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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Case Studies in Neurology, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 34-3
    • Randolph W. Evans
    • English
    This issue of the Neurologic Clinics is being edited by the series Consulting Editor, Dr. Randolph Evans, and will be a special issue focusing on patient case studies of a board range of neurological diseases and disorders. Topics and cases covered include, but are not limited to: cerebrovascular disease, multiple sclerosis, syncope, epilepsy, tremor, dementia, neurologic issues in pregnancy, and medicolegal cases.

  • The Pediatric Cerebellum, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 26-3
    • Thierry A. G. M. Huisman + 1 more
    • English
    This issue of Neuroimaging Clinics of North America focuses on The Pediatric Cerebellum, and is edited by Drs. Huisman and Andrea Poretti. Articles will include: The role of the pediatric cerebellum in motor functions, neurocognition and behavior: a clinical perspective; Normal development of the cerebellum: from the fetus to the adolescent; Cerebellar malformations; Cerebellar disruptions; Metabolic disorders with cerebellar involvement; Neurocutaenous syndromes with cerebellar involvement; Vascular disorders of the cerebellum; Tumors of the cerebellum; Infectious and inflammatory diseases of the cerebellum; Cerebro-cerebellar network, and more!

  • Trace Amines and Neurological Disorders

    Potential Mechanisms and Risk Factors
    • 1st Edition
    • Tahira Farooqui + 1 more
    • English
    Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders.

  • Neuroimaging, Part I

    • 1st Edition
    • Volume 135
    • English
    Neuroimaging, Part One, a text from The Handbook of Clinical Neurology illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This first volume specifically covers a description of imaging techniques used in the adult brain, aiming to bring a comprehensive view of the field of neuroimaging to a varying audience. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, and the entire field is moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to this new horizon in the study of neurological disorders.

  • Neuroimaging, Part II

    • 1st Edition
    • Volume 136
    • English
    Neuroimaging, Part Two, a volume in The Handbook of Clinical Neurology series, illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This second volume covers imaging of the adult spine and peripheral nervous system, as well as pediatric neuroimaging. In addition, it provides an overview of the differential diagnosis of the most common imaging findings, such as ring enhancement on MRI, and a review of the indications for imaging in the most frequent neurological syndromes. The volume concludes with a review of neuroimaging in experimental animals and how it relates to neuropathology. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, with the entire field moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to the new horizon in the study of neurological disorders.

  • The Neurobiology of Schizophrenia

    • 1st Edition
    • Ted Abel + 1 more
    • English
    The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance.

  • Astrocytes and Epilepsy

    • 1st Edition
    • Jacqueline A. Hubbard + 1 more
    • English
    Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy.

  • Electrophysiology and Microinjection

    • 1st Edition
    • Volume 4
    • P. Michael Conn
    • English
    Electrical activity is central to the functioning and nature of neural cells. Every effort has been made in this volume to provide representative examples of useful techniques that have made this area a productive component of the neurosciences.

  • Methods in Neurosciences

    Quantitative and Qualitative Microscopy
    • 1st Edition
    • Volume 3
    • P. Michael Conn
    • English
    Because of the significance of morphology and cellular communication unique to the functioning and interdependence of neural systems, many of the advances in the neurosciences rely on classic as well as new microscopy techniques.

  • L'enfant dyspraxique et les apprentissages

    Coordonner les actions thérapeutiques et scolaires
    • 2nd Edition
    • Michèle Mazeau + 2 more
    • French
    Au sein des « dys- », les dyspraxies sont des troubles du développement gestuel et/ou visuo-spatial dont les répercussions sociales et scolaires peuvent être sévères, envahissant le quotidien et compromettant l’avenir. Ces pathologies ont en effet de graves conséquences sur l’ensemble des apprentissages.L’ouv... par des cliniciennes dont la pratique auprès de jeunes dyspraxiques s’inscrit dans l’indispensable interaction quotidienne entre rééducation et école, cet ouvrage vise à fournir des clés pour comprendre les ressorts cachés de ces échecs scolaires, afin de mieux les prévenir ou tout au moins les pallier. C’est pourquoi sont abordés ici à la fois les stratégies de remédiation (dévolues aux rééducateurs) et les aménagements qui, dans le même temps, doivent prendre place en classe, en partenariat avec les enseignants. Comportant de nombreux exemples qui illustrent les difficultés rencontrées tous les jours par ces enfants, ce livre constitue un ensemble cohérent de propositions pratiques et concrètes visant à rétablir les chances de réussite scolaire et d’épanouissement du jeune dyspraxique.Cet ouvrage permet non seulement de comprendre la spécificité des processus en jeu dans les apprentissages du jeune dyspraxique (gestuels, scolaires ou rééducatifs), mais il constitue un outil de terrain précieux pour assurer la réussite scolaire et l’épanouissement du jeune dyspraxique. Les auteures précisent les conditions d’un véritable projet thérapeutique global, avant d’aborder les différents aspects des accompagnements dans les apprentissages : écrire, e-écrire, compter, lire. Puis un chapitre de synthèse offre une méthode générale d’analyse des supports scolaires, spécifiquement dans les aspects qui croisent et sollicitent le handicap de l’élève. Enfin, sont abordées les difficultés liées à la vie quotidienne (repas, habillage, sports et loisirs) et leurs répercussions sur l’estime de soi. Cette nouvelle édition propose une révision de l’ensemble des données et une refonte complète des chapitres dédiés aux supports pédagogiques et à l’informatique qui ont considérablement évolué.

  • The Mathematical Brain Across the Lifespan

    • 1st Edition
    • Volume 227
    • English
    The Mathematical Brain Across the Lifespan is the latest volume in the Progress in Brain Research series that focuses on new trends and developments. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields.

  • Mechanisms of Sensory Working Memory

    Attention and Perfomance XXV
    • 1st Edition
    • Pierre Jolicoeur + 2 more
    • English
    Mechanisms of Sensory Working Memory: Attention and Performance XXV provides an update on research surrounding the memory processes that are crucial for many facets of cognitive processing and experience, with new coverage of emerging areas of study, including a new understanding of working memory for features of stimuli devoid of verbal, phonological, or long-term memory content, such as memory for simple visual features (e.g., texture or color), simple auditory features (e.g., pitch), or simple tactile features (e.g., vibration frequency), now called sensory memory to distinguish from verbal memory. This contemporary focus on sensory memory is just beginning, and this collection of original contributions provides a foundational reference for the study mechanisms of sensory memory. Students, scholars, and researchers studying memory mechanisms and processes in cognitive neuroscience, cognitive science, neuroscience, and psychology will find this book of great value to their work.

  • Neurobiology of Epilepsy

    From Genes to Networks
    • 1st Edition
    • Volume 226
    • English
    Neurobiology of Epilepsy: From Genes to Networks is the latest volume in the Progress in Brain Research series that focuses on new trends and developments. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields.

  • Sport and Exercise Psychology Research

    From Theory to Practice
    • 1st Edition
    • Markus Raab + 4 more
    • English
    Sport and Exercise Psychology Research: From Theory to Practice provides a comprehensive summary of new research in sport and exercise psychology from worldwide researchers. Encompassing theory, research, and applications, the book is split into several themed sections. Section 1 discusses basic antecedents to performance including fitness, practice, emotion, team dynamics, and more. Section 2 identifies factors influencing individual performance. Section 3 discusses applied sport psychology for athletes and coaches, and section 4 includes approaches from exercise psychology on motivation and well-being. The book includes a mix of award winning researchers from the European Sport Psychology Association, along with top researchers from the U.S. to bring an international overview to sport psychology.

  • Neuropsychopharmacology: A Tribute to Joseph T. Coyle

    • 1st Edition
    • Volume 76
    • English
    Neuropsychopharmacol... A Tribute to Joseph T. Coyle is a new volume from Advances in Pharmacology presenting reviews of recent breakthroughs in glutamate pharmacology and a tribute to one of the most influential neuroscientists of our times. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

  • Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

    • 1st Edition
    • Thomas Lehner + 2 more
    • English
    This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders.

  • Developing Therapeutics for Alzheimer's Disease

    Progress and Challenges
    • 1st Edition
    • Michael S. Wolfe
    • English
    Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics.

  • Continuous Issues in Numerical Cognition

    How Many or How Much
    • 1st Edition
    • Avishai Henik
    • English
    Continuous Issues in Numerical Cognition: How Many or How Much re-examines the widely accepted view that there exists a core numerical system within human beings and an innate ability to perceive and count discrete quantities. This core knowledge involves the brain’s intraparietal sulcus, and a deficiency in this region has traditionally been thought to be the basis for arithmetic disability. However, new research findings suggest this wide agreement needs to be examined carefully and that perception of sizes and other non-countable amounts may be the true precursors of numerical ability. This cutting-edge book examines the possibility that perception and evaluation of non-countable dimensions may be involved in the development of numerical cognition. Discussions of the above and related issues are important for the achievement of a comprehensive understanding of numerical cognition, its brain basis, development, breakdown in brain-injured individuals, and failures to master mathematical skills.

  • The Gut-Brain Axis

    Dietary, Probiotic, and Prebiotic Interventions on the Microbiota
    • 1st Edition
    • Niall Hyland + 1 more
    • English
    The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota examines the potential for microbial manipulation as a therapeutic avenue in central nervous system disorders in which an altered microbiota has been implicated, and explores the mechanisms, sometimes common, by which the microbiota may contribute to such disorders.

  • Translational Neuroimmunology in Multiple Sclerosis

    From Disease Mechanisms to Clinical Applications
    • 1st Edition
    • Ruth Arnon + 1 more
    • English
    Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development.

  • Pediatric Brain Stimulation

    Mapping and Modulating the Developing Brain
    • 1st Edition
    • Adam Kirton + 1 more
    • English
    Pediatric Brain Stimulation: Mapping and Modulating the Developing Brain presents the latest on this rapidly expanding field that has seen an exponential growth in publications over the past 10 years. Non-invasive modalities like TMS can painlessly map and measure complex neurophysiology in real patients. Neuromodulatory applications like rTMS and tDCS carry increasingly proven therapeutic applications. Rapidly advancing technological methodologies are increasing opportunities and indications. Despite all these benefits, applications in the more plastic developing brains of children are only just emerging. This book provides a comprehensive overview of brain stimulation in children. Chapters include Transcranial Magnetic Stimulation (TMS) fundamentals, brain stimulation in pediatric neurological conditions, and invasive brain stimulation. The main audience for this research will be those interested in applying brain stimulation technologies to advance clinical research and patient care, although a wide variety of clinicians and scientist will find this to be a valuable reference on brain stimulation with specific chapters on a variety of conditions.

  • Congenital Heart Disease and Neurodevelopment

    Understanding and Improving Outcomes
    • 1st Edition
    • Christopher McCusker + 1 more
    • English
    Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes brings together the work of leading researchers from the U.K., Europe, and the U.S. to provide a comprehensive examination of the causes, risks, and neurodevelopmental and psychological outcomes in children with congenital heart disease. The book includes longitudinal studies which have tracked outcomes from birth through late childhood and explores the emergent phenotype and etiologies, risk, and protective factors that strengthen proposed models. Medical and surgical advances have meant that greater numbers of children with even the most severe congenital heart disease (CHD) now survive well into adulthood. Studies over the past 20 years have suggested certain neurodevelopmental and psychological features are common, with clinical interventions being internationally articulated. The U.K. Belfast Center has developed and evaluated unique early intervention programs to circumvent the common problems discerned and promote optimal adjustment and outcomes. The first edition of Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes describes these programs in detail and outlines promising results obtained by researchers worldwide. Such interventions, together with the U.S. consensus statement (Circulation, 2012) on neurodevelopmental screening, hold great promise for clinical interventions.

  • Functional Neuromarkers for Psychiatry

    Applications for Diagnosis and Treatment
    • 1st Edition
    • Juri D. Kropotov
    • English
    Functional Neuromarkers for Psychiatry explores recent advances in neuroscience that have allowed scientists to discover functional neuromarkers of psychiatric disorders. These neuromarkers include brain activation patterns seen via fMRI, PET, qEEG, and ERPs. The book examines these neuromarkers in detail—what to look for, how to use them in clinical practice, and the promise they provide toward early detection, prevention, and personalized treatment of mental disorders. The neuromarkers identified in this book have a diagnostic sensitivity and specificity higher than 80%. They are reliable, reproducible, inexpensive to measure, noninvasive, and have been confirmed by at least two independent studies. The book focuses primarily on the analysis of EEG and ERPs. It elucidates the neuronal mechanisms that generate EEG spontaneous rhythms and explores the functional meaning of ERP components in cognitive tasks. The functional neuromarkers for ADHD, schizophrenia, and obsessive-compulsive disorder are reviewed in detail. The book highlights how to use these functional neuromarkers for diagnosis, personalized neurotherapy, and monitoring treatment results.

  • Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

    • 1st Edition
    • Carlo Sala + 1 more
    • English
    Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms.

  • Controversies In Diabetic Neuropathy

    • 1st Edition
    • Volume 127
    • English
    This latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

  • Neuropathology of Drug Addictions and Substance Misuse Volume 3

    General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions
    • 1st Edition
    • Victor R. Preedy
    • English
    Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances.

  • New Horizons in Neurovascular Coupling: A Bridge Between Brain Circulation and Neural Plasticity

    • 1st Edition
    • Volume 225
    • English
    New Horizons in Neurovascular Coupling: A Bridge Between Brain Circulation and Neural Plasticity is the latest volume in the Progress in Brain Research series that focuses on new trends and developments in neurovascular coupling. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields. This volume takes an integrated approach to review and summarize some of the most recent progress reported on the connection between brain circulation and neural plasticity.

  • The Inner Ear

    Including Otoneurology, Otosurgery, and Problems in Modern Warfare
    • 1st Edition
    • Joseph Fischer + 1 more
    • English
    The Inner Ear: Including Otoneurology, Otosurgery, and Problems in Modern Warfare covers the anatomical, physiological and the central pathways of the inner ear. This book is composed of 15 chapters that particularly consider the pathologic anatomy of the various forms of labyrinthine diseases. The first three chapters deal with the clinical anatomy and physiological features of the inner ear. The next chapter examines certain conditions that can be observed during induced and abnormal excitability of the labyrinth. These topics are followed by considerable chapters on various forms of labyrinthine diseases, including otosclerosis, inflammatory diseases, intracranial complications, congenital diseases, neoplasms, facial palsy, vascular lesions, and war trauma. A chapter evaluates the potential use of sulfa drugs in chemotherapy for inner ear cases. Another chapter surveys the role of the inner ear in the aeronautics and the functional tests for aviation fitness. The last chapter discusses the effects of atmospheric pressure changes on the ear. This book will be of value to otologists, otoneurologists, and otosurgeons.

  • Neurology Secrets

    • 6th Edition
    • Eli M. Mizrahi + 1 more
    • English
    Part of the bestselling Secrets Series, the updated sixth edition of Neurology Secrets continues to provide an up-to-date, concise overview of the most important topics in neurology today. It serves as a comprehensive introduction for medical students, physician assistants, and nurse practitioners, and is also a handy reference and refresher for residents and practitioners. Lists, tables, and clear illustrations throughout expedite review, while the engaging Secrets Series format makes the text both enjoyable and readable. New lead editors, Drs. Kass and Mizrahi, join this publication from a leading neurology program to lend a fresh perspective and expert knowledge.

  • Brain Metastases from Primary Tumors, Volume 3

    Epidemiology, Biology, and Therapy of Melanoma and Other Cancers
    • 1st Edition
    • M. A. Hayat
    • English
    Brain Metastases from Primary Tumors Volume Three: Epidemiology, Biology, and Therapy of Melanoma and Other Cancers provides a comprehensive overview of the metastasis of cancer, the main cause of approximately 90% of cancer associated deaths, yet the mechanisms governing this clinically important process remain poorly understood. Melanoma is the third most common diagnosis among patients with brain metastases, after lung and breast cancer. Approximately 75% of patients with metastatic melanoma develop brain metastases during the course of their disease. Although tumorigenesis of melanoma remains poorly understood, recent advances in gene expression profiling have revealed molecular mechanisms of this deadly disease. In addition, high-throughput gene expression has many advantages over techniques in cancer transcriptomic studies and has led to the discovery of numerous diagnostic, prognostic, and therapeutic targets, which are also detailed in this book. The book discusses the link between primary tumors and brain metastasis of melanoma, including molecular mechanisms, treatment options, prognosis, and general applications. Comprehensive chapters discuss systemic therapy, integrin inhibitors, stereotaxic radiosurgery, and more, making this book a great resource for neurooncologists, neurosurgeons, neurologists, and cancer researchers.

  • Animal Models for Medications Screening to Treat Addiction

    • 1st Edition
    • Volume 126
    • Richard L Bell + 1 more
    • English
    Animal Models for Medications Screening to Treat Addiction, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

  • Handbook of Neuro-Oncology Neuroimaging

    • 2nd Edition
    • Herbert B. Newton
    • English
    Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment. With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

  • The Auditory System and Human Sound-Localization Behavior

    • 1st Edition
    • John van Opstal
    • English
    The Auditory System and Human Sound-Localization Behavior provides a comprehensive account of the full action-perception cycle underlying spatial hearing. It highlights the interesting properties of the auditory system, such as its organization in azimuth and elevation coordinates. Readers will appreciate that sound localization is inherently a neuro-computational process (it needs to process on implicit and independent acoustic cues). The localization problem of which sound location gave rise to a particular sensory acoustic input cannot be uniquely solved, and therefore requires some clever strategies to cope with everyday situations. The reader is guided through the full interdisciplinary repertoire of the natural sciences: not only neurobiology, but also physics and mathematics, and current theories on sensorimotor integration (e.g. Bayesian approaches to deal with uncertain information) and neural encoding.

  • Neuropathology of Drug Addictions and Substance Misuse Volume 2

    Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects
    • 1st Edition
    • Victor R. Preedy
    • English
    Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances.

  • Adult Neurogenesis in the Hippocampus

    Health, Psychopathology, and Brain Disease
    • 1st Edition
    • Juan J. Canales
    • English
    Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease.

  • Introduction to EEG- and Speech-Based Emotion Recognition

    • 1st Edition
    • Priyanka A. Abhang + 2 more
    • English
    Introduction to EEG- and Speech-Based Emotion Recognition Methods examines the background, methods, and utility of using electroencephalogram... (EEGs) to detect and recognize different emotions. By incorporating these methods in brain-computer interface (BCI), we can achieve more natural, efficient communication between humans and computers. This book discusses how emotional states can be recognized in EEG images, and how this is useful for BCI applications. EEG and speech processing methods are explored, as are the technological basics of how to operate and record EEGs. Finally, the authors include information on EEG-based emotion recognition, classification, and a proposed EEG/speech fusion method for how to most accurately detect emotional states in EEG recordings.

  • Systems Neuroscience in Depression

    • 1st Edition
    • Thomas Frodl
    • English
    Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry.

  • Autoimmune Neurology

    • 1st Edition
    • Volume 133
    • English
    Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders.

  • Stress: Concepts, Cognition, Emotion, and Behavior

    Handbook of Stress Series, Volume 1
    • 1st Edition
    • George Fink
    • English
    Stress: Concepts, Cognition, Emotion, and Behavior: Handbook in Stress Series, Volume 1, examines stress and its management in the workplace and is targeted at scientific and clinical researchers in biomedicine, psychology, and some aspects of the social sciences. The audience is appropriate faculty and graduate and undergraduate students interested in stress and its consequences. The format allows access to specific self-contained stress subsections without the need to purchase the whole nine volume Stress handbook series. This makes the publication much more affordable than the previously published four volume Encyclopedia of Stress (Elsevier 2007) in which stress subsections were arranged alphabetically and therefore required purchase of the whole work. This feature will be of special significance for individual scientists and clinicians, as well as laboratories. In this first volume of the series, the primary focus will be on general stress concepts as well as the areas of cognition, emotion, and behavior.

  • Neuropathology of Drug Addictions and Substance Misuse Volume 1

    Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids
    • 1st Edition
    • Victor R. Preedy
    • English
    Neuropathology of Drug Addictions and Substance Misuse, Volume One: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids, Opioids and Emerging Addictions provides the latest research in an area that shows that the neuropathological features of one addiction are often applicable to those of others. The book also details how a further understanding of these commonalties can provide a platform for the study of specific addictions in greater depth, all in an effort to create new modes of understanding, causation, prevention, and treatment. The three volumes in this series address new research and challenges, offering comprehensive coverage on the adverse consequences of the most common drugs of abuse, with each volume serving to update the reader’s knowledge on the broader field of addiction, while also deepening our understanding of specific addictive substances. Volume One addresses tobacco, alcohol, cannabinoids, and opioids, with each section providing data on the general, molecular/cellular, and structural/functiona... neurological aspects of a given substance, along with a focus on the adverse consequences of addictions.

  • Fundamentals of Brain Network Analysis

    • 1st Edition
    • Alex Fornito + 2 more
    • English
    Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization.

  • Gliomas

    • 1st Edition
    • Volume 134
    • English
    Researchers’ knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book’s discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care.

  • Genes, Environment and Alzheimer's Disease

    • 1st Edition
    • Orly Lazarov + 1 more
    • English
    Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease.

  • Pharmacological Mechanisms and the Modulation of Pain

    • 1st Edition
    • Volume 75
    • English
    Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

  • Chemosensory Transduction

    The Detection of Odors, Tastes, and Other Chemostimuli
    • 1st Edition
    • Frank Zufall + 1 more
    • English
    Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals.

  • Intracellular Consequences of Amyloid in Alzheimer's Disease

    • 1st Edition
    • Michael R. D'Andrea
    • English
    Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.

  • Fundamental Statistical Principles for the Neurobiologist

    A Survival Guide
    • 1st Edition
    • Stephen W. Scheff
    • English
    Fundamental Statistical Principles for Neurobiologists introduces readers to basic experimental design and statistical thinking in a comprehensive, relevant manner. This book is an introductory statistics book that covers fundamental principles written by a neuroscientist who understands the plight of the neuroscience graduate student and the senior investigator. It summarizes the fundamental concepts associated with statistical analysis that are useful for the neuroscientist, and provides understanding of a particular test in language that is more understandable to this specific audience, with the overall purpose of explaining which statistical technique should be used in which situation. Different types of data are discussed such as how to formulate a research hypothesis, the primary types of statistical errors and statistical power, followed by how to actually graph data and what kinds of mistakes to avoid. Chapters discuss variance, standard deviation, standard error, mean, confidence intervals, correlation, regression, parametric vs. nonparametric statistical tests, ANOVA, and post hoc analyses. Finally, there is a discussion on how to deal with data points that appear to be "outliers" and what to do when there is missing data, an issue that has not sufficiently been covered in literature.

  • Making a Scientific Case for Conscious Agency and Free Will

    • 1st Edition
    • William R. Klemm
    • English
    Making a Scientific Case for Conscious Agency and Free Will makes a series of arguments that certain human behaviors are impossible to explain in the absence of free will, and that free will emerges from materialistic processes of brain function. It outlines future directions for neuroscience studies that can harness emerging technologies and tools for systems-level analysis. All humans have the sensation that they consciously will certain things to happen and that, in the absence of external constraints, they are free to choose from among alternatives. This notion of free will is deemed obvious by the average person based on common experience. Free will is frequently defended with arguments stemming from social, legal, philosophical, and religious perspectives. But these arguments appeal to consequences—not causes—of choices and decisions. In the past 3 decades, debate has raged within the scientific community over whether free will is in fact an illusion. Because free will would require conscious agency, the supporting corollary is that consciousness itself cannot do anything and is merely an observer rather than an actor.

  • Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Head and Neck

    • 1st Edition
    • Paul Rea
    • English
    Essential Clinically Applied Anatomy of the Nerves in the Head and Neck presents the reader with an easy access format to clinically-applied peripheral nervous system (PNS) anatomy. Perfect for a quick reference to essential details. The chapters review nerves of the head and neck, the origin(s), course, distribution and relevant pathologies affecting each are given, where relevant. The pathologies present typical injuries to the nerves of the PNS, as well as clinical findings on examination and treatments. It details modern clinical approaches to the surgery and other treatments of these nerve pathologies, as applicable to the clinical scenario.

  • Complications in Neuroanesthesia

    • 1st Edition
    • Hemanshu Prabhakar
    • English
    Complications in Neuroanesthesia focuses on complications that may arise related to neuroanesthesia practice and discusses its various causes. Each complication is written as a separate chapter, and the pathophysiology and mechanisms of each complication, as well as measures for diagnosis, treatment and prevention are discussed. Towards the end of the book, several case scenarios are provided to the readers that challenge readers to diagnose the possible complication for each case. Chapters include brain and spinal cord problems, cardiovascular and hematological problems, and nerve and muscle problems. Written in a standard format, Complications in Neuroanesthesia provides quick and easy access to understanding problems in neuroanesthesia. It provides insight into all possible complications occurring during perioperative management of neurosurgical and neurologic patients. It is useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, and neurology by providing an understanding of preventable mishaps that may occur in neurosurgical or neurologic patients.

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