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Elsevier

Books in Risk assessment

This collection emphasizes hazard identification, dose-response analysis, and exposure evaluation. Supporting regulators and industry, it features methodologies and case studies that drive informed decision-making to protect public health and the environment.

  • Micro(nano)plastics in Organ Systems

    Health Impacts, Challenges, and Future Prospects
    • 1st Edition
    • Charan Singh + 4 more
    • English
    Micro(nano)plastics in Organ Systems: Health Impacts, Challenges, and Future Prospects comprehensively discusses the impact of micro(nano)plastics on human health, analyzing their sources, classification, and exposure pathways, while also exploring their interactions with biological systems, their potential effects on various organ systems, and concerns related to bioaccumulation and toxicity. The book begins with an in-depth analysis of their classification, sources, and exposure pathways, and progressing through interactions with biological systems and the resulting toxicological effects. Furthermore, the book delves into recent advances in detection technologies, the development of more sustainable advances such as bioplastic-based nanoparticles, and the need for regulatory frameworks.The text meticulously examines the implications of these particles on various organ systems—including the gastrointestinal, respiratory, cardiovascular, renal, neurological, reproductive, and metabolic systems—while addressing critical issues such as bioaccumulation, immunological responses, and their potential harmful impact on health. It is an essential resource for toxicologists, environmental scientists, healthcare professionals, public health advocates, and others interested in the implications of micro(nano)plastics on health.

  • Mycotoxins in Food

    Detection and Control
    • 1st Edition
    • N Magan + 1 more
    • English

  • Foodborne Pathogens

    Hazards, Risk Analysis and Control
    • 2nd Edition
    • Clive de W Blackburn + 1 more
    • English

  • Physiologically Based Pharmacokinetic (PBPK) Modeling

    Methods and Applications in Toxicology and Risk Assessment
    • 1st Edition
    • Jeffrey W. Fisher + 2 more
    • English

  • Hazardous Chemicals in Medical Devices

    Safety, Risk Analysis, and Regulations
    • 1st Edition
    • Prakash Srinivasan Timiri Shanmugam + 1 more
    • English
    Hazardous Chemicals in Medical Devices: Safety, Risk Analysis, and Regulations provides a comprehensive overview of the hazardous chemicals used in medical device manufacturing. The book discusses the basics of these chemicals, their presence in various components, and the regulations that govern their use. It also delves into the processes involved in manufacturing and the added chemicals during these stages. With a focus on risk assessment and analysis, the book emphasizes the importance of safety in medical devices and outlines the types of hazards associated with these substances.The book further explains the regulatory classification of hazardous chemicals and the labeling and safety data sheet requirements. It includes a list of notified bodies that discuss hazardous substance data, aiding in risk assessment and toxicological profiling. Additionally, it underscores the critical understanding of toxicological profiles of materials used in medical devices, ensuring that readers are well-informed about the safety measures and regulations in place to protect both manufacturers and users.

  • Computational Methods in Medicinal Chemistry, Pharmacology, and Toxicology

    • 1st Edition
    • Muhammad Ishfaq
    • English
    Computational Methods in Medicinal Chemistry, Pharmacology, and Toxicology is a comprehensive resource that offers an advanced overview of computational techniques employed in drug discovery, design, and toxicity prediction. The book discusses various topics, including molecular modeling, virtual screening, machine learning, and network pharmacology. It serves as an essential guide for researchers, practitioners, and students in pharmacology, toxicology, medicinal chemistry, bioinformatics, and systems biology fields, showcasing practical applications and future perspectives on new technologies. In addition to covering computational approaches, the book provides real-world examples of drug discovery, candidate optimization, and safety assessment.Other sections explore computer applications in pharmacology and toxicology and discusses the importance of these methods in advancing medicinal research.

  • Public Health and Toxicology Issues in Drug Research, Volume 2

    Toxicity and Toxicodynamics
    • 1st Edition
    • Rakesh K. Tekade
    • English
    Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics, Volume Two examines implications on public health and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments. The book cover topics on pharmacokinetics and toxicokinetics, such as population pharmacokinetics/tox... the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. In addition, it investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body.Final sections discuss the mechanistic pathways of food toxicants and illustrate the molecular mechanisms of the chemopreventive role of dietary phytochemicals. Ethical, legal, societal, and professional issues in toxicology round off coverage, making this a valuable resource for anyone interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.

  • Oxidative Stress

    Its Mechanisms and Impacts on Human Health and Disease Onset
    • 1st Edition
    • Harold Zeliger
    • English
    Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation. Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset. With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.

  • Handbook on the Toxicology of Metals: Volume II: Specific Metals

    • 5th Edition
    • Gunnar F. Nordberg + 1 more
    • English
    Handbook on the Toxicology of Metals, Volume II: Specific Metals, Fifth Edition provides complete coverage of 38 individual metals and their compounds. This volume is the second volume of a two-volume work which emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health.

  • Toxicological Aspects of Medical Device Implants

    • 1st Edition
    • Prakash Srinivasan Timiri Shanmugam + 2 more
    • English
    Toxicological Aspects of Medical Device Implants provides comprehensive information on the use of medical implant and devices and the balance between the application of the devices in relation to any potential adverse effects. In order to ensure the safety and effectiveness of medical devices, many international policies, regulations, and standards have been established, and the book also discusses medical devices within this regulatory framework. The book covers a broad range of disease topics and disease-specific implants and an interdisciplinary team of experts brings a wealth of information on implants used in various disease models and associated risk factors. Toxicological Aspects of Medical Device Implants is a comprehensive resource for toxicologists, biomedical engineers, immunologists, medical staff, regulators, and manufacturers working in the field who need to be aware of the potential toxicity and device management of such a wide variety of implants and devices and their health risks.

  • Engineered Nanoparticles

    Structure, Properties and Mechanisms of Toxicity
    • 1st Edition
    • Ashok K. Singh
    • English
    Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity is an indispensable introduction to engineered nanomaterials (ENM) and their potential adverse effects on human health and the environment. Although research in the area of pharmacology and toxicology of ENM is rapidly advancing, a possible correlation between their physicochemical properties and biomedical properties or toxicity is not yet fully understood. This understanding is essential to develop strategies for the safe applications and handling of ENM. The book comprehensively defines the current understanding of ENM toxicity, first describing these materials and their physicochemical properties, and then discussing the toxicological theory and methodology before finally demonstrating the potential impact of ENM on the environment and human health. It represents an essential reference for students and investigators in toxicology, pharmacology, chemistry, material sciences, medicine, and those in related disciplines who require an introduction to ENM and their potential toxicological effects.

  • Therapeutic Risk Management of Medicines

    • 1st Edition
    • Stephen J. Mayall + 1 more
    • English
    Therapeutic risk management of medicines is an authoritative and practical guide on developing, implementing and evaluating risk management plans for medicines globally. It explains how to assess risks and benefit-risk balance, design and roll out risk minimisation and pharmacovigilance activities, and interact effectively with key stakeholders.A more systematic approach for managing the risks of medicines arose following a number of high-profile drug safety incidents and a need for better access to effective but potentially risky treatments. Regulatory requirements have evolved rapidly over the past decade. Risk management plans (RMPs) are mandatory for new medicinal products in the EU and a Risk Evaluation and Mitigation Strategy (REMS) is needed for certain drugs in the US.This book is an easy-to-read resource that complements current regulatory guidance, by exploring key areas and practical implications in greater detail. It is structured into chapters encompassing a background to therapeutic risk management, strategies for developing RMPs, implementation of RMPs, and the continuing evolution of the risk management field.The topic is of critical importance not only to the pharmaceutical and biotechnology industries, but also regulators and healthcare policymakers.Some chapters feature contributions from selected industry experts.

  • Tissue-Specific Toxicity

    Biochemical Mechanisms
    • 1st Edition
    • Wolfgang Dekant + 1 more
    • English
    This volume provides an up-to-date review of the molecular mechanisms of toxicity. Individual chapters deal with specific aspects of toxicity problems associated with selected organs.