Substance Use and Addiction Research
Methodology, Mechanisms, and Therapeutics
- 1st Edition - February 10, 2023
- Imprint: Academic Press
- Editors: Alan David Kaye, Richard D. Urman, Elyse M. Cornett, Amber Edinoff
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 8 8 1 4 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 6 2 7 - 4
Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance use and a… Read more
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Request a sales quoteSubstance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance use and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Use and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances.
The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions.
- Presents a practical, easy to read text designed to appeal to both experienced and beginner researchers in the field of substance abuse/addiction science
- Provides a concise, well-organized handbook that is a complete guide to methodologies in conducting substance abuse/addiction research
- Contains contributions from leading academic institutions
- Includes ample diagrams, tables and figures to help organize the information for easy reference, along with a list and explanation of existing useful measurement tools, websites, statistical methods and other resources
All researchers and clinician-scientists in the field of addiction science and substance abuse, including addiction counsellors, psychiatrists, psychologists, addiction medicine physicians, interventionalists, pain management specialists, and substance abuse social workers; intended for both seasoned researchers and clinicians as well as students and trainees at all levels (undergraduate, graduate, post-graduate
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Foreword
- Part 1: Research methodology for clinical trials, animal research, and retrospective studies
- Chapter 1. Reliability and validity in substance misuse and addiction research
- Abstract
- Introduction
- Reliability
- Validity
- References
- Chapter 2. Animal models
- Abstract
- Introduction
- Self-administration
- Schedules of reinforcement
- Conditioned place preference
- Drug discrimination
- Other topics in animal research
- References
- Chapter 3. Translational research strategies
- Abstract
- Translational research
- Neurobiology of substance use disorders and addictions
- Synaptic plasticity
- Genetics
- Epigenetics
- References
- Chapter 4. Experimental designs for addiction research
- Abstract
- Introduction
- Paper 1
- Paper 2: observational study
- Paper 3: experimental design
- Conclusion
- References
- Chapter 5. Experimental design in clinical trials
- Abstract
- Introduction
- Target population and recruitment
- Sample size; outcome measures
- Statistical analyses
- Scales in addiction
- Modes of data collection (surveys, interviews, etc.)
- Conclusion
- References
- Chapter 6. Qualitative and quantitative research methods
- Abstract
- Theory
- Collecting and organizing data
- Conclusion
- References
- Chapter 7. Ethical issues in substance misuse and addiction-related research
- Abstract
- Introduction
- Major ethical frameworks
- Closing remarks
- References
- Chapter 8. Informatics
- Abstract
- Introduction
- Informatics ethics
- Clinical Research Informatics Applications
- Conclusion
- References
- Chapter 9. Artificial intelligence and machine learning
- Abstract
- Introduction
- Natural language processing
- Applicability to addiction medicine
- Limitations and considerations
- Conclusion
- References
- Chapter 10. Methods for data collection and analysis in epidemiology-of-substance-use research
- Abstract
- Introduction
- Large cross-section observational surveys
- National Survey of Drug Use and Health
- National Epidemiologic Survey on Alcohol and Related Conditions
- Monitoring the Future Study
- Prospective studies
- Case-control studies
- Genetic epidemiology study designs
- Limitations
- Conclusions
- References
- Chapter 11. Utility of neuroimaging for substance misuse and addiction research: methodology, mechanisms, and therapeutics
- Abstract
- Introduction
- Structural magnetic resonance imaging and functional magnetic resonance imaging
- Magnetic resonance spectroscopy
- Positron emission tomography
- Single-photon emission computed tomography
- Conclusion
- References
- Chapter 12. Systematic review and meta-analysis
- Abstract
- Introduction
- Methodology
- Statistical methods
- Methodology checklists
- Examples of meta-analyses studying substance misuse risk factors
- Examples of meta-analyses studying substance misuse management
- Conclusion
- References
- Part 2: Mechanisms of drug misuse and addiction
- Chapter 13. Misuse and addiction definitions, demographics, and general concepts
- Abstract
- Introduction
- Definition of substance-related and addiction disorders
- Demographics
- General concepts and conclusion
- References
- Chapter 14. Assessment of addiction/pain and neurobiology
- Abstract
- Introduction
- Assessing different forms of pain
- Assessing addiction
- The neurobiology of pain
- The neurobiology of addiction
- References
- Chapter 15. Physiological considerations in opioid addiction
- Abstract
- Introduction
- Normal physiology and anatomy
- Pathophysiologic considerations
- Stages of addiction
- Neurotransmitters and projections
- Stress and relapse
- Motive circuit
- Conclusion
- References
- Chapter 16. Basic pharmacology of opioid substances
- Abstract
- Introduction
- Pharmacokinetics
- Pharmacodynamics
- Drug interactions
- References
- Chapter 17. Basic pharmacology of nonopioid substances
- Abstract
- Introduction
- Nicotine
- Cocaine
- Amphetamines
- Sedatives and tranquilizers
- References
- Chapter 18. Types of addiction
- Abstract
- Introduction
- Overview
- Specific drug addictions
- Discussion
- References
- Chapter 19. Substance misuse
- Abstract
- Introduction
- Definitions
- Risk factors and protective factors to substance misuse
- Diagnosis of substance misuse
- Conclusion
- References
- Chapter 20. Special study populations
- Abstract
- Introduction
- Women and pregnant women
- Pediatrics
- Elderly
- Conclusion
- References
- Further reading
- Part 3: Investigative therapeutics: designing and measuring outcomes
- Chapter 21. General therapy strategies in opioid addiction
- Abstract
- Introduction
- Therapy and groups for treatment of opioid use disorder
- Other individual-based therapy
- Medication-assisted treatment
- Detoxification
- Opioid sparing drugs
- Conclusion
- References
- Further reading
- Chapter 22. The role of alternative therapies in a comprehensive addiction treatment
- Abstract
- Introduction
- Addiction in general
- Neurobiological evidence of addiction
- The role of complementary alternative medicine in the treatment of addictions
- Strategy for implementing acupuncture as part of the rehabilitation program
- References
- Chapter 23. Drug testing and adherence monitoring
- Abstract
- Introduction
- Biological specimens that can be drug tested with a focus on urine
- Drug testing methods
- Metabolism of illicit and prescribed drugs
- Conclusion
- References
- Chapter 24. Pharmacogenetics: a comprehensive review of genes, genetics, genomics, and epigenetics
- Abstract
- Introduction
- Alcohol use, metabolism, and pharmacogenetics
- Opioid use, metabolism, and pharmacogenetics
- Nicotine use, metabolism, and pharmacogenetics
- Pharmacogenetics and epigenetics studies
- Conclusion
- References
- Chapter 25. Medical treatments for opioid use disorder
- Abstract
- Introduction
- Opioid overdose: detection and intervention
- Opioid withdrawal symptoms: assessment and treatment
- Medications for opioid use disorder
- Role of psychosocial interventions in opioid use disorder treatment
- Summary
- References
- Chapter 26. Principles of vaccine development
- Abstract
- Introduction
- Components of a vaccine
- Food and Drug Administration recommendations
- Conclusion
- References
- Chapter 27. Drug policy analysis
- Abstract
- Introduction
- Comparative drug policy analysis
- Drug policies versus laws
- Drug policy reform
- Health impact of drug policy based on enforcement of prohibition
- Conclusion
- References
- Chapter 28. Designing and testing population-based prevention programs
- Abstract
- Introduction
- Why do most drug prevention programs fail?
- School-based prevention programs
- Advances and future directions for population-based prevention programs
- Conclusion
- References
- Chapter 29. New vistas in addiction therapy
- Abstract
- Introduction
- Revised definitions
- Binge intoxication
- Withdrawal syndrome
- Craving
- Abstinence
- Naltrexone implants
- Buprenorphine implants and depot injections
- The perverse economics of opiate maintenance programs
- Conclusion
- References
- Further reading
- Index
- Edition: 1
- Published: February 10, 2023
- No. of pages (Paperback): 446
- No. of pages (eBook): 446
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323988148
- eBook ISBN: 9780323986274
AK
Alan David Kaye
Alan David Kaye, MD, PhD, is the Professor and Chairman of the Department of Anesthesiology at LSU Health Sciences Center in New Orleans since January 2005. He is Board Certified as a Consultant in Anesthesiology and has a special certificate in Pain Management for the American Board of Anesthesiology. He is also a Diplomate of the American Board of Pain Medicine and the American Board of Interventional Pain Physicians. His PhD is in pharmacology, and he was awarded first place in the National Student Research Forum as a resident. He has authored or co-authored over 150 abstracts and 200 manuscripts and book chapters in the fields of pulmonary vascular pharmacology and anesthesiology. He serves on a number of national committees including as a National Board of Directors of ASIPP and ABIPP. He is editor-in-chief of the journal Pain Physicians and is on the FDA Advisory Board on Anesthetics and Analgesics.
Affiliations and expertise
Department of Anesthesiology, School of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Louisiana Addiction Research Center, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Departments of Anesthesiology and Pharmacology, School of MeRU
Richard D. Urman
Richard D. Urman, MD, MBA, FASA is a staff anesthesiologist at the Brigham and Women’s Hospital in Boston, MA and Associate Professor of Anesthesia at Harvard Medical School. He currently serves as Associate Chair for Dana-Farber Cancer Institute, as well as Medical Director of Sedation for Interventional Medicine, Director, Center for Perioperative Research (C.P.R.), and Perioperative Medicine Fellowship Director. He is also the founder of the Incubator for Patient Safety and Outcomes (IPSO).
Dr. Urman received his MD from Harvard Medical School and MBA from Harvard Business School, and completed a residency in anesthesia at Beth Israel Deaconess Medical Center. On the national level, Dr. Urman currently serves on various committees of the American Society of Anesthesiologists (ASA) including as Chair of the subcommittee on Patient Safety and Practice Management, Foundation of Anesthesia Education and Research (FAER), Society for Preoperative Assessment and Quality Improvement, and Enhanced Recovery After Surgery-USA.
Affiliations and expertise
Associate Chair for Dana-Farber Cancer Institute; Associate Professor and Director of the Perioperative Medicine Fellowship in the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USAEC
Elyse M. Cornett
Affiliations and expertise
Department of Anesthesiology, School of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Louisiana Addiction Research Center, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Department of Anesthesiology, School of Medicine, Louisiana StaAE
Amber Edinoff
Affiliations and expertise
Harvard Medical School, Massachusetts General Hospital, Department of Psychiatry, Boston, MA, United StatesRead Substance Use and Addiction Research on ScienceDirect