Receptor Endocytosis and Signalling in Health and Disease - Part B

1st Edition, Volume 196 - February 20, 2023
Editors: Indra Mani, Vijai Singh
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 5 5 9 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 5 6 0 - 7

Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors… Read more

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Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors which are associated with different organs and that play a key role in normal functioning in the body, including somatostatin, Mas receptor, AMPA, Dopamine, 5-HT1-2, GABA, GPCR, nuclear receptor, Integrin, BCR, CRHR1, etc. Chapters in this new release include Internalization of somatostatin receptors in brain and periphery, Mas receptor, signaling and trafficking in health and disease, Endocytosis of AMPA receptors: Role in neurological conditions, Endocytosis of dopamine receptor: Signaling in brain, and more.

Additional chapters cover Endocytosis of LXRs: Signalling in liver, Endocytosis of LDL receptor: Importance in cardiovascular diseases, Advances in the molecular level understanding of G-protein-coupled receptor, Nuclear receptor: Structure and function, Integrin receptor trafficking in health and disease, B Cell Receptor (BCR) endocytosis,CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling, and much more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Advances in the molecular level understanding of G-protein coupled receptor
Abstract
1: Introduction
2: Molecular basis of GPCR activation and its dynamic interaction with cellular components
3: GPCR in drug discovery, human health and diseases
4: Conclusion
References
Chapter Two: Prion receptors, prion internalization, intra- and inter-cellular transport
Abstract
1: Prion protein
2: Prion protein structure and processing
3: PrPC expression and functions
4: PrPC interactors
5: Intracellular routing of PrPC
6: Intercellular trafficking of PrPC
7: PrPC to PrPSc conversion
8: PrPSc structures
9: Intracellular routing of PrPSc
10: Intercellular trafficking PrPSc
11: Concluding remarks
References
Chapter Three: Internalization of somatostatin receptors in brain and periphery
Abstract
1: Introduction
2: Internalization of somatostatin receptors
3: Concluding remarks
References
Chapter Four: Endocytosis of AMPA receptors: Role in neurological conditions
Abstract
1: Overview on AMPA receptor structure and functions
2: Basal and activity-dependent trafficking and regulation of AMPA receptors
3: AMPA receptors in neurodevelopmental disorders
4: AMPARs in neurodegenerative disorders
5: Tumors
6: Traumatic brain injury, ischemic stroke, and seizures
7: Conclusion and outlook
References
Chapter Five: Endocytosis of dopamine receptor: Signaling in brain
Abstract
1: Introduction
2: Pharmacology of dopamine receptors
3: Physiological functions of endocytosis
4: Endocytosis of dopamine receptors
5: Signal transduction of dopamine receptors
6: Potential therapeutics for dopamine receptors-related disorders
7: Conclusion
References
Chapter Six: Endocytosis and signaling of 5-HT1A receptor
Abstract
1: Introduction
2: Ligand mediated internalization of 5-HT1A receptor
3: Role of clathrin adaptor protein in internalization of 5-HT1A receptor
4: Subcellular trafficking of 5-HT1A receptor
5: Role of short amino acid motif in the internalization and trafficking of 5-HT1A receptor
6: Signaling of 5-HT1A receptor
7: Conclusion and future perspectives
Conflict of interest
References
Chapter Seven: Endocytosis of GABA receptor: Signaling in nervous system
Abstract
1: Introduction
2: Neurotransmitters and their role
3: GABA
4: GABA receptors
5: Diseases associated to GABA/GABA receptors
6: Conclusion and future remarks
References
Chapter Eight: The endocytosis, trafficking, sorting and signaling of neurotrophic receptors
Abstract
1: Introduction
2: Neurotrophic receptor endocytosis and trafficking
3: Neurotrophic receptor signaling
4: Discussion and concluding remarks
Acknowledgments
References
Chapter Nine: Glutamate receptor endocytosis and signaling in neurological conditions
Abstract
1: Introduction
2: Types of glutamate receptor
3: Internalization and trafficking of metabotropic glutamate receptors
4: Internalization and trafficking of ionotropic glutamate receptors
5: Role of glutamate receptors in neurological diseases
6: Conclusion and future perspectives
References
Chapter Ten: Nuclear receptor: Structure and function
Abstract
1: Introduction
2: Classification of nuclear receptor superfamily
3: Nuclear receptor structure
4: The mechanism behind nuclear receptors functions
5: Positive regulation by nuclear receptors
6: Negative regulation by nuclear receptors
7: The role of NRs in various pathophysiological conditions
8: Future perspective
References
Chapter Eleven: CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling
Abstract
1: Introduction
2: The physiological framework of the extrahypothalamic CRH system
3: Dissecting CRH system signaling
4: Endocytosis: The end or a new beginning for CRHR1 signaling?
5: Prolonged signaling of CRHR1
6: Significance of prolonged signaling from endomembranes
7: Perspectives: CRH system signaling leading to discovery of drug targets
Acknowledgments
References
Chapter Twelve: Amyloid precursor protein in Alzheimer's disease
Abstract
1: Introduction
2: Structure of amyloid beta protein
3: Signaling and function of amyloid beta protein
4: CRISPR-based gene editing of amyloid precursor proteins
5: Treatment of Alzheimer's disease
6: Conclusion and future remarks
References
Chapter Thirteen: Integrin receptor trafficking in health and disease
Abstract
1: Introduction
2: Classical model of integrin trafficking
3: Trafficking of active and inactive integrins
4: Integrin modifications that effect trafficking
5: Integrin exocytosis using the exocyst complex
6: Small GTPases in integrin trafficking
7: Integrin trafficking in physiological contexts
8: Cell polarity and development
9: Pathophysiology associated with integrin trafficking
10: Integrin trafficking in immune cells
11: Tools and methods to study integrin trafficking
12: Conclusions and future directions
References
Chapter Fourteen: Synthetic receptors in medicine
Abstract
1: Introduction
2: Types of receptors
3: Synthetic receptors
4: Types of synthetic receptors
5: Applications of synthetic receptors in medicine
6: Conclusions and future perspective
References
Chapter Fifteen: Receptor biology: Challenges and opportunities
Abstract
1: Introduction
2: Chimeric antigen receptor T (CAR-T) cell therapy
3: Liver X receptors (LXRs) as therapeutic targets
4: G protein-coupled receptors (GPCRs) as therapeutic targets
5: Receptors as cancer drug targets
6: Receptor endocytosis and signaling associated disease
7: Conclusion and future perspectives
Conflict of interest
References
Index

Indra Mani

Dr. Indra Mani is an Assistant Professor in the Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India. He received M.Sc. in Microbiology from Bundelkhand University (BU), Jhansi, UP, India and Ph.D. in Biochemistry from Banaras Hindu University (BHU), Varanasi, UP, India. He completed postdoctoral training in the Department of Physiology, School of Medicine, Tulane University, New Orleans, USA. He has also worked as a Senior Research Officer (SRO) in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 10 years of research and teaching experience in Microbiology, Molecular Genetics, Cell Signaling, and Bioinformatics. He has published 49 articles in peer reviewed journals and 22 book chapters. He has presented several papers in the different national and international conferences. He has extensive experience in fluorescence/confocal microscopy, receptor internalization, trafficking and signaling, molecular cytogenetics, microbial characterization, and in silico analysis. He serves as a reviewer of peer-reviewed journals and also a member of national and international societies.

Affiliations and expertise

Assistant Professor, Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India

Vijai Singh

Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and expertise

Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health