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Epidemiology of Cannabis
Genotoxicity, Neurotoxicity, Epigenomics and Aging
- 1st Edition - March 1, 2025
- Authors: Albert Stuart Reece, Gary Kenneth Hulse
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 4 9 2 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 4 9 3 - 7
Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging provides a novel and comprehensive exploration of four areas that have previously been associ… Read more
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Request a sales quoteEpidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging provides a novel and comprehensive exploration of four areas that have previously been associated with cannabis use, namely mental health in adults and young adults, pediatric autism, congenital anomalies, and pediatric cancers, including testicular cancer. The book also explores the possibility of how these associations might be reflected in overall disease trends at the population health level. This book surveys these four areas in detail and applies cutting-edge analytical software and geospatial space–time analytical techniques to these questions.
With all this information gathered into one book in an easily readable form, this book is a reference for clinicians, health science and allied health practitioners, public health and basic science researchers and drug and health regulators interested in these topics. It is also suitable for inclusion in course work and study preparation courses at both the undergraduate and postgraduate levels.
With all this information gathered into one book in an easily readable form, this book is a reference for clinicians, health science and allied health practitioners, public health and basic science researchers and drug and health regulators interested in these topics. It is also suitable for inclusion in course work and study preparation courses at both the undergraduate and postgraduate levels.
- Examines adult and pediatric neurotoxicity and genotoxicity from cannabis use, along with health impacts
- Analyzes epigenetics and the observed pattern of teratological, cancerogenic, and age-accelerated disease
- Utilizes advanced statistical and geotemporalspatial analysis to investigate cannabis exposure and health
Researchers and epidemiologists studying the neurotoxic and genotoxic health impact of cannabis including neurological aspects of long-term use of cannabis usage and cannabis related cancers, Industry professionals and clinicians interested in epidemiology of addiction, genetics, and neurology
SECTION 1: Mental Illness Close Parallels between Cannabis Use and Deteriorating US Mental Health at Four Levels Supports and Extends the Epidemiological Salience of Demonstrated Causal Mental Health Relationships: A Geospatiotemporal Study
1. National Trends
2. Regional Trends
3. State Trends
4. Sub-State Trends
5. Geospatial Analysis
6. Causality Criteria
SECTION 2: Autistic Spectrum Disorder Linked Rise of Cannabis Use and Autism Incidence Demonstrated by Close Three Level Geospatiotemporal Relationships, USA, 1990-2011.
7. National Trends
8. Regional Trends
9. State Trends
10. Geospatial Analysis
11. Changes in State Trends
12. Legal Status and Autism
13. Geospatial Analysis of Legal Status and Autism
SECTION 3: Congenital Anomalies Geotemporospatial Analysis of United States 38-44 Congenital Anomalies as a Function of Multiple Cannabinoid- and Substance- Exposure in the Decades of Cannabis Legalization: Phenocopying Thalidomide and Hundred Megabase-Scale Genotoxicity
14. Drug Use by Race
15. Drugs and Defects Overview
16. Chromosomal Anomalies: Anomalies 1:5
17. Gastroschisis: Anomaly 6
18. Atrial Septal Defect (Secundum): Anomaly 7
19. Cardiovascular Defects of Interest: Anomalies 8-11
20. Hawaiian - American Review: Anomalies 12-37
21. Conclusion: Time Course, Quintile Analysis, Canada, Thalidomide, Legal Status, Causality
SECTION 4: Cancer and Heritable Cancer Reflections of Heritable Cannabis-Related Genotoxicity in Rising Adult and Pediatric Cancer Rates Across USA in Time- and Ethnicity- Denominated Analyses
22. General Introduction and Overview
23. Sequential Analysis of Cancer Types
24. Geospatiotemporal Modelling - Fitted Values
25. Geospatiotemporal Modelling - Matrix Multiplication
26. Summary of Geospatiotemporal Modelling
27. Overall Conclusions
SECTION 5: Epigenetics and Aging As modern epigenetic studies provide profound insights into the observed pattern of teratological, cancerogenic and age-accelerated disease it becomes important to consider new findings in detail.
28. Epigenetics of Cannabinoids - Introduction
29. Epigenetics of Cannabinoids – Historical Studies
30. Epigenetics of Cannabinoids – Longitudinal Sperm Study - Overview
31. Epigenetics of Cannabinoids – Longitudinal Sperm Study – Stem Cells
32. Epigenetics of Cannabinoids – Longitudinal Sperm Study - Chromosomes
33. Epigenetics of Cannabinoids – Longitudinal Sperm Teratology - Brain
34. Epigenetics of Cannabinoids – Longitudinal Sperm Teratology - Cardiovasculature
35. Epigenetics of Cannabinoids – Longitudinal Sperm Teratology – Other Organs
36. Epigenetics of Cannabinoids – Longitudinal Sperm Study - Carcinogenesis
37. Epigenetics of Cannabinoids – Accelerated Aging
- No. of pages: 1150
- Language: English
- Edition: 1
- Published: March 1, 2025
- Imprint: Academic Press
- Paperback ISBN: 9780443134920
- eBook ISBN: 9780443134937
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Albert Stuart Reece
Dr. Stuart Reece has been a registered medical practitioner in Australia since 1982. He has worked with a special interest in addiction medicine since 1997 when he was introduced to naltrexone medicine in Perth. He has worked in a variety of hospital and community-based environments in Australia, UK, France, and Papua New Guinea. In addition to his basic medical qualification, Dr Reece holds surgical fellowships from the Royal College of Surgeons of Edinburgh and the Royal College of Physicians and Surgeons of Glasgow, a Fellowship of the Royal Australian College of General Practitioners, and a Doctorate of Medicine in liver transplantation. Dr Reece was appointed as Associate Professor of Medicine at the University of Western Australia in 2010, and a full Professor of Medicine at both the University of Western Australia and the Edith Cowan University in 2018.
Affiliations and expertise
Professor, University of Western Australia, AustraliaGH
Gary Kenneth Hulse
Professor Gary Hulse has worked in the area of problem alcohol and drug use for the past 30 years, For the past fourteen years he has held an academic appointment as ‘Coordinator of Alcohol and Drug Education and Training’ within the Faculty of Medicine, University of Western Australia, based at Sir Charles Gairdner Hospital Perth. Research and clinical activities have been primarily directed at developing evidence- based information which will enhance clinical practice. Between 1992-2009, Professor Hulse chaired the Committee on Alcohol and Drug Education in Medical Schools on behalf of the Committee of Deans Australian and New Zealand Medical Schools. Professor Hulse has published in excess of 150 peer review publications. He is Chief Editor of two evidence based clinical alcohol and drug texts published by Oxford University Press which have been adopted as the standard text for medical training by the Australian Medical Schools [Committee of Deans].
Affiliations and expertise
Professor, University of Western Australia, Australia