Migraine Management

1st Edition, Volume 199 - February 1, 2024
Editors: Jerry W. Swanson, Manjit Matharu
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 3 5 7 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 4 8 1 - 5

Migraine Management, Volume 199 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classific… Read more

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Migraine Management, Volume 199 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classification and diagnostic criteria of common and uncommon subtypes of migraine is explored in detail, including childhood variants. An in-depth analysis of the pharmacology of acute and prophylactic agents is presented, along with an evidence-based review of pharmacologic management. This includes recently developed CGRP monoclonal antibodies and non-peptide small molecule CGRP antagonists. Advances in neuromodulatory treatments, both noninvasive and implantable are also critically reviewed.

Finally, specific treatment-related issues in pregnancy and lactation and childhood as well as the elderly are covered. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also explored.

Cover image
Title page
Table of Contents
Series Page
Copyright
Handbook of Clinical Neurology 3rd Series
Foreword
Preface
Contributors
Section I: Migraine management
Chapter 1 Nonspecific analgesics, combination analgesics, and antiemetics
Abstract
Introduction
How to Evaluate the Outcomes?
Strategies
References
Chapter 2 The 5-HT1B and 5-HT1D agonists in acute migraine therapy: Ergotamine, dihydroergotamine, and the triptans
Abstract
Introduction
Ergotamine
Dihydroergotamine
Triptans
References
Chapter 3 5-HT1F agonists
Abstract
Introduction
History and Development
Pharmacology
Efficacy
Tolerability/Safety
Clinical Approach
Conclusion
References
Chapter 4 CGRP receptor antagonists (gepants)
Abstract
Introduction
Gepants as a New Class of Migraine Medications
Evidence for Efficacy of Acute Treatment
Safety and Tolerability
Pharmacology
Gepants in Migraine Prevention
Limitations
Future Perspectives and Conclusions
References
Chapter 5 Preventive treatment of migraine: Non-specific oral agents
Abstract
Introduction
Antidepressants
Antihypertensives
Anticonvulsants
Other anticonvulsants
Other anticonvulsants with insufficient evidence for use in migraine prevention
Miscellaneous Migraine Preventives
Conclusions
References
Chapter 6 OnabotulinumtoxinA: Discussion of the evidence for effectiveness of OnabotulinumA and its place in chronic migraine treatment
Abstract
Introduction
Botulinum Neurotoxins
Mechanism of Action of OnabotulinumtoxinA
Injection technique
Efficacy of OnabotulinumtoxinA in headache disorders
PREEMPT 1 and 2. The study injection paradigm
Real life studies
Safety and tolerability of OnabotulinumtoxinA
Place of OnabotulinumtoxinA in the prevention of chronic migraine
Final considerations
Conclusions
References
Chapter 7 CGRP monoclonal antibodies and CGRP receptor antagonists (Gepants) in migraine prevention
Abstract
Introduction
CGRP Mechanism
Anti-CGRP Monoclonal Antibodies
Gepants
References
Chapter 8 Nutraceuticals in migraine
Abstract
Nutraceuticals in Migraine
Phytomedicines in Migraine
Phytomedicines With Clinical Evidence in Migraine
Cannabis sativa
Summary
Functional Foods and Diet Interventions in Migraine
Polyunsaturated Fatty Acids (PUFAs) in Migraine
Melatonin in Migraine
Probiotics and Prebiotics in Migraine
Traditional Medicine Approaches Worldwide in Migraine Treatment
l-Carnitine Supplementation in Migraine
Conclusions
References
Chapter 9 Interventional treatments
Abstract
Introduction
Indications
Clinical Outcomes and Evidence for Efficacy in Migraine
Complications
Discussion
References
Chapter 10 Biobehavioral treatments of migraine
Abstract
Introduction
Behavioral and Psychosocial Factors in Migraine Headache
The Self-Management Model and Its Application to Headache
Overview of Behavioral Interventions for the Self-Management for Migraine
Effectiveness of Behavioral Treatments for Migraine
Alternate Treatment Formats for Behavioral Headache Interventions
Emerging Nonpharmacologic Therapies for Migraine
Underutilization of Behavioral Interventions for Migraine
Conclusion
References
Chapter 11 Physical treatment of migraine
Abstract
Introduction
Acupuncture
Spinal Manipulation
Massage
Physical Therapy and Exercise
Conclusion
References
Chapter 12 Neuromodulation in migraine
Abstract
Introduction
Central Neuromodulation
Peripheral Neuromodulation
Conclusion
References
Section II: Guidelines
Chapter 13 Evidence-based symptomatic treatment of migraine
Abstract
Introduction
Treatment Strategy
Patient Education
Pharmacological Treatment
Nonpharmacological Treatment
Rescue Treatment and Symptomatic Treatment in the Emergency Department
Unmet Needs and Emerging Treatments
Conclusions
References
Chapter 14 Evidence-based preventive treatment of migraine☆
Abstract
Introduction
Oral Migraine Preventatives
OnabotulinumtoxinA
CGRP Monoclonal Antibodies
CGRP Antagonists
Evidence-Based Preventive Treatment (a World Perspective)
References
Section III: Special cases/situations
Chapter 15 Treatment in the emergency department
Abstract
Introduction
Epidemiology and Role of ED in Migraine Treatment
Treatments
Conclusion
References
Chapter 16 Special considerations in migraine during pregnancy and lactation
Abstract
Introduction
Effects of Migraine on Pregnancy
References
Chapter 17 Special considerations in management of migraine in the elderly
Abstract
Introduction
Epidemiology of Migraine in the Elderly
Diagnosis of Migraine in the Elderly
Differential Diagnosis of Migraine in the Elderly
Relevant Comorbidities of Migraine in the Elderly
Interaction of Migraine With Cognitive Impairment in the Elderly
Conclusion
References
Chapter 18 Management of medication overuse headache
Abstract
Introduction
Classification
Epidemiology
Prevention
Prescription of Prophylactic Treatment
Effects of Treatments on MOH-Related Burden and PROs
Predictors of Failure of Treatments
Conclusions
Future Research
References
Further reading
Section IV: Outcome measures
Chapter 19 Outcome measures for migraine: Measuring the impact of migraine and results of migraine treatment
Abstract
Introduction
Selecting What to Measure
Selecting How to Measure
Considerations for Selecting PRO Measures
Conclusions
Acknowledgments
References
Section V: Diagnosis and treatment of other migraine subtypes
Chapter 20 Menstrually associated migraine
Abstract
Introduction
Definition and Diagnosis
Epidemiology
Pathophysiology
Clinical Manifestations
Treatment
Future Directions
Conclusions
References
Chapter 21 Hemiplegic migraine
Abstract
Introduction
Clinical Characteristics
Investigations
Differential Diagnosis
Pathophysiology
Genetically Related Disorders
Treatment
Conclusion
References
Chapter 22 Migraine with brainstem aura
Abstract
Introduction
Migraine With Brainstem Aura (2013–present): ICHD-3 beta, ICHD-3
Basilar Artery Migraine (1961–87): Prior to availability of ICHD classification criteria
Basilar-type Migraine (1988–2003): ICHD-1
Basilar-type Migraine (2004–13): ICHD-2
Summary and Practical Conclusions
References
Chapter 23 Retinal migraine
Abstract
Introduction
Pathogenesis and Pathophysiology
Epidemiology
Differential Diagnosis
Diagnostic Workup
Prognosis and Complications
Management
References
Chapter 24 Vestibular migraine and persistent postural perceptual dizziness
Abstract
Introduction
Vestibular Migraine
Persistent Postural Perceptual Dizziness
Areas of Uncertainty Between Vestibular Migraine and PPPD
Managing Coexisting VM and PPPD and Other Common Comorbidities
Conclusion
References
Chapter 25 Status migrainosus
Abstract
Introduction
Pathophysiology of Status Migrainosus
Epidemiology and Clinical Presentation of Status Migrainosus
The Burden of Status Migrainosus
Secondary Mimics
Treatment of Status Migrainosus
References
Chapter 26 Persistent aura, visual snow, and other visual symptoms
Abstract
Introduction
Transient Visual Phenomena
Migraine Aura, Migraine Aura Status, Prolonged Aura, Persistent Aura Without Infarction
Visual Snow and Visual Snow Syndrome
References
Chapter 27 Migrainous infarction
Abstract
Introduction
The Migraine–Stroke Association
The ICHD-3 Definition of Migrainous Infarction
Epidemiology
Possible Pathophysiology
Clinical and Radiological Presentation
Risk Factors
Evaluation and Treatment
Conclusion
Conflict of interest statement
References
Further reading
Chapter 28 Migraine in children and adolescents: Assessment and diagnosis
Abstract
Introduction
Clinical History for the Diagnosis of Childhood Migraine
Assessment for Comorbidities
Past History and Evolution of the Headache Disorder
Summary
References
Chapter 29 Management of migraine in children and adolescents
Abstract
Introduction
Management of Acute Migraine Episodes
Preventive Treatment
Other Medications
Nutraceuticals
Other Treatment Options
The Future of Migraine Treatment in Child/Young People
Summary
References
Section VI: Comorbidities of migraine
Chapter 30 Psychiatric comorbidities of migraine
Abstract
Introduction
Epidemiology
Mechanisms
Clinical Implications
Referring Patients for Treatment of Psychiatric Disorders
Conclusions
References
Chapter 31 Relationship of migraine and other forms of chronic pain
Abstract
Introduction
Visceral Pain Conditions
Nonvisceral Pain Conditions
Treatment of Other Pain Conditions in Migraine
Conclusion
References
Chapter 32 Comorbidities of migraine: Sleep disorders
Abstract
Introduction
Mechanistic Considerations
Summary
References
Chapter 33 The evolving concept of multimorbidity and migraine
Abstract
Introduction
Cerebrovascular Diseases and Migraine
Metabolic and Endocrine Disorders and Migraine
Epilepsy and Migraine
Psychiatric Disorders and Migraine
Chronic Pain Syndromes and Migraine
Sleep Disorders and Migraine
Gastrointestinal Disorders and Migraine
Immunological Disorders and Migraine
Conclusions
References
Further reading
Section VII: Future directions
Chapter 34 Healthcare disparities encountered by patients with headache disorders and potential mitigation strategies
Abstract
Introduction
The Societal Burden of Headache Disorders
Disparities in Emergency Room Management
Disparities in Outpatient/Subspecialty Clinic
Socioeconomic Status/Insurance Status
Geography
Why Do These Disparities Exist?
Lack of Representation in Research
Potential Solutions to Address Headache Disparities
Conclusion
References
Further reading
Chapter 35 Emerging and future directions of migraine research and treatment
Abstract
Introduction
Headache Diagnosis and Classification
Biomarkers
Potential Future Treatment Targets
Conclusions
References
Index

Jerry W. Swanson

Jerry W. Swanson, MD, is a consultant in the Department of Neurology and Professor of Neurology in the Mayo Clinic College of Medicine and Science. Dr. Swanson received his medical degree from the Feinberg School of Medicine at Northwestern University in Chicago. He completed a neurology residency at Mayo Clinic. He earned the Master of Health Professions degree at the University of Illinois at Chicago. He has been on the staff of Mayo Clinic in Rochester, Minn., since 1982. He is former chair of the Headache Division in the Department of Neurology and founding director of the headache medicine fellowship at Mayo Clinic in Minnesota. Dr. Swanson is board-certified in Neurology and in the subspecialty of Headache Medicine. He has written extensively about headache and other neurologic disorders. Swanson has made more than 100 presentations at national and international meetings, published more than 60 peer-reviewed articles, and numerous book chapters; he is an associate editor for the journal Headache and is a neurology editor for MayoClinic.com, a leading site for health information for the public. He has co-edited two books including The Mayo Clinic on Headache, a highly praised book for the lay public. He is a neurology editor for MayoClinic.com and is the headache topic editor and neurology editor-in-chief for UpToDate. He was a founding member for the UCNS Headache Medicine examination committee and is currently serving another term on the committee. He was the founding director of the Headache Medicine fellowship at Mayo Clinic in Rochester, Minn. Dr. Swanson has served in several leadership roles in the American Academy of Neurology and the American Headache Society and was a member of the International Headache Congress scientific program committee. He has been the recipient of the Mayo Medical School Dean’s Recognition Award.

Affiliations and expertise

Mayo Clinic College of Medicine and Science, Rochester, MN, United States

Manjit Matharu

Dr. Manjit Matharu is a Consultant Neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London. He received a BSc (First Class Honours) University of Manchester and MB, ChB (Honours Degree) University of Manchester. He earned a PhD at the University of London. He completed his residency in Neurology at The National Hospital for Neurology and Neurosurgery, The Royal London Hospital and Homerton Hospital in London in 2007. Dr Matharu’s major research interests include functional and structural imaging in Primary headaches, trigeminal autonomic cephalalgias and neurostimulation for intractable headaches. He has authored over 100 scientific papers. Dr. Matharu is the clinical and academic lead of the Headache Group at The National Hospital for Neurology and Neurosurgery, which is widely recognized as one of the foremost Headache Centers worldwide. He has lectured on headache topics both domestically and internationally.

Affiliations and expertise

Consultant Neurologist, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom

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