Adrenal Gland
- 1st Edition, Volume 124 - February 23, 2024
- Imprint: Academic Press
- Editor: Gerald Litwack
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 4 0 0 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 4 0 1 - 6
Adrenal Gland, Volume 124 in the Vitamins and Hormones series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is writt… Read more
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Request a sales quoteAdrenal Gland, Volume 124 in the Vitamins and Hormones series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in Vitamins and Hormones series
- Updated release includes the latest information on the Adrenal Gland
Undergraduates, graduates, academics, and researchers in the field of vitamins and hormones
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Former Editors
- Contributors
- About the editor
- Chapter One: MicroRNA regulation of adrenal glucocorticoid and androgen biosynthesis
- Abstract
- 1 Steroid hormones—An overview
- 2 Metabolic functions and biosynthesis of adrenal steroid hormones
- 3 miRNA—An overview
- 4 miRNA regulation of adrenal glucocorticoids and androgens production
- 5 Conclusions
- Acknowledgments
- References
- Chapter Two: Serotonin and the serotonin transporter in the adrenal gland
- Abstract
- 1 Functional organization of the adrenal gland
- 2 Introduction to serotonin and serotonin signaling
- 3 Serotonin and the adrenal cortex
- 4 Serotonin and SERT in the adrenal medulla
- Acknowledgements
- References
- Chapter Three: Regulation of lipid droplets and cholesterol metabolism in adrenal cortical cells
- Abstract
- Abbreviations
- 1 Adrenal cortical compartmentalization and lipid storage
- 2 Lipid droplets
- 3 Cholesterol in adrenal cortex: Synthesis, uptake, storage and steroidogenesis
- 4 Lipid disturbances causing abnormal cortical CE storage and its effect on steroidogenesis
- 5 Concluding remarks
- References
- Chapter Four: MicroRNAs in aldosterone production and action
- Abstract
- 1 Aldosterone
- 2 MicroRNA
- 3 The role of microRNA in aldosterone production
- 4 The role of microRNA in aldosterone action
- 5 Circulating microRNAs and their role in aldosterone-associated diagnostics
- References
- Chapter Five: Genetic variants in the renin-angiotensin-aldosterone system: Impact on cancer risk, prognosis, and therapeutic directions
- Abstract
- 1 Introduction
- 2 RAAS structure
- 3 RAAS pathophysiology
- 4 RAAS and carcinogenesis
- 5 RAAS variants and cancer risk
- 6 RAAS variants and cancer prognosis
- 7 RAAS variants and response to therapy
- 8 Conclusion and future perspectives
- References
- Chapter Six: Adaptive remodeling of the stimulus-secretion coupling: Lessons from the ‘stressed’ adrenal medulla
- Abstract
- 1 Introduction
- 2 Adrenomedullary stimulus-secretion coupling: A multi-faceted mechanism for a continuous adaptation to stress-induced homeostasis changes
- 3 The ‘stressed’ adrenal medulla
- 4 Conclusion and futures directions
- Acknowledgments
- References
- Chapter Seven: Current insight into the transient X-zone in the adrenal gland cortex
- Abstract
- 1 Development of the fetal adrenal gland in mice
- 2 Postnatal development of the adrenal X-zone and strain-dependent phenotypes
- 3 X-zone marker genes and the functional significance of the X-zone
- 4 Gene mutations that cause aberrant X-zone formation/development
- 5 Gene mutations that cause abnormal X-zone regression
- 6 The sexually-dimorphic response of the X-zone
- 7 Summary
- References
- Chapter Eight: Aging of the adrenal gland and its impact on the stress response
- Abstract
- 1 Introduction
- 2 The stress response
- 3 Adrenal aging
- 4 Altered thyroid function effects on adrenal activity and stress responsiveness
- 5 Conclusions
- References
- Chapter Nine: 3D organization of the rat adrenal medulla
- Abstract
- 1 Introduction
- 2 Difficulties and successes in studying the 3D organization of the rat adrenal medulla
- 3 General parameters of the shape and volume of the rat adrenal gland
- 4 Structure of the rat adrenal medulla
- 5 Vessels
- 6 Nerve elements
- 7 Connective tissue stroma
- 8 Modules of the rat adrenal medulla
- 9 Interrelation of 3D organization of different tissue components
- 10 Some practical conclusions based on data on the 3D organization of the tat adrenal medulla
- 11 Perspective directions
- References
- Chapter Ten: Angiotensin II-dependent aldosterone production in the adrenal cortex
- Abstract
- 1 Introduction
- 2 Angiotensin II and G protein-mediated aldosterone production
- 3 Angiotensin II and βarrestin-mediated aldosterone production
- 4 Implications for inverse agonism of ARBs
- 5 Conclusions and future directions
- References
- Chapter Eleven: A cholesterol-centric outlook on steroidogenesis
- Abstract
- 1 Cholesterol—A versatile lipid
- 2 Steroidogenic mitochondria
- 3 Cholesterol distribution in organelle membranes
- 4 The adrenal cortex—A superior steroidogenic tissue
- 5 Does cholesterol play a regulatory role in steroidogenesis
- 6 The interplay between cholesterol and the mitochondria in steroidogenesis
- 7 Conclusions & future directions
- Acknowledgments
- References
- Further reading
- Chapter Twelve: Functional interaction of Clock genes and bone morphogenetic proteins in the adrenal cortex
- Abstract
- Abbreviations
- 1 Introduction
- 2 BMP system in the adrenal cortex
- 3 BMP activity in adrenocortical steroidogenesis
- 4 Roles of clock genes in adrenocortical steroidogenesis
- 5 Mutual interaction of clock and BMPs in the adrenal cortex
- 6 Functional network of clock genes, BMP system and HPA axis
- 7 Conclusion and perspectives
- Acknowledgments
- References
- Chapter Thirteen: Waterhouse–Friderichsen syndrome, septic adrenal apoplexy
- Abstract
- 1 Introduction
- 2 Etiology
- 3 Epidemiology
- 4 Pathophysiology
- 5 Clinical presentation
- 6 Diagnosis
- 7 Differential diagnosis
- 8 Management
- 9 Prognosis
- References
- Chapter Fourteen: The changes in adrenal developmental programming and homeostasis in offspring induced by glucocorticoids exposure during pregnancy
- Abstract
- 1 Introduction
- 2 Current status of glucocorticoids exposure during pregnancy
- 3 The effects of maternal glucocorticoids exposure during pregnancy on fetal development and its regulatory factors
- 4 Effects of the changes in glucocorticoids levels on fetal adrenal development during pregnancy
- 5 Epigenetic mechanisms of adrenal dysplasia in offspring programmed by intrauterine glucocorticoid
- 6 The association between adrenal developmental programming and fetal-originated disease
- 7 Sex difference and intergenerational effects in adrenal developmental programming
- 8 Summary and outlook
- Acknowledgments
- References
- Edition: 1
- Volume: 124
- Published: February 23, 2024
- No. of pages (Hardback): 300
- No. of pages (eBook): 300
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443194009
- eBook ISBN: 9780443194016
GL
Gerald Litwack
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)
Affiliations and expertise
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States
Emeritus Professor, Rutgers University, United StatesRead Adrenal Gland on ScienceDirect