profiles of Drug Substances and Excipients; Methodology Related to the Characterization of Drug Substances and Excipients; and Methods of Chemical Synthesis. In addition, it includes comprehensive profiles of five drug compounds: Deferasirox, Duvelisib, Regorafenib, Ponatinib and Avanafil. Finally, the book contains a chapter on Regulation and Standardization of Herbal Drugs: Current status, Limitation, Challenge’s, and Future Prospectives.

  • Early Vascular Aging (EVA)

    New Directions in Cardiovascular Protection
    • 2nd Edition
    • Pedro Guimarães Cunha + 4 more
    • English
    Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA.

  • Evaporation Technology in Food Processing

    Unit Operations and Processing Equipment in the Food Industry
    • 1st Edition
    • Seid Mahdi Jafari + 2 more
    • English
    Evaporation Technology in Food Processing, in the Unit Operations and Processing Equipment in the Food Industry series, explains the processing operations and equipment necessary for recent invented non-thermal processing of different food products, including ozonation, plasma processing, pulsed electric fields, high pressure processing, irradiation and high frequency processing. These processes and unit operations are very important in terms of achieving favorable sensory properties and energy usage. Written by experts in the field of food engineering, this book targets industrial engineers working in the field of food processing and within food factories. The book is divided into four sections: “Evaporation basics," “Different types of evaporators,” “Application of evaporators in the food industry”, and “Design, control and efficiency of evaporators”. All chapters emphasize basic texts relating to experimental, theoretical, computational, and/or applications of food engineering principles and the relevant processing equipment to evaporation unit operations.

  • Secondary Metabolites and Biotherapeutics

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Secondary Metabolites and Biotherapeutics presents the latest biotechnological advancements in the production of target secondary metabolites for medicinal use, including topics such as transcriptomics, nanotechnology, gene editing tools like CRISPR/CAS, secondary metabolites source and production.  Secondary metabolites derived from plants as a response to stress have always played a vital role in the pharmaceutical industry to produce medicines. However, their limited production in plants have always raised concerns for large-scale production. With the advancement of modern biotechnology, researchers around the globe are now able to engineer plants with specific chemical compositions.This book is a valuable resource to researchers in biotechnology, medical sciences, pharmaceutical biotechnology, pharmacology and plant biology.

  • A Biologist’s Guide to Artificial Intelligence

    Building the foundations of Artificial Intelligence and Machine Learning for Achieving Advancements in Life Sciences
    • 1st Edition
    • Ambreen Hamadani + 3 more
    • English
    A Biologist’s Guide to Artificial Intelligence: Building the Foundations of Artificial Intelligence and Machine Learning for Achieving Advancements in Life Sciences provides an overview of the basics of Artificial Intelligence for life science biologists. In 14 chapters/sections, readers will find an introduction to Artificial Intelligence from a biologist’s perspective, including coverage of AI in precision medicine, disease detection, and drug development. The book also gives insights into the AI techniques used in biology and the applications of AI in food, and in environmental, evolutionary, agricultural, and bioinformatic sciences. Final chapters cover ethical issues surrounding AI and the impact of AI on the future.This book covers an interdisciplinary area and is therefore is an important subject matter resource and reference for researchers in biology and students pursuing their degrees in all areas of Life Sciences. It is also a useful title for the industry sector and computer scientists who would gain a better understanding of the needs and requirements of biological sciences and thus better tune the algorithms.

  • Pediatric and Adult Celiac Disease

    A Clinically Oriented Perspective
    • 1st Edition
    • Gino Roberto Corazza + 3 more
    • English
    Pediatric and Adult Coeliac Disease: A Clinically Oriented Perspective provides an up-to-date, comprehensive, and critical overview of coeliac disease, its complications, and related disorders. The book covers epidemiological, pathogenetic, diagnostic, and treatment issues, including pediatric and adult cases, with a broad and international view. This is the perfect reference for researchers dedicated to advancing the field of translational coeliac disease research as well as clinicians who are diagnosing and managing coeliac disease throughout all of its various stages.

  • Transglutaminase

    Fundamentals and Applications
    • 1st Edition
    • Yi Zhang + 1 more
    • English
    Transglutaminase: Fundamentals and Applications, a new volume in the Foundations and Frontiers in Enzymology series, stands as a comprehensive resource on this increasingly important class of enzymes. Following an introduction to the field, international experts discuss basic biology and structure – function relationships of transglutaminases, ongoing fundamental research, and new application areas, including food processing, material synthesis, biomedicine, disease treatment, and biotechnology. Approaches for sourcing transglutaminases from animals, plants, and microorganisms are considered, followed by chapters on applied uses in biomedicine, skin, bone biology, medicine, drug development, tissue engineering, seafood bioprocessing, dairy bioprocessing, synthesis of materials and polymers, and as an immobilization agent.Research protocols are also provided, including research rationale, design, substrates, assays, and microassay steps for studying transglutaminases.

  • Organic Agriculture and Biodiversity in China

    • 1st Edition
    • Xiao Han + 1 more
    • English
    Organic Agriculture and Biodiversity in China provides a comprehensive introduction to the development of organic agriculture in China, covering its origins, government policies, management and institutional systems, and socio-economic benefits. It also provides insights into China's policies on biodiversity conservation and the implementation of biodiversity conventions. Through the use of case studies, the book showcases the role and effectiveness of organic agriculture in conserving biodiversity. Additionally, it presents an outlook on the future development of organic agriculture and biodiversity conservation in China. Written by experts from the Nanjing Institute of Environmental Science, Ministry of Ecology and Environment (MEE), Jiangsu Vocational College of Agriculture and Forestry, Hebei University of Engineering, and other esteemed institutions, this book explores the role that organic agriculture plays in protecting biodiversity and how the government can support or hinder organic agriculture. Through the utilization of in-depth interviews with farmers and government agencies, field surveying, and literature review, the book critically reviews novel research to provide a systematic comparison of biodiversity between organic and conventional agriculture. Organic Agriculture and Biodiversity in China is an important resource for researchers, students, policymakers, and the general public seeking to understand the environmental impact of organic agriculture.

  • Adrenal Gland

    • 1st Edition
    • Volume 124
    • English
    Adrenal Gland, Volume 124 in the Vitamins and Hormones series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Sustainable Agricultural Practices

    • 1st Edition
    • Ajay Kumar + 2 more
    • English
    Sustainable Agricultural Practices, a volume in the Plant and Soil Microbiome series, presents foundational information into the successful utilization of different biocontrol agents (especially bacteria and fungi actinomycetes) under field conditions which can help relieve the pressure of overexploitation of synthetic pesticides in agriculture.The need for sustainable advancement in agriculture practices continues to increase. Traditionally, achieving optimum yields of crops has meant farmers continuously using large amounts of chemical fertilizers or pesticides, but the indiscriminate use of these pesticides has adversely affected the environment, nontarget microorganisms, soil textures, and human health. As many microorganisms, including nitrogen-fixing bacteria and cyanobacteria, can be used as bioinoculants, they offer opportunities not only to enhance the crop productivity but also to maintain the natural properties of agricultural soils.Sustainable Agricultural Practices explores the multifaceted benefits derived from varieties of microorganisms existing in different components of the ecosystem, many of which could potentially be employed as probiotics for improved human and livestock health.Researchers seeking to expand their understanding of related fields and students seeking foundational concept coverage will find this volume valuable.

  • Nanofertilizer Synthesis: Methods and Types

    • 1st Edition
    • Kamel A. Abd-Elsalam
    • English
    Nanofertilizer Synthesis: Methods and Types discusses the production of a variety of nano-fertilizers, including biological, chemical, and mechanical types. The book presents the latest information, highlights the benefits and impacts of each, and provides a single-volume resource to help effectively and efficiently identify options based on use-case. Exploring the topic from the various mechanistic types to the relevant regulatory, safety, and economic aspects, this volume will be appropriate for those working with and researching new nano-fertilizers which aid in nutrition control by increasing nutrient consumption efficiency as nutrients are bonded to nano-dimensional adsorbents, which in turn release nutrients considerably more slowly than traditional fertilizers. As the nano-fertilizer sector advances, one approach is to concentrate on macro elements (N, P, K), as switching to nano-fertilizers may result in significant environmental benefits by replacing the majority of these nutrients. Furthermore, the biosynthesis of nanomaterials employing bacteria, algae, yeast, fungus, actinomycetes, and plants has opened up a new field of study for the creation of inorganic nanoparticles as environmentally benign fertilizers. Because of the several-fold increase in the surface-to-volume ratio of nano-forms of nutrients, and their appropriateness for foliar application, where environmental losses are further decreased, nano-fertilizers may achieve higher efficiency.

  • Concepts and Models for Drug Permeability Studies

    Cell and Tissue based In Vitro Culture Models
    • 2nd Edition
    • Bruno Sarmento + 2 more
    • English
    Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs.This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-deriv... tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route.Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models.Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.

  • Microbiota Brain Axis

    A Neuroscience Primer
    • 1st Edition
    • Jane Foster + 1 more
    • English
    Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research.

  • The Lateralized Brain

    The Neuroscience and Evolution of Hemispheric Asymmetries
    • 2nd Edition
    • Sebastian Ocklenburg + 1 more
    • English
    The second edition of The Lateralized Brain: The Neuroscience and Evolution of Hemispheric Asymmetries provides for readers a volume detailing the functional and structural differences between the left and right hemispheres of the brain, highlighting how the widespread use of modern neuroimaging techniques such as fMRI and DTI have completely changed the way hemispheric asymmetries are currently investigated.In this new edition, all chapters have been updated with recent advances in the field, and a new chapter on hemispheric asymmetries in development and aging has been integrated. Also featured is a new, larger section on laterality in social behavior, alongside a comprehensive overview about key topics in laterality research, including its history, evolutionary perspectives, brain structure, and the role of the corpus callosum. Chapters cover functional hemispheric asymmetries in language processing, motor behavior, spatial attention, self- and face-perception, emotion processing, and social behavior. Additional topics include the ontogenesis of hemispheric asymmetries and their development over the life span, as well as sex differences and associations with clinical syndromes. This volume can be used by anyone working on hemispheric biology or in courses on hemispheric asymmetries.

  • HIV-Associated Neurocognitive Disorders

    • 1st Edition
    • Guoku Hu + 2 more
    • English
    HIV-Associated Neurocognitive Disorders (HAND) presents a complex and evolving challenge in the context of HIV-1 infection and treatment. This comprehensive volume dives into the clinical manifestations, molecular and cellular mechanisms, and therapeutic strategies underlying HAND and its associated comorbidities. This book brings together cutting-edge research and clinical insights, making it an essential resource for researchers, clinicians, and students engaged in HIV-related studies and neurocognitive research. This resource also aims to advance our understanding of HAND to contribute to the development of novel diagnostic tools and therapeutic interventions for improved patient outcomes.

  • Biocontrol Agents for Improved Agriculture

    • 1st Edition
    • Ajay Kumar + 3 more
    • English
    Biocontrol Agents for Improved Agriculture, a volume in the Plant and Soil Microbiome series, presents both an advanced and current description of the important role of plant and soil microbiome in plant disease management. Including the latest biotechnological interventions for harnessing plant and soil microbiome and their potential in controlling plant pathogen/ disease, as well as the commercialization of biocontrol products and exploration of microbial derived bioactive compounds, this book provides an important reference on the challenges of biocontrol products. Sections explore the bacterial and fungal species successfully applied as plant and soil inoculant for the effective management of plant diseases. As these microbial biocontrol agents not only suppress the plant disease, but also enhance the growth or agricultural production in sustainable ways, the book focuses on the molecular aspect of plant- pathogen interactions and their biocontrol strategies via the use of plant and soil microbiome. This book is an important reference for those seeking sustainable, safe options for protecting against microbial agricultural loss and environmental damage.

  • Ureases

    Functions, Classes, and Applications
    • 1st Edition
    • Rodrigo Ligabu Braun + 1 more
    • English
    Ureases: Foundations, Classes, and Applications provides a thorough, practical analysis of ureases—enzymes of growing relevance across a range of biotechnological applications and drug discovery. Unique in many aspects, ureases are one of the few enzymes to have nickel in their active sites. This book covers all aspects of this enzymatic class starting with foundational overview and then providing historical urease research and current state, from basic biochemistry to the use of ureases as hallmarks in enzymology, crystallography, and bioinorganic chemistry. The different classes of ureases, structurally diverse but chemically equivalent, are individually discussed.The multi-protein, multi-step activation of ureases (with chemical modification of residues, transport, and transfer of nickel ions) are examined in-depth, along with the catalytic mechanisms of ureolysis and its inhibitors. The final two sections of the book address multiple applications of ureases in health and biotechnology, respectively, going from gastric ulcer treatment to architectural uses in buildings and engineering. Future applications and next steps in research are also considered.

  • Neurología

    • 7th Edition
    • Juan José Zarranz Imirizaldu
    • Spanish
    Texto eminentemente docente para el período de formación de grado y, sobre todo, para los residentes que van a especializarse en Neurología. Especialistas en otras disciplinas, como medicina interna, psiquiatría y neurocirugía, entre otras, pueden encontrar en este libro un libro de referencia y de consulta. Mantiene su estructura básica, con los primeros 14 capítulos destinados las bases del diagnóstico clínico, los fundamentos de las exploraciones complementarias, y los grandes síndromes o trastornos neurológicos. Las cefaleas, el dolor y los trastornos de la consciencia forman también parte de estos primeros capítulos. Los siguientes 15 capítulos se ocupan de las entidades nosológicas (enfermedades infecciosas o vasculares, epilepsias, las que cursan con movimientos anormales, los tumores, las enfermedades desmielinizantes o las neurodegenerativas que afectan a las motoneuronas, a los sistemas espinocerebelosos o las que culminan con deterioro cognitivo y demencia). Se cierra con tres capítulos dedicados a la neurogenética, los mecanismos de la neurodegeneración (en un capítulo nuevo) y la bioética en neurología. El texto ha sido revisado y actualizado con la adición de nuevas figuras, tablas y algoritmos de diagnóstico, y se ha puesto al día la bibliografía. El material online, además de contar también con nuevas figuras, tablas y algoritmos de diagnóstico, se ha ampliado con nuevos casos clínicos para el razonamiento del problema, más vídeos de semiología y preguntas de autoevaluación.

  • Fundamentals of Weed Science

    • 6th Edition
    • Robert L Zimdahl + 1 more
    • English
    Fundamentals of Weed Science, Sixth Edition, places weed management in the context of weed research and science, presenting the latest advances in the role, control, and potential uses of weed plants. This book uses an ecological framework to explore the role of responsible and effective weed control in agriculture from the emergence and genetic foundation of weeds to the latest means of control and environmental effects.Fully revised, updated, and expanded, Fundamentals of Weed Science now includes insights into international trad eand consumer preferences, weed seedbanks, advancements in robotic weeding, weed flaming, and the potential of precision agriculture in weed science.

  • Epigenetic Regulation of Cancer - Part B

    • 1st Edition
    • Volume 383
    • English
    Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer.

  • RNA Therapeutics Part A

    • 1st Edition
    • Volume 203
    • English
    RNA Therapeutics, Part A, Volume 203 presents the latest on a new class of medication based on RNA molecules. The book includes timely chapters that focus on An introduction to RNA therapeutics and potentials, The development and technologies of RNA therapeutics, Types of RNA therapeutics, Molecular mechanisms of RNA therapeutics, IT, and AI applications in RNA therapeutics, The application of data sciences and bioinformatics in RNA therapeutics, RNA therapeutics history and future perspectives, Recent applications of RNA therapeutic in clinics, Advantages and disadvantages of RNA therapeutics, RNA therapeutics for neurological disease, RNA therapeutics for metabolic disorders, and RNA therapeutics for metabolic disorders.

  • Proteomics Mass Spectrometry Methods

    Sample Preparation, Protein Digestion, and Research Protocols
    • 1st Edition
    • Paula Meleady
    • English
    Proteomics Mass Spectrometry Methods: Sample Preparation, Protein Digestion, and Research Protocols shares best practices collected across key laboratories and core facilities, taking the reader through key tactics for executing the most usual mass spectrometry experiments. Sections review research making use of MS proteomics experiments, focus on critical sample preparation, cover mammalian cell lines and samples from clinical tissue and biological fluids, discuss subcellular fractionation, provide methods for protein digestion both for in gel and in solution, and delve into key MS proteomics analysis protocols, including label-free LC-MS, TMT and iTRAQ labelled LC-MS, phosphorylation enrichment, ubiquination enrichment, and more. This book is the perfect lab manual for research teams or for use as a new staff training material. Core facility managers may also find it useful for sharing best practices with their staff and researchers.

  • Rare and Complex Urology

    • 1st Edition
    • Jen Tidman + 1 more
    • English
    Rare and Complex Urology has been produced by the European Reference Network (ERN) for rare urogenital diseases and complex conditions, ERN eUROGEN.The book combines information on network developments and clinical and surgical aspects, allowing for better diagnoses, treatments, and patient outcomes.The expertise areas covered include those relating to the bladder, stone and kidney diseases, congenital malformations, pelvic floor disorders, the urethra, reconstruction, and rare cancers and tumours.This is a must-have reference for clinicians and basic scientists interested in translational urology and surgery, including urologists, paediatric surgeons, and multidisciplinary team members seeking guidance on how to implement novel research.

  • DNA Damage and Chromosomal Instability

    • 1st Edition
    • Volume 182
    • English
    DNA Damage and Chromosomal Instability, Volume 182 in the Methods in Cell Biology series, presents interesting chapters on a variety of timely topics, including Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation, Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents, Genetic reporters to detect and quantify homologous recombination in yeast, Mapping histone variant genomic distribution: exploiting SNAP- Tag labelling to follow the dynamics of incorporation of H3 variants, Enrichment of DNA replication intermediates by EdU pull down, Nascent DNA sequencing and its diverse applications in genome integrity research, and much more. Additional chapters cover Enrichment of DNA replication intermediates by EdU pull down, DNA curtains for studying phase separation mechanisms of DNA-organizing proteins, Visualizing the Dynamics of DNA Replication and Repair at the Single-Molecule Molecule Level, Cloning and Expansion of Repetitive DNA Sequences, Using an ImageJ-based script to detect replication stress and associated cell cycle exit from G2 phase by fluorescence microscopy Arne Lindqvist

  • Systems Biology Approaches for Host-Pathogen Interaction Analysis

    • 1st Edition
    • Mohd. Tashfeen Ashraf + 2 more
    • English
    Application and utilization of data science approaches has revolutionized scientific research including host–pathogen interaction analyses. Host–pathogen interactions are generally considered highly specific interactions, resulting in a variety of consequences. Data science approaches coupled with network biology has taken host–pathogen interaction analysis from specific interaction to a new paradigm of understanding the consequences of these interactions within a biological network. Unfortunately, basic biological researchers are mostly unaware of these advancements. Conversely, data scientists are not familiar with biological aspects of such data.Systems Biology Approaches for Host–Pathogen Interaction Analyses benefits biological researchers by expanding the scope of their research and utilization of their accumulated data using recent technological advancements. In addition, the book also opens avenues for bioinformatics and computer science researchers to utilize their expertise in biologically meaningful ways.

  • A Comprehensive Guide to Toxicology in Nonclinical Drug Development

    • 3rd Edition
    • Ali S. Faqi
    • English
    **Selected for 2025 Doody’s Core Titles® in Toxicology**A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

  • Dysphagia

    A Clinical Guide
    • 1st Edition
    • Michael B. Ujiki + 1 more
    • English
    Dysphagia: A Clinical Guide will help practitioners and surgeons learn and understand how best to diagnose and treat dysphagia. It provides a complete picture of dysphagia through the experiences of leaders who cover the latest techniques and evidence-based outcomes in the field. Coverage includes recent advances in the diagnosis and treatment of the disease processes that cause dysphagia, gastric problems, and surgical intervention. The book includes the latest research and perspectives from both gastroenterologists and surgeons to enable clinicians to stay up-to-date on the most current and effective management strategies. Each chapter provides summary statements and recommendations based on recent literature.Recent discoveries regarding the diagnosis and management of dysphagia are exemplified by illustrations of both diagnostic methods and descriptions of interventional techniques. This an important reference for general surgeons, general practitioners, and ENT surgeons while also bringing new data dedicated specifically to gastroenterologists and foregut surgeons.

  • Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson’s disease

    • 1st Edition
    • Volume 174
    • English
    Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as A general clinical overview of the non-motor symptoms, Stress/fatigue/cogni... decline Sleep/autonomic failure, A general clinical overview of the non-motor symptoms – psychiatric symptoms, Psychosis, Cognitive Decline, Non-clinical Aspect of non-motor symptoms: Animal Models, Assessment and treatment of cognitive decline in rodent and primate models, Pain in PD models, Affective disorders in PD models, Sleep and circadian dysregulation and EEG disruption in rodent models, and much more.

  • The Neuroscience of Bach’s Music

    Perception, Action, and Cognition Effects on the Brain
    • 1st Edition
    • Eric Altschuler
    • English
    The Neuroscience of Bach’s Music: Perception, Action, and Cognition Effects on the Brain is a comprehensive study of Johann Sebastian Bach’s music through the lens of neuroscience, examining neuroscience using Bach’s music as a tool. This book synthesizes cognitive neuroscience, music theory, and musicology to provide insights into human cognition and perception. It also explores how a neuroscience perspective can improve listening and performing experiences for Bach’s music. Written by a physician-neuroscien... recognized for scholarly articles on Bach’s music, this book uses specific examples to explore neuroscience across Bach’s compositions.The book is structured to discuss the brain’s action, perception, and cognition as connected to specific Bach concertos, tones, notes, and performances. Two guest contributors provide insight into exact mathematical, or topologic, and music theoretic aspects of Bach’s music with implications for cognitive neuroscience.

  • Advances in Agronomy

    • 1st Edition
    • Volume 184
    • English
    Advances in Agronomy, Volume 184, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors, with this new release including new chapters on The Role of Artificial Intelligence in Crop Improvement, Dealing with the Impact of Climate Change-Induced Drought on the Management of Soil, Challenges and Emerging Opportunities of Weed Management in Organic Agriculture, The Broadbalk Wheat Experiment, Rothamsted, UK: Crop Yields and Soil Changes During the Last 50 Years.

  • Huntington’s Disease

    Pathogenic Mechanisms and Implications for Therapeutics
    • 1st Edition
    • X. William Yang + 2 more
    • English
    Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical triad of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington’s Disease: Pathogenic Mechanisms and Implications for Therapeutics reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge thinking on therapeutic strategies for HD. Chapters explore areas that include the clinical features and genetic studies of HD, the cellular and molecular biology of normal huntingtin, a range of HD models, the diverse pathogenic mechanisms linked to mutant huntingtin, new approaches to HD pathogenesis, as well as emerging preclinical therapeutic approaches and clinical programs in the field.

  • Many-Sorted Algebras for Deep Learning and Quantum Technology

    • 1st Edition
    • Charles R. Giardina
    • English
    Many-Sorted Algebras for Deep Learning and Quantum Technology presents a precise and rigorousdescription of basic concepts in quantum technologies and how they relate to deep learning and quantum theory. Current merging of quantum theory and deep learning techniques provides the need for a source that gives readers insights into the algebraic underpinnings of these disciplines. Although analytical, topological, probabilistic, as well as geometrical concepts are employed in many of these areas, algebra exhibits the principal thread; hence, this thread is exposed using many-sorted algebras. This book includes hundreds of well-designed examples that illustrate the intriguing concepts in quantum systems. Along with these examples are numerous visual displays. In particular, the polyadic graph shows the types or sorts of objects used in quantum or deep learning. It also illustrates all the inter and intra-sort operations needed in describing algebras. In brief, it provides the closure conditions. Throughout the book, all laws or equational identities needed in specifying an algebraic structure are precisely described.

  • Migraine Management

    • 1st Edition
    • Volume 199
    • Jerry W. Swanson + 1 more
    • English
    Migraine Management, Volume 199 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classification and diagnostic criteria of common and uncommon subtypes of migraine is explored in detail, including childhood variants. An in-depth analysis of the pharmacology of acute and prophylactic agents is presented, along with an evidence-based review of pharmacologic management. This includes recently developed CGRP monoclonal antibodies and non-peptide small molecule CGRP antagonists. Advances in neuromodulatory treatments, both noninvasive and implantable are also critically reviewed.Finally, specific treatment-related issues in pregnancy and lactation and childhood as well as the elderly are covered. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also explored.

  • Brody's Human Pharmacology

    • 7th Edition
    • Lynn Wecker + 1 more
    • English
    **Selected for 2026 Doody's Core Titles in Pharmacology**Brody’... Human Pharmacology, 7th Edition, is a well-established and much-loved textbook that guides students of medicine, pharmacology and other health professions through pharmacology from both basic and clinical perspectives.What can be a very difficult and complex topic is divided into easily digestible chapters, each of which is clearly structured from a therapeutic overview to mechanisms of action, relationships to clinical responses, pharmacokinetics, pharmacovigilance, new developments, and clinical relevance for all health professionals.

  • Development of Gluten-Free Pasta

    • 1st Edition
    • Amir Gull + 2 more
    • English
    Development of Gluten-Free Pasta summarizes current progress in the development of gluten-free (GF) products, focusing particularly on pasta products. Presented in 11 chapters, the book focuses on the role of prebiotic fiber, hydrocolloids, fruit and vegetable by-product pomace and the physical, microstructural, sensory, and nutritional properties of the gluten-free pasta. The science of gluten intolerance is explained as well, with all relevant literature gathered and summarized in one place. Hence, this book lays a very solid foundation for the development of GF pasta which can be exploited as an essential therapeutic tool in the prevention of celiac disease. This comprehensive reference, written by world renowned scientists who elaborate on the study of different selected additives of plant origin, provides immense assistance in the field of research as many areas are still unexplored in the field of cereal science & technology.

  • Type 1 Diabetes, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 53-1
    • Osagie Ebekozien
    • English
    In this issue of Endocrinology and Metabolism Clinics of North America, guest editor Dr. Osagie Ebekozien brings his considerable expertise to the topic of Type 1 Diabetes. Top experts in the field provide a timely update on type 1 diabetes care in children and adults, and provide recommendations for treatment and improving access to care.

  • Biocontamination Control for Pharmaceuticals and Healthcare

    • 2nd Edition
    • Tim Sandle
    • English
    Biocontamination Control for Pharmaceuticals and Healthcare, Second Edition outlines a biocontamination strategy that tracks bio-burden control and reduction at each transition in classified areas of a facility. The first edition of the book covers many of the aspects of the strategy, but the new official guidance signals that a roadmap is required to fully comply with its requirements. Completely updated with the newest version of the EU-GPM (EN17141), this new edition expands coverage of quality risk management and contains completely new examples to help professionals bridge the gap between regulation and implementation. This book offers professionals in pharma quality control and related areas guidance on building a complete biocontamination strategy.

  • The Microbiology, Pathogenesis and Zoonosis of Milk Borne Diseases

    Milk Hygiene in Veterinary and Public Health
    • 1st Edition
    • Tanmoy Rana
    • English
    The Microbiology, Pathogenesis, and Zoonosis of Milk Borne Diseases offers comprehensive coverage of milk-borne infection, diagnosis, and treatment. With a strong focus on milk hygiene, zoonotic diseases, and the pathogenesis of milk-borne microbial agents, this book discusses various pathogenic diseases, evaluates the severity of diseases from milk and milk products, and describes remedial measures after the application of drugs.This book also introduces the reader to the microbiology, pathogenesis, and zoonosis of milk-borne diseases. It not only describes the general aspects of milk-borne zoonosis and prevention, but also covers risk analysis, assessment, practice, and quality management in milk hygiene.In 22 chapters, The Microbiology, Pathogenesis, and Zoonosis of Milk Borne Diseases provides researchers, academicians, industry professionals, and students with a better understanding on how to assess zoonotic diseases from milk-borne pathogens and address their clinical manifestations.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 118
    • English
    Advances in Clinical Chemistry, Volume 118, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, including chapters on Advances in Endotoxin Analysis, Molecular biology of SARS-CoV-2 and techniques of diagnosis and surveillance, Osteopontin in Cancer, Gastrointestinal Hormones: History, Biology, and Measurement, Natriuretic Peptide Testing Strategies in Heart Failure: a 2023 Update, and Defining Allowable Total Error Limits in the Clinical Laboratory.

  • Trends in Clinical Diseases, Production and Management of Goats

    • 1st Edition
    • Tanmoy Rana
    • English
    Trends in Clinical Diseases, Production and Management of Goats, Two Volume Set examines goat diseases and their remedial measures after drug application. The book elaborates on disease and pathogenesis in a systematic way, describing disease evaluation, pathogenesis, identifications of pathogens and their severity to animals, exhibition of disease manifestation, and preventive and treatment strategies to counteract the aetiopathogenesis caused by pathogens. Further, the book gives insights on the microbial pathogenesis of goats, an overview of clinicals diseases of goats, and the impact on human health, aiming its content towards a broad audience, including microbiologists, veterinary scientists, and those working in the industry.

  • Frozen Shoulder

    Present and Future
    • 1st Edition
    • Filip Struyf
    • English
    Frozen Shoulder: Present and Future provides insights into one of the most mysterious diseases of the human body, frozen shoulder, a condition characterized by severe shoulder pain and functional restriction of shoulder motion. About 4% of the general population develops a frozen shoulder, with numbers rising to 59% in patients with diabetes mellitus. It curiously only develops between the age of 40 and 60 years, affects more women than men, and seems to be more common in patients with sedentary jobs. Disease duration varies between 1 and 3 years and consequently has a large impact on health and economic well-being.

  • New Insights, Trends, and Challenges in the Development and Applications of Microbial Inoculants in Agriculture

    • 1st Edition
    • Sergio de los Santos Villalobos
    • English
    New Insights, Trends and Challenges in the Development and Applications of Microbial Inoculants in Agriculture provides information about how to develop high-quality microbial inoculants (biofertilizers and biopesticides) for increasing crop yields and quality and reducing the economic, environmental and health costs of food production. The book's chapters discuss cutting-edge approaches and techniques to develop bioformulations as reliable, viable solutions for food production, including the importance of a legal framework to guarantee the quality and safety of these bio-products. Additionally, it provides information on the current limitations and future approaches to enhance microbial inoculant development for contributing to global food security. Interest in biofertilizers and the potential for their use in sustainable agriculture is increasing. However, many commercial bioproducts are low quality due to the lack of quality standards which causes a decrease in efficiency, high variability in the field, and loss of confidence from farmers.

  • MicroRNA in Human Infectious Diseases

    • 1st Edition
    • Vijay Kumar Prajapati + 1 more
    • English
    MicroRNA in Human Infectious Diseases offers an overview of the therapeutic and diagnostic role microRNAs can play in treating infectious diseases. Beginning with an introduction on microRNAs and their mechanisms, the book then delves into the therapeutic role of microRNAs in various categories of diseases, including bacterial, viral, and parasitic. A wide range of diseases are explored, including STDs, typhoid, tuberculosis, Dengue fever, Ebola, Covid-19, Malaria, Leishmaniasis, and Lymphatic filariasis. The final section of the book covers microRNA-based system approaches, considering aspects such as web-based tools available for detecting and predicting microRNA targets and the latest technologies for modifying and manipulating microRNAs.This volume explores microRNA across a multitude of conditions and is an ideal reference for those involved in the investigation and development of treatments in this area.

  • Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer

    From Molecular Insights to Precision Solutions
    • 1st Edition
    • Volume 21
    • Zodwa Dlamini
    • English
    Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer: From Molecular Insights to Precision Solutions, Volume 21 highlights different strategies to reverse chemotherapy resistance in cervical cancer. The book puts a strong focus on strategies to reverse chemotherapy resistance as well as strategies for early detection of the resistance, enhancing precision oncology in terms of patient care and maximizing patient management. The book also looks at virally induced resistance to chemotherapy and recommends combination therapies that can maximize the reversal of this resistance.In 10 chapters, the book not only gives an overview of cervical cancer and chemotherapy as treatment, but also investigates resistance to chemotherapy and treatment for resistance. It defines treatment mechanisms, options, and limitations to beat chemotherapy resistance and the reversal of the resistance mechanisms. It gives insights into future directions of cervical cancer treatment using epigenetic silencing, chemotherapy splicing, the involvement of MicroRNAs to chemotherapy resistance, and the application of Artificial Intelligence.

  • Microbiome-Assisted Bioremediation

    Rehabilitating Agricultural Soils
    • 1st Edition
    • Javid A. Parray + 1 more
    • English
    Microbiome-Assisted Bioremediation: Rehabilitating Agricultural Soils provides a complete reference on the opportunities, technologies, and challenges of remediating contaminated soils through use of microbial means. Environmental pollution and human exposure associated with heavy metals are attributed to anthropogenic activities such as mining, industrial wastes, and metal containing compounds in domestic and agricultural systems. Addressing the foundational aspects of microbe-based approaches, this book provides a valuable gateway resource for those entering the field, as well as providing in-depth insights into the various tools and techniques for real-world application.Microbia... remediation has appeared as a promising approach to lessen the heavy metal concentration in the environment due to their sequestration and transforming ability of xenobiotic compounds. Microbial bioremediation is an efficient, economical, and environmentally-frie... procedure that reduces the cost of the cleanup process associated with heavy and toxic metal contamination.

  • Handbook of Digital Technologies in Movement Disorders

    • 1st Edition
    • Roongroj Bhidayasiri + 1 more
    • English
    Handbook of Digital Technologies in Movement Disorders aims to unite these factors to provide a comprehensive guide to patient focused treatments for movement disorders. Sections cover an introduction to digital technologies, concepts, and terminologies, review various perspectives on technology in movement disorders, including patient and medical professionals, and present technologies used in detecting, measuring progression, and determining response to treatments. Additional chapters review the technology used in various treatments of movement disorders, including assistive and robotic technologies. Finally, the last section examines the challenges with technology, including privacy and other ethical issues. Over the past few years, there have been fundamental changes in the diagnosing and treating patients with chronic diseases, significantly affecting management of neurological movement disorders. In addition, the health and fitness sector developed several devices to better classify, track, and potentially treat chronic diseases. Both handling and interpreting these large datasets has been revolutionized, by machine and deep learning approaches, leading to new and more effective therapies, resulting in longer survival rates.

  • Development in Wastewater Treatment Research and Processes

    Advanced Oxidation Processes for Tannery Effluent
    • 1st Edition
    • Maulin P. Shah + 1 more
    • English
    Advanced Oxidation Processes for Tannery Effluent provides a detailed overview of currently applied and tested sewage treatment technologies and the integration of advanced processes to remove trace organic contaminants and micro-organisms. The book discusses the potential of improved biological treatment to produce reusable wastewater, new municipal wastewater disinfection processes, the reduction of bacteria resistant to antibiotics, as well as the effects of advanced oxidation processes on microbial and chemical contaminants. It features membrane bioreactors, moving bed bioreactors, light and solar technology, ozonation and immobilized heterogeneous photocatalysis, and more. In addition, the book discusses issues and standards for water reuse, the state of application of membrane bioreactors, and the treatment of reverse osmosis concentrate for better water use in wastewater treatment. Final sections present the latest developments in the field of drinking water reuse and address various important issues in this context, such as proper public health protection, reliability and monitoring.

  • Engineering Applications in Livestock Production

    • 1st Edition
    • Ayon Tarafdar + 4 more
    • English
    Engineering Applications in Livestock Production covers the recent advancements and technological developments in the field of livestock production engineering in great detail. The major advances covered in this book include the use of artificial intelligence, image processing, Internet of Things, novel animal product processing technologies, farm automation systems, sensor technology, bioengineering practices and even engineered housing systems among others.

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