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Axon Growth and Regeneration: Part 1
1st Edition - December 11, 2012
Editors: Jeffrey Louis Goldberg, Ephraim F. Trakhtenberg
eBook ISBN:9780123983220
9 7 8 - 0 - 1 2 - 3 9 8 3 2 2 - 0
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led… Read more
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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding Axon Growth and Regeneration.
Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Neuroscientists, neurologists, psychologists
Series Page
Contributors
Preface
Chapter One. Optic Nerve Disease and Axon Pathophysiology
1. Introduction
2. The Anterior Visual Pathways and Disease
3. Axonal Degeneration
4. Therapies for Optic Nerve Disease
5. Conclusions
References
Chapter Two. Role of Electrical Activity of Neurons for Neuroprotection
1. Introduction
2. Importance of Neuronal Activity During Normal Development
3. CNS Neurons Lose Neuronal Activity After Injury
4. Survival-Promoting Effects of Electrical Activity on Neurons In Vitro
5. Survival-Promoting Effects of Electrical Activity on Neurons In Vivo
6. Mechanism of Neuroprotective Effects of Electrical Activity on CNS
7. Conclusions: Significance of Activity-Dependent Survival
References
Further reading
Chapter Three. Molecular Control of Axon Growth
1. Introduction
2. Comparisons Across CNS Development
3. Comparisons Across Species
4. Peripheral Versus Central Nervous System
5. Conclusions and Future Directions
References
Chapter Four. Gatekeeper Between Quiescence and Differentiation
1. Introduction
2. p53 in Neural Development and Neural Stem Cell Regulation
3. p53 in Neurite Growth and Axonal Regeneration
4. Effects of Posttranslational Modifications on p53 Function
5. Conclusions and Perspectives
References
Chapter Five. Cyclin-Dependent Kinase 5 in Axon Growth and Regeneration
1. Regulation of Axon Growth and Regeneration
2. Cdk5 in the Control of Axon Growth and Regeneration
3. Concluding Remarks and Future Perspectives
References
Further reading
Chapter Six. Rho Signaling and Axon Regeneration
1. The Growth Inhibitory Proteins in the CNS Signal to Rho
2. Axon Regeneration and Functional Recovery in Preclinical Studies
3. Clinical Study with Cethrin
4. Summary
References
Chapter Seven. Neuron-Intrinsic Inhibitors of Axon Regeneration
1. Introduction
2. PTEN: A Negative Regulator of Cell and Axon Growth
3. SOCS3: An Inhibitor of Cytokine-Induced Axon Regeneration
4. Synergistic Effects from Simultaneously Targeting PTEN and Other Growth-Promoting Factors
5. Summary and Perspectives
References
Subject Index
Contents of Recent Volumes
No. of pages: 248
Language: English
Published: December 11, 2012
Imprint: Academic Press
eBook ISBN: 9780123983220
JG
Jeffrey Louis Goldberg
Affiliations and expertise
Assistant Professor of Ophthalmology, and of Neurosciences