Mitochondria and Bacterial Pathogens - Part A
- 1st Edition, Volume 374 - February 24, 2023
- Imprint: Academic Press
- Editors: Lorenzo Galluzzi, Saverio Marchi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 0 3 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 1 1 - 8
Mitochondria and Bacterial Pathogens, Volume 374, Part A. Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes… Read more
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Request a sales quoteMitochondria and Bacterial Pathogens, Volume 374, Part A. Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. In the IRCMB volume 375, the authors discus different pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.
- Collection of articles reporting the role of mitochondria during bacterial infection
- Mitochondria, the evolutionary successors of an ancient endosymbiotic prokaryote, occupy a central position in the biology of modern eukaryotic cells
- Numerous pathogenic bacteria have evolved strategies to subvert the mitochondrial functions of host cells in support of proliferation and dissemination
Researchers interested in mitochondrial dynamics and bacterial infections
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: The bacterial origin of mitochondria: Incorrect phylogenies and the importance of metabolic traits
- Abstract
- 1: Introduction
- 2: Impact of mass extinction events on the evolution of animals and their mitochondria
- 3: Syntrophic models for eukaryogenesis and their metabolic implications
- 4: The aerobic ancestry of mitochondria: Systems for cytochrome c biogenesis
- 5: Incorrect phylogenies of proteins shared by bacteria and mitochondria
- 6: Was the ancestor of mitochondria photosynthetic?
- 7: Was the ancestor of mitochondria a facultative or obligate aerobe?
- 8: Conclusion
- Acknowledgments
- References
- Chapter Two: Legionella and mitochondria, an intriguing relationship
- Abstract
- 1: Introduction
- 2: The dynamic contacts between mitochondria and Legionella-containing phagosomes
- 3: Regulation of mitochondrial functions by L. pneumophila with metabolic consequences
- 4: Regulation of mitochondria during L. pneumophila infection allows to bypass cell-autonomous immunity and to control host cell death
- 5: Conclusions
- Acknowledgments
- References
- Chapter Three: Role of mitochondrial outer membrane permeabilization during bacterial infection
- Abstract
- 1: Introduction
- 2: Mitochondria: Organization and function
- 3: Relevance of mitochondria in the context of bacterial infection
- 4: Apoptosis and its players
- 5: Mitochondrial outer membrane permeabilization (MOMP)
- 6: Incomplete MOMP and sub-lethal signals in the mitochondrial apoptosis machinery
- 7: Modulation of mitochondrial apoptosis by bacterial infection
- 8: Induction of MOMP by individual pathogenic bacteria
- 9: Induction of sub-lethal signals by infection
- 10: Inhibition of MOMP by individual pathogenic bacteria
- 11: Concluding remarks
- References
- Chapter Four: The interplay between selective types of (macro)autophagy: Mitophagy and xenophagy
- Abstract
- 1: Introduction
- 2: Xenophagy and mitophagy act through common molecular mechanisms
- 3: Immunity and disease
- 4: Conclusions
- References
- Chapter Five: Role of mitochondria in regulating immune response during bacterial infection
- Abstract
- 1: Introduction
- 2: Mitochondria and metabolism
- 3: Mitochondrial dynamics and molecular machineries
- 4: Mitochondria mediated immune pathways
- 5: Mitochondria mediated cell death and ATP generation
- 6: Mitochondria regulating immune functions against specific bacterial infections
- 7: Crosstalk between microbiome and mitochondria
- 8: Mitochondria centric therapeutics against bacterial infection
- 9: Conclusion and future direction
- Acknowledgments
- References
- Edition: 1
- Volume: 374
- Published: February 24, 2023
- No. of pages (Hardback): 208
- No. of pages (eBook): 208
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323994033
- eBook ISBN: 9780323994118
LG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USASM
Saverio Marchi
Saverio Marchi obtained his PhD in ‘Pharmacology and Molecular Oncology’ from University of Ferrara (Italy), under the supervision of Prof. Rosario Rizzuto, where he investigated the role of Ca2+ signalling and mitochondrial dynamics in cancer. He did a short term research stay at the Gustave Roussy Institute (Paris, France) in the Guido Kroemer’s lab, for the study of the mechanisms of autophagy regulation. On 2011 he joined the Laboratory of Dr. Paolo Pinton at the University of Ferrara (Italy) where he carried out his postdoctoral studies. During his postdoctoral training, he studied the implications of Endoplasmic Reticulum-mitochondria connection in diseases, especially cancer. In 2014, he was the recipient of the Young Researcher award, which allowed him to work at the Cancer Center, University of Hawai’i (Prof. Michele Carbone’s lab), where he was introduced to the study of the signalling pathways regulating mesothelioma progression. Now, he is associate professor at the Marche Polytechnic University, where he leads his own group. He is interested in the involvement of the MCU complex and mitochondrial Ca2+ in the evolution of cancer. More recently, he has become interested in the alteration of mitochondrial dynamics during bacterial infection.
He published 77 papers on “peer-reviewed” journals (h-index: 41; n° of citations > 5800. Source: Scopus).
Affiliations and expertise
Dept. of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, ItalyRead Mitochondria and Bacterial Pathogens - Part A on ScienceDirect