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Books in Risk assessment

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Public Health and Toxicology Issues in Drug Research, Volume 2

  • 1st Edition
  • March 26, 2024
  • Rakesh Kumar Tekade
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 5 8 4 2 - 1
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 8 4 3 - 8
Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics, Volume Two examines implications on public health and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments. The book cover topics on pharmacokinetics and toxicokinetics, such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. In addition, it investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body.Final sections discuss the mechanistic pathways of food toxicants and illustrate the molecular mechanisms of the chemopreventive role of dietary phytochemicals. Ethical, legal, societal, and professional issues in toxicology round off coverage, making this a valuable resource for anyone interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.

Essentials of Pharmatoxicology in Drug Research, Volume 1

  • 1st Edition
  • March 22, 2023
  • Rakesh Kumar Tekade
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 5 8 4 0 - 7
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 8 4 1 - 4
Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.

Oxidative Stress

  • 1st Edition
  • October 23, 2022
  • Harold Zeliger
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 1 8 9 0 - 9
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 4 5 8 - 1
Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation.  Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset. With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.

Toxicological Aspects of Medical Device Implants

  • 1st Edition
  • June 10, 2020
  • Prakash Srinivasan Timiri Shanmugam + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 0 7 2 8 - 4
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 0 9 2 0 - 2
Toxicological Aspects of Medical Device Implants provides comprehensive information on the use of medical implant and devices and the balance between the application of the devices in relation to any potential adverse effects. In order to ensure the safety and effectiveness of medical devices, many international policies, regulations, and standards have been established, and the book also discusses medical devices within this regulatory framework. The book covers a broad range of disease topics and disease-specific implants and an interdisciplinary team of experts brings a wealth of information on implants used in various disease models and associated risk factors. Toxicological Aspects of Medical Device Implants is a comprehensive resource for toxicologists, biomedical engineers, immunologists, medical staff, regulators, and manufacturers working in the field who need to be aware of the potential toxicity and device management of such a wide variety of implants and devices and their health risks.

Physiologically Based Pharmacokinetic (PBPK) Modeling

  • 1st Edition
  • May 20, 2020
  • Jeffrey W. Fisher + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 8 5 9 6 - 4
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 9 6 8 2 - 3
Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.

History of Risk Assessment in Toxicology

  • 1st Edition
  • September 20, 2017
  • Sol Bobst
  • English
  • Paperback
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  • eBook
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History of Risk Assessment in Toxicology guides the reader through the historical narrative of the evolution of risk assessment thinking in human and environmental practices. Risk assessment concepts are used in many different professional practice areas. In the health and environmental practices of risk assessment, the critical issue is often what chemical concentration in air, water, food, or a solid substance is acceptable, or considered not to result in any adverse effect. The book reviews examples from early scientific and health studies to showcase the foundations of risk assessment. The book also explores the development of risk assessment as practiced by major regulatory bodies such as the US Food and Drug Administration (FDA), the Occupational Safety & Health Administration (OSHA), and the US Environmental Protection Agency (EPA) to reveal how risk assessment has evolved in the 20th and 21st centuries. Modern technology has created opportunities in silicon in vitro, computational modeling, omics, and big data techniques to assess the toxicity of chemicals, while traditional approaches to risk assessment are being challenged with new and innovative approaches. Finally, current issues being debated and tested in risk assessment are outlined with possible future avenues suggested.

Neurotoxicity of Nanomaterials and Nanomedicine

  • 1st Edition
  • September 28, 2016
  • Xinguo Jiang + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 4 5 9 8 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 4 6 2 0 - 3
Neurotoxicity of Nanomaterials and Nanomedicine presents an overview of the exciting research in neurotoxicity and nanomaterials. Nanomaterials have been extensively used in medicine, including diagnosis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most nanomaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation. This comprehensive book includes chapters on the most commonly used individual nanoparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that nanomaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of nanomaterials. Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching nanomaterials.

Molecular Biological Markers for Toxicology and Risk Assessment

  • 1st Edition
  • June 8, 2016
  • Bruce A. Fowler
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 9 5 8 9 - 8
  • eBook
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Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice.

Engineered Nanoparticles

  • 1st Edition
  • November 24, 2015
  • Ashok K. Singh
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 1 4 0 6 - 6
  • eBook
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Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity is an indispensable introduction to engineered nanomaterials (ENM) and their potential adverse effects on human health and the environment. Although research in the area of pharmacology and toxicology of ENM is rapidly advancing, a possible correlation between their physicochemical properties and biomedical properties or toxicity is not yet fully understood. This understanding is essential to develop strategies for the safe applications and handling of ENM. The book comprehensively defines the current understanding of ENM toxicity, first describing these materials and their physicochemical properties, and then discussing the toxicological theory and methodology before finally demonstrating the potential impact of ENM on the environment and human health. It represents an essential reference for students and investigators in toxicology, pharmacology, chemistry, material sciences, medicine, and those in related disciplines who require an introduction to ENM and their potential toxicological effects.

Wildlife Toxicity Assessments for Chemicals of Military Concern

  • 1st Edition
  • May 20, 2015
  • Marc Williams + 3 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 0 0 2 0 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 0 4 8 0 - 7
Wildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on terrestrial wildlife for risk assessment applications. Substances covered include military-related chemicals including explosives, propellants, pesticides and metals. Wildlife Toxicity Assessments for Chemicals of Military Concern is a much-needed resource designed to meet the needs of those seeking toxicological information for ecological risk assessment purposes. Each chapter targets a specific chemical and considers the current knowledge of the toxicological impacts of chemicals to terrestrial wildlife including mammalian, avian, amphibian and reptilian species.