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Experimental and Clinical Advances
1st Edition - June 1, 2024
Editors: Barry Rumack, Hartmut Jaeschke, Mitchell McGill
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Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of… Read more
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Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity.Divided into two parts, the foundation aspects of the book cover the mechanism of toxicity in a detailed manner beginning with the history of acetaminophen to newly explored areas in newly explored areas of genetics, proteomics, and metabolomics. The second half goes on to discuss clinical practices and examine where further research and therapeutic approaches may be headed. This part answers key questions about who to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments. With contributions from experts in the field, the book is a thorough, well-researched, and valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with of acetaminophen toxicity.
Includes comprehensive coverage of pharmacological mechanisms of toxicity.
Provides risk analysis regardless of patient presentation or timing of ingestion or amount with algorithmic support
Covers how to determine level of toxicity and need for liver transplant with algorithmic support.
Outlines new therapeutic approaches
Research Toxicologists, Research Pharmacologists, Medical Toxicologists (MD, MD and MPH, MD and PhD), Clinical Toxicologists (RN, BSN, MSN, RPh, PharmD, PhD trained), Medical Toxicology and Emergency Medicine Physician trainees, Emergency Medicine Nurse or Nurse Practitioner Trainees, Poison Control Center Staffs, Pharmacy Students
Part 1: Foundational Aspects
1. History of Acetaminophen
2. Intracellular Signaling Mechanisms of Cell Death.
3. Mode of Cell Death
7. Emerging Mechanisms
8. Renal Toxicity
9. Pulmonary Toxicity
10. Genomics, Proteomics and Metabolomics
Part II: Clinical and Therapeutic
11. N-Acetylcysteine (NAC)
13. Pre-Hospital and Poison Center Care of Overdose and Potential Overdoses Patients
14. Acetaminophen and Co-Ingestions
15. Current Standard of Care and New Developments
17. Risk Analysis and Acetylcysteine Treatment Protocols
19. Epidemiology NPDS (Poison Center Data) CDC and Other Databases
20. Emerging Treatments
21. Liver Transplantation
Published: June 1, 2024
Imprint: Academic Press
Paperback ISBN: 9780443158773
eBook ISBN: 9780443158780
Dr. Barry H. Rumack, MD is currently Professor Emeritus of Pediatrics and Emergency Medicine at the University of Colorado School of Medicine, Chairman Emeritus, Micromedex, Inc., and Director Emeritus of the Rocky Mountain Poison Center of the Denver Department of Health & Hospitals, University of Colorado Health Sciences Center. His research interests include Acetaminophen Overdose and General Medical Toxicology. He has published over 230 peer-reviewed articles, authored or edited numerous books and book chapters. He is on the editorial board of a number of journals including Clinical Toxicology, Emergency Medicine, among others. He is a Fellow of the American Academy of Clinical Toxicology, American College of Medical Toxicology, and American Academy of Pediatrics and member of Society of Toxicology, American Association of Poison Control Centers, and American College of Emergency Medicine
Affiliations and expertise
Professor Emeritus of Pediatrics and Emergency Medicine, University of Colorado School of Medicine, USA
Dr. Hartmut Jaeschke, PhD, is the University Distinguished Professor and Chairman of the Department of Pharmacology, Toxicology, and Therapeutics at the University of Kansas Medical Center, Kansas City, Kansas. He joined KUMC in 2006. He is a Fellow of the Academy of Toxicological Sciences and Fellow of the American Association for the Study of Liver Diseases. He has published more than 470 peer-reviewed manuscripts, invited reviews, and book chapters in the areas of liver toxicology and liver pathophysiology. He currently serves as Associate Editor for Toxicological Sciences, the inaugural Editor-in-Chief of Livers (since 2020) and is a member of 14 editorial boards. In 2019, he was the recipient of the Translational Impact Award from the Society of Toxicology. His major research interests include basic mechanisms and translational aspects of xenobiotic-induced hepatotoxicity and tissue repair with a focus on acetaminophen overdose and mechanisms of inflammatory liver injury in animal models and humans.
Affiliations and expertise
University Distinguished Professor, Pharmacology, Toxicology and Therapeutics; Department Chair, SOM-Kansas City, Pharmacology, Toxicology and Therapeutics, USA
Dr. Mitchell R. McGill is currently an Assistant Professor in the Dept. of Environmental and Occupational Health, at the Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences. He received his PhD at the University of Kansas School of Medicine where he studied toxicology and liver injury biomarkers and pursued his postdoctoral studies in clinical chemistry and liver metabolism at Washington University School of Medicine. Areas of research interests include toxicology, disease biomarkers, and liver pathophysiology. Dr. McGill has over 90 journal publications and numerous book chapters, oral presentations, and meeting abstracts on this the topic of acetaminophen research. He has served as a reviewer and is on the editorial board of Food and Chemical Toxicology, Livers, Toxicological Sciences, and Cells Tissues Organs. He is a member of Society of Toxicology, the American Association for the Study of Liver Diseases, and the American Association for Clinical Chemistry.
Affiliations and expertise
Assistant Professor, University of Arkansas for Medical Sciences, USA