Epigenetic Regulation of Cancer - Part B
- 1st Edition, Volume 383 - February 13, 2024
- Editors: Sheila Spada, Lorenzo Galluzzi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 6 5 3 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 6 5 4 - 2
Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume pr… Read more
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Request a sales quoteEpigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer.
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- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Epigenetic regulation of cancer
- Acknowledgments
- References
- Chapter One: Epigenetic therapeutic strategies in pancreatic cancer
- Abstract
- 1 Introduction
- 2 Epigenetic changes in the PDAC tumor microenvironment and therapeutic implications
- 3 Epigenetic markers for PDAC diagnosis and prognosis
- 4 Epigenetic alterations in pancreatic cancer metastasis
- 5 Conclusions
- References
- Further reading
- Chapter Two: Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications
- Abstract
- 1 Introduction
- 2 NEPC development as a mechanism of treatment resistance
- 3 Current approach to NEPC diagnosis and management
- 4 Genetic and epigenetic landscape of NEPC
- 5 Emerging treatment options in NEPC
- 6 Circulating tumour cells in NEPC
- 7 Conclusion
- Acknowledgements
- References
- Chapter Three: Epigenetic control of cell signalling in cancer stem cells
- Abstract
- 1 Introduction
- 2 Wnt/β-catenin signalling pathway
- 3 Hedgehog signalling pathway
- 4 Notch signalling pathway
- 5 TGFβ/BMP signalling pathway
- 6 Therapeutic interventions targeting epigenetic regulators in CSCs
- 7 Conclusion
- References
- Chapter Four: Epigenetic inhibitors for cancer treatment
- Abstract
- 1 Introduction
- 2 The molecular cascade of epigenetic modifications (summarized as Fig. 1)
- 3 The role of epigenetic regulation in cancers
- 4 Current development of epigenetic inhibitors for cancer treatment
- 5 Discussion
- 6 Conclusion
- References
- Chapter Five: Epigenetics as a determinant of radiation response in cancer
- Abstract
- 1 Introduction
- 2 Epigenetic code
- 3 DNA methylation
- 4 Histone modifications and chromatin remodeling
- 5 RNA methylation
- 6 Radiotherapy resistance pathways and epigenetic mechanisms in cancer
- 7 Cancer stem cells
- 8 Tumor microenvironment and radioresistance
- 9 Epigenetic mechanisms in tumor immunology and radiation resistance
- 10 Stroma cells and tumor communication
- 11 Conclusion and future perspectives
- Acknowledgments
- References
- Chapter Six: Epigenome editing in cancer: Advances and challenges for potential therapeutic options
- Abstract
- 1 Introduction
- 2 Dysregulation of epigenetic components in cancer
- 3 Technology modulating cancer epigenomes
- 4 Challenges and future directions of current epigenome modulating tools for cancer therapeutic options
- 5 Closing remarks
- Funding
- References
- No. of pages: 395
- Language: English
- Edition: 1
- Volume: 383
- Published: February 13, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443136535
- eBook ISBN: 9780443136542
SS
Sheila Spada
Sheila Spada is at Weill Cornell Medical College, NY, USA
Affiliations and expertise
Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USALG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USARead Epigenetic Regulation of Cancer - Part B on ScienceDirect