
Oxidative Stress
Its Mechanisms and Impacts on Human Health and Disease Onset
- 1st Edition - October 23, 2022
- Imprint: Academic Press
- Author: Harold Zeliger
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 8 9 0 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 4 5 8 - 1
Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation… Read more

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Request a sales quoteOxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation. Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset.
With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.
- Covers the chemical exposures and environmental factors that cause oxidative stress
- Provides further understanding on the mechanisms of oxidative damage response and disease
- Shows how oxidative stress and its role can be determined non-invasively via the Oxidative Stress Index
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- Part I. Oxidative stress and disease
- Chapter 1. Introduction
- 1.1. Oxidative stress
- 1.2. Oxidative stress measuremnt
- 1.3. Major book topics
- Chapter 2. Chemicals and chemical mixtures
- 2.1. Historical perspective
- 2.2. Chemical characteristics–octanol: water partition coefficients
- 2.3. Lipophilic organic chemicals
- 2.4. Hydrophilic organic compounds
- 2.5. Metals
- 2.6. Nonmetallic inorganic chemicals
- 2.7. Chemical mixtures
- 2.8. Traditional toxicology
- 2.9. Chemical mixtures
- 2.10. Unanticipated effects of mixtures
- 2.11. Lipophile–hydrophile mixtures
- 2.12. Lipophile–lipophile mixtures
- 2.13. Sequential absorption
- 2.14. Diseases caused by chemicals
- 2.15. Chemically caused disease and oxidative stress
- Chapter 3. Particles and fibers
- 3.1. Introduction
- 3.2. Particle and fiber sources and content
- 3.3. Oxidative stress (OS)
- 3.4. Dust
- Chapter 4. Air pollution and oxidative stress
- 4.1. Introduction
- 4.2. Ambient air pollutants
- 4.3. Confined air pollutants
- 4.4. Air pollution and oxidative stress
- Chapter 5. Water and soil pollution
- 5.1. Introduction
- 5.2. Water polluting chemicals
- 5.3. Chemical reactions in groundwater
- 5.4. Disinfection bye-products
- 5.5. Soil pollution
- 5.6. Plant absorption of soil toxins and bioacculation
- 5.7. Effects of mixtures
- 5.8. Oxidative stress from polluted water and soil
- Chapter 6. Alcohol
- 6.1. Introduction
- 6.2. Effect of alcohol on nutrients and pharmaceuticals
- 6.3. Effect of alcohol on toxicities of other chemicals
- 6.4. Alcohol metabolism
- 6.5. Alcohol and oxidative stress
- Chapter 7. Tobacco
- 7.1. Tobacco toxicity: introduction
- 7.2. Tobacco and cancer
- 7.3. Tobacco smoke and disease rate synergism
- 7.4. Tobacco and oxidative stress
- 7.5. Electronic cigarettes
- Chapter 8. Electromagnetic radiation
- 8.1. Introduction
- 8.2. The electromagnetic spectrum
- 8.3. Ionizing radiation
- 8.4. Ionizing radiation and chemical mixtures
- 8.5. Ultraviolet radiation
- 8.6. Ultraviolet radiation and toxic chemical mixtures
- 8.7. Nonionizing radiation
- 8.8. Visible light radiation
- 8.9. Radiation and oxidative stress
- Chapter 9. Inflammation
- 9.1. Introduction
- 9.2. Acute inflammation
- 9.3. Chronic inflammation
- 9.4. Inflammation and oxidative stress
- Chapter 10. Food
- 10.1. Introduction
- 10.2. Uptake from soil and plant surfaces
- 10.3. Animal ingestion
- 10.4. Persistent organic pollutants (POPs)
- 10.5. Mercury in food
- 10.6. Food preparation. Deliberate incorporation of additive chemicals into food
- 10.7. Chemical impurities in food - allowable xenobiotics
- 10.8. Allowable chemical impurities in food
- 10.9. Artificial colors
- 10.10. Flavor enhancers
- 10.11. Esthetic and storage additives
- 10.12. Volatile organic compounds (VOCs) in food
- 10.13. Chemicals in food packaging
- 10.14. Irradiated food
- 10.15. Chemical preservatives in food
- 10.16. Food chemicals and oxidative stress
- 10.17. Dietary choices and oxidative stress
- Chapter 11. Sleep deprivation
- 11.1. Introduction
- 11.2. Temperature extremes
- 11.3. Sleep apnea
- 11.4. Circadian cycle interruption
- 11.5. Prevalent health conditions and lifestyle choices
- 11.6. Sleep deprivation and oxidative stress
- Chapter 12. Pharmaceuticals
- 12.1. Introduction
- 12.2. Pharmaceutical use
- 12.3. Pharmaceutical adverse drug reactions
- 12.4. Excipients in pharmaceuticals
- 12.5. Pharmaceuticals and oxidative stress
- Chapter 13. Psychological stress
- 13.1. Introduction
- 13.2. Chronic stress and disease
- 13.3. Psychological stress and oxidative stress
- Chapter 14. Genetics and epigenetics
- 14.1. Introduction
- 14.2. Genetics
- 14.3. Epigenetics
- 14.4. Chemical environmental and other factors in epigenetic effects
- 14.5. Role of oxidative stress in genetic and epigenetic effects
- Chapter 15. Aging
- 15.1. Introduction
- 15.2. Clinical conditions associated with aging
- 15.3. Lowering age of disease onset
- 15.4. Age-related disease and oxidative stress
- 15.5. Hallmarks of aging
- 15.6. Summary
- Chapter 16. Diseases and comorbidities
- 16.1. Introduction
- 16.2. Systems, organs, oxidative stress and disease
- 16.3. Diseases associated with oxidative stress
- 16.4. Multimorbidity
- 16.5. Conclusion
- Chapter 17. Total oxidative stress and disease
- 17.1. Introduction
- 17.2. Diseases and oxidative stress
- 17.3. Malondialdehyde as an indicator of oxidative stress
- 17.4. Oxidative stress additivity - infectious disease
- 17.5. Multimorbidity
- 17.6. Disease prevention strategies
- 17.7. Obesity
- 17.8. Limits to oxidative stress-mediated disease prevention
- 17.9. Disease onset prediction
- 17.10. Conclusions
- Chapter 18. Free radicals
- 18.1. Introduction
- 18.2. Free radical stability
- 18.3. The Fenton reaction
- 18.4. Free radical reactions with DNA
- 18.5. Free radical reactions with proteins
- 18.6. Free radical reactions with lipids
- 18.7. Free radical signaling
- 18.8. Diseases associated with free radicals
- 18.9. Antioxidants
- 18.10. Immune system and free radicals
- 18.11. Hypothalamus-pituitary-adrenal (HPA) axis
- 18.12. Summary
- Part II. Mechanisms of oxidative stress driven disease
- Chapter 19. Aging mechanism
- 19.1. Introduction
- 19.2. Hallmarks of aging
- 19.3. Summary
- Chapter 20. Obesity
- 20.1. Introduction
- 20.2. Statistics
- 20.3. Causes of obesity
- 20.4. Biomarkers of obesity
- 20.5. Comorbidities
- 20.6. Obesity, adipose tissue and chemical toxicity
- 20.7. Obesity and oxidative stress
- 20.8. Psychological impact of obesity
- 20.9. Summary
- Chapter 21. Cancer
- 21.1. Introduction
- 21.2. Hallmarks of cancer—Hanahan and Weinberg
- 21.3. Other hallmarks
- 21.4. Cancer initiation promotion and progression
- 21.5. Exogenous carcinogens
- 21.6. Metals, metalloids and cancer
- 21.7. Food and cancer
- 21.8. Metastasis
- 21.9. Mechanisms associated with specific cancers
- 21.10. Summary
- Chapter 22. Atherosclerosis
- 22.1. Introduction
- 22.2. Hallmark of atherosclerosis
- 22.3. Atherosclerosis risk factors
- 22.4. Atherosclerosis progression
- 22.5. Mechanism of onset
- 22.6. Oxidative stress and Artherosclerosis
- Chapter 23. Alzheimer's disease
- 23.1. Introduction
- 23.2. Hallmarks of Alzheimer’s disease
- 23.3. Risk factors for Alzheimer’s disease
- 23.4. Alzheimer’s disease co-morbidity data
- 23.5. Mechanisms of Alzheimer’s disease onset
- Chapter 24. Type 2 diabetes (T2D)
- 24.1. Introduction
- 24.2. Risk factors for type 2 diabetes
- 24.3. Chemical exposure as a cause of type 2 diabetes
- 24.4. Mechanisms of type 2 diabetes onset
- 24.5. Effects of ROS
- 24.6. Type 2 diabetes and oxidative stress
- 24.7. Type 2 diabetes complications
- 24.8. Diabetes outlook
- Chapter 25. Rheumatoid arthritis
- 25.1. Introduction
- 25.2. Complications of rheumatoid arthritis
- 25.3. Biomarkers of rheumatoid arthritis
- 25.4. Risk factors for rheumatoid arthritis
- 25.5. Mechanisms of rheumatoid arthritis onset
- 25.6. Oxidative stress in rheumatoid arthritis
- Chapter 26. Asthma
- 26.1. Introduction
- 26.2. Phenotypes of asthma
- 26.3. Biomarkers of asthma
- 26.4. Risk factors for asthma
- 26.5. Cross sensitization
- 26.6. Mechanisms of asthma and oxidative stress
- 26.7. Summary
- Chapter 27. Liver cirrhosis
- 27.1. Introduction
- 27.2. Liver fibroproliferative diseases
- 27.3. Oxidative stress and liver disease
- Chapter 28. Chronic kidney disease (CKD)
- 28.1. Introduction
- 28.2. Causes of chronic kidney disease
- 28.3. Hallmarks of chronic kidney disease
- 28.4. Risk factors for chronic kidney disease
- 28.5. Mechanisms of chronic kidney disease and oxidative stress
- Chapter 29. Disease comorbidities
- 29.1. Introduction
- 29.2. Comorbidity
- 29.3. Oxidative stress, the common thread
- Part III. Disease onset prediction
- Chapter 30. Oxidative stress index
- 30.1. Introduction
- 30.2. Oxidative Stress Index (OSI)
- 30.3. OSI basis
- 30.4. Oxidative Stress Index questionnaire
- 30.5. OSI score and disease
- 30.6. Additional applications
- Chapter 31. OSI condensed questionnaire
- 31.1. Introduction
- 31.2. Age
- 31.3. Weight
- 31.4. Preexisting chronic conditions
- 31.5. Medications regularly taken
- 31.6. Genetics
- 31.7. Education level
- 31.8. Place of residence
- 31.9. Chronic psychological stress
- 31.10. Condensed OSI form
- 31.11. Condensed OSI applications
- 31.12. Conclusions
- Chapter 32. OSI and Alzheimer's disease
- 32.1. Introduction
- 32.2. Alzheimer's disease and oxidative stress
- 32.3. Alzheimer's disease and dose response relationship (DRR)
- 32.4. Parameters known to increase likelihood of AD onset
- 32.5. Late onset AD
- 32.6. The OSI and AD
- 32.7. AD prevention
- 32.8. Questionnaire use
- 32.9. Strengths and limitations
- 32.10. Conclusions
- Chapter 33. OSI public health surveys
- 33.1. Introduction
- 33.2. Toxicity as a function of emission distance
- 33.3. Disease impact as a function of exposure time
- 33.4. Summary
- Chapter 34. Predicting COVID-19 severity
- 34.1. Introduction
- 34.2. Oxidative stress and COVID-19 severity
- 34.3. Oxidative stress index and COVID-19 severity
- 34.4. Validation of OSI use in predicting COVID-19 severity
- 34.5. Covid-19 as a cause of oxidative stress
- 34.6. Summary
- Part IV. Prevention
- Chapter 35. Disease prevention: oxidative stress control, antioxidants, and social factors
- 35.1. Introduction
- 35.2. Oxidative stress overproduction control
- 35.3. Antioxidants
- 35.4. Antioxidants and disease prevention
- 35.5. Diet
- 35.6. Treating prevalent illness
- 35.7. Psychological stress
- 35.8. Exercise
- 35.9. Treating illness
- 35.10. Inequalities
- 35.11. Summary
- Chapter 36. Global warming, oxidative stress and disease
- 36.1. Introduction
- 36.2. Global warming, oxidative stress
- 36.3. Stress
- 36.4. Human extinction?
- Index
- Edition: 1
- Published: October 23, 2022
- Imprint: Academic Press
- No. of pages: 500
- Language: English
- Paperback ISBN: 9780323918909
- eBook ISBN: 9780323914581
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