Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds
- 1st Edition - March 1, 2024
- Imprint: Academic Press
- Editors: Yongjun Wei, Xiao-Jun Ji, Mingfeng Cao
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 5 5 8 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 5 5 9 - 8
Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds will be of great interest to undergraduate and graduate students, scientists, researche… Read more
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Request a sales quoteEngineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds will be of great interest to undergraduate and graduate students, scientists, researchers, and engineers who work on the microbial production of plant-derived bioactive compounds. As many plant-derived bioactive compounds are the foundation of effective drugs to cure diseases, it's important to understand the limits of their applications in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast.
This book summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing the content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks.
- Provides valuable information for engineers, scientists, and industrial researchers who want to obtain microbial strains with the ability of plant-derived bioactive compound production
- Guides microbial production of plant-derived bioactive compounds at the laboratory and industrial levels
- Ideal resource for anyone who works on the microbial production of plant-derived bioactive compounds
students, scientists, and other academic researchers who work at the field of metabolic engineering and synthetic biology
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Mining bioparts for the biosynthesis of plant-derived bioactive compounds via omics and bioinformatics technologies
- Abstract
- 1.1 Status of omics and bioinformatics in mining bioparts of plant-derived bioactive compounds
- 1.2 The biosynthetic pathways and key enzymes of plant-derived bioactive compounds
- 1.3 The bioparts of plant-derived bioactive compounds
- 1.4 Bioinformatics integrates omics data to efficiently mine bioparts
- 1.5 Conclusions and future prospects
- References
- Chapter 2. DNA assembly techniques for the reconstitution of plant natural product biosynthetic pathways in Saccharomyces cerevisiae
- Abstract
- 2.1 Introduction
- 2.2 Techniques for the assembly of multigene biosynthetic pathways in plasmids
- 2.3 Techniques for the assembly of multigene biosynthetic pathways in the yeast genome
- 2.4 Summary and perspectives
- Acknowledgments
- Declaration of interests
- References
- Chapter 3. The application of gene-editing technologies in the biosynthesis of plant-derived bioactive compounds
- Abstract
- 3.1 Introduction
- 3.2 Brief principle of CRISPR-Cas9 system
- 3.3 Metabolic engineering of plant-derived bioactive compounds in fungi by CRISPR-Cas9 technology
- 3.4 Metabolic engineering in bacteria by CRISPR-Cas9 technology
- Acknowledgments
- Declaration of interest
- References
- Chapter 4. Pathway engineering of plant-derived bioactive compounds in microbes
- Abstract
- 4.1 Introduction
- 4.2 Discovery and pathway elucidation of natural products in plants
- 4.3 Reconstitution of plant-derived bioactive compound pathways in microbes
- 4.4 Novel methods
- 4.5 Applications and future horizons of plant-derived bioactive compounds
- 4.6 Perspectives
- Acknowledgments
- CRediT authorship contribution statement
- Declaration of interests
- References
- Chapter 5. Construction and application of a genome-scale metabolic network model for plants
- Abstract
- 5.1 Research status of plant metabolic network model
- 5.2 The construction of plant metabolic network model
- 5.3 Application of plant metabolic network model
- 5.4 Prospects
- Acknowledgment
- Declaration of interest
- References
- Chapter 6. Metabolic design–build–test–learn cycle used for the biosynthesis of plant-derived bioactive compounds
- Abstract
- 6.1 Introduction
- 6.2 Design
- 6.3 Build
- 6.4 Test
- 6.5 Learn
- 6.6 Perspectives
- References
- Chapter 7. Microbial cell factories for the synthesis of plant-derived bioactive compounds: metabolic flux dynamic regulation
- Abstract
- 7.1 Fine-tuning gene expression
- 7.2 Cofactor balance
- 7.3 Coculture system
- 7.4 Future perspective
- Acknowledgment
- Declaration of interest
- References
- Chapter 8. Yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids
- Abstract
- 8.1 Introduction
- 8.2 Monoterpenes
- 8.3 Sesquiterpenes
- 8.4 Diterpenoids
- 8.5 Triterpenoids
- 8.6 Tetraterpenes
- Acknowledgment
- Declaration of interest
- References
- Chapter 9. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids
- Abstract
- 9.1 Introduction
- 9.2 Biosynthetic pathway of terpenoids
- 9.3 Typical terpenoid products
- 9.4 Metabolic engineering strategy for optimizing terpenoids synthesis
- 9.5 Conclusion and prospect
- Acknowledgments
- Authorship contribution statement
- Declaration of competing interests
- References
- Chapter 10. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive flavonoids
- Abstract
- 10.1 Introduction
- 10.2 The biosynthetic pathway of flavonoids
- 10.3 Nonconventional yeasts for the biosynthesis of flavonoids
- 10.4 Metabolic engineering strategies for optimizing flavonoids synthesis
- 10.5 Conclusion and prospects
- Acknowledgments
- Authorship contribution statement
- Declaration of competing interests
- References
- Chapter 11. Non-yeast fungal cell factories for the biosynthesis of plant-derived bioactive compounds
- Abstract
- 11.1 Common industrial mold-based fungal cell factories
- 11.2 Plant-associated endophytes
- 11.3 Mushroom-based cell factories
- 11.4 Conclusions and future perspectives
- Acknowledgment
- Declaration of interest
- References
- Chapter 12. Fine-tuning and dynamic control of microbial cell factories for the biosynthesis of plant-derived bioactive compounds
- Abstract
- 12.1 Introduction
- 12.2 Fine-tune strategies for reconstruction of metabolic flux balance
- 12.3 Dynamic control strategies and their applications in the biosynthesis of plant-derived bioactive compounds
- 12.4 Future perspectives
- References
- Chapter 13. Biofoundries for plant-derived bioactive compounds
- Abstract
- 13.1 Biofoundries
- 13.2 Laboratory automation
- 13.3 Cloud laboratory
- 13.4 The robot scientist
- 13.5 The successful biofoundries
- 13.6 Perspective
- Acknowledgment
- Declaration of interest
- References
- Chapter 14. Engineering biology fundamental for plant-derived bioactive compounds: challenges and prospects
- Abstract
- 14.1 Introduction
- 14.2 Challenges and strategies at the “point” level
- 14.3 Challenges and strategies at the “line” level
- 14.4 Challenges and strategies at the “plane” level
- 14.5 Challenges and strategies at the “system” level
- References
- Chapter 15. Reprogramming microbial cell factories to overproduce plant natural products through directed genome evolution
- Abstract
- 15.1 Terpenoids
- 15.2 Phenylpropanoids
- 15.3 Conclusion and perspective
- Acknowledgment
- Declaration of interest
- References
- Index
- Edition: 1
- Published: March 1, 2024
- Imprint: Academic Press
- No. of pages: 382
- Language: English
- Paperback ISBN: 9780443155581
- eBook ISBN: 9780443155598
YW
Yongjun Wei
Dr. Yongjun Wei, PhD, completed his bachelor’s degree in biology at Shaanxi Normal University, China, before pursuing his PhD in microbiology from the Chinese Academy of Sciences (CAS) in 2014. Following his doctoral studies, he conducted a postdoctoral fellowship at the Chalmers University of Technology from 2014 to 2016. After that, he worked as an assistant researcher at CAS for a year before joining Zhengzhou University’s faculty in 2018. Currently he serves as an associate professor at Zhengzhou University, Dr. Wei has published over 80 peer-reviewed papers and holds more than 20 patents. Furthermore, he serves as an editorial board member or youth editor for over 10 different journals. His research primarily focuses on microbial production of plant bioactive natural products and the utilization of microorganisms for disease treatment and pollution eradication.
Affiliations and expertise
School of Pharmaceutical Sciences, Laboratory of Synthetic Biology, Food Laboratory of Zhongyuan, Zhengzhou University, Zhengzhou, ChinaXJ
Xiao-Jun Ji
Dr. Xiao-Jun Ji, PhD, is currently a professor of bioengineering and biochemical engineering at Nanjing Tech University (NanjingTech), China. He received his BSc and PhD degrees from NanjingTech in 2005 and 2009 and conducted the visiting research in the Systems and Synthetic Biology lab headed by Prof. Jens Nielsen at Chalmers, Sweden during 2016 and 2017. His recent research focuses on biomanufacturing pharmaceutical and nutritional chemicals using the nonconventional yeasts through the metabolic engineering and the emerging synthetic biology tools. He has many awards such as the Fok Ying-Tung Foundation Young Scholars Award (2014), the Hou De-Bang Chemical Youth Award of CIESC (2016), the National Technological Invention Award of China (2018), the Excellent Young Scholars of NSFC (2019), and the Newton Advanced Fellowships of the Royal Society (2020).
Affiliations and expertise
NanjingTech University, National Engineering Research Centre for Biotechnology , Nanjing, ChinaMC
Mingfeng Cao
Dr. Mingfeng Cao, PhD, is the Minjiang distinguished professor in the Department of Chemical and Biochemical Engineering, the director of the Institute of Bioengineering, and an honorary research fellow of the Tan Kah Kee Innovation Laboratory at the Xiamen Laboratory, China. He was awarded his PhD from the Nankai University in 2011, and between 2011 and 2013 worked as a research associate at the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences. He completed postdoctoral studies at Iowa State University, USA and was a research scientist at the University of Illinois from 2018 to 2021. His research focuses on the development of synthetic biology and metabolic engineering strategies to establish microbial cell factories for value-added and green chemical production. Dr. Cao has published over 60 journal articles and holds 10 patents. He also serves as the editor-in-chief of Biotechnology Reports and the associate editor for journals such as Microbial Cell Factories and Biotechnology for Biofuels and Bioproducts.
Affiliations and expertise
Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Key Laboratory for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen, ChinaRead Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds on ScienceDirect