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Negative Affective States and Cognitive Impairments in Nicotine Dependence
1st Edition - August 17, 2016
Editors: F. Scott Hall, Jared W. Young, Andre Der-Avakian
Hardback ISBN:9780128025741
9 7 8 - 0 - 1 2 - 8 0 2 5 7 4 - 1
eBook ISBN:9780128026694
9 7 8 - 0 - 1 2 - 8 0 2 6 6 9 - 4
Negative Affective States and Cognitive Impairments in Nicotine Dependence is the only book of its kind that addresses nicotine use and abuse in the context of negative… Read more
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Negative Affective States and Cognitive Impairments in Nicotine Dependence is the only book of its kind that addresses nicotine use and abuse in the context of negative reinforcement mechanisms. Written and edited by leading investigators in addiction, affective, genetic, and cognitive research, it provides researchers and advanced students with an overview of the clinical bases of these effects, allowing them to fully understand the various underlying dysfunctions that drive nicotine use in different individuals. In addition, this book examines animal models that researchers have utilized to investigate the biological bases of these dysfunctions.
The combination of clinical and preclinical approaches to understanding nicotine dependence makes this book an invaluable resource for researchers and practitioners seeking to develop targeted treatments aimed at ameliorating symptoms of nicotine dependence, as well as identifying premorbid differences in affective or cognitive function.
Provides a unique perspective on nicotine dependence that emphasizes negative reinforcement rather than positive reinforcement
Examines psychiatric comorbidities and alleviation of withdrawal states as motivation for continued tobacco use
Includes both clinical and preclinical perspectives
Includes genetic and multi-neurotransmitter perspectives on nicotine use and withdrawal
Emphasizes heterogeneity of underlying reasons for smoking, the need for multiple animal models to understand this heterogeneity, and the expectation of heterogeneous responses to potential treatments, underscoring the need for personalized therapeutics
Researchers, clinicians, graduate students, and health professionals in cognitive neuroscience, behavioral neuroscience, pharmacology, psychopathology, and addiction
Dedication
List of Contributors
Preface
Acknowledgments
Chapter 1. Overview of Nicotine Withdrawal and Negative Reinforcement (Preclinical)
Introduction
Tobacco Dependence and Nicotine
Theoretical Framework
Positive Reinforcement Associated With Nicotine Use
Negative Reinforcement Associated With Nicotine Use
Neurobiological Mechanisms of Positive Reinforcement
Neurobiological Mechanisms of Negative Reinforcement
Translational Aspects of the Neurobiology of Negative Reinforcement
Chapter 2. Nicotine Withdrawal and Attentional Deficit Studies Across Species: Conflation With Attentional Dysfunction in Psychiatric Patients
Nicotine Use, Withdrawal, and Cognition
Attentional Deficits Resulting From Nicotine Withdrawal in Humans
Attentional Dysfunction in Psychiatric Patients: Overlap With Nicotinic Research
Mechanisms Underlying Nicotinic Effects on Attention
Attentional Deficits from Nicotine Withdrawal in Animals
Implications and Future Studies
Conclusions
Chapter 3. Preclinical Models of Nicotine Withdrawal: Targeting Impaired Cognition
Introduction
Nicotine Withdrawal in Laboratory Rodents
Nicotine Exposure to Induce Physical Dependence in Rodents
Pharmacological Screening
Measures of Cognition in Rodent Models of Nicotine Withdrawal
Animal Models of Nicotine Dependence: Withdrawal Effects on Attention
Pharmacological Treatment of Nicotine Dependence
Summary
Chapter 4. Genetic, Developmental, and Receptor-Level Influences on Nicotine Withdrawal-Associated Deficits in Learning
Introduction
Hippocampus-Dependent Learning Is More Sensitive to the Effects of Nicotine Withdrawal than Hippocampus-Independent Learning
Chronic Nicotine Acts Directly in the Hippocampus to Change nAChR Function and Disrupt Learning during Withdrawal
Genetic Background Modulates Nicotine Withdrawal Effects on Learning
Effects of Nicotine Withdrawal on Learning Vary With Age
Conclusion
Chapter 5. Enhanced Tobacco Use Vulnerability in Adolescents, Females, and Persons With Diabetes
Introduction
Nicotine Reward and Withdrawal
Adolescents
Females
Persons With Diabetes
Other Populations to Consider
Conclusion and Clinical Implications
Chapter 6. Detrimental Effects of Prenatal Exposure to Tobacco Smoke and Nicotine
Introduction
Functional Role of Nicotinic Acetylcholine Receptors in the Developing Nervous System
Somatic Effects of Prenatal Exposure to Tobacco Smoke and Nicotine
Long-Term Neurobehavioral Effects of Prenatal Exposure to Tobacco Smoke and Nicotine
Conclusions
Chapter 7. Contribution of Translational Genetic Research to Our Understanding of Nicotine Dependence
Human Genetics: What Should We Seek to Model in Animal Studies?
Genetic Studies of Positive Reinforcement in Mice
Mouse Models of Negative Reinforcement
Genetic Predisposition to Affective Deficits
Genetic Predisposition to Cognitive Deficits
Where Do We Go Next?
Chapter 8. Transmitters and Receptors in Nicotine Withdrawal Syndrome
Influence of Differing Laboratory Models of Nicotine Withdrawal
Cholinergic Mechanisms
Dopamine
Serotonin and Norepinephrine
Glutamate
Gamma Aminobutyric Acid (GABA)
Endogenous Opiate Mechanisms
Nonopioid Peptides
Signal Transduction Mechanisms
Concluding Thoughts
Chapter 9. The Cannabinoid System in Nicotine Dependence and Withdrawal
Introduction to the Cannabinoid System
The Cannabinoid System and the Reward Pathway
The Cannabinoid System and Nicotine Dependence
CB1 Receptors
CB2 Receptors
Endocannabinoids and Nicotine Dependence
The Cannabinoid System and Nicotine Withdrawal
CB1 Receptors and Nicotine Withdrawal
CB2 Receptors and Nicotine Withdrawal
Endocannabinoids and Nicotine Withdrawal
Conclusions
Chapter 10. Critical Role for Brain Stress Systems in the Negative Affective State Associated With Nicotine Withdrawal
Introduction
Dysphoria and Nicotine Withdrawal
CRF and Dysphoria Associated With Nicotine Withdrawal
Norepinephrine and Dysphoria Associated With Nicotine Withdrawal
Chapter 11. The Habenulo-Interpeduncular Pathway and Nicotine Withdrawal
Characterization of the Habenular Nuclei
The Habenulo-Interpeduncular Pathway and Nicotine
Conclusions
Chapter 12. A Clinical Overview of Nicotine Dependence and Withdrawal
A Clinical Overview of Nicotine Dependence and Withdrawal
Summary
Chapter 13. Epidemiologic Research on the Relationship of Nicotine Dependence to Psychiatric and Substance Use Disorders
Introduction
Nicotine Dependence and Psychiatric Disorders
Nicotine Dependence and Substance Use Disorders
Summary and Conclusions
Chapter 14. Nicotine and Tobacco Smoking and Withdrawal in Schizophrenia
Tobacco Use Disorder in Schizophrenia
Smoking Abstinence and Reinstatement
Greater Difficulty Quitting
Summary and Conclusions
Chapter 15. Emergent Cognitive Impairment During Early Nicotine Withdrawal
Introduction
Neurophysiological Mechanisms of Cognitive Effects of Nicotine Withdrawal
Bench to Bedside Models of Cognition During Nicotine Withdrawal
Summary and Conclusions
Chapter 16. Nicotine and Posttraumatic Stress Disorder
Introduction
Tobacco Use and PTSD
Nicotine and PTSD Phenotypes
Summary
Chapter 17. Nicotine Withdrawal and Depression: Clinical Studies—A Four-Factor Model for More Accurate Characterization
Introduction
Factor 1: Differential Relapse and Dropout
Studies Explicitly Designed to Characterize Abstinence Effects
Factor 2: Downward Drift in Self-Reported Negative Affect
The Ups and Downs of Affective Drift and Withdrawal Scores
Factor 4: Long- and Short-Term Chronodynamic Life Changes and Events
Other Valuable Designs
Summary, Conclusions, and New Directions
Chapter 18. Neuroimaging Insights Into the Multifaceted Nature of the Nicotine Withdrawal Syndrome
Introduction
Affective Disturbances
Cognitive Impairments
Reward Dysregulation
Summary and Future Considerations
Index
No. of pages: 362
Language: English
Published: August 17, 2016
Imprint: Academic Press
Hardback ISBN: 9780128025741
eBook ISBN: 9780128026694
FH
F. Scott Hall
Dr. F. Scott Hall is an Assistant Professor of Pharmacology and Experimental Therapeutics in the College of Pharmacy and Pharmaceutical Sciences at the University of Toledo. Dr. Hall’s research investigates the genetic and environmental determinants of susceptibility to addiction and related psychiatric disorders. After a B.A. from Harvard University (1987) and a Ph.D. from the University of Cambridge in 1994, Dr. Hall completed a postdoctoral fellowship at the National Institute on Alcoholism and Alcohol Abuse. Dr. Hall joined the Molecular Neurobiology Branch at the National Institute on Drug Abuse in 1999 where he led the behavioral genetics group until 2014. He has authored over a hundred scientific publications and is a fellow of the International Behavioral Neuroscience Society. Dr. Hall is recognized internationally as an expert in the genetic basis of addiction and the role that early social experience plays in shaping adult behavior and behavioral pathology.
Affiliations and expertise
Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, MD, USA
JY
Jared W. Young
I am a Scottish Neuropsychopharmacologist in Sunny California, Dept. of Psychiatry, UCSD. My primary interest is investigating the neural mechanisms underlying cognitive dysfunction in order to develop targeted therapeutics. I specialize in cross-species testing and as such have developed/aided in the development of many such tests including the 5-choice continuous performance test, now in use across the globe, in patients, rats, and mice, with fMRI and EEG recording also available. With regards to clinical populations, I have investigated diseases such as schizophrenia, bipolar disorder, HIV, Tourette’s syndrome, as well as methamphetamine, nicotine, and cannabis abuse. Using this cross-species behavioral testing approach, any work we conduct we hope will have relevance to clinical populations and vice-versa. With this dual approach combined with networking with great collaborators, I hope that more promising therapeutics will not be far away.
Affiliations and expertise
Department of Psychiatry, University of California, San Diego, USA
AD
Andre Der-Avakian
Andre Der-Avakian, Ph.D., is an Assistant Research Scientist in the Department of Psychiatry at University of California, San Diego and an Adjunct Instructor in the Department of Psychological Sciences at University of San Diego. He received his Ph.D. in Neuroscience from University of Colorado, Boulder and completed a National Institute of Mental Health-sponsored postdoctoral fellowship at University of California, San Diego. Dr. Der-Avakian has published several research articles, reviews, and book chapters on the neurobiology of stress-induced disruption of normal reward processing in rats that may contribute to symptoms like anhedonia and motivational deficits in psychiatric disorders. His research, which is funded by grants from the National Institute of Mental Health and the National Institute on Drug Abuse, is focused on designing and implementing new translational behavioral and neurophysiological assessments of reward and cognitive processes in rats with high relevance to human psychiatric disorders like depression, schizophrenia, and drug addiction.
Affiliations and expertise
Department of Psychiatry, School of Medicine, University of California, San Diego, USA