Microbiota Brain Axis
A Neuroscience Primer
- 1st Edition - February 22, 2024
- Latest edition
- Authors: Jane Foster, Gerard Clarke
- Language: English
Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the ap… Read more
Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research.
- Reviews the many approaches to manipulating the microbiota in animal studies - including the use of germ-free animals, antibiotics and diet - and covers the strengths and limitations of each
- Outlines available microbiota research tools, such as 16S sequencing and shot-gun metagenomics
- Provides a comprehensive guide to analyzing microbiota-related data and the many choices for bioinformatics
Advanced students, basic researchers, and clinical researchers in behavioral neuroscience, neuroimmunology, biological psychiatry, developmental neuroscience, and related fields; researchers in physiology, nutrition, immunology, and gastroenterology
1. The gut-brain axis
2. What is a healthy microbiome?
3. Gene-environment factors influence microbiota composition, diversity, and function
4. Microbiota to brain communication
5. Microbiota influence behaviour – work in animal models
6. Microbiota influence brain systems – work in animal models
7. Microbiota in neurodevelopmental disorders
8. Microbiota in psychiatry
9. Microbiota-brain interactions in aging and neurodegeneration
10. Pharmacological treatments and the microbiome - Antibiotics and nonantibiotic drugs
11. Microbial-related treatments
12. Microbiota-related biomarkers for precision medicine and drug discovery
2. What is a healthy microbiome?
3. Gene-environment factors influence microbiota composition, diversity, and function
4. Microbiota to brain communication
5. Microbiota influence behaviour – work in animal models
6. Microbiota influence brain systems – work in animal models
7. Microbiota in neurodevelopmental disorders
8. Microbiota in psychiatry
9. Microbiota-brain interactions in aging and neurodegeneration
10. Pharmacological treatments and the microbiome - Antibiotics and nonantibiotic drugs
11. Microbial-related treatments
12. Microbiota-related biomarkers for precision medicine and drug discovery
- Edition: 1
- Latest edition
- Published: February 22, 2024
- Language: English
JF
Jane Foster
Dr. Jane Foster, Ph.D., is a Professor in the Department of Psychiatry, at
the Center for Depression Research and Clinical Care at UT Southwestern
Medical Center in Dallas, Texas. In the past 20 years, Dr. Foster has
developed an internationally recognized translational research program that
uses a ‘bench to bedside’ and back again approach to studying microbiota -
brain and immune - brain systems. As one of the early proponents of the
role of gut - brain axis in mental health, her lab produced important data
demonstrating a role for the microbiome in brain development and
behavior in animal studies and recently has extended this work to study the
complex neurobiological underpinnings of microbiota - brain and neuroimmune
systems in psychiatric illness in clinical populations. Her multidisciplinary
expertise includes behavioral neuroscience, molecular biology,
immunology, neuroimaging, microbiome, and bioinformatics in both
preclinical and clinical research domains. Dr. Foster’s research program has
developed high-quality analytical pipelines for biological data and novel
analytical tools for integrating data across modalities.
Affiliations and expertise
Professor, Center for Depression Research and Clinical Care, Department of Psychiatry, UT Southwestern Medical Center, Dallas, TXGC
Gerard Clarke
Prof. Gerard Clarke, Ph.D., is a Professor of Neurobehavioral Science in
the Department of Psychiatry and Neurobehavioral Science and a Principal
Investigator in APC Microbiome Ireland at University College Cork. His
research program includes a focus on translational biomarkers of stress-related
neuropsychiatric disorders, the impact of the gut microbiome on
brain and behavior across the life span, and microbial regulation of tryptophan
metabolism. Key achievements of his lab in the generation of
knowledge around the microbiota - gut - brain axis include the demonstration
that the gut microbiome regulates the hippocampal serotonergic
system in a sex-dependent manner, findings that paved the way for
numerous lines of inquiry on the effects of the gut microbiome on neurodevelopment,
brain function, and behavior. He is regularly included in
Clarivate Analytics Highly Cited Researchers list, placing him among the
world’s top one percent of researchers by citation. His current approach is
based on advancing frontier knowledge in microbiome research to yield
potential new therapeutic targets for the effective treatment of the central
nervous system and gastrointestinal disorders.
Affiliations and expertise
Lecturer, Department of Psychiatry and Neurobehavioural Science and Principal Investigator, APC Microbiome Ireland, University College Cork, Cork, IrelandRead Microbiota Brain Axis on ScienceDirect