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Principles of Animal Research for Graduate and Undergraduate Students

  • 1st Edition - November 16, 2016
  • Latest edition
  • Authors: Mark A. Suckow, Kay Stewart
  • Language: English

Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all a… Read more

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Description

Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all aspects of the research experience, including the research and development of a thesis, model selection, experimental design, IACUC protocol preparation, and animal husbandry and technical procedural needs, the book is a necessary addition to every student, technician, and researcher’s education.

Key features

  • Provides background material for students to understand the broader backdrop against which animal research is undertaken
  • Includes ethical and regulatory information
  • Covers commonly used animal models and the process to choose a model for biomedical research

Readership

Early researchers, undergraduate and graduate students, researchers and professors studying laboratory animal research; technicians in laboratory animal science; pre-veterinarians and veterinarians; and students/early researchers working with laboratory animals across biological and biomedical research

Table of contents

  • Preface
  • Chapter 1. Brief Historical Overview on the Use of Animals in Research
    • 1.1. Introduction
    • 1.2. Early Attitudes Toward Animal Health and Disease
    • 1.3. Development and Emergence of New Animal Models
    • 1.4. Improvements in Approaches to Animal Care
    • 1.5. Summary
  • Chapter 2. Philosophical and Ethical Foundations
    • 2.1. Basic Approaches
    • 2.2. Animal Welfare Versus Animal Rights
    • 2.3. Opposition to and Benefits of Animal Experimentation
    • 2.4. Professional Ethics Relating to Biomedical Research
  • Chapter 3. Regulations and Guidelines
    • 3.1. Introduction
    • 3.2. US Animal Welfare Act
    • 3.3. Public Health Service Policy
    • 3.4. FDA Good Laboratory Practices
    • 3.5. Other Laws, Regulations, and Policies
    • 3.6. Fish and Wildlife Service and NIH Positions on Chimpanzees
    • 3.7. Professional and Scientific Associations
    • 3.8. International Laws and Regulations
    • 3.9. Conclusions
  • Chapter 4. Institutional Animal Care and Use Committee
    • 4.1. Purpose and Function
    • 4.2. Committee Composition
    • 4.3. IACUC Review of Proposed Activities and Projects
    • 4.4. Periodic Review of the Animal Care and Use Program and Facilities
    • 4.5. Investigation of Concerns Regarding the Use and Treatment of Vertebrate Animals
    • 4.6. Sample Size Estimation in Laboratory Animal Experiments
  • Chapter 5. Experimental Variables
    • 5.1. The Research Environment
    • 5.2. Environmental Enrichment
    • 5.3. Animal Health Monitoring Program
    • 5.4. Summary
  • Chapter 6. Model Selection
    • 6.1. Selection Criteria
    • 6.2. Types of Models
    • 6.3. Spontaneous Mutation Models
    • 6.4. Random Mutation Models
    • 6.5. Genetically Manipulated Models
    • 6.6. Chemically Induced Models
    • 6.7. Physically Induced Models
    • 6.8. Surgical Models
    • 6.9. Behavioral Models
    • 6.10. Production Models
  • Chapter 7. Commonly Used Animal Models
    • 7.1. The Mouse
    • 7.2. The Rat
    • 7.3. The Rabbit
    • 7.4. Zebrafish
    • 7.5. Amphibians and Reptiles
    • 7.6. Birds
    • 7.7. Other Small Mammals
    • 7.8. Summary
  • Chapter 8. Common Technical Procedures in Rodents
    • 8.1. Handling and Restraint Methods
    • 8.2. Identification
    • 8.3. Common Technical Procedures
    • 8.4. Rodent Anesthesia
    • 8.5. Rodent Surgery
    • 8.6. Euthanasia
    • 8.7. Necropsy
    • 8.8. Summary
  • Chapter 9. Considerations for Use of Vertebrates in Field Studies
    • 9.1. Reasons for Conducting Field Research
    • 9.2. Sources for Specific Technique Information
    • 9.3. Initial Steps for Undertaking Field Research Involving Vertebrates
    • 9.4. Observational Techniques
    • 9.5. Capturing Animals
    • 9.6. Handling Animals
    • 9.7. Identification and Marking of Animals
    • 9.8. Conclusion
  • Chapter 10. Personnel Safety in the Care and Use of Laboratory Animals
    • 10.1. Introduction
    • 10.2. Occupational Health and Safety Programs
    • 10.3. Hazards Associated With Animal Research
    • 10.4. Best Practices for Prevention
    • 10.5. Conclusions: Personnel Engagement and Awareness
  • Chapter 11. Thesis Development
    • 11.1. Preparation
    • 11.2. Thesis Sections
    • 11.3. Finalizing the Thesis
    • 11.4. Conclusion
  • Glossary of Terms and Acronyms
  • Index

Review quotes

"...an excellent resource for research personnel and undergraduate and graduate students who seek a basic foundation in experimental animal research...This book will efficiently support formal courses for students and appeal to a broader audience."—Journal of the American Veterinary Medical Association

Product details

  • Edition: 1
  • Latest edition
  • Published: December 7, 2016
  • Language: English

About the authors

MS

Mark A. Suckow

Mark A. Suckow is a private consultant in laboratory animal medicine and Professor (Emeritus) in Biomedical Engineering at the University of Kentucky where he previously served as Attending Veterinarian and Associate Vice President for Research. He received his DVM from the University of Wisconsin and subsequently completed a post-doctoral residency in laboratory animal medicine at the University of Michigan. Dr. Suckow has 35 years of experience in laboratory animal medicine, regulatory compliance, and animal facility management. With an interest in the use of animal models for cancer research, vaccinology, and biomaterials development, Dr. Suckow has published greater than 115 papers in refereed journals and has seven issued patents related to vaccine adjuvants and cancer vaccines. He has written or edited over 20 books on topics related to research and laboratory animal medicine. Further, he served as the 2006 President of the American Association for Laboratory Animal Science and the 2011 President of the American Society of Laboratory Animal Practitioners; and he currently serves as an emeritus member of the Council on Accreditation of AAALAC, International and as Editor in Chief for the Journal of the American Association for Laboratory Animal Science.
Affiliations and expertise
Private Consultant

KS

Kay Stewart

Kay Stewart is the Associate Director of the Freimann Life Science Centre at the University of Notre Dame. Her research straddles both the role of animals in biomedical research and the ethics and treatment of animals in academic settings.
Affiliations and expertise
Associate Director of Freimann Life Science Center, University of Notre Dame, Notre Dame, IN, USA

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