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Novel Psychoactive Substances
Classification, Pharmacology and Toxicology
- 1st Edition - August 6, 2013
- Editors: Paul I. Dargan, David M. Wood
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 1 5 8 1 6 - 0
- eBook ISBN:9 7 8 - 0 - 1 2 - 4 1 5 9 1 1 - 2
Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psy… Read more
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Request a sales quoteNovel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.
- Includes chapters written by international experts in the field.
- Provides a comprehensive look at the classification, detection, availability and supply of novel psychoactive substances, in addition to the pharmacology and toxicology associated with the substance.
- Offers a single source for all interested parties working in this area, including scientists, academics, clinicians, law enforcement and regulatory agencies.
- Provides a full treatment of novel psychoactive substances that have recently emerged onto the recreational drug scene including mephedrone and the synthetic cannabinoid receptors in ‘spice’ / ‘K2’.
Research scientists and academics in pharmacology and toxicology, biochemists and healthcare professionals, including physicians, nurses and paramedics, law enforcement and legislative authorities.
Forewords
List of Contributors
Section 1: Background
Chapter 1. Legal Classification of Novel Psychoactive Substances: An International Comparison
Introduction
Traditional Control Mechanisms
Recent Developments
References
Chapter 2. Monitoring Novel Psychoactive Substances: A Global Perspective
Introduction
Definitions
The Identification, Risk Assessment and Monitoring of Novel Psychoactive Substances
The EU Ews Information Exchange
International, Regional and National Drug Monitoring Systems
Sources for Detecting and Monitoring Novel Psychoactive Substances
Conclusions
References
Chapter 3. Availability and Supply of Novel Psychoactive Substances
Background
Novel Psychoactive Substance Market
NPS Origins and Market Entry
NPS Market Structure
Products
Conclusions
References
Chapter 4. Epidemiology of Use of Novel Psychoactive Substances
Introduction
General Population Surveys
Summary and Conclusions
References
Chapter 5. Social Issues in the Use of Novel Psychoactive Substances: Differentiated Demand and Ideological Supply
Introduction
Availability
Prevalence in Context: Differentiated Demand in Different Leisure Venues
Understanding Motivations: The Displacement Question
Exploring Social Harms: Legislative Control and the Supply of NPS
Policy Options in a Changing World
The NPS Debate: Historical Stagnation and Vested Interests (A UK Perspective)
Conclusion
References
Section 2: Analytical Techniques
Chapter 6. Analytical Techniques for the Detection of Novel Psychoactive Substances and Their Metabolites
Introduction
Analytical Methods Covering Several Classes of Novel Psychoactive Substances
Methods for Screening and/or Quantification of Novel Psychoactive Substances from Specific Drug Classes
Recommendations for Setting up Analytical Methods for Analysis of Novel Psychoactive Substances
References
Section 3: Individual Novel Psychoactive Substances
Chapter 7. Synthetic Amphetamine Derivatives
Pharmacology
Monomethoxy Derivatives
Dimethoxy Derivatives
Trimethoxy Derivatives
Thiol-Derivatives
4-Fluoroamphetamine
Monomethyl Derivatives
Summary
References
Chapter 8. 1-Benzylpiperazine and other Piperazine-based Derivatives
Introduction
Pharmacology
Toxicology
Treatment
Chronic Toxicity
Dependence and Abuse Potential
Conclusion
Acknowledgment
References
Chapter 9. Mephedrone
Introduction
Pharmacology
Prevalence of Use
Acute Toxicity
Mephedrone-Related Deaths
Chronic Toxicity
Dependence and Abuse Potential
References
Chapter 10. Pipradrol and Pipradrol Derivatives
Pharmacology
Prevalence of Use
Acute Toxicity
Chronic Toxicity
Dependence and Abuse Potential
Conclusions
References
Chapter 11. Aminoindane Analogues
Introduction
Pharmacology
Prevalence of Use
Regulation of the Aminoindanes
Acute and Chronic Toxicity
Dependence and Abuse Potential
Conclusions
References
Chapter 12. Ketamine
Introduction
Pharmacology and Animal Models of Ketamine Toxicity
Physical and Chemical Description
Acute Toxicity
Chronic Toxicity
Dependence and Abuse Liability
References
Chapter 13. Synthetic Cannabinoid Receptor Agonists
Introduction
Pharmacology
Prevalence of Use
Acute Toxicity
Chronic Toxicity
Dependence and Abuse Potential
Forensic Relevance
Conclusions
References
Chapter 14. Natural Product (Fungal and Herbal) Novel Psychoactive Substances
Introduction
Fungal NPS
Conclusions
Acknowledgments
References
Chapter 15. Tryptamines
Tryptamines
Pharmacology
Prevalence of Use
Acute Toxicity
Chronic Toxicity
Dependence and Abuse Potential
Conclusions
References
Chapter 16. Benzofurans and Benzodifurans
Benzofurans
Pharmacology
Prevalence of Use
Acute Toxicity
Chronic Toxicity
Dependence and Abuse Potential
References
Chapter 17. Miscellaneous Compounds
Methoxetamine
Dimethylamylamine (DMAA)
Synthetic Cocaines
References
Index
- No. of pages: 440
- Language: English
- Edition: 1
- Published: August 6, 2013
- Imprint: Academic Press
- Hardback ISBN: 9780124158160
- eBook ISBN: 9780124159112
PD
Paul I. Dargan
Professor Dargan and Dr Wood are both expert advisors on novel psychoactive substances to expert bodies in the UK (Advisory Council on the Misuse of Drugs, ACMD), Europe (European Monitoring Centre for Drugs and Drug Addiction, EMCDDA) and Worldwide (United Nations Office on Drugs and Crime, UNODC). They run a clinical service managing patients with acute drug toxicity, and have a clinical and research interest in novel psychoactive substances. They publish widely in this field and have both been invited to give keynote lectures at International meetings on this topic.
Affiliations and expertise
Consultant Physician and Professor of Clinical Toxicology, London, UKDW
David M. Wood
David Wood is a Consultant Physician and Clinical Toxicologist at Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.
Affiliations and expertise
Consultant Physician and Clinical Toxicologist, Reader in Clinical Toxicology, London, UK