Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson’s disease
- 1st Edition, Volume 174 - February 7, 2024
- Imprint: Academic Press
- Editors: Mahmoud Iravani, Susan Duty
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 1 8 3 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 1 8 4 - 1
Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the… Read more
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Request a sales quoteTranslational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as A general clinical overview of the non-motor symptoms, Stress/fatigue/cognitive decline Sleep/autonomic failure, A general clinical overview of the non-motor symptoms – psychiatric symptoms, Psychosis, Cognitive Decline, Non-clinical Aspect of non-motor symptoms: Animal Models, Assessment and treatment of cognitive decline in rodent and primate models, Pain in PD models, Affective disorders in PD models, Sleep and circadian dysregulation and EEG disruption in rodent models, and much more.
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Undergraduates, graduates, academics, and researchers in the field of Non-Motor Symptoms of Neurodegenerative Diseases
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface
- Chapter One: Setting the clinical context to non-motor symptoms reflected by Park-pain, Park-sleep, and Park-autonomic subtypes of Parkinson’s disease
- Abstract
- 1 Introduction
- 2 Park-pain subtype of Parkinson’s disease
- 3 Park-sleep subtype of Parkinson’s disease
- 4 Park-autonomic subtype of Parkinson’s disease
- 5 Conclusion
- References
- Chapter Two: A general clinical overview of the non-motor symptoms in Parkinson’s disease: Neuropsychiatric symptoms
- Abstract
- 1 Cognitive impairment
- 2 Psychosis
- 3 Depression
- 4 Anxiety
- 5 Apathy
- 6 Conclusions
- References
- Chapter Three: Insight gained from using animal models to study pain in Parkinson’s disease
- Abstract
- 1 Introduction
- 2 Pain pathways
- 3 Measuring nociception in animal models of Parkinson’s disease
- 4 Insight gained about pain in PD from studies in animal models
- 5 Closing remarks
- Acknowledgements
- References
- Chapter Four: Investigating affective neuropsychiatric symptoms in rodent models of Parkinson’s disease
- Abstract
- 1 Neuropsychiatric symptoms in Parkinson’s disease
- 2 Rodent models of PD for the study of affective neuropsychiatric symptoms
- 3 Behavioral assessment of PD-related depression and apathy
- 4 Behavioral assessment of PD-related anxiety
- 5 Other α-Syn based models of PD
- 6 Conclusions and perspectives
- References
- Chapter Five: Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson’s disease
- Abstract
- 1 Introduction
- 2 Macro sleep dysfunctions and their replication in animal models of PD
- 3 Micro sleep dysfunctions and their replication in animal models of PD
- 4 Exploring the link between PD-related genes and sleep dysfunction
- 5 Mathematical/computational models of electrophysiological dysfunctions in PD
- 6 Conclusion
- References
- Chapter Six: Review: Lower urinary tract dysfunction in animal models of Parkinson’s disease (PD): Translational aspects for the treatment of PD patients with overactive bladder
- Abstract
- Abbreviations
- 1 Introduction
- 2 PD animal models and lower urinary tract symptoms
- 3 Methods for assessing lower urinary tract function
- 4 PD models
- 5 Dopaminergic control of bladder function
- 6 Effects of antiparkinsonian drugs on the lower urinary tract
- 7 Conclusions
- References
- Chapter Seven: Executive dysfunction and cognitive decline, a non-motor symptom of Parkinson’s disease captured in animal models
- Abstract
- 1 Introduction
- 2 Cognitive and executive dysfunction in PD
- 3 Role of animal models in advancing our understanding of cognitive dysfunction in PD
- 4 Experimental approaches used to interrogate cognitive behaviours in rodent models
- 5 Learning and memory impairment in rats
- 6 Rodent tests of cognition in PD that reveal hippocampal pathology
- 7 Executive dysfunction in Parkinsonian rats
- 8 Experimental approaches used in primate models
- 9 Conclusions
- References
- Further reading
- Edition: 1
- Volume: 174
- Published: February 7, 2024
- Imprint: Academic Press
- No. of pages: 322
- Language: English
- Hardback ISBN: 9780323991834
- eBook ISBN: 9780323991841
MI
Mahmoud Iravani
Mahmoud Iravani has a long standing research interest in neurodegeneration mechanisms in Parkinson’s Disease and L-Dopa induced dyskinesia with Peter Jenner at Neurodegenerative Disease Research Centre at King's College London. Most recently at King’s College London, in collaboration with Professors Paul Francis and Clive Ballard, he investigated the anti-apoptotic and anti-aggregative role of various agents in the lactacystin model of Parkinson’s disease. A second project, which is still ongoing, has involved imaging of the structural changes in the primate brains following MPTP treatment, using MRI at the Institute of Psychiatry.
At the University of Herfordshire his focus will be primarily on Parkinson’s disease neuropathology as well as novel treatments for L-dopa induced dyskinesia. Specifically, he will focus on the non-dopaminergic aspects of the parkinsonian pathology and role of inflammation in protein aggregation and the treatment of of l-dopa induced dyskinesia. In the first instance, achieving these goals, will be pursued by collaborating with colleagues at King’s College London. In addition, he will be submitting grant applications to identify the mechanisms of PD induced non-motor dysfunction.
Affiliations and expertise
Associate Professor, University of Hertfordshire, Hatfield, UKSD
Susan Duty
Professor Susan Duty PhD, FBPhS is a Professor in Pharmacology & Neuroscience in King's College London. She is also Head of Department of Pharmacology & Therapeutics, responsible for delivery of pharmacology education to undergraduate and masters students. She has received Teaching Excellence Awards from King’s College London and the British Pharmacology Society in recognition of her innovative education.
Her research is dedicated to better understanding, and finding improved treatments for, Parkinson’s disease. A key focus is to find drugs to combat the neurodegeneration underpinning Parkinson’s. As well as identifying novel targets for achieving this, such as mGlu4 receptors, we use targeted repurposing strategies to identify existing drugs that boost protective growth factor levels and explore novel delivery mechanisms for the growth factors themselves. Another key focus is to define the mechanisms behind pain in Parkinson’s and identify ways in which patients’ pain can be better managed.
Affiliations and expertise
Professor in Pharmacology and Neuroscience, King's College London, London, UKRead Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson’s disease on ScienceDirect