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Elsevier

Books in Toxicology general

Providing a broad overview of toxicological principles, mechanisms, and testing methods, this portfolio supports researchers, regulators, and clinicians. It features foundational concepts, emerging trends, and case studies that underpin safe chemical and drug use.

  • Toxicology Disasters

    Causes and Consequences
    • 1st Edition
    • Sue Ford
    • English
    Toxicology Disasters: Cause and Consequences, a volume in the History of Toxicology and Environmental Health series, provides an historical overview of significant toxicological disasters which involved chemical exposure of humans, animals or the environment. The book documents the timeline of events and the legacy of the resulting exposure which occurred within a specific period of time, but with long lasting consequences. Case studies of toxicological incidents and a wide range of categories, including environmental, industrial, pharmaceutical, domestic and international are not only discussed from a historical perspective but also regarding their impacted toxicology, regulation and our current use of these chemicals.The book will help toxicologists, academics and students from environmental health and toxicology departments, environmental/occupa... health regulators, and industrial hygiene/safety personnel gain a better understanding of the arc of a toxicological disaster from its origins, root causes of the problem, and initial and long-term assessments and management.

  • Stem Cell Toxicology

    Principles, Models, and Applications
    • 1st Edition
    • Guibin Jiang + 2 more
    • English
    Stem Cell Toxicology: Principles, Models, and Applications is the first comprehensive and practical academic book to systematically present cutting-edge progress of stem cell technologies for toxicological research and applications. This book addresses the current paradigm shift in toxicology by exploring the application value of stem cell models in assessing risks associated with complex exposures, including environmental pollutants, drugs, and food additives. It offers a complete theoretical framework and technical toolkit for professionals engaged in toxicology, stem cell biology, drug safety assessment, and environmental health research.

  • Mitochondrial Intoxication

    • 2nd Edition
    • Marcos Roberto de Oliveira
    • English
    Mitochondrial Intoxication, Second Edition, offers a comprehensive and fully updated exploration of the impact of toxic molecules on mitochondrial physiology and the diseases that result from their dysfunction. Divided into three sections, the book opens with a detailed overview of mitochondrial physiology, molecular markers of mitochondrial intoxication, and challenges of mitochondrial profiling during pre-clinical studies. The book then focuses on endogenous toxicants and their impact on mitochondria, including new chapters on lipids, glucose and microbiota-derived toxicants. Amyloid-β peptide and its impact on mitochondrial dysfunction is also a new addition to this book, as well as inflammation-induced mitochondrial intoxication.The final section explores exogenous toxicants, such as pollutants, food additives, illicit and pharmaceutical drugs, pesticides, and heavy metals. The effects of micro- and nanoplastics on mitochondrial function are newly covered. Furthermore, the latest computational tools in mitochondrial toxicity research are investigated. Incorporating the latest advances in the field, this new release offers cutting-edge insights on mitochondrial toxicity, serving as an invaluable resource for researchers and advanced students in cell biology, molecular biology, toxicology, biochemistry, pharmacology, and related fields.

  • Comprehensive Toxicology

    • 4th Edition
    • Charlene McQueen
    • English
    Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicology researchers. This edition focuses on understanding the mechanisms by which chemicals affect biological systems and cause adverse health effects. Edited by a distinguished editorial board and featuring 400 in-depth contributions from experts around the globe, this comprehensive work spans fifteen volumes and nearly 9,000 pages, covering all major organ systems and general principles of toxicology. This extensively revised edition includes around 30 new chapters on modern testing strategies and novel in vitro models, such as organ-on-a-chip systems.It also explores computational approaches, new risk and safety assessment methods, harmonization, artificial intelligence, and the microbiome. As the most authoritative resource in toxicology, it continues to support researchers, faculty, and students in toxicology, as well as professionals in medical, veterinary, food, environmental, chemical, and pharmaceutical industries and international regulatory agencies.

  • Epidemiology of Cannabis

    Genotoxicity, Neurotoxicity, Epigenomics and Aging
    • 1st Edition
    • Albert Stuart Reece + 1 more
    • English
    Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging provides a novel and comprehensive exploration of five areas that have previously been associated with cannabis use, namely mental health in adults and young adults, pediatric autism, congenital anomalies, cancers, and aging. The book also explores the possibility of how these associations might be reflected in overall disease trends at the population health level. This book surveys these five areas in detail and applies cutting-edge analytical software and geospatial space–time analytical techniques to these questions. With all this information gathered into one book in an easily readable form, this book is a reference for clinicians, health science and allied health practitioners, public health and basic science researchers and drug and health regulators interested in these topics. It is also suitable for inclusion in course work and study preparation courses at both the undergraduate and postgraduate levels.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology Volume 5: Toxicologic Pathology of Organ Systems

    • 4th Edition
    • Wanda M Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, Volume Five: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals, and biologics. This book continues coverage of Organ-Specific Toxicologic Pathology and major organ systems not covered in Volume Four, and has been completely revised, making it an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.

  • Acetaminophen Toxicity

    Experimental and Clinical Advances
    • 1st Edition
    • Barry Rumack + 2 more
    • English
    Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity.Divided into two parts, the foundational aspects of this book cover the mechanism of toxicity in a detailed manner beginning with the history of acetaminophen to newly explored areas of genetics, proteomics, and metabolomics. The second half goes on to discuss clinical practices and examine where further research and therapeutic approaches may be headed. This part answers key questions about whom to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments.With contributions from experts in the field, this book is a thorough, well-researched, and valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with acetaminophen toxicity.

  • Nonclinical Development of Biologics, Vaccines and Specialty Biologics

    • 2nd Edition
    • Lisa M. Plitnick + 1 more
    • English
    Nonclinical Development of Biologics, Vaccines and Specialty Biologics, Second Edition, is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, vaccines, cell and gene therapies, and oncology therapeutics. Updated and revised, the new edition compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory guidelines. This book discusses the different types of biologics, as well as early characterization strategies, principles of study design, nonclinical pharmacokinetics and pharmacodynamics, nonclinical assays, and regulatory guidelines. A coedited book with chapters authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late-stage biologics.

  • Biomarkers in Environmental and Human Health Biomonitoring

    An Integrated Perspective
    • 1st Edition
    • Ritu Mishra + 3 more
    • English
    Biomarkers in Environmental and Human Health Biomonitoring: An Integrated Perspective provides a holistic view of the biomonitoring of environmental degradation, accumulated toxicity, and associated human health concerns. The book incorporates theoretical and practical aspects of the biomonitoring of environmental pollution and the health surveillance of ecological communities using samples from living organisms which are analyzed for contaminants and toxin levels. In the first half, the book provides a general overview if the different types of biomarkers, their significance as bioindicators for contaminants and detection of toxicity, as well as how they can be utilized in the restoration of degraded ecosystems.The second half of the book discusses molecular biomarkers and how they are used as diagnostic and prognostic tools for pollution monitoring. It also reviews analytical tools used to validate the biomarkers in the detection and monitoring of pollution and disease. Finally, the book delves into how novel approaches like genetic ecotoxicology; Big Data, and artificial intelligence calculates the potential consequences of environmental pollution on the ecosystems and on human health.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 4: Toxicologic Pathology of Organ Systems

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.

  • Personal Care Products and Human Health

    • 1st Edition
    • Philippa D. Darbre
    • English
    Personal Care Products and Human Health provides background, historical context and the latest research results on personal care products (PCPs) and their impact on human health and the environment. Sections provide an overview of the functions and mechanisms of action of components of personal care products, discuss environmental toxicology, outline the problems of contamination of water systems from increasing use of personal care products and the resulting toxicities to aquatic wildlife, and offer chapters written by specialists on different aspects of concern for the effects of excessive personal care product usage on human health. This is a comprehensive reference for toxicologists, environment scientists and those interested in learning about the science behind personal care products and current concerns for environmental and human health.

  • Biocompatibility Protocols for Medical Devices and Materials

    • 1st Edition
    • Prakash Srinivasan Timiri Shanmugam + 2 more
    • English
    Biocompatibility Protocols for Medical Devices and Materials provides comprehensive coverage of the basic science and toxicological testing protocols necessary for the risk assessment and safety analysis of medical devices and materials which are based on the ISO guidelines for body contact and duration of contact. The book begins with device/component selection for toxicological experiments and provides an introduction to topics such as sensitization, irritation tests, material-mediated pyrogenicity, and bacterial-mediated pyrogenicity. Toxicology-related chapters explain the protocols for cytotoxicity, acute systemic toxicity, repeated-exposure systemic toxicity, genotoxicity, carcinogenicity, and reproductive toxicity testing. Biocompatibility Protocols for Medical Devices and Materials is a practical guide that provides step-by-step toxicological protocols ranging from materials selection to data interpretation for toxicologists, biomedical researchers, healthcare professionals, product developers, and others working in risk assessment and safety analysis of medical devices.

  • Essentials of Pharmatoxicology in Drug Research, Volume 1

    Toxicity and Toxicodynamics
    • 1st Edition
    • Rakesh K. Tekade
    • English
    Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3: Environmental Toxicologic Pathology and Major Toxicant Classes

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, this book covers the toxicologic pathology of major classes of environmental toxicants. Volumes emphasize the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. This series comprises the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2: Safety Assessment and Toxicologic Pathology

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety.

  • Environmental Contaminants and Medicinal Plants Action on Female Reproduction

    • 1st Edition
    • Alexander V. Sirotkin + 1 more
    • English
    Environmental Contaminants and Medicinal Plants Action on Female Reproduction discusses the problem of environmental pollution, medicinal and food plants, and their impact on reproduction. The book describes the mechanisms of environmental contaminants' action, outlines the key causes of their harmful impact on reproduction, and explores what regulatory substances and processes should be targeted due to the negative effect of pollutants on reproduction. Furthermore, it describes the provenance, properties, physiological and therapeutic effects, and possible areas of application of the known medicinal and functional food plants and their constituents with a focus on female reproductive processes. This book will be a useful resource for reproductive biologists, specialists in assisted reproduction, animal production and phytotherapy, toxicologists, pharmacologists, pharmaceutical scientists, endocrinologists, medicinal and natural product chemists, nutritionists and others engaged in the study of environmental contaminants and medicinal and functional food plants.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology

    • 4th Edition
    • Wanda M. Haschek + 3 more
    • English
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.　

  • History of Modern Clinical Toxicology

    • 1st Edition
    • Alan Woolf
    • English
    History of Modern Clinical Toxicology describes the extraordinary advances in the practice of clinical toxicology within the past 70 years and brings together stories of the people – the champions of clinical toxicology - who contributed to these advances, discovered new therapies and antidotes, and made change happen. This book lays out the poison control system they built and the fascinating story of how they created a new and evolving medical specialty. With the participation of renowned international experts as authors, the book showcases the development of poison control centers around the world and the growth of the professional societies that represent and support them today. This book also tells the stories of the modern-day toxic disasters and recent toxic exposures that gained worldwide attention and notoriety. It outlines the public health responses to such calamities which have led to improvements in our understanding of the science and changes in public health policies and regulations to forestall future such events. Finally, the book covers key policies and agencies affecting poison control centers, addresses the challenges facing clinical toxicologists of today, and predicts advances and future innovations in the field. History of Modern Clinical Toxicology is a unique resource that provides the historical and international perspective that will help students, practitioners, scientists, and health policy makers put current issues and methods in perspective. It will help them understand how infrastructure and processes in clinical toxicology have evolved and why poison control systems are configured as they are.

  • Contamination of Water

    Health Risk Assessment and Treatment Strategies
    • 1st Edition
    • Arif Ahamad + 2 more
    • English
    Water containing significant amounts of inorganic and organic contaminants can have serious environmental consequences and serious health implications when ingested. Contamination of Water: Health Risk Assessment and Treatment Strategies takes an interconnected look at the various pollutants, the source of contamination, the effects of contamination on aquatic ecosystems and human health, and what the potential mitigation strategies are. This book is organized into three sections. The first section examines the sources of potential contamination. This includes considering the current scenario of heavy metal and pesticide contamination in water as well as the regions impacted due to industrialization, mining, or urbanization. The second section goes on to discuss water contamination and health risks caused by toxic elements, radiological contaminants, microplastics and nanoparticles, and pharmaceutical and personal care products. This book concludes with a section exploring efficient low-cost treatment technologies and remediation strategies that remove toxic pollutants from water. Contamination of Water incorporates both theoretical and practical information that will be useful for researchers, professors, graduate students, and professionals working on water contamination, environmental and health impacts, and the management and treatment of water resources.

  • Nutraceuticals

    Efficacy, Safety and Toxicity
    • 2nd Edition
    • Ramesh C. Gupta + 2 more
    • English
    Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition, brings together everything that is currently known about nutraceuticals and their potential toxic effects. The book introduces readers to nutraceuticals, herbal medicines, Ayurvedic medicines, prebiotics, probiotics, adaptogens, and their uses and specific applications. This essential reference discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered. Completely revised and updated, this updated edition provides toxicologists, pharmacologists, pharmaceutical scientists, and those interested in medicinal plants and natural products with a comprehensive overview of the most effective tools upon which to evaluate the safety and toxicity of nutraceuticals, prebiotics, probiotics and alternative medicines.

  • Handbook of Toxicology of Chemical Warfare Agents

    • 3rd Edition
    • Ramesh C. Gupta
    • English
    Handbook of Toxicology of Chemical Warfare Agents, Third Edition, covers every aspect of deadly toxic chemicals used in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this essential reference offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors and biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, and countermeasures. Expanding on the second edition, Handbook of Toxicology of Chemical Warfare Agents has been completely updated, presenting the most recent advances in field. Brand new chapters include a new chapter on emergency preparedness, coverage of the chemical warfare agents used in Syria, the use of the Novichok agent in the UK, and more.

  • Advances in Molecular Toxicology

    • 1st Edition
    • Volume 13
    • James C. Fishbein + 1 more
    • English
    Advances in Molecular Toxicology, Volume Thirteen, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The work not only documents these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

  • Clinical Research in Paediatric Psychopharmacology

    A Practical Overview of the Ethical, Scientific, and Regulatory Aspects
    • 1st Edition
    • Philippe Auby
    • English
    Clinical Research in Paediatric Psychopharmacology: An Overview of the Ethical, Scientific and Regulatory Aspects provides a practical guide and overview of the ethical, scientific and regulatory aspects of clinical research in pediatric psychopharmacology, also discussing practical points to consider when developing clinical research in this field. The book is ideal for professionals involved in clinical research in pediatric psychopharmacology, i.e., including, but not limited to pediatricians, health care professionals, researchers, investigators, pharmaceutical company personals and potentially ethics committee members. Topics discussed include the role of patient organization and advocacy groups in research, the role of families and patients: ‘should I involve my kid in clinical research, and historical, ethical, regulatory, clinical, scientific, intercultural and practical aspects of clinical research in child and adolescent psychopharmacology.

  • Biomarkers in Toxicology

    • 2nd Edition
    • Ramesh C. Gupta
    • English
    Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields.

  • Management of Emerging Public Health Issues and Risks

    Multidisciplinary Approaches to the Changing Environment
    • 1st Edition
    • Benoit Roig + 2 more
    • English
    Management of Emerging Public Health Issues and Risks: Multidisciplinary Approaches to the Changing Environment addresses the threats facing the rapidly changing world and provides guidance on how to manage risks to population health. Unlike conventional and recognized risks (major, industrial, and natural), emerging risks are characterized by low or non-existent scientific knowledge, high levels of uncertainty, and different levels of acceptability by the relevant authorities and exposed populations. Emerging risk must be analyzed through multiple and crossed approaches identifying the phenomenon linked to the emergence of risk but also by combining scientific, policy and social data in order to provide more enlightened decision making. Management of Emerging Public Health Issues and Risks: Multidisciplinary Approaches to the Changing Environment provides examples of transdisciplinary approaches used to characterize, analyze, and manage emerging risks. This book will be useful for public health researchers, policy makers, and students as well as those working in emergency management, risk management, security, environmental health, nanomaterials, and food science.

  • Advances in Molecular Toxicology

    • 1st Edition
    • Volume 12
    • James C. Fishbein + 1 more
    • English
    Advances in Molecular Toxicology, Volume Twelve, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The work not only documents these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

  • Illustrated Toxicology

    With Study Questions
    • 1st Edition
    • PK Gupta
    • English
    Illustrated Toxicology: With Study Questions is an essential, practical resource for self-study and guidance catering to a broad spectrum of students. This book covers a range of core toxicological areas, including pesticides, radioactive materials and poisonous plants, also presenting a section on veterinary toxicology. Across 16 chapters, the book presents key concepts with the aid of over 250 detailed, full-color illustrations. Each section is supplemented with practical exercises to support active learning. This combination of clear illustrations and sample testing will help readers gain a deeper understanding of toxicology. This book is useful for toxicology, pharmacy, medical and veterinary students, and also serves as a refresher for academics and professionals in the field, including clinical pharmacists, forensic toxicologists, environmentalists and veterinarians.

  • Psychopharmacology in Family Practice

    • 1st Edition
    • David Wheatley
    • English
    Psychopharmacology in Family Practice discusses the concept of psychopharmacology in the context of family practice. The book is an account of the group of studies done by the author’s group regarding the various concerns in psychopharmacology. The text covers the rationale, organization, and methodology. Next, the book deals with the placebo response. The next two chapters discuss the drugs in anxiety and depression, respectively. Chapter Six discusses the alternative ideas for treating anxiety and depression, such as the use of non-psychotropic drugs. Chapter Seven describes the factors that influence response, while Chapter Eight deals with psychosomatic pharmacotherapy. The next two chapters tackle the side-effects and transcultural aspects, respectively. The closing chapter presents the summary of the conclusions of the studies. The book will be of great use to psychiatric researchers and practitioners. It can also benefit psychologists.

  • Register for Recording Purchases and Supplies of Dangerous Drugs

    • 1st Edition
    • Sam Stuart
    • English
    Register for Recording Purchases and Supplies of Dangerous Drugs is a list of registration forms for use by qualified medical practitioners, dentists, veterinarians, who can possess, supply or prepare dangerous drugs in exercise of their professions. This compilation of registration forms includes extracts from regulations made under the Dangerous Drugs Act, 1920 outlining the withdrawal of authority of an authorized person from by the Secretary of State. This book defines the form of prescription, the provisions as to dispensing of prescriptions, and the keeping of records in the register. This book also requires the authorized practitioners to preserve documents such as all registers, records, books, or prescriptions, as well as lists the preparations exempted from the regulations. These exempted preparations include Pasta Arsenicalis, B.P.C. 1934, Pil. Ipecac. c. Scila, B.P.C. 1934, Pulv. Cretae Aromat. C. Opio, B.P. 1932. The practitioner should scan and consult medical journals from time to time for any announcement of changes in the list of exempted drugs. This book lists forms for purchases and supplies for various drugs such as morphine, diamorphine, cocaine, medicinal opium, Indian hemp, Eucodal, Dicodide, Dilaudide, Desomorphine, and Pethidine. This book is intended for the use of physicians, surgeons, dentists, and veterinarians. It can also benefit pharmacists and pharmacologists.

  • The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence

    Proceedings of the Society for the Study of Addiction, London, 1 and 2 September 1966
    • 1st Edition
    • C. W. M. Wilson
    • English
    The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence is a collection of proceedings presented at the International Symposium on the Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence, held in London on September 1-2, 1966 under the auspices of the Society for the Study of Addiction to Alcohol and Other Drugs. The symposium provided a forum for discussing the pharmacological and epidemiological aspects of drug dependence in adolescents. Comprised of 10 chapters, this volume begins with an overview of the chemistry and pharmacology of narcotic drugs in adolescence, as well as narcotic addiction in young people in the United States. The discussion then turns to pharmacology and clinical observations on stimulant drugs and hallucinogenic drugs; the epidemiology and social pharmacology of drugs of dependence; and features of adolescent drug dependence. Regulations aimed at controlling drugs of dependence are also analyzed in relation to the national incidence of adolescent dependence in certain countries such as Britain, Belgium, Israel, and the Netherlands. The remaining chapters focus on the language, evidence, and patterns of drug abuse, together with research in relation to drugs of dependence. This book will be of interest to pharmacologists, epidemiologists, and policymakers concerned with drug dependence.

  • Advances in Molecular Toxicology Vol 11

    • 1st Edition
    • Volume 11
    • English
    Advances in Molecular Toxicology, Volume 11, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

  • Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens

    • 7th Edition
    • Richard P. Pohanish
    • English
    Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Seventh Edition, has proven to be a reliable, accessible, must-have reference on hazardous materials for over thirty years. This updated and revised seventh edition is the most comprehensive listing of the hazardous chemicals commonly used, transported, and regulated in industry and the workplace. Information is the most vital resource anyone can have when dealing with potential hazardous substance accidents, spillages, fires, or acts of terror. It is also essential for the safe day-to-day operation of chemical processes and environmental protection. Sittig's Handbook provides extensive data for over 2,200 chemicals in a uniform format, enabling fast and accurate decisions in any situation. The chemicals are presented alphabetically and classified as a carcinogen, hazardous substance, hazardous waste, or toxic pollutant. This new edition contains expanded and reviewed information for each chemical listed (including chemicals classified as WMD) and has been updated to keep pace with world events, standards, and regulations. This seventh edition includes over 100 new records, and every single record has been checked and updated as necessary.

  • Toxicology: What Everyone Should Know

    • 1st Edition
    • Aalt Bast + 1 more
    • English
    Toxicology: What Everyone Should Know is an essential reference for anyone looking for an entry into this fascinating field of study. This innovative book describes important discoveries in toxicology through the ages, explores their historical and sociological impacts, and shows how they still influence recent, state-of-the-art developments. In addition, the book shows how these developments are extrapolated into public and political perceptions on risks and the regulatory consequences, emphasizing environmental issues, such as manmade and natural chemicals, their interaction and impact, nutrition, and drugs. Users will find a cutting-edge approach to nutritional and combinatorial toxicology, risk evaluation modeling and the benefits of chemicals exposure (nutrition versus man-made chemicals), environmental health, and legislative frameworks to control the public’s chemical exposure. This is an essential reference for those looking for an introduction to toxicology, its past, and exciting future.

  • A Text-Book of Medical Jurisprudence and Toxicology

    • 1st Edition
    • Rai Bahadur Jaising P. Modi
    • English
    Medical Jurisprudence and Toxicology for India covers some essential details and practical aspects of medical jurisprudence and toxicology. This book is organized into two part encompassing 34 chapters. The opening chapters of Part I deal with legal procedure in criminal courts, physical evidence of the crime, autopsy, exhumation, and some medico-legal practices. Considerable chapters are devoted to other aspects of legal medicine, including determination of death causation, legitimacy of evidence, incident of rape and unnatural offenses, miscarriage, infanticide, insanity, and the privileges of medical men. Part II focuses on the toxicological aspects. This part emphasizes the medico-legal aspects of some classes of poisons, such as corrosive, irritant, neurotic, cerebral, spinal, cardiac, and peripheral poisons. This book will prove useful to medical college students.

  • Physico-Chemical Aspects of Drug Action

    Proceedings of the Third International Pharmacological Meeting
    • 1st Edition
    • E. J. Ariëns
    • English
    Physico-Chemical Aspects of Drug Action, Volume 7 covers topics on drug kinetics and the overall physicochemical properties of the drug in relation therewith, and the physicochemical aspects of the drug-receptor interaction, putting emphasis on receptor mechanisms and specific properties required for certain types of drugs in this respect. The book starts with some contributions dealing with various general aspects of drug kinetics followed by some contributions dealing with the relationship between certain physicochemical properties of drug molecules and their action. The text describes the pharmacokinetics and dose-concentration relationships; the time course of the biological response to drugs; and the empirical equations for correlating biological efficiency of organic compounds. The text also describes molecular basis for the action of chemotherapeutic drugs; the structure-activity studies on sulphonamides; and the water extrusion hypothesis. The mathematical treatment of two-point attachment between drug and receptor; the molecular properties and biological activity of catecholamines and certain related compounds; and the structure-activity relationships of diarylcarbinolethers are also considered. The book further tackles quantum mechanically-derived electronic distributions in the conformers of 2-pam; and the molecular basis for the action of certain drugs in the central nervous system. Pharmacologists and chemists will find the book invaluable.

  • Mycotoxins in Foodstuffs — 3

    Invited Lectures Presented at the Third International IUPAC Symposium on Mycotoxins in Foodstuffs, Paris, France, 16 - 18 September, 1976
    • 1st Edition
    • M. Jemmali
    • English
    Mycotoxins in Foodstuffs—3 is a collection of invited lectures presented at the International Union of Pure and Applied Chemistry's Third International Symposium on Mycotoxins in Foodstuffs, held in Paris, France, on September 16-18, 1976. The papers explore the health hazards posed by mycotoxins found in foodstuffs, including aflatoxins and trichothecenes, as well as ways of addressing the problem. This book is comprised of 11 chapters and begins with a discussion on how to design a program for monitoring problem foods and surveying potential problem foods for a number of mycotoxins. The next chapter describes a methodology for the design and evaluation of testing programs to estimate aflatoxin concentrations in granular foodstuffs. The action taken by various countries regarding mycotoxins in foodstuffs (food and feed), under legislative provision or code of practice, is then examined. Subsequent chapters deal with the metabolism of aflatoxin and other mycotoxins in relation to their toxicity and the accumulation of residues in animal tissues; mode of action of trichothecenes; and mode of action and human health aspects of aflatoxin carcinogenesis. The human health hazards associated with mycotoxins are also considered, along with prevention, elimination, and detoxification of aflatoxins. This monograph will be a useful resource for chemists, nutritionists, food scientists, and toxicologists.

  • Pharmacology of Cholinergic and Adrenergic Transmission

    Proceedings of the Second International Pharmacological Meeting, August 20—23, 1963
    • 1st Edition
    • G. B. Koelle + 2 more
    • English
    Section on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume 3: Pharmacology of Cholinergic and Adrenergic Transmission focuses on the effects of drugs on muscles, nerve fibers, and the central nervous system. The selection first offers information on the role of sodium ions in the release of acetylcholine and the distribution and release of acetylcholine in muscles. Discussions focus on the effects of sodium deficiency on ACh release in perfused ganglia; effects of sodium pump inhibitors on ganglionic and myoneural transmission; distribution of ACh and choline acetylase in muscle; and ACh release after denervation. The text then ponders on the roles of acetylcholine and acetylcholinesterase in junctional transmission and correlated studies of monoamines and acetylcholinesterase in sympathetic ganglia, manifesting the distribution of adrenergic and cholinergic neurons. The publication examines the action of acetylcholine and related drugs on mammalian nonmyelinated nerve fibers; possible mechanisms of acetylcholine action in muscles; and electrophysiological analysis of cholinergic transmission in sympathetic ganglia. The text then reviews the interactions of cholinomimetic and cholinergic blocking drugs at sympathetic ganglia; evolution of cholinoreceptive sites of locomotor muscle; and pharmacological blocking of central cholinoreactive systems and the possibilities of its therapeutic application. The selection is a dependable source of data for readers interested in the pharmacology of cholinergic and adrenergic transmission.

  • Drugs, Alcohol and Tobacco in Britain

    • 1st Edition
    • Jim Zacune + 1 more
    • English
    Drugs, Alcohol, and Tobacco in Britain focuses on the use and misuse of drugs, alcohol, and tobacco and the British response to these substances. The manuscript first tackles alcohol production, sale, and control and production of drugs. Discussions focus on licensing laws in England and Wales, taxation, home brewing and distilling, detailed incidence of liquor duties, illicit production of alcoholic beverages, overseas trade, and tied-house system. The book then elaborates on the control of drugs, including international control, Dangerous Drugs Act, 1965, United Kingdom laws, and control of specific psycho-active drugs. The publication examines the "normal" use of alcohol in Great Britain, medical use of drugs, and a historical perspective of alcohol abuse in Great Britain. Topics include medical use of cannabis, amphetamines, and opiates, student drinking, medical use of alcohol, expenditure on alcohol, and alcohol consumption. The text then takes a look at the misuse of alcohol in Great Britain, non-medical use of cannabis, non-medical use of Lysergic Acid Diethylamide and hallucinogenic drugs, and non-medical use of hypnotics and tranquillizers. The book is a valuable source of information for readers wanting to study the use and abuse of drugs, alcohol, and tobacco in Great Britain.

  • Clinical and Experimental Toxicology of Organophosphates and Carbamates

    • 1st Edition
    • Bryan Ballantyne + 1 more
    • English
    Clinical & Experimental Toxicology of Organophosphates and Carbamates considers the histochemical localization of cholinesterase in anticholinesterase poisoning. This book is organized into eight parts encompassing 59 chapters that discuss the pharmacology and toxicology of carbamates, as well as the neurobehavioral toxicology of anticholinesterases. Some of the topics covered in the book are the overview of biological and clinical aspects of organophosphates and carbamates; biochemical determination of cholinesterase activity in fluids and tissues; intermediate syndrome in anticholinesterase neurotoxicity; structure-activity relationships and anticholinesterase activity; and the molecular events in delayed neuropathy. Other parts deal with the cardiac effects of anticholinesterase agents and the ecotoxicological consequences of interactions between avian esterases and organophosphorus compounds. These topics are followed by discussions on the analysis of the cutaneous and respiratory tract absorption of anticholinesterases and the use of organophosphorus compounds as chemical warfare agents. The final parts are devoted to the toxicity of anticholinesterases to aquatic organisms. The book can provide useful information to toxicologists, doctors, students, and researchers.

  • Immunopharmacology

    Proceedings of the Third International Pharmacological Meeting July 24–30, 1966
    • 1st Edition
    • H. O. Schild + 1 more
    • English
    Immunopharmacology is the 11th volume of the proceedings of the Third International Pharmacological Meeting held at Sao Paulo, Brazil on July 26, 1966. The volume covers papers that deal with immunoglobulins responsible for hypersensitivity reactions and with the mechanisms of these reactions; pharmacological mediators of immediate and delayed hypersensitivity; Arthus reactions; and soluble factors released by the action of antigen on sensitized lymphocytes. The book concludes with a single paper on the subject of penicillin allergy. Immunologists and pharmacologists will find the volume invaluable.

  • A Comprehensive Guide to Toxicology in Nonclinical Drug Development

    • 2nd Edition
    • Ali S. Faqi
    • English
    A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

  • Perspectives in Basic and Applied Toxicology

    • 1st Edition
    • Bryan Ballantyne
    • English
    Perspectives in Basic and Applied Toxicology features a collection of essays on various aspects of toxicology. It aims to relate fundamental knowledge of toxicology to its application in assessing relevance of that information to the causation of adverse health effects, predicting hazardous situations, defining protective and precautionary measures, and the recognition and management of intoxication in humans. Another objective of this volume is to encourage those with responsibility for the training of toxicologists to instill a greater concern about ethical and moral issues as fundamental to the practice of toxicology as a profession with wide-ranging social implications. This book is organized into 14 chapters. The coverage of these chapters include assessment of chemical hazards in the workplace, the relation between animal studies and epidemiology in the context of industrial toxicology, carcinogenicity testing in animals, and biochemical evaluation of neurotoxicity. This book will be of interest to undergraduate and graduate toxicologists, pharmacologists, physicians, industrial hygienists, and other health professionals.

  • Chemotherapy

    Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
    • 1st Edition
    • M. Adolphe
    • English
    Advances in Pharmacology and Therapeutics, Volume 10: Chemotherapy covers the proceedings of the 7th International Congress of Pharmacology. The title presents papers that detail the advancement of pharmacological research in chemotherapy. The text first covers the chemotherapy of schistosomiasis. Next, the selection presents the trends in malaria and cancer chemotherapy, along with their pharmacological research. The text also details the use of cell cultures as tools in pharmacological investigations. The book will be of great interest to pharmacologists and oncologists.

  • Alcohol, Drugs, Genes and the Clinical Laboratory

    An Overview for Healthcare and Safety Professionals
    • 1st Edition
    • Amitava Dasgupta
    • English
    Alcohol, Drugs, Genes and the Clinical Laboratory provides an overview and quick reference to genetic relationships and clinical laboratory information related to the serious public health issue of alcohol and drug abuse. Written in a clear and concise manner, this book discusses the necessary information for health and safety professionals working in public health to learn about complex issues quickly to better help their patients, employees, and others affected by alcohol and drug abuse. Alcohol, Drugs, Genes and the Clinical Laboratory covers the important aspects of drugs and alcohol abuse including genetic aspects along with laboratory methods for analysis of alcohol and abused drugs with emphasis on false positive test results. The book is helpful to healthcare professionals, such as pathologists who oversee alcohol and drug testing, emergency room physicians, family practice physicians who are first healthcare professionals who identify patients susceptible to drug and alcohol abuse, and psychiatrists involved with drug and alcohol rehabilitation programs. It will also be useful to safety professionals who have to assess individuals for workplace responsibilities, ranging from police and recruitment to occupational safety and occupational medicine and public health officials.

  • Pharmacology of Pain

    Proceedings of the First International Pharmacological Meeting, Stockholm, 22-25 August, 1961
    • 1st Edition
    • R. K. S. Lim + 2 more
    • English
    Pharmacology of Pain, Volume 9 presents the proceedings of the 3rd International Pharmacological Meetings held in Sao Paulo in 1966. The book includes papers on the mediators of pain; proteolytic enzymes as mediators of pain; and desensitization with capsaicin and related acylamides as a tool for studying the function of pain receptors. The text also covers the sensitization of nociceptors by 5-hydroxytryptamine in man; the possible role of serotonin in affective component of pain behavioral reaction in the rat; and the use of pain induced functional impairment for assessing analgesic action. Papers on the clinical pharmacology of analgesics and analgesic antagonists; behavioral mechanisms of human pain; and central nervous mechanisms involved in pain and analgesia are also considered. The book further tackles the neuropharmacology of pain and analgesia; the interrelationship of cortical and subcortical pain systems; and the interaction of fast- and slow-conducting fiber systems involved in pain and analgesia.

  • The Evaluation of Toxicological Data for the Protection of Public Health

    Proceedings of the International Colloquium, Luxembourg, December 1976
    • 1st Edition
    • W. J. Hunter + 1 more
    • English
    The Evaluation of Toxicological Data for the Protection of Public Health: Proceedings of the International Colloquium, Luxembourg, December 1976 focuses on the review of toxicological tests and methods used in toxicological evaluation of chemicals and reconsideration of these procedures in identifying decision-making processes involved in the protection of public health. The selection first discusses reviews of toxicological tests, including introductory remarks and comments on acute toxicity; problems associated with the testing of environmental mutagens; and the testing of carcinogenic potentials. The publication also examines the uncertainties related to the evaluation of the health hazards of environmental chemicals from toxicological data and epidemiological monitoring of indices of chemical hazards. The book takes a look at safety factors and their application in toxicological evaluation; ecotoxicological approaches for the protection of environment and health; and use of biological materials as environmental pollution gauges. The text also discusses acute toxicity, teratogenic effects of pollutants, and examples of ecotoxicological research. The selection is a dependable source of data for readers interested in the evaluation of toxicological data relative to the protection of public health.

  • Fungal Toxins

    A Comprehensive Treatise
    • 1st Edition
    • Alex Ciegler + 2 more
    • English
    Microbial Toxins, Volume VI: Fungal Toxins covers information on the evaluation of the chemical, biological, and biomedical aspects of the fungal toxins. The book discusses the historical structure chemistry, production, analysis, detoxification, biosynthesis, pharmacology, toxicology, and molecular biochemistry of aflatoxins and related compounds. The text also describes the isolation, analysis, production, chemistry, biological effects, and biogenesis of the ochratoxins, as well as the bioproduction, biosynthesis, and chemical properties of misclellaneous Aspergillus toxins. Various species of storage fungi, including yellowed rice toxins, luteoskyrin and related compounds, chlorine-containing compounds, citrinin, and citreoviridin are also considered. The book further tackles the physical and chemical properties and the biological activity of the rubratoxins; the biosynthesis and biochemical effects of patulin, penicillic acid, and other carcinogenic lactones; as well as the structure, production, biosynthesis, and biological effects of cyclopiazonic acid and related toxins. The text also encompasses bioproduction, properties, chemical structure, and biological activity of miscellaneous Penicillium toxins. Microbiologists, biochemists, epidemiologists, pharmacologists, toxicologists, medical students and people involved in other related fields will find the book useful.

  • Introduction to the Principles of Drug Design

    • 1st Edition
    • H. J. Smith + 1 more
    • English
    Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.

  • Bacterial Endotoxins

    A Comprehensive Treatise
    • 1st Edition
    • Solomon Kadis + 2 more
    • English
    Microbial Toxins, Volume V: Bacterial Endotoxins covers the physiology, pathology, and immunology of bacterial endotoxins. The book discusses the relationship of lipopolysaccharide structure to bacterial virulence; the importance of blood-group and Forssman antigenic determinants in interactions between human and microbes; and the chemical modification of endotoxin and inactivation of its biological properties. The text also describes the effects of endotoxic lipopolysaccharides on the complement system; the host-dependent detoxification of bacterial endotoxin; and the metabolic effects of bacterial endotoxins. The release of vasoactive agents and the vascular effects of endotoxin are also considered. The book further tackles the febrile response to endotoxin; some major aspects and the relationship between shock and endotoxemia; as well as the effects of lipopolysaccharides (endotoxins) on the susceptibility to infections. The text also encompasses the role of hypersensitivity and tolerance in reactions to endotoxins. Pathologists, immunologists, physiologists, and microbiologists will find the book invaluable.

  • Current Concepts in Kinin Research

    Proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology, Paris, 22 July 1978
    • 1st Edition
    • Gert L. Haberland + 1 more
    • English
    Current Concepts in Kinin Research contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Paris on July 22, 1978. The book is organized into four parts. Part I explains the functions and mechanisms of the kinin system. Part II focuses on kallikreins and the methods of their determination. Part III describes the intrinsic blood clotting and plasma kinin formation. The last part deals with the characterization of plasma kininogens.

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