Comparative Mammalian Immunology
The Evolution and Diversity of the Immune Systems of Mammals
- 1st Edition - February 9, 2023
- Author: Ian R. Tizard
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 2 1 9 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 2 2 0 - 0
Comparative Mammalian Immunology: The Evolution and Diversity of the Immune Systems of Mammals provides a review on the current knowledge of mammalian immune systems from a compara… Read more
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Request a sales quoteComparative Mammalian Immunology: The Evolution and Diversity of the Immune Systems of Mammals provides a review on the current knowledge of mammalian immune systems from a comparative viewpoint. This reference encompasses recent work on the immune systems of marine mammals, bats and marsupials in addition to other lesser-known species, with the immune systems of humans and laboratory mice as components of chapters on primates and rodents respectively. The book also makes use of the most recent studies on the genomic sequences of the mammals to identify both common and unique features of each mammal's immune system.
The book elucidates the complex, but coordinated and controlled series of interactions involving cells and molecules that has evolved to protect the host against disease. Mammals consist of a highly diverse group of animals in which the immune system has been subjected to a variety of selective pressures. This is reflected in differences in the organization and function of their immune systems, and is especially seen in those gene families characterized by complexity and polymorphism.
- Demonstrates multiple diverse pathways and mechanisms to optimize resistance and survival in the face of infectious diseases
- Shows the clear patterns of emergence of different immunologic traits among the diverse orders of mammals
- Reflects issues with innate or adaptive immune systems
- Serves as a comprehensive review of the current state of knowledge of the immune system of each mammalian order
Immunologists, Comparative Biologists, Evolutionary Scientists, Mammologists, Geneticists Possibly some Veterinarians and interested laypersons Advanced
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- What are its features?
- What are its weak links?
- What is next?
- Acknowledgments
- Acronyms
- Immunologists are incorrigible users of acronyms. Here are some that are widely employed in this text
- Section 1: Mammalian immunology
- Chapter 1. The evolution of the mammals and their immune systems
- Abstract
- 1.1 Amniotes
- 1.2 The origins of the mammals
- 1.3 Mammalian phylogeny
- 1.4 The evolution of mammalian immunity
- References
- Chapter 2. The evolution of viviparity
- Abstract
- 2.1 The evolution of the placenta
- 2.2 Transfer of immunoglobulins
- 2.3 Maternal-fetal tolerance
- 2.4 Mechanisms of tolerance
- 2.5 Regulatory cells
- 2.6 Other immunosuppressive mechanisms
- References
- Chapter 3. The evolution and role of lactation
- Abstract
- 3.1 The origins of lactation
- 3.2 The functions of milk
- 3.3 Lactation and the microbiota
- 3.4 Adaptive immunity
- 3.5 Colostrum
- 3.6 Milk
- References
- Chapter 4. Endothermy and immunity
- Abstract
- 4.1 The evolution of endothermy and homeothermy
- 4.2 The benefits of endothermy
- 4.3 The role of brown adipose tissue
- 4.4 Fevers
- 4.5 Fevers, fungi, and the rise of the mammals
- References
- Chapter 5. The microbiota–immune system relationship
- Abstract
- 5.1 Herbivores
- 5.2 Carnivores
- 5.3 The microbiota–immune relationship
- 5.4 The location of the microbiota
- 5.5 The functions of the microbiota
- 5.6 Dysbiosis
- 5.7 Behaviors
- 5.8 Environmental microbiota
- References
- Chapter 6. Innate immunity: basic features
- Abstract
- 6.1 Constitutive innate immunity
- 6.2 Induced innate immunity
- 6.3 Inflammasomes
- 6.4 Inflammatory cytokines
- 6.5 Leukocytes
- 6.6 The costs of innate immunity
- References
- Chapter 7. The mammalian major histocompatibility complex
- Abstract
- 7.1 Major histocompatibility complex structure
- 7.2 Major histocompatibility complex class Ia molecules
- 7.3 Major histocompatibility complex class II molecules
- 7.4 Major histocompatibility complex class III molecules
- 7.5 Mammalian variations
- 7.6 Major histocompatibility complex and body odors
- References
- Chapter 8. T Cells and their receptors
- Abstract
- 8.1 Flexible immunity
- 8.2 T cell evolution
- 8.3 T cell antigen receptors
- 8.4 T cell antigen receptor functions
- 8.5 Antigen receptor diversity
- 8.6 T cell receptor diversity
- 8.7 γ/δ T cells
- 8.8 Memory T cells
- References
- Chapter 9. Mammalian B cells
- Abstract
- 9.1 Before the mammals
- 9.2 B cell antigen receptor structure
- 9.3 B cell antigen receptor diversity
- 9.4 Evolution
- 9.5 Generation of immunoglobulin diversity
- References
- Chapter 10. Mammalian innate lymphoid cells
- Abstract
- 10.1 Innate helper cells
- 10.2 Natural killer cells
- 10.3 Nature killer cell receptors
- 10.4 “Trained” immunity
- 10.5 Natural killer cell subsets
- 10.6 Natural killer T cells
- References
- Chapter 11. The mammalian lymphoid system
- Abstract
- 11.1 Sources of lymphocytes
- 11.2 Primary lymphoid organs
- 11.3 Thymus
- 11.4 Peyer’s patches
- 11.5 Bone marrow
- 11.6 Secondary lymphoid organs
- 11.7 Spleen
- 11.8 Lymph nodes
- References
- Section 2: Mammalian orders
- Chapter 12. The monotremes: echidnas and platypus
- Abstract
- 12.1 Reproduction
- 12.2 Hematology
- 12.3 Innate immunity
- 12.4 Lymphoid tissues
- 12.5 B cells and immunoglobulins
- 12.6 T cells and cell-mediated immunity
- References
- Chapter 13. Marsupials: Opossums to Kangaroos
- Abstract
- 13.1 Reproduction and lactation
- 13.2 Hematology
- 13.3 Innate immunity
- 13.4 Lymphoid organs
- 13.5 The marsupial MHC
- 13.6 B cells and immunoglobulins
- 13.7 T cells and cell-mediated immunity
- References
- Chapter 14. Tylopoda: Camels and llamas
- Abstract
- 14.1 Reproduction and lactation
- 14.2 Hematology
- 14.3 Innate immunity
- 14.4 Lymphoid organs
- 14.5 The major histocompatibility complex
- 14.6 B cells and Immunoglobulins
- 14.7 Heavy-chain-only antibodies
- 14.8 New-world camels
- 14.9 T cells and cell-mediated immunity
- References
- Chapter 15. Suiformes: Pigs and Peccaries
- Abstract
- 15.1 Reproduction and lactation
- 15.2 Hematology
- 15.3 Innate immunity
- 15.4 Lymphoid organs
- 15.5 Major histocompatibility complex
- 15.6 B cells and immunoglobulins
- 15.7 B cell receptor development
- 15.8 T cells and cell-mediated immunity
- References
- Chapter 16. The cetaceans: whales and dolphins
- Abstract
- 16.1 Reproduction and lactation
- 16.2 Hematology
- 16.3 Innate immunity
- 16.4 Lymphoid organs
- 16.5 The major histocompatibility complex
- 16.6 B cells and immunoglobulins
- 16.7 T cells and cell-mediated immunity
- References
- Chapter 17. Ruminants: cattle, sheep, and goats
- Abstract
- 17.1 Reproduction and lactation
- 17.2 Hematology
- 17.3 Innate immunity
- 17.4 Lymphoid organs
- 17.5 The major histocompatibility complex
- 17.6 B cells and immunoglobulins
- 17.7 T cells and cell-mediated immunity
- 17.8 Sheep (Ovis aires) and goats (Capra hircus)
- 17.9 Reproduction and lactation
- 17.10 Innate immunity
- 17.11 Lymphoid organs
- 17.12 Major histocompatibility complex
- 17.13 B cells and immunoglobulins
- 17.14 T cells and cell-mediated immunity
- 17.15 Other species
- References
- Chapter 18. Chiropterans: the bats
- Abstract
- 18.1 Reproduction and lactation
- 18.2 Hematology
- 18.3 Innate immunity
- 18.4 Lymphoid organs
- 18.5 The major histocompatibility complex
- 18.6 B cells and immunoglobulins
- 18.7 T cells and cell-mediated immunity
- References
- Chapter 19. Feliformes: The cats and their relatives
- Abstract
- 19.1 The evolution of carnivory
- 19.2 Dendritic cells
- 19.3 Cytokines
- 19.4 Bronchus-associated lymphoid tissue
- 19.5 Mucosal lymphoid tissues
- 19.6 The natural killer cell receptor complex
- 19.7 Other cats
- 19.8 Hyenas
- References
- Chapter 20. Caniforms: Dogs, bears, and their relatives
- Abstract
- 20.1 The domestic dog (Canis lupus familiaris)
- 20.2 Hematology
- 20.3 Innate immunity
- 20.4 Lymphoid organs
- 20.5 Major histocompatibility complex
- 20.6 B cells and immunoglobulins
- 20.7 T cells and cell-mediated immunity
- 20.8 MUSTELIDS
- 20.9 PROCYONIDS
- 20.10 URSIDS
- 20.11 PINNIPEDS
- References
- Chapter 21. The perissodactyls: horses and their relatives
- Abstract
- 21.1 Reproduction and lactation
- 21.2 Hematology
- 21.3 Innate immunity
- 21.4 Lymphoid organs
- 21.5 The major histocompatibility complex
- 21.6 B cells and immunoglobulins
- 21.7 T cells and cell-mediated immunity
- References
- Chapter 22. The Lagomorpha: rabbits, hares, and picas
- Abstract
- 22.1 Reproduction and lactation
- 22.2 Hematology
- 22.3 Innate immunity
- 22.4 Lymphoid organs
- 22.5 Major histocompatibility complex
- 22.6 B cells and immunoglobulins
- 22.7 Appendix
- 22.8 Other mammals
- 22.9 T cells and cell-mediated immunity
- References
- Chapter 23. The rodents: mice, rats, and their relatives
- Abstract
- 23.1 Wild rodents versus laboratory rodents
- 23.2 Myomorpha (rats and mice)
- 23.3 Reproduction and lactation
- 23.4 Hematology
- 23.5 Innate immunity
- 23.6 Lymphoid organs
- 23.7 Major histocompatibility complex
- 23.8 B cells and immunoglobulins
- 23.9 T cells and cell-mediated immunity
- 23.10 Rats (Rattus norvegicus)
- 23.11 Other rodents
- References
- Chapter 24. The primates: humans and their relatives
- Abstract
- 24.1 Infectious disease history
- 24.2 Reproduction and lactation
- 24.3 Hematology
- 24.4 Innate immunity
- 24.5 Lymphoid organs
- 24.6 Major histocompatibility complex
- 24.7 B cells and immunoglobulins
- 24.8 T cells and cell-mediated immunity
- References
- Chapter 25. The Afrotheria: Elephants, manatees, and their relatives
- Abstract
- 25.1 Elephants
- 25.2 MANATEES
- 25.3 Mammalian life-spans
- 25.4 The r/K trade-off
- 25.5 Body mass and immunity
- References
- Chapter 26. Four other orders: the Xenarthra, the Scandentia, the Eulipotyphla, and the Pholidota
- Abstract
- 26.1 Xenarthra: sloths, armadillos, and anteaters
- 26.2 Scandentia. The tree-shrews
- 26.3 Eulipotyphla. The shrews
- 26.4 Pholidota. The Pangolins
- References
- Index
- No. of pages: 458
- Language: English
- Edition: 1
- Published: February 9, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323952194
- eBook ISBN: 9780323952200
IT
Ian R. Tizard
Ian R. Tizard, BVMS, BSc, PhD, DSc (Hons), DACVM, is a Diplomate of the American College of Veterinary Microbiologists and a University Distinguished Professor Emeritus of Immunology, Department of Veterinary Pathobiology, The Texas Veterinary Medical Center at Texas A &M University (TAMU), College Station, Texas, USA. Dr. Tizard earned his Bachelor of Veterinary Medicine and Surgery from the University of Edinburgh, Scotland, in 1965. He then completed a Bachelor of Science in Pathology and a PhD in Immunology. After completing his studies, Dr. Tizard became a Post-Doctoral Fellow at the University of Guelph, where he remained as a professor until 1982 when he moved to TAMU. Dr. Tizard wrote the first standardized textbook on Veterinary Immunology in 1977. This text, now in its 11th edition, is used worldwide, and has played a major role in establishing Immunology among the key disciplines.
Affiliations and expertise
University Distinguished Professor of Immunology Emeritus, Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, USARead Comparative Mammalian Immunology on ScienceDirect