
Comprehensive Toxicology
- 4th Edition - September 1, 2025
- Imprint: Elsevier Science
- Editor: Charlene McQueen
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 4 8 8 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 4 8 9 - 1
Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicolog… Read more

Purchase options

Institutional subscription on ScienceDirect
Request a sales quoteComprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicology researchers. This edition focuses on understanding the mechanisms by which chemicals affect biological systems and cause adverse health effects. Edited by a distinguished editorial board and featuring 400 in-depth contributions from experts around the globe, this comprehensive work spans fifteen volumes and nearly 9,000 pages, covering all major organ systems and general principles of toxicology. This extensively revised edition includes around 30 new chapters on modern testing strategies and novel in vitro models, such as organ-on-a-chip systems.
It also explores computational approaches, new risk and safety assessment methods, harmonization, artificial intelligence, and the microbiome. As the most authoritative resource in toxicology, it continues to support researchers, faculty, and students in toxicology, as well as professionals in medical, veterinary, food, environmental, chemical, and pharmaceutical industries and international regulatory agencies.
- Covers both the fundamental principles of toxicology and unique aspects of major organ systems
- Revised edition with new chapters on topics such as new approaches in testing strategies, novel in vitro models such as organ on a chip, and microphysiological systems to name a few
- Includes computational approaches, ‘omics’, new approaches to risk and safety assessment, harmonization, artificial intelligence, and the microbiome
- Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts
Graduate and postgraduate students, academic researchers, faculty in toxicology, medical toxicology and pharmacology.Professionals in medical practices, the chemical industry, food science research, environmental research and consulting, forensic science, regulatory agencies, patent and environmental law, and occupational health and safety
1. General Principles
2. Hepatic Toxicology
3. Reproductive and Endocrine Toxicology
4. Developmental Toxicology
5. Nervous System and Behavioral Toxicology
6. Carcinogenesis
7. Cellular and Molecular Toxicology
8. Toxicology Testing and Evaluation
9. Biotransformation
10. Immune System Toxicology
11. Hematopoietic Systems Toxicology
12. Cardiovascular Toxicology
13. Gastrointestinal and Renal Toxicology
14. Respiratory Toxicology
- Edition: 4
- Published: September 1, 2025
- Imprint: Elsevier Science
- No. of pages: 8704
- Language: English
- Hardback ISBN: 9780323954884
- eBook ISBN: 9780323954891
CM