Reproductive and Developmental Toxicology
- 3rd Edition - February 11, 2022
- Imprint: Academic Press
- Editor: Ramesh C. Gupta
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 9 7 7 3 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 5 6 0 - 1
**Selected for Doody’s Core Titles® 2024 in Toxicology**Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the lat… Read more
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Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife
With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies.
- Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development
- Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis
- Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more
Researchers and advanced students in toxicology; biologists, pharmacologists, and teratologists from academia, industry, and governmental agencies; environmental scientists; regulatory agencies
Section I. General
1. Reproductive Anatomy and Physiology
2. Pharmacokinetics in Pregnancy
3. Physiologically Based Pharmacokinetic Models in Reproductive and Developmental Toxicology
4. Adverse Outcome Pathways in Reproductive and Developmental Toxicology
Section II. Toxicity Testing Models, Safety Evaluation, and Regulatory Aspect
5. Juvenile Toxicology Testing
6. Relevance of Animal Testing and Sensitivity of End Points in Reproductive and Developmental Toxicity
7. Alternative Methods to Animal Experimentation for Testing Dvelopmental Toxicity
8. Use of Computational Toxicology Tools to Predict In Vivo Endpoints
9. Guidelines for Reproductive and Developmental Toxicity Testing and Risk Assessment of Chemicals
10. Reproductive Toxicity: In Vivo Testing Guidelines from OECD
11. In Vitro Biomarkers of Developmental Neurotoxicity
12. Reproductive and Developmental Safety Evaluation of New Pharmaceutical Compounds
13. Using Zebrafish to Assess Developmental Neurotoxicity
14. Caenorhabditis elegans as a Model to Assess Reproductive and Developmental Toxicity
15. Postmarket Surveillance and Regulatory Considerations in Reproductive and Developmental Toxicology: A Food and Drug Administration Perspective
Section III. Nanoparticles and Radiation
16. Developmental Toxicity of Engineered Nanomaterials
17. Effects of Ionizing Radiation on Reproduction and Development
Section IV. Gases and Solvents
18. Reproductive and Developmental Toxicity of Solvents and Gases
Section V. Drugs of Abuse and Addiction, Smoking, and Alcohol
19. Developmental Neurotoxicity of Abused Drugs
20. Effects of Alcohol on Embryo/Fetal Development
21. Cigarette and E-cigarettes Smoking and Reproductive and Developmental Toxicity
Section VI. Pharmaceuticals, Nutraceuticals and Food Additives
22. Thalidomide
23. Retinoids
24. Safety of Cannabis- and Hemp-Derived Constituents in Reproduction and Development
25. Caffeine
26. Melamine and Cyanuric Acid
27. Ionophores
Section VII. Metals
28. Boron
29. Arsenic, Cadmium, and Lead
30. Mercury
31. Manganese
32. Selenium
Section VIII. Pesticides, Industrial, and Other Environmental Contaminants
33. Organophosphates and Carbamates
34. Chlorinated Hydrocarbons and Pyrethrins/Pyrethroids
35. Herbicides and Fungicides
36. Brominated Flame Retardants
37. Polychlorinated Biphenyls, Polybrominated Biphenyls, Polychlorinated Dibenzo-p-dioxins, and Polychlorinated Dibenzofurans
38. Reproductive Toxicity of Polycyclic Aromatic Hydrocarbons
39. Bisphenol A – Toxicity and Risk Assessment Update with Academic and Regulatory Perspectives and Physiologically Based Pharmacokinetic Modeling
40. Ethylene Glycol
41. Perfluorooctane Sulfonate and Perfluorooctanoic Acid
42. Traffic-related Air Pollution and the Developing Brain
43. Environmental Pollutants and Embryonic Implantation and Embryonic Development.
44. Personal Care Products and Cosmetics
45. UV Screening Chemicals
Section IX. Phytotoxicants and Mycotoxins
46. Toxic Plants
47. Fumonisins
48. Aflatoxins, Ochratoxins, and Citrinin
49. Trichothecenes and zearalenone
Section X. Special Topics
50. Drugs and Chemical Contaminants in Human Breast Milk
51. Stem Cells in Developmental Toxicity Testing
52. Embryonic and Fetal Toxic Lesions and Stem Cell Therapy
53. Epigenetics in Reproduction and Development
54. Mitochondrial Dysfunction in Reproductive and Developmental Toxicity
55. Cell Signaling Mechanisms in Developmental Neurotoxicity
56. Neuroinflammation and Oxidative Injury in Developmental Neurotoxicity
57. Effects of Stress on Reproductive Function and Fetal Development
Section XI. Endocrine Disruption
58. Endocrine Disruption
59. Role of Endocrine Disruptors in Male Infertility and Impact of COVID-19 on Male Reproduction
Section XII. Infertility and Teratogenicity
60. Toxicology of Reproduction Process and Problems of Male Infertility
61. Environmental Pollutants and Neural Tube Defects
62. Teratogenicity
63. Micro–CT and Volumetric Imaging in Developmental Toxicology
Section XIII. Toxicologic Pathology
64. Toxicologic Pathology of the Reproductive System
Section XIV. Placental Toxicity
65. The Placental Role in Developmental Programming
66. Strategies for Investigating Hemochorial Placentation
67. The Significance of ABC Transporters in Human Placenta for the Exposure of Fetus to Xenobiotics
68. Placental Toxicity
69. Placental Pathology
Section XV. Domestic and Wildlife Species
70. Endocrine Disruption in Wildlife Species
71. Teratogenesis in Livestock
72. Reproductive and Developmental Toxicity in Avian Species
- Edition: 3
- Published: February 11, 2022
- No. of pages (Hardback): 1556
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323897730
- eBook ISBN: 9780323915601
RG
Ramesh C. Gupta
Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer’s disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including seven major books with Elsevier: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology and (7) Neutraceuticals. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.
Affiliations and expertise
Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USARead Reproductive and Developmental Toxicology on ScienceDirect