Antimicrobial Dressings

The Wound Care Applications

1st Edition - February 10, 2023
Editors: Raju Khan, Sorna Gowri
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 0 7 4 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 0 7 5 - 6

Antimicrobial Dressings: The Wound Care Applications explores the literature surrounding the catalytic behavior of proteolytic enzymes immobilized together with nanopa… Read more

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Antimicrobial Dressings: The Wound Care Applications explores the literature surrounding the catalytic behavior of proteolytic enzymes immobilized together with nanoparticles. As numerous applications using proteolytic enzymes for debridement, silver as antibiotic and nanoparticles for enzyme immobilization were developed in the last years, this book explores interdisciplinary information combining nanotechnology, biotechnology and medicine and how it's still in early stages. The book adopts a holistic approach in a lifecycle context to evaluate their final feasibility, including industrial exploitability without disregard of the potential risks of enzymes and nanomaterials to human health and the environment.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Chapter 1. Overview and summary of antimicrobial wound dressings and its biomedical applications
Abstract
List of abbreviations
1.1 Introduction
1.2 Pathophysiology of wound and healing process
1.3 Wound dressings
1.4 Ideal wound dressing requirements
1.5 Antimicrobial wound dressing
1.6 Antimicrobial agents for wound dressing
1.7 Conclusions and future perspectives
Competing interests declaration
Acknowledgments
References
Chapter 2. Traditional and modern wound dressings—characteristics of ideal wound dressings
Abstract
2.1 Introduction
2.2 Wound dressings from passive to smart dressings
2.3 Ideal wound dressings requirements
2.4 Traditional wound dressings
2.5 Types of traditional wound dressings
2.6 Limitations of traditional wound dressings
2.7 Smart wound dressings
2.8 Biomechanical wound dressing
2.9 pH responsive wound dressing
2.10 Thermo-responsive wound dressing
2.11 Self-healing wound dressing for motional wound
2.12 Wound dressing for infection monitoring
2.13 Conclusion and prospects
References
Chapter 3. Nanoparticles as potential antimicrobial agents for enzyme immobilization in antimicrobial wound dressings
Abstract
3.1 Introduction
3.2 Antimicrobial activity of nanoparticles
3.3 Pathophysiology of wound healing
3.4 Antimicrobial wound dressings
3.5 Conclusions and future prospects
References
Chapter 4. Polyelectrolyte assembly with nanoparticle-immobilized enzymes
Abstract
4.1 Introduction
4.2 Enzyme immobilization methods
4.3 Recent advancement in enzyme immobilization
4.4 Polyelectrolyte assembly and fabrication
4.5 Layer-by-layer assembly for immobilization of enzyme
4.6 Further applications of layer-by-layer assembly
4.7 Conclusion
Acknowledgments
Authors’ contributions
Conflict of Interest
References
Chapter 5. Role of debridement and its biocompatibility in antimicrobial wound dressings
Abstract
5.1 Introduction
5.2 Wound
5.3 Wound healing
5.4 Debridement
5.5 Debridement in different wounds
5.6 Biocompatibility and safety evaluation for the debridement process
5.7 Postdebridement
5.8 Wound dressing
5.9 New technique other than traditional debridement
5.10 Concluding remarks
Acknowledgment
References
Chapter 6. Different methods for nanomaterial-based immobilization of enzymes
Abstract
6.1 Introduction
6.2 Enzyme immobilization
6.3 Properties of immobilized enzymes
6.4 Methods of immobilization
6.5 Nanoparticles as immobilization matrix
6.6 Conclusions
Acknowledgment
References
Chapter 7. Kinetic, stability, and activity of the nanoparticles-immobilized enzymes
Abstract
List of abbreviations
7.1 Introduction
7.2 Active nanoparticles-immobilized enzymes
7.3 Immobilized antimicrobial hydrolytic enzymes
7.4 Immobilized proteases nanoparticles
7.5 Immobilized antimicrobial oxidoreductases
7.6 Choice of immobilization method and nanoparticles
7.7 Kinetics of nanoparticles-immobilized enzymes
Acknowledgment
References
Chapter 8. Antibacterial hydrogel dressings and their applications in wound treatment
Abstract
8.1 Introduction
8.2 Contact-killing-based hydrogels
8.3 Release-killing-based hydrogels
8.4 Stimuli-responsive hydrogels
8.5 Sensor and imaging hydrogels for wound healing
8.6 Concluding remarks and future perspectives
References
Chapter 9. Medicated wound dressings
Abstract
9.1 Introduction
9.2 General wound healing mechanism
9.3 Integra
9.4 Nanoparticles and nanomaterials
References
Chapter 10. Clinical effectiveness of antimicrobial dressings
Abstract
10.1 Introduction
10.2 Types of wounds & factors affecting healing
10.3 Wound microbiology
10.4 What are antimicrobial dressings
10.5 Dressings with antiseptic agents
10.6 Conclusions
References
Chapter 11. Future research directions of antimicrobial wound dressings
Abstract
11.1 Introduction
11.2 The areas that need a particular emphasis on antimicrobial activity
11.3 The need for different antimicrobial agents in wound healing
11.4 The different antimicrobial agents and their mode of action in wound healing
11.5 The different methods under consideration for preventing wounds from microbes
11.6 Future perspective of wound dressings
11.7 Conclusion
References
Index

Raju Khan

Raju Khan is a Senior Principal Scientist and Professor, at CSIR-Advanced Materials and Processes Research Institute, Bhopal. He did his PhD in Chemistry in 2005 from Jamia Millia Islamia, Central University, New Delhi, and Postdoctoral researcher at the “Sensor Research Laboratory” University of the Western Cape, Cape Town. His current research involved synthesizing novel materials to fabricate electrochemical and fluorescence-based biosensors integrated with microfluidics to detect target disease risk biomarkers for health care monitoring. He has published over 150 papers in SCI journal, which attracted over 5500 citations as per Google Scholar, published 45 book chapters in the reputed book Elsevier and Taylor Francis, editing of 28 books from Elsevier and Taylor Francis, and his research has been highlighted in Nature India. He has supervised 5 PhD and 30 undergraduate/postgraduate theses and has supervised 4 numbers of postdoctoral fellows under the scheme of N-PDF, CSIR-Nehru Fellowship, and DST-Women Scientist Projects.

Affiliations and expertise

Senior Principal Scientist & Professor, CSIR-Advanced Materials & Processes Research Institute, Bhopal, Madhya Pradesh, India

Sorna Gowri

V Sorna Gowri PhD is currently working as a Principal Technical officer, in CSIR-Advanced Materials and Processes Research Institute (AMPRI. Her recent research is on development of multifunctional nanocoatings on textiles. She has more than 21 years of R&D experience in CSIR-AMPRI, Bhopal Govt. of India. She worked as a Postdoctoral Fellow at Institute Curie, Paris France, and also worked as a Postdoctoral Fellow at University of Minho. Dr. S. Gowri was involved in synthesizing polymer nanocomposites for multifunctional surface coatings. She has published more than 21 SCI journals, Granted and Filed 2 patents. She is also team member of two technology transfers to industries

Affiliations and expertise

Principal Technical officer, CSIR-Advanced Materials and Processes Research Institute (AMPRI), Bhopal, India

Life Sciences

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