Advances in Clinical Chemistry
- 1st Edition, Volume 113 - February 24, 2023
- Imprint: Academic Press
- Editor: Gregory S. Makowski
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 2 8 6 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 2 8 7 - 6
Advances in Clinical Chemistry, Volume 113, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scient… Read more
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Request a sales quoteAdvances in Clinical Chemistry, Volume 113, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry with sections in this release focusing on Biosensors for saliva biomarkers, Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel, Protein Glycation in Diabetes Mellitus, Biomarkers of Oxidative Stress and Reproductive Complications, Cortisol: Analytical and Clinical Determinants, and Hemophilia A: Emicizumab monitoring and impact on coagulation testing.
- Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science
- Authored by world-renowned clinical laboratory scientists, physicians and research scientists
- Presents the international benchmark for novel analytical approaches in the clinical laboratory
Clinical Laboratory Professionals, Physicians and Research Scientists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Biosensors for saliva biomarkers
- Abstract
- 1: Introduction
- 2: Saliva as a noninvasive diagnostic fluid
- 3: Biomarkers in human saliva
- 4: Biosensors for saliva biomarkers
- 5: Conclusions and future perspectives
- References
- Chapter Two: Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel
- Abstract
- 1: Introduction
- 2: The TRPV6 gene
- 3: Physiology of TRPV6
- 4: Analytical methods
- 5: Molecular structure and mechanics of TRPV6
- 6: Establishing the roles of TRPV6 in vivo
- 7: TRPV6 deficiency due to gene mutations
- 8: TRPV6 in intestinal Ca2+ absorption
- 9: TRPV6 deficiency in pregnancy
- 10: Male infertility in TRPV6 deficiency
- 11: Alopecia in TRPV6-deficient mice
- 12: TRPV6 in cancers
- 13: Concluding remarks
- References
- Chapter Three: Protein glycation in diabetes mellitus
- Abstract
- 1: Introduction
- 2: Diabetes mellitus
- 3: Protein glycation
- 4: Glucose and Hyperglycemia
- 5: Glycated hemoglobin
- 6: Glycated albumin
- 7: Other glycated proteins
- 8: Application of proteomics workflows for glycated proteins
- 9: Conclusion
- References
- Chapter Four: Biomarkers of oxidative stress and reproductive complications
- Abstract
- 1: Introduction
- 2: Free radicals in biology and health: ROS and RNS
- 3: Biomarkers measuring evidence of the direct chemical impact of free radicals in biological systems
- 4: Oxidative stress and healthy pregnancy
- 5: Oxidative stress in reproductive complications
- 6: Summary and future perspectives
- Acknowledgments
- References
- Chapter Five: Cortisol: Analytical and clinical determinants
- Abstract
- 1: Cortisol biochemistry and metabolism
- 2: Evolution of cortisol assays
- 3: Cortisol measurement in serum
- 4: Cortisol measurement in urine
- 5: Cortisol measurement in saliva
- 6: Cortisol measurement in hair
- 7: Clinical value of cortisol measurement
- 8: Summary
- References
- Chapter Six: Hemophilia A: Emicizumab monitoring and impact on coagulation testing
- Abstract
- 1: Introduction
- 2: Emicizumab
- 3: Clinical studies of emicizumab
- 4: Laboratory testing
- 5: Guidelines for monitoring emicizumab in the clinical laboratory
- 6: The future
- 7: Conclusion
- References
- Index
- Edition: 1
- Volume: 113
- Published: February 24, 2023
- Imprint: Academic Press
- No. of pages: 332
- Language: English
- Hardback ISBN: 9780443192869
- eBook ISBN: 9780443192876
GM
Gregory S. Makowski
Dr Gregory S Makowski is a board-certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President Clinical Laboratory Services Hartford HealthCare in Connecticut.
Affiliations and expertise
Vice President and Chief Scientific Officer, Clinical Laboratory Partners, Newington, CT, USARead Advances in Clinical Chemistry on ScienceDirect