Environmental Carcinogenesis
- 1st Edition, Volume 96 - February 24, 2023
- Imprint: Academic Press
- Editor: Max Costa
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 7 7 5 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 7 7 6 - 8
Environmental Carcinogenesis, Volume 96 in the Advances in Pharmacology series, reports on work done with carcinogenic metals and the mechanisms of their carcinogenicity, including… Read more
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Request a sales quoteEnvironmental Carcinogenesis, Volume 96 in the Advances in Pharmacology series, reports on work done with carcinogenic metals and the mechanisms of their carcinogenicity, including Arsenic and Chromate. Chapters in this release include Breast cancer carcinogenesis by organophosphate pesticides, Polyadenylation of Canonical histone H3.1 in Carcinogenesis, Epigenomic reprogramming in iAs-mediated carcinogenesis, MicroRNAs and epigenetic regulation in metal-induced angiogenesis and carcinogenesis, Environmental epigenetics and new mechanistic markers of chemical exposure, Arsenic carcinogenesis by inhibition of DNA repair, Genetic and environmental reprogramming of the sarcoma epigenome, Mechanism of chromate carcinogenesis by chromatin alterations, and more.
Other chapters cover Arsenic carcinogenesis and microRNAs, Epigenetic mechanism of Cr(VI)-induced cell malignant transformation and tumorigenesis, The dark side of NRF2 in arsenic carcinogenesis, and Chemical mechanisms of DNA damage by carcinogenic chromium(VI).
- Covers metal carcinogens
- Includes discussions on the mechanisms of cancer formation
- Provides updates on the diverse mechanisms that drive cancer formation by metals
Toxicologist, Cancer researchers, Pharmacologist
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Mechanisms of chromate carcinogenesis by chromatin alterations
- Abstract
- 1: Introduction
- 2: Chromatin organization and mechanisms of chromium-mediated disruption
- 3: Conclusion
- Conflict of interest
- References
- Further reading
- Chapter Two: Chemical mechanisms of DNA damage by carcinogenic chromium(VI)
- Abstract
- 1: Introduction
- 2: Cellular metabolism of Cr(VI)
- 3: DNA damage during Cr(VI) reduction by GSH
- 4: DNA damage during reduction of Cr(VI) with cysteine
- 5: DNA damage during thiol-driven metabolism of Cr(VI) in cells
- 6: DNA damage during Cr(VI) reduction by ascorbate
- 7: DNA damage by Cr(VI) in ascorbate-restored cells
- 8: Conclusion
- References
- Chapter Three: The dark side of NRF2 in arsenic carcinogenesis
- Abstract
- 1: Introduction
- 2: The “light” vs “dark” side of NRF2
- 3: Arsenic metabolism and intracellular targets
- 4: Arsenic carcinogenesis
- 5: Involvement of non-canonical activation of NRF2 in arsenic promotion of other metabolic diseases
- 6: Conclusion
- Conflict of interest
- References
- Chapter Four: Breast carcinogenesis induced by organophosphorous pesticides
- Abstract
- 1: Introduction
- 2: Studies in rat mammary gland carcinogenesis
- 3: Studies on carcinogenesis in MCF-10F cell line
- 4: Conclusion
- References
- Chapter Five: Tungsten toxicity and carcinogenesis
- Abstract
- 1: Introduction
- 2: Susceptible human populations to high exposure to tungsten
- 3: Tungsten deposition and retention in the body
- 4: Tungsten carcinogenesis
- 5: Tungsten pulmonary toxicity
- 6: Tungsten cardiometabolic toxicity
- 7: Tungsten bone toxicity
- 8: Tungsten immunotoxicity
- 9: Conclusion
- References
- Chapter Six: Arsenic and cancer: Evidence and mechanisms
- Abstract
- 1: Introduction
- 2: Human studies
- 3: Mechanisms of arsenic carcinogenesis
- 4: Chemical forms of arsenic and carcinogenesis
- 5: Conclusion
- Conflict of interest
- References
- Further reading
- Chapter Seven: miRNAs and arsenic-induced carcinogenesis
- Abstract
- 1: Introduction
- 2: Arsenical species and arsenic metabolism
- 3: Arsenic exposure
- 4: Arsenic-induced cancers
- 5: Considerations for models of arsenic-induced carcinogenesis
- 6: miRNAs: A proposed mechanism of arsenic-induced carcinogenesis
- 7: miRNAs
- 8: miRNAs and arsenic-induced carcinogenesis
- 9: Conclusion
- References
- Chapter Eight: Epigenetic and epitranscriptomic mechanisms of chromium carcinogenesis
- Abstract
- 1: Introduction
- 2: Epigenetics and epitranscriptomics
- 3: Epigenetic mechanisms of hexavalent chromium carcinogenesis
- 4: Epitranscriptomic mechanisms of hexavalent chromium carcinogenesis
- 5: Conclusion
- References
- Chapter Nine: Polyadenylation of canonical histone H3.1 in carcinogenesis
- Abstract
- 1: Introduction
- 2: Stem loop binding protein loss and polyadenylation of H3.1 (H3.2?) induce carcinogenesis
- 3: Carcinogens that cause the loss of SLBP and polyadenylation of H3.1
- 4: Conclusion
- Conflict of interest
- References
- Chapter Ten: Genetic and environmental reprogramming of the sarcoma epigenome
- Abstract
- 1: Introduction
- 2: Sarcoma genetics
- 3: Epigenetic alterations in sarcoma
- 4: Types of epigenetic alterations
- 5: Environmental risk factors in sarcoma and associated epigenetic changes
- 6: Viruses
- 7: Conclusion
- Conflicts of interest
- References
- Chapter Eleven: Epigenomic reprogramming in iAs-mediated carcinogenesis
- Abstract
- 1: Introduction
- 2: Epigenetic modifications mediated by arsenic exposure
- 3: Transcriptional products and outcomes of iAs-mediated epigenetic alterations
- 4: Conclusion
- References
- Edition: 1
- Volume: 96
- Published: February 24, 2023
- No. of pages (Hardback): 380
- No. of pages (eBook): 380
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780323997751
- eBook ISBN: 9780323997768
MC
Max Costa
Professor Max Costa's research interests include molecular mechanisms of metal carcinogenesis, cancer, pharmacology, epigenetics, and chromatin structure. Dr. Costa has published over 380 papers and has authored a book on Metal Carcinogenesis Testing. He serves on the Editorial Board as an Associate Editor for the Elsevier Journal, Toxicology and Applied Pharmacology.
Affiliations and expertise
Chair and Professor, Department of Environmental Medicine, and Professor, Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, NY, USARead Environmental Carcinogenesis on ScienceDirect