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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Intracellular Messengers

    • 1st Edition
    • C.M. Taylor
    • English
    This important new reference work offers an outstanding collection of articles devoted to the discussion of "intracellular messengers". Extracellular stimuli ("first messengers") bind to receptors on the plasma membrane of cells to trigger changes in the concentration of intracellular messengers ("second messengers") which leads, in turn, to changes in cellular activity. However, the intracellular activities of so called "third messengers" may also be involved complicating the concept of a rigid sequence of events between receptor and response. The preference for the term "intracellular messengers", and, hence, the title of this volume, recognizes that a complex web of interactions between intercellular messengers determines the concentrations and ultimate effects of each.

  • Neuroepidemiology

    Theory and Method
    • 1st Edition
    • Bozzano G Luisa
    • English
    As a collection of neuroepidemiology papers, this book captures the range and excitement of the discipline. Researchers in the field have been at the forefront in the study of slow viruses, retroviral epidemiology, chronic neuroloical diseases, as well as injuries and other disabilities of the neurological system. The intersection of epidemiology, neurology, and behavioral/social science is a unique feature of this book. Furthermore, Molgaard's collection differs from similar titles in that it focuses on minorities and international work in neuroepidemiology.

  • Biology of Conidial Fungi, Volume 1

    • 1st Edition
    • Garry T. Cole
    • English
    Biology of Conidial Fungi, Volume I covers the history, classification, distribution, and ecology of conidial fungi. Conidial fungi are anamorphic (asexual) fungi of presumed ascomycetous or basidiomycetous origin. Organized into three parts encompassing 14 chapters, the book begins with a brief introduction to the history of conidial fungi. It then describes the systematics, classification, and taxonomy of a particular group of fungi, such as Hyphomycetes, Celomycete, conidial yeasts, and conidial lichen-forming fungi. The dimorphism and pleomorphism properties of these fungi are also examined. Significant topics on the general aspects of the soil, freshwater, marine, and aerial ecology of conidial fungi are considered in other chapters. This volume is of value to researchers and advanced students who are interested in the basic aspects of conidial fungi.

  • Visual Perception

    The Neurophysiological Foundations
    • 1st Edition
    • Lothar Spillmann + 1 more
    • English
    This book presents an interdisciplinary overview of the main facts and theories that guide contemporary research on visual perception. While the chapters cover virtually all areas of visual science, from philosophical foundations to computational algorithms, and from photoreceptor processes to neuronal networks, no attempt has been made to provide an exhaustive treatment of these topics. Rather, researchers from such diverse disciplines as psychology, neurophysiology, anatomy, and clinical vision sciences have worked together to review some of the most important correlations between perceptual phenomena and the underlying neurophysiological processes and mechanisms. The book is thus intended to serve as an advanced text for graduate students and as a guide for all vision researchers to understanding current progress outside their specialized fields of interest.

  • Thirst and Sodium Appetite

    Physiological Basis
    • 1st Edition
    • Sebastian Grossman
    • English
    Thirst and Sodium Appetite: Physiological Basis describes the phenomenon of thirst and the mechanisms that define the need for water. Thirst and appetite has generated much study and research about the physiological, endocrinological, and pharmacological mechanisms that influence water intake. However, in this book, other concerns have been emphasized, such as the significance of brain mechanisms in the subject matter. This book, consisting of 11 chapters, starts with a basic description of thirst then to an analysis of basic physiological mechanisms that determine water intake. Another topic also discussed in this book is various experimental paradigms that resulted to the dual-depletion theory of thirst. The neuroanatomical, neuroendocrinologica... and neuropharmacological brain mechanisms are covered in three chapters of this book. These brain mechanisms respond to different peripheral signals that stimulate the thirst. The final chapters are dedicated to sodium appetite. Although it has lesser literature than thirst has, there have been significant developments in the understanding of the role of sodium appetite in extracellular thirst. The last chapter reviews the questions that has kept investigators at bay and recommends direction of where future research may go.

  • The Human Nervous System

    • 1st Edition
    • George Paxinos
    • English
    The Human Nervous System is a definitive account of human neuroanatomy, with a comprehensive coverage of the brain, spinal cord, and peripheral nervous system. The cytoarchitecture, chemoarchitecture, connectivity, and major functions of neuronal structures are examined by acknowledged authorities in the field, such as: Alheid, Amaral, Armstrong, Beitz, Burke, de Olmos, Difiglia, Garey, Gerrits, Gibbins, Holstege, Kaas, Martin, McKinley, Norgren, Ohye, Paxinos, Pearson, Pioro, Price, Saper, Sasaki, Schoenen, Tadork, Voogd, Webster, Zilles, and their associates.

  • Principles of Neurobiological Signal Analysis

    • 1st Edition
    • Edmund Glaser
    • English
    Principles of Neurobiological Signal Analysis deals with the principles of signal analysis as applied to the electrical activity of the nervous system. Topics covered include biological signals, the basics of signal processing, and power spectra and covariance functions. Evoked potentials, spontaneous and driven single unit activity, and multiunit activity are also considered, along with the relations between slow wave and unit activity. This book consists of eight chapters and begins by establishing the theoretical groundwork of signal analysis, with emphasis on the properties of signal and noise; sampling and conversion of biological signals into sequences of digital numbers readily digestible by a computer; and the concepts of power spectrum and covariance analysis. The following chapters explore techniques for extracting evoked responses from background noise; multivariate statistical procedures for treating evoked response waveshapes as variables dependent upon the experimental manipulations performed upon a subject; and spike (action potential) activity generated by neurons. The final chapter describes methods for studying how such spike activity may be related to the concurrently observed slow wave (EEG-like) activity of the nervous system. This monograph will be of interest to physiologists and neurobiologists.

  • Spinal Cord Injury

    • 1st Edition
    • Volume 109
    • Joost Verhaagen + 1 more
    • English
    Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists.

  • Fundamental Neuroscience

    • 4th Edition
    • Larry Squire + 5 more
    • English
    The fourth edition of Fundamental Neuroscience reinvents itself as an engrossing and comprehensive presentation of the discipline of neuroscience, from molecules to cognition. Thorough but succinct, and lavishly illustrated, the book builds from an introductory section that includes fundamental neuroanatomy and goes on to cover cellular and molecular neuroscience, development, sensory systems, motor systems, regulatory systems, and behavioral and cognitive neuroscience. The book has been retooled to better serve its audience in the neuroscience and medical communities. The chapters include more than 100 boxes describing clinical conditions, techniques, and other special topics. Each chapter went through a thorough review process, giving the book an evenness of tone. The chapters are authored by outstanding working scientists who are experts on the topics they cover.

  • Sleep Disorders, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 30-4
    • Bradley Vaughn
    • English
    Sleep disorders are a widely recognized consequence of many neurological pathologies. This issue of Neurologic Clinics features the following articles: Sleep Physiology; Sleep Assessment Tools for the Neurologist; Fitting Sleep into Neurological Practice; Insomnia; Parasomnias and look-alikes; Sleep Apnea: Obstructive and central; Restless Legs syndrome; Circadian Rhythm; Pediatric Sleep Disorders; Dementia; Stroke; Epilepsy; CNS Immunological and Infectious; Movement Disorders; Neuromuscular ; Headache; Traumatic Brain Injury; and Psychiatry in Sleep.

  • The Neuroscience of Autism Spectrum Disorders

    • 1st Edition
    • Joseph D. Buxbaum + 1 more
    • English
    Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise.

  • Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates

    • 4th Edition
    • George Paxinos + 1 more
    • English
    In the years since its first publication, Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates has received virtually universal acceptance in neuroscience as the authoritative source for stereotaxic coordinates and delineations. This atlas is constructed in the style of The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. The completely revised and updated 4e of Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates features high-quality color plates scanned by the renowned microscopy unit of the Allen Institute for Brain Science. Constructed by the leaders in neuroanatomical atlas development, the new edition will maintain the position of the atlas as an indispensable resource for scientists working on the mouse brain.

  • Epilepsy, Part I: Basic Principles and Diagnosis

    • 1st Edition
    • Volume 107
    • Hermann Stefan + 1 more
    • English
    Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part II, Treatment, Volume 108, continues coverage of epilepsy with a focus on treatment. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.

  • Rational Constructivism in Cognitive Development

    • 1st Edition
    • Volume 43
    • English
    Volume 43 of Advances in Child Development and Behavior includes chapters that highlight some of the most recent research in the area of Rational Constructivism. Each chapter provides in-depth discussions, and this volume serves as an invaluable resource for Developmental or educational psychology researchers, scholars, and students.

  • Management of Pituitary Tumors, An Issue of Neurosurgery Clinics

    • 1st Edition
    • Volume 23-4
    • Manish K. Aghi + 1 more
    • English
    This issue of the Neurosurgery Clinics of North America, Guest Edited by Drs. Manish Aghi and Lewis Blevins, is devoted to Management of Pituitary Tumors. Experts in the field have assembled to provide articles on Imaging of the pituitary and parasellar region; Management of Incidentally Found Nonfunctional Pituitary Tumors; Endoscopic Surgery for Pituitary Tumors; Prolactinomas – Medical versus Surgical Management; Neurosurgery for Cushing’s Disease; Postoperative radiotherapy and stereotactic radiosurgery for pituitary tumors; Management options for persistent postoperative acromegaly; Medical management of persistent and recurrent Cushing’s disease; Management of Large Aggressive Nonfunctional Pituitary Tumors – Experimental Medical Options when Surgery and Radiation Fail; Pituitary Carcinoma; Visual Outcomes after Surgery For Nonfunctional Adenomas Causing Visual Compromise; and Hypopituitarism and Central Diabetes Insipidus: Peri-Operative Diagnosis and Management.

  • Epilepsy, Part II: Treatment

    • 1st Edition
    • Volume 108
    • Hermann Stefan + 1 more
    • English
    Epilepsy, Part II, Treatment, Volume 108, provides a full description of epilepsy pathology and etiology, antiepileptic drug treatment, the approach to surgical evaluation and alternative procedures to be considered, in both children and adults, as well as brain stimulation and diet treatment. Economic and psychosocial issues such as stigma are fully covered. The special problems of epilepsy treatment in the developing world are described. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, establishes the scientific and practical diagnosis of epilepsy. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.

  • Translational Neuroimaging

    Tools for CNS Drug Discovery, Development and Treatment
    • 1st Edition
    • Robert A. McArthur
    • English
    Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field.

  • Atlas of the Spinal Cord

    Mouse, Rat, Rhesus, Marmoset, and Human
    • 1st Edition
    • Gulgun Sengul + 3 more
    • English
    The Atlas of the Spinal Cord is the first comprehensive atlas of rodent and primate spinal cords. This atlas features histological images and labeled drawings of every segment from rat, mouse, marmoset monkey, rhesus monkey, and human spinal cords. Nissl-stained section images and matching drawings for each segment are supplemented by up to four histochemical or immunohistochemical images on a facing page. The neuron groups supplying major limb muscles are identified in each species. Constructed by the established leaders in neuroanatomical atlas development, this new atlas will be the indispensible resource for scientists who work on rodent or primate spinal cord.

  • Neuropsychological Rehabilitation

    Principles and Applications
    • 1st Edition
    • Jamuna Rajeswaran
    • English
    Traumatic Brain Injury (TBI) can occur through road traffic incidents, falls, or violence, and is therefore an extremely prevalent type of injury, constituting a significant burden on health care around the world. As more people are able to recover physically from TBI, it is important to consider how to help repair the cognitive functions of the brain. The cognitive functions could be greatly maximized by appropriate Neuropsychological rehabilitation, which occurs within months of the damage. This book discusses both the theoretical and practical applications of Neuropsychological rehabilitation techniques, offering a comprehensive overview of the process. Using several case studies from India, gained over years of clinical practice, research and academic teaching, this book offers an excellent guide to the procedures and tasks needed to respond effectively to patients with TBI. Although focused on the Indian context, this book will appeal to students and practitioners around the world as a useful resource on Neuropsychological rehabilitation techniques in India.

  • Gap Junctions in the Brain

    Physiological and Pathological Roles
    • 1st Edition
    • Ekrem Dere
    • English
    Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.

  • The Neurobiology of Circadian Timing

    • 1st Edition
    • Volume 199
    • English
    Approx.498 pages

  • Cellular Imaging Techniques for Neuroscience and Beyond

    • 1st Edition
    • Floris G. Wouterlood
    • English
    The imaging of small cellular components requires powerful instruments, and an entire family of equipment and techniques based on the confocal principle has been developed over the past 30 years. Such methods are commonly used by neuroscience researchers, but the majority of these users do not have a microscopy or a cell biology backgrounds and do can encounter difficulties in obtaining and interpreting results. This volume brings experts in high-resolution optical microscopy applications in neuroscience and cell biology together to document the state of the art. Outlining what is currently possible, the volume also discusses promising developments for the future and aids readers in selecting the most scientifically meaningful approach to solve their questions. Each chapter discusses instrumentation and technology in relationship to application in research. All of the common and cutting edge trends are covered - fluorescence / laser electron / nonlinear microscopy, infrared fluorescence, multiphoton imaging, tomography, FRAP, live imaging, STED, PALM/STORM, etc.

  • Pregnancy and Neurologic Illness, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 30-3
    • Autumn Klein
    • English
    Neurologic illness in pregnant women requires special consideration on the part of the neurologist. These disorders can impact pregnancy in distinct ways, and their therapies must often be modified to protect the health of the mother and fetus. This issue of Neurologic Clinics features 11 articles on the interaction of the main neurologic disorders and pregnancy.

  • Inflammation in Neuropsychiatric Disorders

    • 1st Edition
    • Volume 88
    • English
    Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/express... proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

  • Orexin/Hypocretin System

    • 1st Edition
    • Volume 198
    • English
    Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.

  • Sleep and Brain Activity

    • 1st Edition
    • Marcos G. Frank
    • English
    In the last few decades, scientists have discovered that far from being a time of neural silence, sleep is characterized by complex patterns of electrical, neurochemical, and metabolic activity in the brain. Sleep and the Brain presents some of the more dramatic developments in our understanding of brain activity in sleep. The book discusses what parts of the brain are active in sleep and how, and presents research on the function of sleep in memory, learning, and further brain development. Coverage encompasses the network and membrane mechanisms responsible for waking and sleeping brain activity, the roles of glial cells in the sleeping brain, the molecular basis of sleep EEG rhythms, and research on songbirds, rodents, and humans indicating the function of sleep.

  • New Perspectives of Central Nervous System Injury and Neuroprotection

    • 1st Edition
    • Volume 102
    • English
    Central nervous system (CNS) diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis affect a large number of populations worldwide for which no suitable cure is currently available. In addition, stroke, nanoparticle intoxication, diabetes, hypertension, and psychostimulant abuse either alone or in combination are capable of inducing potential brain damage. Thus, there is an urgent need to expand our knowledge to find suitable therapeutic strategies to enhance neurorepair processes in such diseases.This volume presents neuroprotection and novel therapeutic strategies developed in the last 5 years by 12 world leaders in the field. The term neuroprotection means rescuing neuronal and non-neuronal cells together. The cerebral endothelium that constitutes the anatomical and physiological site of the blood-brain barrier (BBB) is one of the most important non-neural cells in the CNS. Any distortion of the BBB leads to brain diseases and restoration of the barrier results in neuroprotection. Thus, the BBB appears to be the "gateway" for neurological diseases and neurorepair. However, to treat brain tumors or infarcts, new therapeutic strategies are needed to enhance brain drug delivery using nanotechnology. In addition, apart from conventional drugs, restoration of BBB function could also be achieved by means of antibodies directed against specific proteins, neurotransmitters or exogenous supplement of neurotrophic factors. Since co-morbidity factors e.g., hypertension, diabetes, and exposure of nanoparticles could complicate the pathogenesis of neurological disorders either an enhanced dose of the drug or nanodelivery of a combination of several drugs is needed to achieve neuroprotection.This volume of International Review of Neurobiology is the first to discuss novel therapeutic strategies in situations of neurological disorders in combination with different co-morbidity factors.

  • Modern Management of High Grade Glioma, Part II, An Issue of Neurosurgery Clinics

    • 1st Edition
    • Volume 23-3
    • Isaac Yang + 1 more
    • English
    Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts on management of high grade glioma. Some of the articles in this issue include: Use of language mapping to aid resection of eloquent gliomas; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Nanotechnology potential applications for GBM therapy; High Grade Gliomas in children; Modern Advances in Brain Tumor Treatments; Molecular pathways of Avastin interactions for the treatment of glioblastoma; and Quality of Life and Outcomes in Glioblastoma management.

  • Fundamentals of Motor Control

    • 1st Edition
    • Mark L. Latash
    • English
    Motor control is a relatively young field of research exploring how the nervous system produces purposeful, coordinated movements in its interaction with the body and the environment through conscious and unsconscious thought. Many books purporting to cover motor control have veered off course to examine biomechanics and physiology rather than actual control, leaving a gap in the literature. This book covers all the major perspectives in motor control, with a balanced approach. There are chapters explicitly dedicated to control theory, to dynamical systems, to biomechanics, to different behaviors, and to motor learning, including case studies.

  • Neurobiology of Psychiatric Disorders

    • 1st Edition
    • Volume 106
    • Thomas E Schlaepfer + 1 more
    • English
    This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment.

  • Down Syndrome: From Understanding the Neurobiology to Therapy

    • 1st Edition
    • Volume 197
    • English
    Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures.

  • Our Genes, Our Choices

    How Genotype and Gene Interactions Affect Behavior
    • 1st Edition
    • David Goldman
    • English
    Our Genes, Our Choices: How Genotype and Gene Interactions Affect Behavior — First Prize winner of the 2013 BMA Medical Book Award for Basic and Clinical Sciences — explains how the complexity of human behavior, including concepts of free will, derives from a relatively small number of genes, which direct neurodevelopmental sequence. Are people free to make choices, or do genes determine behavior? Paradoxically, the answer to both questions is "yes," because of neurogenetic individuality, a new theory with profound implications. Author David Goldman uses judicial, political, medical, and ethical examples to illustrate that this lifelong process is guided by individual genotype, molecular and physiologic principles, as well as by randomness and environmental exposures, a combination of factors that we choose and do not choose. Written in an authoritative yet accessible style, the book includes practical descriptions of the function of DNA, discusses the scientific and historical bases of genethics, and introduces topics of epigenetics and the predictive power of behavioral genetics.

  • A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates

    • 2nd Edition
    • Kadharbatcha S. Saleem + 1 more
    • English
    A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates, Second Edition maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This edition of the atlas is unlike anything else available as it includes the detailed cyto- and chemoarchitectonic delineations of the brain areas in all three planes of sections (horizontal, coronal, and sagittal) that are derived from the same animal. This is a significant progress because in functional imaging studies, such as fMRI, both the horizontal and sagittal planes of sections are often the preferred planes given that multiple functionally active regions can be visualized simultaneously in a single horizontal or sagittal section. This combined MRI and histology atlas is designed to provide an easy-to-use reference for anatomical and physiological studies in macaque monkeys, and in functional-imaging studies in human and non-human primates using fMRI and PET.

  • Molecular Biology of Neurodegenerative Diseases

    • 1st Edition
    • Volume 107
    • English
    Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson’s, Alzheimer’s and Huntington’s disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases.

  • Encyclopedia of Body Image and Human Appearance

    • 1st Edition
    • Thomas F. Cash
    • English
    This scholarly work is the most comprehensive existing resource on human physical appearance—how people’s outer physical characteristics and their inner perceptions and attitudes about their own appearance (body image) affect their lives. The encyclopedia’s 117 full-length chapters are composed and edited by the world’s experts from a range of disciplines—social, behavioral, and biomedical sciences. The extensive topical coverage in this valuable reference work includes: (1) Important theories, perspectives, and concepts for understanding body image and appearance; (2) Scientific measurement of body image and physical attributes (anthropometry); (3) The development and determinants of human appearance and body image over the lifespan: (4) How culture and society influences the meanings of human appearance; (5) The psychosocial effects of appearance-altering disease, damage, and visible differences; (6) Appearance self-change and self-management; (7) The prevention and treatment of body image problems, including psychosocial and medical interventions. Chapters are written in a manner that is accessible and informative to a wide audience, including the educated public, college and graduate students, and scientists and clinical practitioners. Each well-organized chapter provides a glossary of definitions of any technical terms and a Further Reading section of recommended sources for continued learning about the topic. Available online via ScienceDirect or in a limited-release print version.

  • Nonhuman Primates in Biomedical Research

    Diseases
    • 2nd Edition
    • Volume 2
    • Christian R. Abee + 3 more
    • English
    The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject.

  • Clinical Electromyography, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 30-2
    • Devon I. Rubin
    • English
    Electromyography remains a main diagnostic tool within neurology. This issue of Neurologic Clinics addresses the most recent developments in the clinical application of EMG. Articles in this issue include: Nerve conduction studies: Basic Concepts and Patterns of Abnormalities; Needle Electromyography–Bas... Concepts andInterpretation of Recorded Potentials;Electrodi... Evaluation of Carpal TunnelSyndrome;Elect... Evaluation of Ulnar Neuropathyand Other Upper Extremity Mononeuropathy; Lower Extremity Mononeuropathies;Ele... Evaluation of Brachial Plexopathies; Evaluation ofRadiculopathies;El... Approach to Motor NeuronDiseases;Elect... Findings in PeripheralNeuropathi... Evaluation of Neuromuscular Junction Disorders in the EMGLaboratory;Electr... Findings inMyopathy;Electrodi... Approach to CranialNeuropathies; Technical Issues with Nerve Conduction Studies and Needle EMG;andCoding and Reimbursement of ElectrodiagnosticStu...

  • Optogenetics

    Tools for Controlling and Monitoring Neuronal Activity
    • 1st Edition
    • Volume 196
    • English
    Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology. These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms.

  • Neuro-Oncology, Part II

    • 1st Edition
    • Volume 105
    • Wolfgang Grisold + 1 more
    • English
    Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.

  • Neuro-Oncology Part I

    • 1st Edition
    • Volume 104
    • Wolfgang Grisold + 1 more
    • English
    Handbook of Clinical Neurology: Neuro-Oncology, Part I summarizes the present state of scientific and clinical knowledge in the field of neuro-oncology, including information related to diagnostic techniques such as imaging, along with immunology, molecular biology, and clinical aspects of tumors. Management and new therapeutic strategies for tumors, including gene therapy and molecularly targeted treatments, are also covered. Divided into eight sections encompassing 61 chapters, the book begins with an overview of the basic principles of tumors, including the epidemiology of primary central nervous system tumors, angiogenesis and invasion in cancer, the link between blood-brain barrier and brain edema, and the role of stem cells in gliomas. It proceeds with a discussion of diagnostic tools such as neuroimaging, the principles of tumor therapy such as radiotherapy and immunotherapy, and clinical trials in neuro-oncology. The reader is also introduced to specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. Furthermore, the book explains the neurological complications of systemic cancer and complications from treatments. This volume will appeal to clinicians and neuroscientists as well as researchers who want to gain a better understanding of the clinical features and management of the neurological manifestations of tumors.

  • Evolution of the Primate Brain

    From Neuron to Behavior
    • 1st Edition
    • Volume 195
    • English
    This volume of Progress in Brain Research provides a synthetic source of information about state-of-the-art research that has important implications for the evolution of the brain and cognition in primates, including humans. This topic requires input from a variety of fields that are developing at an unprecedented pace: genetics, developmental neurobiology, comparative and functional neuroanatomy (at gross and microanatomical levels), quantitative neurobiology related to scaling factors that constrain brain organization and evolution, primate palaeontology (including paleoneurology), paleo-anthropology, comparative psychology, and behavioural evolutionary biology. Written by internationally-reno... scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.

  • Fundamentals of Cognitive Neuroscience

    A Beginner's Guide
    • 1st Edition
    • Bernard Baars + 1 more
    • English
    Fundamentals of Cognitive Neuroscience is a comprehensive and easy-to-follow guide to cognitive neuroscience. Winner of a 2013 Most Promising New Textbook Award from the Text and Academic Authors Association, this book was written by two leading experts in the field to be highly accessible to undergraduates with limited neuroscience training. It covers all aspects of the field—the neural framework, sight, sound, consciousness, learning/memory, problem solving, speech, executive control, emotions, socialization and development—in a student-friendly format with extensive pedagogy and ancillaries to aid both the student and professor. This introductory text takes a unique thematic approach, guiding students along a clear path to understand the latest findings whether or not they have a background in neuroscience. It includes case studies and everyday examples designed to help students understand the more challenging aspects of the material. It is richly illustrated with carefully selected color graphics to enhance understanding. Enhanced pedagogy highlights key concepts for the student and aids in teaching. Chapter outlines, study questions, glossary, and image collection are also available on the student's companion website. Ancillary support saves instructors time and facilitates learning; test questions, image collection, and lecture slides are available on the instructor's manual website. This book will be of interest to undergraduate students in Neuroscience, Psychology, and related disciplines that teach cognitive neuroscience.

  • Les troubles du sommeil

    • 2nd Edition
    • Michel Billiard + 1 more
    • French
    La médecine du sommeil est une discipline récente et les manuels qui lui sont consacrés sont encore peu nombreux. Les troubles du sommeil et de l'éveil touchent pourtant une part importante de la populati on et ont de graves répercussions sur la santé physique et mentale ainsi que sur la qualité de vie. Cette 2° édition, largement revue et augmentée fait le point sur le sommeil normal, l'exploration du sommeil et de l'éveil, la somnolence et la vigilance, les troubles du sommeil et de l'éveil, et sur les nombreuses maladies organiques et psychiatriques dépendant du sommeil ou ayant un impact sur lui. D'un usage très pratique, cet ouvrage de référence est agrémenté d'index et de questionnaires, d'inventaires et échelles utilisés pour préciser les troubles du sommeil et de l'éveil. Il est complété par un glossaire étendu nécessaire à une bonne compréhension de la terminologie du sommeil et de ses troubles. Cet ouvrage s'adresse aux médecins généralistes et spécialistes. Ils y trouveront des réponses à leurs questi ons ainsi que de nombreuses indicati ons pour la prise en charge des pati ents et la prescripti on de traitements. Il s'adresse également aux étudiants en médecine, aux infi rmiers, aux psychologues désireux de s'ouvrir à un domaine encore peu enseigné dans les facultés et écoles, et enfin, à tous les chercheurs intéressés par ce sujet. Il est rédigé par une équipe de spécialistes du sommeil, chercheurs et cliniciens, européens et nord-américains reconnus internationalement.

  • The Human Nervous System

    • 3rd Edition
    • Juergen K Mai + 1 more
    • English
    The previous two editions of the Human Nervous System have been the standard reference for the anatomy of the central and peripheral nervous system of the human. The work has attracted nearly 2,000 citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with new chapters covering genes and anatomy, gene expression studies, and glia cells. The book continues to be an excellent companion to the Atlas of the Human Brain, and a common nomenclature throughout the book is enforced. Physiological data, functional concepts, and correlates to the neuroanatomy of the major model systems (rat and mouse) as well as brain function round out the new edition.

  • Primer on the Autonomic Nervous System

    • 3rd Edition
    • Phillip A. Low
    • English
    The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist’s bookshelf!

  • Basic Neurochemistry

    Principles of Molecular, Cellular, and Medical Neurobiology
    • 8th Edition
    • Scott Brady + 5 more
    • English
    Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology.

  • Biomarkers of Neurological and Psychiatric Disease

    • 1st Edition
    • Volume 101
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia.

  • The Human Cerebral Cortex

    An MRI Atlas of the Sulci and Gyri in MNI Stereotaxic Space
    • 1st Edition
    • Michael Petrides
    • English
    As MRI research becomes more detailed and specialized, it becomes essential to have detailed atlases that also explain individual variability, but other atlases do not provide this detail and leave users without illustration of, or guidance regarding how to deal with the variability they inevitably encounter in research and practice. This book serves as the first cortex atlas to address this growing need, appealing to clinicians, researchers and graduate students in neuroscience, neurology, neurosurgery and radiology. The atlas provides nearly 200 photographs of 3D reconstructions of human brains in a standard series of coronal, sagittal, and horizontal sections. It illustrates in detail and labels 95% of the cortex sulci and gyri, and images are presented in the MNI stereotaxic space. In addition to the standard brain and its sections are numerous examples of brains that exhibit patterns of deviating sulci and gyri. Examples of these variants are presented next to the standard illustration, accompanied by brief commentary aimed at helping users identify these variants and use them in their own work

  • The Marmoset Brain in Stereotaxic Coordinates

    • 1st Edition
    • George Paxinos + 4 more
    • English
    The Marmoset Brain in Stereotaxic Coordinates is the most comprehensive atlas of the brain of this animal available. The atlas is constructed in the style of The Rat Brain in Stereotaxic Coordinates, the most-cited book in neuroscience. It represents a collaboration between world leaders in neuroanatomy of the primate cortex and subcortex. It will be an indispensible tool for neuroanatomists, behavioral neuroscientists, and molecular biologists trying to understand the primate brain. ENDORSED BY SOCIETY FOR BRAIN MAPPING AND THERAPEUTICS (SBMT) - SBMT is a non-profit society organized for the purpose of encouraging basic and clinical scientists who are interested in areas of Brain Mapping, engineering, stem cell, nanotechnology, imaging and medical device to improve the diagnosis, treatment and rehabilitation of patients afflicted with neurological disorders. This society promotes the public welfare and improves patient care through the translation of new technologies/therapi... into life saving diagnostic and therapeutic procedures. The Society is focused in breaking boundaries of science, technology, medicine, art and healthcare policy. For more information about how to become a member or participate in SBMT programs please visit: www.WorldBrainMappin...

  • Monoamine Oxidases and their Inhibitors

    • 1st Edition
    • Volume 100
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. In this volume, invited experts provide authoritative reviews on various aspects of Monoamine Oxidase and its Inhibitors.

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