Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson’s disease

1st Edition, Volume 174 - February 1, 2024
Editors: Mahmoud Iravani, Susan Duty
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 1 8 3 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 1 8 4 - 1

Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the… Read more

Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson’s disease

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Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as A general clinical overview of the non-motor symptoms, Stress/fatigue/cognitive decline Sleep/autonomic failure, A general clinical overview of the non-motor symptoms – psychiatric symptoms, Psychosis, Cognitive Decline, Non-clinical Aspect of non-motor symptoms: Animal Models, Assessment and treatment of cognitive decline in rodent and primate models, Pain in PD models, Affective disorders in PD models, Sleep and circadian dysregulation and EEG disruption in rodent models, and much more.

Mahmoud Iravani

Mahmoud Iravani has a long standing research interest in neurodegeneration mechanisms in Parkinson’s Disease and L-Dopa induced dyskinesia with Peter Jenner at Neurodegenerative Disease Research Centre at King's College London. Most recently at King’s College London, in collaboration with Professors Paul Francis and Clive Ballard, he investigated the anti-apoptotic and anti-aggregative role of various agents in the lactacystin model of Parkinson’s disease. A second project, which is still ongoing, has involved imaging of the structural changes in the primate brains following MPTP treatment, using MRI at the Institute of Psychiatry. At the University of Herfordshire his focus will be primarily on Parkinson’s disease neuropathology as well as novel treatments for L-dopa induced dyskinesia. Specifically, he will focus on the non-dopaminergic aspects of the parkinsonian pathology and role of inflammation in protein aggregation and the treatment of of l-dopa induced dyskinesia. In the first instance, achieving these goals, will be pursued by collaborating with colleagues at King’s College London. In addition, he will be submitting grant applications to identify the mechanisms of PD induced non-motor dysfunction.

Affiliations and expertise

Associate Professor, University of Hertfordshire, Hatfield, UK

Susan Duty

Professor Susan Duty PhD, FBPhS is a Professor in Pharmacology & Neuroscience in King's College London. She is also Head of Department of Pharmacology & Therapeutics, responsible for delivery of pharmacology education to undergraduate and masters students. She has received Teaching Excellence Awards from King’s College London and the British Pharmacology Society in recognition of her innovative education. Her research is dedicated to better understanding, and finding improved treatments for, Parkinson’s disease. A key focus is to find drugs to combat the neurodegeneration underpinning Parkinson’s. As well as identifying novel targets for achieving this, such as mGlu4 receptors, we use targeted repurposing strategies to identify existing drugs that boost protective growth factor levels and explore novel delivery mechanisms for the growth factors themselves. Another key focus is to define the mechanisms behind pain in Parkinson’s and identify ways in which patients’ pain can be better managed.

Affiliations and expertise

Professor in Pharmacology and Neuroscience, King's College London, London, UK