Antimicrobial Dressings
The Wound Care Applications
- 1st Edition - February 10, 2023
- Editors: Raju Khan, Sorna Gowri
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 0 7 4 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 0 7 5 - 6
Antimicrobial Dressings: The Wound Care Applications explores the literature surrounding the catalytic behavior of proteolytic enzymes immobilized together with nanopa… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteAntimicrobial Dressings: The Wound Care Applications explores the literature surrounding the catalytic behavior of proteolytic enzymes immobilized together with nanoparticles. As numerous applications using proteolytic enzymes for debridement, silver as antibiotic and nanoparticles for enzyme immobilization were developed in the last years, this book explores interdisciplinary information combining nanotechnology, biotechnology and medicine and how it's still in early stages. The book adopts a holistic approach in a lifecycle context to evaluate their final feasibility, including industrial exploitability without disregard of the potential risks of enzymes and nanomaterials to human health and the environment.
- Describes the drawback of using unstable enzymes in wound debridement such as infections, irritations, low availability, rapid elimination from the body, and impossibility of creating a high local concentration of the preparation without increasing its systemic concentration
- Provides information on higher efficient antimicrobial property and enzyme stability using nanoparticles as carriers for enzyme immobilization due to minimum diffusional limitation, maximum surface area per unit mass, and high enzyme loading
- Discusses the physical characteristics of the nanoparticles through multilayer polyelectrolytes encasing, such as diffusion and particle mobility that will influence the catalytic activity, pH and thermal stability of attached enzymes
Universities, institutes, and industrial Units, R&D institutes in microbiology, biotechnology, immunology students microbiologists / engineering colleges and universities/ Industrialists, Graduate students of research and development in the field of nanotechnology, medical and healthcare workers, commercial industries
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Overview and summary of antimicrobial wound dressings and its biomedical applications
- Abstract
- List of abbreviations
- 1.1 Introduction
- 1.2 Pathophysiology of wound and healing process
- 1.3 Wound dressings
- 1.4 Ideal wound dressing requirements
- 1.5 Antimicrobial wound dressing
- 1.6 Antimicrobial agents for wound dressing
- 1.7 Conclusions and future perspectives
- Competing interests declaration
- Acknowledgments
- References
- Chapter 2. Traditional and modern wound dressings—characteristics of ideal wound dressings
- Abstract
- 2.1 Introduction
- 2.2 Wound dressings from passive to smart dressings
- 2.3 Ideal wound dressings requirements
- 2.4 Traditional wound dressings
- 2.5 Types of traditional wound dressings
- 2.6 Limitations of traditional wound dressings
- 2.7 Smart wound dressings
- 2.8 Biomechanical wound dressing
- 2.9 pH responsive wound dressing
- 2.10 Thermo-responsive wound dressing
- 2.11 Self-healing wound dressing for motional wound
- 2.12 Wound dressing for infection monitoring
- 2.13 Conclusion and prospects
- References
- Chapter 3. Nanoparticles as potential antimicrobial agents for enzyme immobilization in antimicrobial wound dressings
- Abstract
- 3.1 Introduction
- 3.2 Antimicrobial activity of nanoparticles
- 3.3 Pathophysiology of wound healing
- 3.4 Antimicrobial wound dressings
- 3.5 Conclusions and future prospects
- References
- Chapter 4. Polyelectrolyte assembly with nanoparticle-immobilized enzymes
- Abstract
- 4.1 Introduction
- 4.2 Enzyme immobilization methods
- 4.3 Recent advancement in enzyme immobilization
- 4.4 Polyelectrolyte assembly and fabrication
- 4.5 Layer-by-layer assembly for immobilization of enzyme
- 4.6 Further applications of layer-by-layer assembly
- 4.7 Conclusion
- Acknowledgments
- Authors’ contributions
- Conflict of Interest
- References
- Chapter 5. Role of debridement and its biocompatibility in antimicrobial wound dressings
- Abstract
- 5.1 Introduction
- 5.2 Wound
- 5.3 Wound healing
- 5.4 Debridement
- 5.5 Debridement in different wounds
- 5.6 Biocompatibility and safety evaluation for the debridement process
- 5.7 Postdebridement
- 5.8 Wound dressing
- 5.9 New technique other than traditional debridement
- 5.10 Concluding remarks
- Acknowledgment
- References
- Chapter 6. Different methods for nanomaterial-based immobilization of enzymes
- Abstract
- 6.1 Introduction
- 6.2 Enzyme immobilization
- 6.3 Properties of immobilized enzymes
- 6.4 Methods of immobilization
- 6.5 Nanoparticles as immobilization matrix
- 6.6 Conclusions
- Acknowledgment
- References
- Chapter 7. Kinetic, stability, and activity of the nanoparticles-immobilized enzymes
- Abstract
- List of abbreviations
- 7.1 Introduction
- 7.2 Active nanoparticles-immobilized enzymes
- 7.3 Immobilized antimicrobial hydrolytic enzymes
- 7.4 Immobilized proteases nanoparticles
- 7.5 Immobilized antimicrobial oxidoreductases
- 7.6 Choice of immobilization method and nanoparticles
- 7.7 Kinetics of nanoparticles-immobilized enzymes
- Acknowledgment
- References
- Chapter 8. Antibacterial hydrogel dressings and their applications in wound treatment
- Abstract
- 8.1 Introduction
- 8.2 Contact-killing-based hydrogels
- 8.3 Release-killing-based hydrogels
- 8.4 Stimuli-responsive hydrogels
- 8.5 Sensor and imaging hydrogels for wound healing
- 8.6 Concluding remarks and future perspectives
- References
- Chapter 9. Medicated wound dressings
- Abstract
- 9.1 Introduction
- 9.2 General wound healing mechanism
- 9.3 Integra
- 9.4 Nanoparticles and nanomaterials
- References
- Chapter 10. Clinical effectiveness of antimicrobial dressings
- Abstract
- 10.1 Introduction
- 10.2 Types of wounds & factors affecting healing
- 10.3 Wound microbiology
- 10.4 What are antimicrobial dressings
- 10.5 Dressings with antiseptic agents
- 10.6 Conclusions
- References
- Chapter 11. Future research directions of antimicrobial wound dressings
- Abstract
- 11.1 Introduction
- 11.2 The areas that need a particular emphasis on antimicrobial activity
- 11.3 The need for different antimicrobial agents in wound healing
- 11.4 The different antimicrobial agents and their mode of action in wound healing
- 11.5 The different methods under consideration for preventing wounds from microbes
- 11.6 Future perspective of wound dressings
- 11.7 Conclusion
- References
- Index
- No. of pages: 268
- Language: English
- Edition: 1
- Published: February 10, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323950749
- eBook ISBN: 9780323950756
RK
Raju Khan
Raju Khan is a Senior Principal Scientist and Professor, at CSIR-Advanced Materials and Processes Research Institute, Bhopal. He did his PhD in Chemistry in 2005 from Jamia Millia Islamia, Central University, New Delhi, and Postdoctoral researcher at the “Sensor Research Laboratory” University of the Western Cape, Cape Town. His current research involved synthesizing novel materials to fabricate electrochemical and fluorescence-based biosensors integrated with microfluidics to detect target disease risk biomarkers for health care monitoring. He has published over 150 papers in SCI journal, which attracted over 5500 citations as per Google Scholar, published 45 book chapters in the reputed book Elsevier and Taylor Francis, editing of 28 books from Elsevier and Taylor Francis, and his research has been highlighted in Nature India. He has supervised 5 PhD and 30 undergraduate/postgraduate theses and has supervised 4 numbers of postdoctoral fellows under the scheme of N-PDF, CSIR-Nehru Fellowship, and DST-Women Scientist Projects.
Affiliations and expertise
Senior Principal Scientist & Professor, CSIR-Advanced Materials & Processes Research Institute, Bhopal, Madhya Pradesh, IndiaSG
Sorna Gowri
V Sorna Gowri PhD is currently working as a Principal Technical officer, in CSIR-Advanced Materials and Processes Research Institute (AMPRI. Her recent research is on development of multifunctional nanocoatings on textiles. She has more than 21 years of R&D experience in CSIR-AMPRI, Bhopal Govt. of India. She worked as a Postdoctoral Fellow at Institute Curie, Paris France, and also worked as a Postdoctoral Fellow at University of Minho. Dr. S. Gowri was involved in synthesizing polymer nanocomposites for multifunctional surface coatings. She has published more than 21 SCI journals, Granted and Filed 2 patents. She is also team member of two technology transfers to industries
Affiliations and expertise
Principal Technical officer, CSIR-Advanced Materials and Processes Research Institute (AMPRI), Bhopal, IndiaRead Antimicrobial Dressings on ScienceDirect