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Elsevier

Books in Life sciences

  • Multimodal Data Fusion in Healthcare

    AI Approaches for Precision Diagnosis
    • 1st Edition
    • Akansha Singh + 3 more
    • English
    Multimodal Data Fusion in Healthcare: AI Approaches for Precision Diagnosis explores the transformative potential of AI in modern medicine by integrating diverse data sources such as medical imaging, genomics, EHRs, and wearable sensors. It highlights how AI technologies are revolutionizing healthcare systems through personalized and proactive diagnostics. The book covers cutting-edge methodologies, real-world applications, and the challenges of multimodal data fusion. Topics include AI-driven diagnostics, precision medicine, real-time patient monitoring, and the integration of clinical, genomic, and wearable data, providing both theoretical foundations and practical insights. This book is essential for healthcare professionals, data scientists, and engineers, offering clear frameworks for integrating diverse data types. It addresses crucial issues like data interoperability, privacy, and technical constraints, providing practical solutions. It serves as an invaluable reference for understanding and applying AI advancements in diagnostic precision and personalized medicine.

  • Cybersecurity for Healthcare Systems in the Internet of Medical Things Era

    • 1st Edition
    • Janmenjoy Nayak + 2 more
    • English
    Cybersecurity for Healthcare Systems in the Internet of Medical Things Era is driven by the imperative to address the intricate convergence of healthcare, technology, and security. In response to the burgeoning challenges presented by the Internet of Medical Things (IoMT), this book is designed to be an indispensable resource for computer systems experts, healthcare staff, and executives. It goes beyond the surface, offering strategic insights and actionable strategies that encompass not only the IoMT landscape but also the intersection of artificial intelligence, signal processing, and cyber security. Cybersecurity for Healthcare Systems in the IoMT Era serves as a problem-solving compass for a diverse readership in the healthcare landscape. For healthcare professionals and IT leaders, the book untangles the complexities of integrating and securing Internet of Medical Things (IoMT) devices, offering a roadmap for understanding and navigating this rapidly evolving terrain. Biomedical engineers, burdened with strategic and everyday decisions, find in this book strategic insights and actionable strategies, empowering them to make informed choices amidst the ever-changing challenges posed by technology and cybersecurity threats. The authors present a comprehensive guide that not only elucidates the challenges and opportunities presented by IoMT but also explores how the synergy of AI and signal processing can elevate healthcare systems. This integration is crucial in deciphering the intricate nuances of medical data, enhancing diagnostics, and fortifying the security of interconnected healthcare networks.

  • Kinase Targets and Drug Discovery

    • 1st Edition
    • Xiaoyun Lu
    • English
    Kinase Targets and Drug Discovery covers the critical role of kinases as regulators of cellular functions and their implications in a range of diseases, from cancers to cardiovascular disorders and inflammatory conditions. Readers will explore foundational concepts on the functions of kinases, the role of kinase inhibitors in disease therapy, and challenges faced. The second section focuses on innovative strategies in kinase drug discovery, covering screening and computational approaches, along with the development of covalent, macrocyclic, allosteric inhibitors, and kinase degraders. Final sections examine clinical applications, detailing how kinase inhibition can be harnessed for cancer therapies, non-oncologic diseases, and even non-catalytic functions.This book will serve as an indispensable resource for pharmacologists, medicinal chemists, and researchers in both academia and industry. By bridging the gap between foundational research and clinical application, it equips professionals with the latest insights and practical approaches to advance their understanding to contribute meaningfully to the evolving landscape of drug discovery.

  • Stratégies motivationnelles pour le rétablissement

    Un guide pour les professionnels et les aidants
    • 1st Edition
    • Laurent Lecardeur
    • French
    Les projets de rétablissement des personnes concernées par des maladies psychiatriques reposent principalement sur leurs ressources propres, mais aussi sur le soutien de leur entourage et des professionnels qui peuvent les accompagner. Ces projets de rétablissement requièrent persévérance et régularité dans le suivi et l’accompagnement, et motivation de la part de la personne concernée pour poursuivre ses efforts, malgré les échecs ponctuels, les périodes de difficulté et de découragement, ou la réactivation des symptômes. Les maladies psychiatriques peuvent également nécessiter des prises en charge à plus ou moins long terme, selon des modalités diverses (médicamenteuses, psychothérapeutiques... sociales…), avec différents intervenants. Elles supposent, pour qu’elles soient bénéfiques et efficaces, l’adhésion et l’engagement de la personne concernée sur le long terme. Ces problématiques, communes aux pathologies chroniques, sont d’autant plus sensibles que la motivation est altérée dans la majorité des pathologies psychiatriques et laissent parfois les soignants démunis face aux difficultés ou aux échecs de la prise en charge.La question de la motivation est donc centrale pour la réussite des souhaits, des aspirations et des choix de vie du patient et de son entourage, tout en tenant compte des soins nécessaires.Dans un objectif résolument pratique, et après un rappel théorique sur les notions de rétablissement et de motivation, l’ouvrage présente les différentes étapes des stratégies motivationnelles pour accompagner le rétablissement de la personne concernée par un trouble psychiatrique. Il explique également l’articulation avec le projet de soins et le suivi avec les différents intervenants. Il décrit les freins qui peuvent intervenir dans la poursuite du projet de rétablissement (et leurs solutions), en apportant des outils concrets pour aider les accompagnants (professionnels ou aidants), selon les diverses situations et difficultés rencontrées. Chaque chapitre s’appuie sur des illustrations cliniques, des fiches outils utilisables par les lecteurs, des recommandations et des conseils qui, au-delà des réponses immédiates, permettront aux accompagnants de prendre de la distance sur leur fonctionnement et de développer leurs propres outils.Fondé sur l’expérience clinique, scientifique et pédagogique de l’auteur, l’ouvrage s’adresse à la fois aux professionnels de la santé mentale (psychiatres, psychologues, neuropsychologues et équipes soignantes et médicosociales) et aux proches et aux aidants dont le rôle est fondamental dans le soutien au rétablissement des personnes concernées par des troubles psychiatriques.Laure... Lecardeur, Ph.D, HDR, est psychologue à Nice.

  • Reverse Aging

    Current Research and Future Directions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.

  • Inflammatory Arthritis Beyond the Joints

    Comorbidities and other Manifestations
    • 1st Edition
    • Volume 18
    • Fabiola Atzeni + 1 more
    • English
    Inflammatory Arthritis Beyond the Joints, Volume 18 in Elsevier’s Handbook for Systemic Autoimmune Diseases series, provides an extensive review of the most recent research on various comorbidities and EAMs associated with inflammatory arthritis. The book emphasizes early detection, which is crucial for improving patient quality of life and survivability outcomes, as many adults with inflammatory arthritis also suffer from other chronic conditions. The book's chapters cover comorbidities and EAMs in both early and late disease stages.They delve into the mechanisms behind the development of these conditions and examine the impact of new treatment strategies specific to inflammatory arthritis and related diseases, including cardiovascular disease, metabolic syndrome, metabolic bone disease, infection, neoplasia, respiratory disease, gastrointestinal disorders, kidney issues, mental health conditions, and neurological diseases. This book serves as a valuable reference for researchers and clinicians focused on inflammatory arthritis and its associated conditions.

  • Telehealth in Movement Disorders

    Principles, Strategies, Applications, and New Directions
    • 1st Edition
    • Wael Mohamed + 2 more
    • English
    The COVID-19 pandemic forced the world to pause and reevaluate how we operate specifically in medicine, shifting to telemedicine and telehealth. Integrating telemedicine and telehealth into the healthcare system enables patient safety and has been proven beneficial to medical and surgical practices including patient primary care. Telehealth in Movement Disorder: Principles, Strategies, Applications, and New Directions provides guidance on how to deliver clinical assessment and treatment to movements disorders patients through telemedicine. This book is divided into three distinct sections. The first section reviews general principles including strategies, standards, policies, and ethical aspects. The second section explores how telemedicine can be integrated into diagnosis, treatment, and care of patients with movement disorders including the use of new AI technologies. The final section discusses the integration and application of telemedicine in developing countries, including challenges and future opportunities.

  • Artificial Intelligence for Multi-omics Analysis Part A

    • 1st Edition
    • Volume 221
    • English
    Artificial Intelligence for Multi-omics Analysis, Part A, Volume 221 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as an Introduction to Artificial Intelligence in Multi-omics Analysis, Multi‐omics application in health and diseases, Artificial Intelligence in Genomics Analysis, Artificial Intelligence in Single-cell and Spatial Transcriptomics Data, Artificial Intelligence in the prediction of 3D chromatin structure and gene regulation, Artificial intelligence in Mass Spectrometry-based Proteomics, Integrating Artificial Intelligence into Metabolomics for Predicting Diseases, and more.Additional chapters cover Artificial Intelligence in Microbial Metagenomics, Artificial Intelligence in Interactomics, Artificial Intelligence Integration in Medical Imaging Data, AI in biomolecular structural data analysis, Artificial intelligence in Cryo-Electron Microscope data, Explainable artificial intelligence for multi-omics data, and Multi-Omics Cancer Stratification: from Statistical to Deep Learning Perspective.

  • From Conventional to Artificial Intelligence-Based Agriculture

    • 1st Edition
    • Vivek Sharma + 2 more
    • English
    From Conventional to Artificial Intelligence-Based Agriculture explores the evolving landscape of agriculture as it transitions from traditional practices to advanced, AI-driven solutions. With AI and machine learning revolutionizing industries worldwide, their impact on agriculture is becoming increasingly significant. These technologies are not only aiding in climate modeling but also opening new possibilities for precision farming, enabling more accurate crop health diagnostics, efficient resource management, and timely intervention strategies.By integrating conventional agricultural knowledge with cutting-edge AI tools, farmers and researchers can better assess soil conditions, predict optimal planting windows, monitor nutrient dynamics, and understand market trends with greater precision. This convergence of tradition and technology supports more resilient, productive, and sustainable agricultural systems, paving the way for a smarter and more food-secure future.

  • Cell Death Part A

    • 1st Edition
    • Volume 205
    • English
    Cell Death, Part A, Volume 205 explores the diverse mechanisms and methodologies underlying cell death, providing an up-to-date resource for researchers and clinicians in the biomedical sciences. Chapters in this new release include Methodologies for Monitoring Alkaliptosis in Cancer Cells, Protein-complementat... assay and DISC analysis, Detecting phosphorylated MLKL in murine tissues, Establishment of different cell death models (Apoptosis, Necroptosis, Pyroptosis), Implementation of the FENIX assay to determine anti-ferroptotic properties of test compounds, CRISPR-Cas9 knockout screens to identify drug resistance genes in Acute Myeloid Leukemia, and much more.Additional chapters cover Cell death assays for the detection of acute kidney tubular necrosis, Methods of cell death imaging by Incucyte and similar platforms, Super-resolution microscopy-based assessment of organellar redox-active iron distribution and its relevance for ferroptosis, Monitoring inflammasome activation by analyzing ASC specks and oligomerization, LPS-induced sepsis/ and TNF-induced SIRS (In vivo cell death models), Evaluating protease activation and inactivation of gasdermin cell death effectors, and Measurement of plasma membrane rupture via confocal microscopy.

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