Aging
How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases
- 1st Edition - February 29, 2024
- Editor: Michael Fossel
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 5 0 0 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 5 0 1 - 7
Aging: How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases explains the process of aging beyond mere entropy, exposing it as a complicated and dynamic p… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteAging: How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases explains the process of aging beyond mere entropy, exposing it as a complicated and dynamic process that undercuts maintenance and permits age-related disease. With a deeper understanding of the aging process, intervention becomes both easy to understand and clinically feasible.
With a solid academic approach, this proposed book builds upon the substantial work published over the past 20 years, citing the newest data, up-to-date models based upon that data, and the implications for improved clinical intervention, including recent developments in gene and cell therapy. Coverage of age-related diseases includes neurodegenerative, cardiovascular, bone and joint, immune system, renal, pulmonary, and skin aging. Future directions of the field focus on interventions, including a summary of previous attempts to intervene in aging and age-related disease, the status of current research, and proposed biotech interventions, as well as their potential obstacles, risks, and benefits.
This is the perfect reference for scientists, clinicians, and researchers interested in the translational research opportunities such as drug discovery, pharmacogenetics, and experimental therapeutics, not only summarizing where the field stands, but giving a clear and cogent view of where clinical medicine is going in the next decade.
- Provides a sophisticated, accurate, and clear explanation of aging
- Gives a clear explanation of the fundamental role of cell aging in age-related disease
- Offers a unified model for the role of epigenetic and telomere changes in cell aging
- Outlines effective approaches to intervention in the fundamental aging process
- Introduces upcoming interventions intended to both cure and prevent age-related diseases
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- About the editor
- Foreword
- Preface
- Acknowledgments
- Chapter 1. Introduction to aging and age-related disease
- 1. Introduction
- 2. How did we get here?
- 3. How to understand aging
- 4. The limited role of biomarkers
- 5. A unified systems model
- 6. Caveats
- 7. Prospects for intervention
- Chapter 2. Age-related disease: Central nervous system
- 1. Introduction
- 2. The dementias
- 3. Therapeutic status
- 4. Neuroanatomy
- 5. Cell types
- 6. Biochemical changes
- 7. Aging as a key process
- 8. Unified systems model: Cell aging in the central nervous system
- 9. Summary
- Chapter 3. Age-related disease: Cardiovascular system
- 1. Determinants of arterial stiffness
- 2. How to define early vascular aging
- 3. Mechanisms important for modifying arterial stiffness and vascular aging
- 4. Factors in early life influencing arterial stiffness and early vascular aging
- 5. Healthy and supernormal vascular aging
- 6. Treatment of cardiovascular risk and clinical manifestations
- 7. Emerging role of polypill for cardiovascular prevention
- 8. Summary: Aging and cardiovascular risk—mechanisms and clinical aspects
- 9. Role of cell aging in cardiovascular disease
- 10. Prospects for intervention
- Chapter 4. Age-related disease: Bones
- 1. Introduction: Bone anatomy and homeostasis
- 2. Skeletal maintenance and remodeling
- 3. Osteoporosis: An overview
- 4. Therapeutic options to treat osteoporosis: Current interventions
- 5. Cellular components of an aging bone
- 6. Biology of an aging bone: Mechanisms and pathways
- 7. Therapeutic options: Future potential interventions and emerging trials
- 8. Conclusion
- Chapter 5. Age-related disease: Joints
- 1. Cartilage structure and function: a primer
- 2. Aging and osteoarthritis
- 3. Replicative senescence in cartilage
- 4. Stress-induced senescence in cartilage
- 5. The senescence-associated secretory profile in chondrocytes
- 6. Autophagy: A complex interrelationship with senescence
- 7. The role of sirtuins in chondrosenescence
- 8. The emerging role of circadian clocks in senescence
- 9. mTOR, nutrient sensing, and senescence in cartilage
- 10. Stem cell exhaustion?
- 11. The role of the extracellular matrix in initiating and stabilising cellular senescence
- 12. Chondrosenescence: Can the advancing tide be reversed?
- 13. Conclusion
- Chapter 6. Age-related disease: Kidneys
- 1. Introduction
- 2. Aging kidney
- 3. Common alterations in cellular and molecular mechanisms of renal aging and CKD
- 4. Prevalence of CKD in the elderly
- 5. Risk factors for CKD in the elderly
- 6. CKD care and management for the elderly
- 7. Conclusion
- Chapter 7. Age-related disease: Immune system
- 1. Introduction
- 2. The aging of the immune system
- 3. Examples of conditions related to immune system aging
- 4. Biomolecular mechanisms of immunosenescence
- 5. Upstream risk factors
- 6. Biomarkers/downstream factors related to aging and immunosenescence
- 7. Future perspectives
- 8. Conclusion
- Chapter 8. Age-related disease: Skin
- 1. Geriatric dermatology
- 2. Fountain of youth and skin health
- 3. Chronological versus biological skin aging
- 4. Clinical manifestations of skin aging
- 5. Regenerative aesthetics
- 6. Cellular senescence
- 7. Function of senescent cells
- 8. Features of senescent cells
- 9. Biochemical markers of cellular senescence
- 10. Senescence in skin aging
- 11. Targeting senescent cells in the skin
- 12. Senotherapeutic agents for skin
- 13. First- and second-generation senolytics
- 14. Translation to clinical practice
- 15. Targeting cellular senescence with senotherapies
- 16. Conclusion
- Chapter 9. Age-related disease: Lungs
- 1. Introduction and relevant anatomy
- 2. The aging lung
- 3. Role of cell aging in age-related lung disease
- 4. Specific lung diseases correlated with advanced age
- 5. Current research, future direction, and potential interventions
- Chapter 10. Age-related disease: Diabetes
- 1. Introduction: Type 2 diabetes is an age-related disease
- 2. Cellular senescence in the pathogenesis of type 2 diabetes
- 3. The diabetic microenvironment drives senescent cell accumulation
- 4. Cellular senescence and diabetic complications
- 5. Current diabetes therapeutics: Impact on cellular senescence
- 6. Targeting cellular senescence in diabetes
- 7. Clinical trials
- 8. Challenges and future directions
- 9. Conclusions
- Chapter 11. Age-related disease: Eyes
- 1. Introduction
- 2. Presbyopia
- 3. Glaucoma
- 4. Lens
- 5. Retina
- 6. The eye as a window to other age-related diseases
- 7. Upstream opportunities for life and health extension
- 8. Summary
- Chapter 12. Age-related disease: Cancer, telomerase, and cell aging
- 1. Introduction
- 2. A short historical perspective
- 3. Current cancer treatments
- 4. Relationship between cancer, aging, and telomerase
- 5. Conclusion
- Chapter 13. Age-related disease: Effective intervention
- 1. Perspective
- 2. Current approaches
- 3. Targeting aging processes
- 4. Targeting a dominant process in cell aging
- 5. Where do we stand now?
- 6. Where we are going
- Chapter 14. Summary
- 1. Introduction
- 2. Is aging a disease?
- 3. Organs
- Index
- No. of pages: 272
- Language: English
- Edition: 1
- Published: February 29, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443155000
- eBook ISBN: 9780443155017
MF