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Elsevier

Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • Toxicology Disasters

    Causes and Consequences
    • 1st Edition
    • Sue Ford
    • English
    Toxicology Disasters: Cause and Consequences, a volume in the History of Toxicology and Environmental Health series, provides an historical overview of significant toxicological disasters which involved chemical exposure of humans, animals or the environment. The book documents the timeline of events and the legacy of the resulting exposure which occurred within a specific period of time, but with long lasting consequences. Case studies of toxicological incidents and a wide range of categories, including environmental, industrial, pharmaceutical, domestic and international are not only discussed from a historical perspective but also regarding their impacted toxicology, regulation and our current use of these chemicals.The book will help toxicologists, academics and students from environmental health and toxicology departments, environmental/occupa... health regulators, and industrial hygiene/safety personnel gain a better understanding of the arc of a toxicological disaster from its origins, root causes of the problem, and initial and long-term assessments and management.

  • Snake Venom and Human Health

    Translating Nature’s Toxins into Therapeutics
    • 1st Edition
    • Subir Chandra Dasgupta + 2 more
    • English
    Snake Venom and Human Health: Translating Nature’s Toxins into Therapeutics offers a detailed exploration of the burgeoning field of venom-derived therapeutics. As biomedical research continues to uncover potential applications of snake venom, this book serves as an essential resource that bridges fundamental science and clinical application and examines how these potent biological substances are being transformed into innovative treatments for a wide array of health conditions, including cancer, infectious and parasitic diseases, cardiovascular issues, neurodegenerative disorders, diabetes, and autoimmune diseases. Starting with an overview of venom classification and structural insights, the book is organized into detailed chapters that cover the biochemical basis of snake venom, its therapeutic applications, and the emerging technologies supporting its development. Subsequent chapters explore specific medical applications—from anticancer and antimicrobial therapies to treatments for cardiovascular, neurological, dermatological, and metabolic disorders. It goes on to explore innovative topics as well as the regulatory and sustainability issues and ongoing challenges—such as safety concerns, ethical considerations, and scalability that surrounding venom research.Enriched by contributions from international experts in the field, Snake Venom and Human Health aims to provide researchers, clinicians, and industry professionals a thorough understanding of both the scientific foundations and the translational aspects of venom-based therapeutics.

  • Micro(nano)plastics in Organ Systems

    Health Impacts, Challenges, and Future Prospects
    • 1st Edition
    • Charan Singh + 4 more
    • English
    Micro(nano)plastics in Organ Systems: Health Impacts, Challenges, and Future Prospects comprehensively discusses the impact of micro(nano)plastics on human health, analyzing their sources, classification, and exposure pathways, while also exploring their interactions with biological systems, their potential effects on various organ systems, and concerns related to bioaccumulation and toxicity. The book begins with an in-depth analysis of their classification, sources, and exposure pathways, and progressing through interactions with biological systems and the resulting toxicological effects. Furthermore, the book delves into recent advances in detection technologies, the development of more sustainable advances such as bioplastic-based nanoparticles, and the need for regulatory frameworks.The text meticulously examines the implications of these particles on various organ systems—including the gastrointestinal, respiratory, cardiovascular, renal, neurological, reproductive, and metabolic systems—while addressing critical issues such as bioaccumulation, immunological responses, and their potential harmful impact on health. It is an essential resource for toxicologists, environmental scientists, healthcare professionals, public health advocates, and others interested in the implications of micro(nano)plastics on health.

  • PFAS Contamination

    Global Prevalence, Toxicological and Ecotoxicological Impacts, and Mitigation Strategies
    • 1st Edition
    • Saranya Narayanasamy + 1 more
    • English
    PFAS Contamination: Global Prevalence, Toxicological and Ecotoxicological Impacts, and Mitigation Strategies offers a comprehensive overview of per- and polyfluoroalkyl substances (PFAS), highlighting their global environmental prevalence, toxicological effects and health risks, and state-of-the-art remediation approaches. The book taps into the increasing recognition of PFAS as “forever chemicals” and explores the widespread contamination of these compounds in water, soil, and air along with their toxicological effects on human health and the ecosystem. It highlights advancements in detection methods as well as physicochemical, biological, and emerging remediation technologies, including plasma-based technologies, bioremediation, and advanced nanotechnology-based methods, such as plasma technology, bioremediation, and adsorption methods.Case studies illustrate successful applications, and the book examines policy frameworks, regulatory measures, and the public health impact of PFAS. This resource serves as a vital source of information for environmental toxicologists, environmental scientists, environmental consultants, engineers, and regulators studying PFAS prevalence, toxicity mechanisms, remediation, and practical strategies for mitigating PFAS contamination and fostering a deeper understanding of the global efforts to address this critical issue.

  • Mitochondrial Intoxication

    • 2nd Edition
    • Marcos Roberto de Oliveira
    • English
    Mitochondrial Intoxication, Second Edition offers a comprehensive and fully updated exploration of the impact of toxic molecules on mitochondrial physiology, and the diseases that result from their dysfunction. Divided into three sections, the book opens with a detailed overview of mitochondrial physiology, molecular markers of mitochondrial intoxication and challenges of mitochondrial profiling during pre-clinical studies. It then focuses on endogenous toxicants and their impact on mitochondria, including new chapters on lipids, glucose and microbiota-derived toxicants. Amyloid-β peptide and its impact on mitochondrial dysfunction is also a new addition to this book, as well as inflammation-induced mitochondrial intoxication. The final section explores exogenous toxicants, such as pollutants, food additives, illicit and pharmaceutical drugs, pesticides and heavy metals. The effects of micro- and nanoplastics on mitochondrial function are newly covered. Furthermore, the latest computational tools in mitochondrial toxicity research are investigated. Incorporating the latest advances in the field, “Mitochondrial Intoxication, Second Edition” offers cutting-edge insights on mitochondrial toxicity, and serves as an invaluable resource for researchers and advanced students in cell biology, molecular biology, toxicology, biochemistry, pharmacology, and related fields.

  • Phytotoxicity of Organic Pollutants

    Impacts and Management
    • 1st Edition
    • Golam Jalal Ahammed + 1 more
    • English
    Phytotoxicity of Organic Pollutants: Impacts and Management provides a comprehensive and up‑to‑date overview of how diverse organic pollutants affect plant physiology, growth, and development. Bringing together contributions from leading experts, the book examines the sources, environmental behavior, and biological impacts of major classes of organic pollutants. The volume highlights recent advances in understanding the physiological, biochemical, and molecular mechanisms underlying plant responses to organic pollutant exposure. It also explores plant‑ and microbe‑based remediation strategies, emphasizing their potential to safeguard food quality and ecosystem health. Phytotoxicity of Organic Pollutants: Impacts and Management serves as an interdisciplinary resource for researchers, academics, graduate students, environmental professionals, and industry practitioners working in plant science, ecotoxicology, environmental chemistry, and sustainable remediation.

  • Toxicological Survey of African Medicinal Plants

    • 2nd Edition
    • Victor Kuete
    • English
    Toxicological Survey of African Medicinal Plants, Second Edition bridges traditional knowledge with modern science, providing a comprehensive and detailed overview of toxicological studies related to traditionally used African medicinal plants with special emphasis on practical insights and scientifically validated methodologies, and tools used for data collection and interpretation. Completely revised and updated, the book considers the physical parameters of novel plants and their effect on specific areas of the body and overall human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.The new edition also considers advances in omics approaches and the increased use of advanced analytical techniques to understand plant toxicity and improved the identification of toxic compounds in medicinal plants. With contributions from a distinguished team of researchers in the field, this book is an invaluable resource for researchers, advanced students and postgraduates, industry professionals, and policymakers who require an integrated understanding of toxicology, pharmacology, ethnopharmacology, as well as regulatory and policy frameworks for African medicinal plants.

  • Hazardous Chemicals in Medical Devices

    Safety, Risk Analysis, and Regulations
    • 1st Edition
    • Prakash Srinivasan Timiri Shanmugam + 1 more
    • English
    Hazardous Chemicals in Medical Devices: Safety, Risk Analysis, and Regulations provides a comprehensive overview of the hazardous chemicals used in medical device manufacturing. The book discusses the basics of these chemicals, their presence in various components, and the regulations that govern their use. It also delves into the processes involved in manufacturing and the added chemicals during these stages. With a focus on risk assessment and analysis, the book emphasizes the importance of safety in medical devices and outlines the types of hazards associated with these substances.The book further explains the regulatory classification of hazardous chemicals and the labeling and safety data sheet requirements. It includes a list of notified bodies that discuss hazardous substance data, aiding in risk assessment and toxicological profiling. Additionally, it underscores the critical understanding of toxicological profiles of materials used in medical devices, ensuring that readers are well-informed about the safety measures and regulations in place to protect both manufacturers and users.

  • Comprehensive Toxicology

    • 4th Edition
    • Charlene McQueen
    • English
    Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicology researchers. This edition focuses on understanding the mechanisms by which chemicals affect biological systems and cause adverse health effects. Edited by a distinguished editorial board and featuring 400 in-depth contributions from experts around the globe, this comprehensive work spans fifteen volumes and nearly 9,000 pages, covering all major organ systems and general principles of toxicology. This extensively revised edition includes around 30 new chapters on modern testing strategies and novel in vitro models, such as organ-on-a-chip systems.It also explores computational approaches, new risk and safety assessment methods, harmonization, artificial intelligence, and the microbiome. As the most authoritative resource in toxicology, it continues to support researchers, faculty, and students in toxicology, as well as professionals in medical, veterinary, food, environmental, chemical, and pharmaceutical industries and international regulatory agencies.

  • Machine Learning and Artificial Intelligence in Toxicology and Environmental Health

    • 1st Edition
    • Zhoumeng Lin + 1 more
    • English
    Machine Learning and Artificial Intelligence in Toxicology and Environmental Health introduces the fundamental concepts and principles of machine learning and AI, providing clear explanations on applying these methods to toxicology and environmental health. The book delves into predictions of chemical ADMET properties, development of PBPK and QSAR models, toxicogenomic analysis, and the evaluation of high-throughput in vitro assays. It aims to guide readers in adapting machine learning and AI techniques to various research problems within these fields. Additionally, the text explores ecotoxicology assessment, impacts of air pollution, climate change, food safety, and chemical risk assessment.It includes case studies, hands-on computer exercises, and example codes, making it a comprehensive resource for researchers, academics, students, and industry professionals. The book highlights how AI can enhance risk assessment, predict environmental hazards, and speed up the identification of harmful substances.

  • Computational Methods in Medicinal Chemistry, Pharmacology, and Toxicology

    • 1st Edition
    • Muhammad Ishfaq
    • English
    Computational Methods in Medicinal Chemistry, Pharmacology, and Toxicology is a comprehensive resource that offers an advanced overview of computational techniques employed in drug discovery, design, and toxicity prediction. The book discusses various topics, including molecular modeling, virtual screening, machine learning, and network pharmacology. It serves as an essential guide for researchers, practitioners, and students in pharmacology, toxicology, medicinal chemistry, bioinformatics, and systems biology fields, showcasing practical applications and future perspectives on new technologies. In addition to covering computational approaches, the book provides real-world examples of drug discovery, candidate optimization, and safety assessment.Other sections explore computer applications in pharmacology and toxicology and discusses the importance of these methods in advancing medicinal research.

  • Veterinary Toxicology

    Basic and Clinical Principles
    • 4th Edition
    • Ramesh C. Gupta
    • English
    Veterinary Toxicology: Basic and Clinical Principles, Fourth Edition is a unique single reference that provides a comprehensive overview on the basic principles of veterinary toxicology to any student at the DVM, MS, or PhD level while also continuing to serve as a clinical reference for practitioners. The book thoroughly updates toxicologists and advanced students on the newest approaches for diagnosing poisoning cases in all animals from chemicals, plants, and accidental or malicious intents. Many chapters are provided on topics not covered in any previous books, such as target organ toxicity, radiation and radioactive materials, FDA regulatory issues, and ethics in veterinary toxicology.Completel... revised and updated to include the most recent developments in the field animal toxins, toxicokinetics mechanism of action, toxicity, and treatment, this book is an essential resource for researchers, practicing veterinary toxicologists, advanced students in toxicology, poison control centers, as well as environmentalists, marine biologists, and animal scientists.

  • Epidemiology of Cannabis

    Genotoxicity, Neurotoxicity, Epigenomics and Aging
    • 1st Edition
    • Albert Stuart Reece + 1 more
    • English
    Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging provides a novel and comprehensive exploration of five areas that have previously been associated with cannabis use, namely mental health in adults and young adults, pediatric autism, congenital anomalies, cancers, and aging. The book also explores the possibility of how these associations might be reflected in overall disease trends at the population health level. This book surveys these five areas in detail and applies cutting-edge analytical software and geospatial space–time analytical techniques to these questions. With all this information gathered into one book in an easily readable form, this book is a reference for clinicians, health science and allied health practitioners, public health and basic science researchers and drug and health regulators interested in these topics. It is also suitable for inclusion in course work and study preparation courses at both the undergraduate and postgraduate levels.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology Volume 5: Toxicologic Pathology of Organ Systems

    • 4th Edition
    • Wanda M Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, Volume Five: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals, and biologics. This book continues coverage of Organ-Specific Toxicologic Pathology and major organ systems not covered in Volume Four, and has been completely revised, making it an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.

  • Acetaminophen Toxicity

    Experimental and Clinical Advances
    • 1st Edition
    • Barry Rumack + 2 more
    • English
    Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity.Divided into two parts, the foundational aspects of this book cover the mechanism of toxicity in a detailed manner beginning with the history of acetaminophen to newly explored areas of genetics, proteomics, and metabolomics. The second half goes on to discuss clinical practices and examine where further research and therapeutic approaches may be headed. This part answers key questions about whom to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments.With contributions from experts in the field, this book is a thorough, well-researched, and valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with acetaminophen toxicity.

  • Nonclinical Development of Biologics, Vaccines and Specialty Biologics

    • 2nd Edition
    • Lisa M. Plitnick + 1 more
    • English
    Nonclinical Development of Biologics, Vaccines and Specialty Biologics, Second Edition, is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, vaccines, cell and gene therapies, and oncology therapeutics. Updated and revised, the new edition compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory guidelines. This book discusses the different types of biologics, as well as early characterization strategies, principles of study design, nonclinical pharmacokinetics and pharmacodynamics, nonclinical assays, and regulatory guidelines. A coedited book with chapters authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late-stage biologics.

  • Immunotoxicogenomics

    A Multidisciplinary Approach in Systems Toxicology
    • 1st Edition
    • Md. Naimat Ali + 2 more
    • English
    Immunotoxicogenomics... A Multidisciplinary Approach in Systems Toxicology covers the major mechanisms and effects of toxic substances on the immune system, and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, and emerging and future trends. The book begins with a discussion of the systemic approach to toxicants, but also looks at current genomic tools used to assess immunotoxicity and systems biology methods used in immuno-toxicogenomic... Other topics include genomic expression profiling, gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomic... as a screening tool, and the assessment and analysis of Immunotoxicogenomics data.This book provides a collaborative, multidisciplinary approach for researchers in the fields of toxicology, genetics, immunology, and others engaged in the study on the effects of toxic substances on immune responses.

  • Hazardous Chemicals

    Overview, Toxicological Profile, Challenges, and Future Perspectives
    • 1st Edition
    • Jaspal Singh + 2 more
    • English
    Hazardous Chemicals: Overview, Toxicological Profile, Challenges, and Future Perspectives offers comprehensive coverage of hazardous chemicals and their routes of exposures, mechanism of toxicity, hazard control measures, handling and storage, emergency guidelines, and safety measures.The book is organized into specific classifications of chemical hazards: pesticides, fertilizers, insecticides, automotive, paint and paint solvents, chemical manufacturing solvents, dyes, cleaning agents, pharmaceuticals, and radioactive products. It discusses the health risk and environmental impact of these toxic substances. It also provides management strategies including risk assessment, risk management, and risk communication. Hazardous Chemicals is a practical resource for researchers, academics, industry professionals, graduate and postgraduate students in toxicology and environmental science engaged in the evaluation of toxic substances and human health concerns.

  • Biomarkers in Environmental and Human Health Biomonitoring

    An Integrated Perspective
    • 1st Edition
    • Ritu Mishra + 3 more
    • English
    Biomarkers in Environmental and Human Health Biomonitoring: An Integrated Perspective provides a holistic view of the biomonitoring of environmental degradation, accumulated toxicity, and associated human health concerns. The book incorporates theoretical and practical aspects of the biomonitoring of environmental pollution and the health surveillance of ecological communities using samples from living organisms which are analyzed for contaminants and toxin levels. In the first half, the book provides a general overview if the different types of biomarkers, their significance as bioindicators for contaminants and detection of toxicity, as well as how they can be utilized in the restoration of degraded ecosystems.The second half of the book discusses molecular biomarkers and how they are used as diagnostic and prognostic tools for pollution monitoring. It also reviews analytical tools used to validate the biomarkers in the detection and monitoring of pollution and disease. Finally, the book delves into how novel approaches like genetic ecotoxicology; Big Data, and artificial intelligence calculates the potential consequences of environmental pollution on the ecosystems and on human health.

  • Health and Environmental Effects of Ambient Air Pollution

    Volume 1: Air Pollution, Human Health, and the Environment
    • 1st Edition
    • Mohammad Hadi Dehghani + 3 more
    • English
    Health and Environmental Effects of Ambient Air Pollution is part of a series of three volumes for Air Pollution, Human Health, and the Environment. Volume 1 discusses the adverse consequences of ambient air pollutants on human health, animals, plants, and structures.This book examines the production of ambient air pollutants in the environment. It begins with an overview of the classifications, sources, and occurrences of outdoor air pollutants. This book covers meteorological, climate, and topographical factors affecting air pollution, discusses how urbanization and industrialization affect air quality, and explores how climate conditions like global warming, acid rain, and airborne particulate matter impact human health. It also looks at epidemiology studies and socioeconomic aspects of outdoor air pollution, estimating health and cost effects, air quality indices, guidelines, standards, and information networks of ambient air pollutants. With contributors from experts in the field, this book is a valuable reference for academicians, researchers, and students in environmental health, public health, and occupational health, as well as environmental engineers, meteorologists, epidemiologists, medical researchers, and environmental toxicologists.

  • Diseases and Health Consequences of Air Pollution

    Volume 3: Air Pollution, Human Health, and the Environment
    • 1st Edition
    • Mohammad Hadi Dehghani + 3 more
    • English
    Diseases and Health Consequences of Air Pollution, Volume Three, Air Pollution, Human Health, and the Environment is part of a three-volume series. This volume focuses on epidemiological studies and diseases attributed to ambient and indoor air pollutants. It opens with an overview of diseases and health consequences due to air pollution. The chapters discuss health conditions such as respiratory issues, cardiovascular diseases, hypertension and blood pressure, diabetes, nervous system, brain, cancer, stroke—cerebrovascul... disease, and skin disease that are linked to exposure to indoor and outdoor air pollutants.The book also evaluates the health cost and economic burden of air pollution and offers risk management and solutions to mitigate the health implications of indoor and ambient air pollution. This book provides a single source solution and the latest information about the diseases attributed to air pollutants and their health impact. It will be a valuable reference for academicians, researchers, and students in environmental health, public health, and occupational health, as well as environmental engineers, meteorologists, epidemiologists, medical researchers, and environmental toxicologists.

  • Health Effects of Indoor Air Pollution

    Volume 2: Air Pollution, Human Health, and the Environment
    • 1st Edition
    • Mohammad Hadi Dehghani + 3 more
    • English
    Health Effects of Indoor Air Pollution, Volume Two, Air Pollution, Human Health, and the Environment is part of a three volume series. This volume covers the various classifications of indoor air pollutants and discusses the health impact of indoor pollutants, such as gaseous pollutants and particulate matter. It also examines epidemiological studies related to different air pollutants on health and the workplace. This book begins with an overview of classifications, sources, and occurrences of indoor air pollutants. It also examines the environmental and health impacts due to organic and inorganic air pollutants and how to mitigate them through exposure and risk management.Other sections explore “sick building syndrome,” which causes acute health and discomfort that appears to be linked to time spent in a building. Recent trends and control strategies for occupation exposure due to poor indoor air quality in industrial and nonindustrial workplaces to human health are also covered. This book is a valuable reference for academicians, researchers, and students in environmental health, public health, and occupational health, as well as environmental engineers, meteorologists, epidemiologists, medical researchers, and environmental toxicologists.

  • Public Health and Toxicology Issues in Drug Research, Volume 2

    Toxicity and Toxicodynamics
    • 1st Edition
    • Rakesh K. Tekade
    • English
    Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics, Volume Two examines implications on public health and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments. The book cover topics on pharmacokinetics and toxicokinetics, such as population pharmacokinetics/tox... the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. In addition, it investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body.Final sections discuss the mechanistic pathways of food toxicants and illustrate the molecular mechanisms of the chemopreventive role of dietary phytochemicals. Ethical, legal, societal, and professional issues in toxicology round off coverage, making this a valuable resource for anyone interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 4: Toxicologic Pathology of Organ Systems

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.

  • A Comprehensive Guide to Toxicology in Nonclinical Drug Development

    • 3rd Edition
    • Ali S. Faqi
    • English
    **Selected for 2025 Doody’s Core Titles® in Toxicology**A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

  • Encyclopedia of Toxicology, 4th edition, 9 volume set

    • 4th Edition
    • Philip Wexler
    • English
    Encyclopedia of Toxicology, Fourth Edition is the most extensive compendium surveying the full scope of toxicology, including its chemical, biological and physical (e.g., radiation) perspectives. Spanning nine volumes, this new edition comprises 1150 thoroughly revised and 70 entirely new entries authored by experts in their respective fields, selected by a globally recognized board who have brought rigorous editorial skills to the project. New areas covered in this release include the bourgeoning field of computational toxicology, research applications of alternatives to animal testing, the rise in development and use of consumer products and their effects on populations, and the increasing introduction and use of pharmaceutical ingredients and their interactions. Other chapters of note cover artificial intelligence models of toxicological exposure and effects, extractables and leachable testing, climate change implications for humans, animals and the environment, screening models, -omics, tools such as sequence alignment to predict across species susceptibility, and much more.

  • History of Food and Nutrition Toxicology

    • 1st Edition
    • Esther Haugabrooks + 1 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Nutrition**History of Food and Nutrition Toxicology, part of the History of Toxicology and Environmental Health series, provides an overview of history in the field to help readers better understand future applications for evaluating newer and valuable approaches and their impacts on human health. The book explores issues associated with chemical contaminants, toxicants, the use of dietary supplements and pharmaceuticals, and increasing concerns surrounding food toxicity and safety. The addition of historical case studies and end-of chapter questions make the book ideal for toxicologists, food scientists, pharmaceutical scientists, and other researchers who want to understand current state and future challenges in the field.

  • Personal Care Products and Human Health

    • 1st Edition
    • Philippa D. Darbre
    • English
    Personal Care Products and Human Health provides background, historical context and the latest research results on personal care products (PCPs) and their impact on human health and the environment. Sections provide an overview of the functions and mechanisms of action of components of personal care products, discuss environmental toxicology, outline the problems of contamination of water systems from increasing use of personal care products and the resulting toxicities to aquatic wildlife, and offer chapters written by specialists on different aspects of concern for the effects of excessive personal care product usage on human health. This is a comprehensive reference for toxicologists, environment scientists and those interested in learning about the science behind personal care products and current concerns for environmental and human health.

  • Biocompatibility Protocols for Medical Devices and Materials

    • 1st Edition
    • Prakash Srinivasan Timiri Shanmugam + 2 more
    • English
    Biocompatibility Protocols for Medical Devices and Materials provides comprehensive coverage of the basic science and toxicological testing protocols necessary for the risk assessment and safety analysis of medical devices and materials which are based on the ISO guidelines for body contact and duration of contact. The book begins with device/component selection for toxicological experiments and provides an introduction to topics such as sensitization, irritation tests, material-mediated pyrogenicity, and bacterial-mediated pyrogenicity. Toxicology-related chapters explain the protocols for cytotoxicity, acute systemic toxicity, repeated-exposure systemic toxicity, genotoxicity, carcinogenicity, and reproductive toxicity testing. Biocompatibility Protocols for Medical Devices and Materials is a practical guide that provides step-by-step toxicological protocols ranging from materials selection to data interpretation for toxicologists, biomedical researchers, healthcare professionals, product developers, and others working in risk assessment and safety analysis of medical devices.

  • Essentials of Pharmatoxicology in Drug Research, Volume 1

    Toxicity and Toxicodynamics
    • 1st Edition
    • Rakesh K. Tekade
    • English
    Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3: Environmental Toxicologic Pathology and Major Toxicant Classes

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, this book covers the toxicologic pathology of major classes of environmental toxicants. Volumes emphasize the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. This series comprises the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

  • Handbook of Arsenic Toxicology

    • 2nd Edition
    • Swaran Jeet Singh Flora
    • English
    Handbook of Arsenic Toxicology, Second Edition presents the latest findings on arsenic, including its chemistry, sources and effects on the environment and human health. The book discusses both acute and chronic effects, discussing many aspects of arsenic, from physical and chemical properties, exposure, epidemiology, organ toxicity, diagnosis, prevention and treatment. Fully updated and revised, this new edition includes new topics on risk assessment, molecular mechanisms of arsenic, advances in the integrated approach to testing, assessment and development, evaluation and application of high content predictive models, and new alternative methods (NAMS) in the context of Adverse Outcome Pathways (AOPs) to assess toxicology. This comprehensive resource allows readers to effectively assess the risks related to arsenic, providing them with all they need to know on arsenic exposure, toxicity and toxicity prevention.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2: Safety Assessment and Toxicologic Pathology

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety.

  • Oxidative Stress

    Its Mechanisms and Impacts on Human Health and Disease Onset
    • 1st Edition
    • Harold Zeliger
    • English
    Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation. Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset. With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.

  • "Venomous" Bites from "Non-Venomous" Snakes

    • 2nd Edition
    • Scott A Weinstein + 2 more
    • English
    "Venomous" Bites from "Non-Venomous" Snakes, Second Edition thoroughly examines the potential hazards associated with bites by non-front-fanged snakes (popularly, but inaccurately, called "rear-fanged snakes"). This diverse group contains approximately 80% of living snake species (approximately 2,900 species). A large proportion of these snakes were previously assigned to the family Colubridae but, as a consequence of expanding systematics investigations, have been split into multiple families and subfamilies. Many of these snakes produce venoms or oral secretions that contain toxins and other biologically active substances. A large variety of non–front-fanged snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-19th century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of this wide variety of snakes. The first edition of this book provided "one-stop shopping" by offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. The second edition expands and updates the content with detailed information about the effects and medical management of bites by a broad representation of non–front-fanged species. The hypothetical venomous nature of some lizards considered as non-venomous such as the Komodo monitor or dragon and their allies, as well as the medical effects of their bites, is also examined. The dynamic taxonomy of advanced snakes is updated, and the bases for some of these fluid changes are discussed. Likewise, terminology is also updated in order to reflect the ongoing debates regarding the definition of "venom" and the balanced reinforcement of nonmedical criteria used to define the biological basis of the term "venomous."

  • Fundamentals of Nanotoxicology

    Concepts and Applications
    • 1st Edition
    • PK Gupta
    • English
    Fundamentals of Nanotoxicology: Concepts and Applications provides an outline to fundamental concepts of nanotoxicology and their applications. The book opens historical oversights on nanotechnology, terminology, comparison of nanomaterial sizes, and an overview of regulations. It then goes on to cover types, classifications, sources and properties. It also delves into mechanisms of toxicity as well as health and safety assessments. Biomedical, agricultural, and food applications are explored, and ecotoxicology and the environmental impact on nanomaterials rounds out the book’s overview of this topic. This book will be a helpful resource for understanding concepts and current knowledge to academics, advanced students, and researchers interested in entering or learning more about this interdisciplinary field of study.

  • Reproductive and Developmental Toxicology

    • 3rd Edition
    • Ramesh C. Gupta
    • English
    **Selected for Doody’s Core Titles® 2024 in Toxicology**Reproduc... and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlifeWith a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies.

  • Environmental Contaminants and Medicinal Plants Action on Female Reproduction

    • 1st Edition
    • Alexander V. Sirotkin + 1 more
    • English
    Environmental Contaminants and Medicinal Plants Action on Female Reproduction discusses the problem of environmental pollution, medicinal and food plants, and their impact on reproduction. The book describes the mechanisms of environmental contaminants' action, outlines the key causes of their harmful impact on reproduction, and explores what regulatory substances and processes should be targeted due to the negative effect of pollutants on reproduction. Furthermore, it describes the provenance, properties, physiological and therapeutic effects, and possible areas of application of the known medicinal and functional food plants and their constituents with a focus on female reproductive processes. This book will be a useful resource for reproductive biologists, specialists in assisted reproduction, animal production and phytotherapy, toxicologists, pharmacologists, pharmaceutical scientists, endocrinologists, medicinal and natural product chemists, nutritionists and others engaged in the study of environmental contaminants and medicinal and functional food plants.

  • Handbook on the Toxicology of Metals: Volume II: Specific Metals

    • 5th Edition
    • Gunnar F. Nordberg + 1 more
    • English
    Handbook on the Toxicology of Metals, Volume II: Specific Metals, Fifth Edition provides complete coverage of 38 individual metals and their compounds. This volume is the second volume of a two-volume work which emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health.

  • Handbook on the Toxicology of Metals: Volume I: General Considerations

    • 5th Edition
    • Gunnar F. Nordberg + 1 more
    • English
    Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and covers topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health.

  • Forensic Toxicology

    Principles and Concepts
    • 2nd Edition
    • Nicholas T. Lappas + 1 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Toxicology**The second edition of Forensic Toxicology: Principles and Concepts takes the reader back to the origins of forensic toxicology providing an overview of the largely unchanging principles of the discipline. The text focuses on the major tenets in forensic toxicology, including an introduction to the discipline, principles of forensic toxicology including pharmacokinetics, pharmacodynamics, drug interactions and toxicogenomics, fundamentals of forensic toxicology analysis, types of interpretations based on analytical forensic toxicology results, and reporting from the laboratory to the courtroom. Also included in the second edition is a Unit focused on the forensic toxicology of individual drugs of abuse.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.　

  • History of Modern Clinical Toxicology

    • 1st Edition
    • Alan Woolf
    • English
    History of Modern Clinical Toxicology describes the extraordinary advances in the practice of clinical toxicology within the past 70 years and brings together stories of the people – the champions of clinical toxicology - who contributed to these advances, discovered new therapies and antidotes, and made change happen. This book lays out the poison control system they built and the fascinating story of how they created a new and evolving medical specialty. With the participation of renowned international experts as authors, the book showcases the development of poison control centers around the world and the growth of the professional societies that represent and support them today. This book also tells the stories of the modern-day toxic disasters and recent toxic exposures that gained worldwide attention and notoriety. It outlines the public health responses to such calamities which have led to improvements in our understanding of the science and changes in public health policies and regulations to forestall future such events. Finally, the book covers key policies and agencies affecting poison control centers, addresses the challenges facing clinical toxicologists of today, and predicts advances and future innovations in the field. History of Modern Clinical Toxicology is a unique resource that provides the historical and international perspective that will help students, practitioners, scientists, and health policy makers put current issues and methods in perspective. It will help them understand how infrastructure and processes in clinical toxicology have evolved and why poison control systems are configured as they are.

  • Endocrine Disruption and Human Health

    • 2nd Edition
    • Philippa D. Darbre
    • English
    **Selected for Doody’s Core Titles® 2024 in Endocrinology/Metabo... Disease**Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered.With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students.

  • Contamination of Water

    Health Risk Assessment and Treatment Strategies
    • 1st Edition
    • Arif Ahamad + 2 more
    • English
    Water containing significant amounts of inorganic and organic contaminants can have serious environmental consequences and serious health implications when ingested. Contamination of Water: Health Risk Assessment and Treatment Strategies takes an interconnected look at the various pollutants, the source of contamination, the effects of contamination on aquatic ecosystems and human health, and what the potential mitigation strategies are. This book is organized into three sections. The first section examines the sources of potential contamination. This includes considering the current scenario of heavy metal and pesticide contamination in water as well as the regions impacted due to industrialization, mining, or urbanization. The second section goes on to discuss water contamination and health risks caused by toxic elements, radiological contaminants, microplastics and nanoparticles, and pharmaceutical and personal care products. This book concludes with a section exploring efficient low-cost treatment technologies and remediation strategies that remove toxic pollutants from water. Contamination of Water incorporates both theoretical and practical information that will be useful for researchers, professors, graduate students, and professionals working on water contamination, environmental and health impacts, and the management and treatment of water resources.

  • Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

    • 1st Edition
    • Aristidis M. Tsatsakis
    • English
    Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment.

  • Hazardous Gases

    Risk Assessment on the Environment and Human Health
    • 1st Edition
    • Jaspal Singh + 2 more
    • English
    Hazardous Gases: Risk Assessment on Environment and Human Health examines all relevant routes of exposure, inhalation, skin absorption and ingestion, and control measures of specifics hazardous gases resulting from workplace exposure from industrial processes, traffic fumes, and the degradation of waste materials and how they impacts the health and environment of workers. The book examines the risk assessment and effect of poisonous gases on the environment human health. It also covers necessary emergency guidelines, safety measures, physiological impact, hazard control measures, handling and storage of hazardous gases. Each chapter is formatted to include an introduction, historical background, physicochemical properties, physiological role discussing mechanisms of toxicity, its effect on human health as well as environment, followed by case studies and recent research on toxic gases. Hazardous Gases: Risk Assessment on Environment and Human Health is a helpful resource for academics and researchers in toxicology, occupational health and safety, and environmental sciences as well as those in the field who work to assess and mitigate the impact of toxic gases on the work environment and the health of the workforce.

  • Nutraceuticals

    Efficacy, Safety and Toxicity
    • 2nd Edition
    • Ramesh C. Gupta + 2 more
    • English
    Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition, brings together everything that is currently known about nutraceuticals and their potential toxic effects. The book introduces readers to nutraceuticals, herbal medicines, Ayurvedic medicines, prebiotics, probiotics, adaptogens, and their uses and specific applications. This essential reference discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered. Completely revised and updated, this updated edition provides toxicologists, pharmacologists, pharmaceutical scientists, and those interested in medicinal plants and natural products with a comprehensive overview of the most effective tools upon which to evaluate the safety and toxicity of nutraceuticals, prebiotics, probiotics and alternative medicines.

  • Toxicological Evaluation of Electronic Nicotine Delivery Products

    • 1st Edition
    • Manuel C. Peitsch + 1 more
    • English
    Toxicological Evaluation of Electronic Nicotine Delivery Products　(ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them.　This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation.

  • Exposure and Risk Assessment of Pesticide Use in Agriculture

    Approaches, Tools and Advances
    • 1st Edition
    • Claudio Colosio + 3 more
    • English
    Exposure and Risk Assessment of Pesticide Use in Agriculture: Approaches, Tools and Advances offers an overview of the different methods available in toxicology for pesticide exposure and risk assessment, ranging from the regulatory field, to in-field research studies. The book provides technical background on each method, describing known and grounded tools, new uses of tools and development prospects. This book is ideal for researchers in pesticide toxicology, exposure toxicology, toxicologic risk assessment, occupational hygiene and medicine, and pesticide toxicology as well as occupational health and industrial hygiene practitioners, regulatory experts of corporate and public bodies, and advanced students.

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