Translational Autoimmunity, Volume 6
Advances in Autoimmune Rheumatic Diseases
- 1st Edition - February 20, 2023
- Editor: Nima Rezaei
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 8 3 1 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 4 5 4 - 6
Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic… Read more
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Request a sales quoteTranslational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic diseases are heterogeneous groups of disorders in which inflammation affects not only joints, but also tendons, ligaments and bones. This updated release focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, osteoarthritis and Sjogren’s syndrome, and will be of interest to researchers, students and clinicians interested in autoimmune diseases, especially rheumatic diseases.
From an introduction to rheumatic diseases to diagnostic laboratory tests, and from the microbiota-immunity to cell-based therapies, the bench to bedside approach to rheumatic diseases is the main subject of discussion in this comprehensive resource.
- Gives an introduction on rheumatic diseases, from bench to bedside
- Describes diagnostic laboratory tests in rheumatic diseases
- Meets the needs of basic scientists, clinicians and translational scientists and industry partners
- Focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases
- Cover
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Series editor’s biography
- Acknowledgment
- Abbreviations
- Chapter 1: Introduction on autoimmune rheumatic diseases
- Abstract
- 1: Introduction
- 2: ARD through the history
- 3: Diagnosis of ARD
- 4: Treatment of ARD
- 5: Conclusion
- References
- Chapter 2: Bone Health in autoimmune inflammatory rheumatic diseases
- Abstract
- 1: Introduction
- 2: Prevalence of bone health impairment in AIIRD
- 3: Risk factors for bone loss in AIIRD
- 4: Pathophysiology of bone loss in AIIRD
- 5: Evaluation and management of bone loss/osteoporosis in patients with AIIRD
- 6: Conclusion
- References
- Chapter 3: Rheumatic diseases: From bench to bedside
- Abstract
- 1: Introduction
- 2: Pathogenesis of autoimmunity in rheumatic diseases (AIRDs)
- 3: Comparisons of the immunopathogenesis in various autoimmune rheumatic diseases
- 4: The clinical implications of the immunopathogenesis of autoimmunity
- 5: Conclusion
- References
- Chapter 4: Rheumatic fever: From pathogenesis to vaccine perspectives
- Abstract
- 1: Introduction
- 2: Diagnosis of acute rheumatic fever
- 3: Major manifestation
- 4: Minor manifestations
- 5: Treatment
- 6: Conclusion
- References
- Chapter 5: Changes in future rheumatoid arthritis treatment in the light of Epstein-Barr virus infection
- Abstract
- 1: Introduction
- 2: Epstein-Barr virus
- 3: Epstein-Barr virus infections
- 4: Associations between Epstein-Barr virus and rheumatoid arthritis disease
- 5: Current and future treatment of rheumatoid arthritis disease
- 6: Conclusion
- References
- Chapter 6: Rheumatic diseases: The microbiota-immunity axis in development and treatment
- Abstract
- 1: Introduction
- 2: The microbiota and the immune system crosstalk
- 3: Microbiota and autoimmune rheumatic diseases
- 4: Microbiota shaping as a potential therapeutic target
- 5: Conclusion
- References
- Chapter 7: The diagnostic laboratory tests in rheumatic diseases
- Abstract
- 1: Introduction
- 2: Acute-phase reactants
- 3: Laboratory tests in rheumatoid arthritis
- 4: Laboratory tests in spondyloarthritis
- 5: Laboratory tests in autoimmune connective tissue diseases
- 6: Laboratory tests in vasculitis
- 7: Laboratory tests in infectious arthritis
- 8: Laboratory tests in microcrystalline arthritis
- 9: Laboratory tests in osteoporosis
- 10: Laboratory tests in periodic fevers
- 11: Appendix: Analysis of the synovial fluid
- 12: Conclusion
- References
- Chapter 8: Autoantibody profiling in autoimmune rheumatic diseases: How research may translate into clinical practice
- Abstract
- 1: Introduction
- 2: The clinical rationale of autoantibody profiling
- 3: Proteomic technology for multiautoantibody profiling
- 4: Autoantibody profiling in autoimmune rheumatic diseases
- 5: Antibody profiling in rheumatoid arthritis
- 6: Autoantibody profiling in autoimmune organ-specific diseases
- 7: Analytical challenges of multiplex technology
- 8: Conclusion
- References
- Chapter 9: Air pollution and rheumatoid arthritis: Current knowledge and state of the art
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Overview of air pollution and its health effects
- 3: Studies linking air pollution with rheumatoid arthritis
- 4: Mechanisms potentially linking air pollution with rheumatoid arthritis
- 5: Future directions
- 6: Conclusion
- References
- Chapter 10: Advanced therapies in rheumatoid arthritis
- Abstract
- 1: Introduction
- 2: Etiology and pathogenesis
- 3: Presentation
- 4: Articular features of RA
- 5: Extra-articular features of RA
- 6: Diagnosis
- 7: Management of the disease
- 8: EULAR treatment recommendations
- 9: Horizon scanning for new agents
- 10: Conclusion
- References
- Chapter 11: A tolerogenic dendritic cell–based therapy targeting heat shock protein–specific regulatory T cells in rheumatoid arthritis
- Abstract
- 1: Introduction
- 2: Heat shock proteins
- 3: Preclinical and clinical studies of HSP-induced tolerance
- 4: Preclinical studies with tolDCs
- 5: Toward HSP-loaded tolDCs as a therapy for RA
- 6: Conclusion
- References
- Chapter 12: T-cell large granular lymphocytic leukemia in the setting of rheumatoid arthritis
- Abstract
- 1: Introduction
- 2: Epidemiology
- 3: Pathogenesis
- 4: Diagnosis
- 5: Clinical manifestations
- 6: Differential diagnosis
- 7: Treatment
- 8: Conclusion
- References
- Chapter 13: Biomaterials as tools for re-balancing skewed immunity in rheumatoid arthritis
- Abstract
- 1: Introduction
- 2: Biomaterials-based strategies for rebalancing the skewed RA immunity
- 3: Conclusion
- References
- Chapter 14: Immunopathogenesis of systemic lupus erythematosus
- Abstract
- 1: Introduction
- 2: Genetic factors in SLE
- 3: Epigenetic mechanisms in SLE
- 4: Environmental factors and gender in SLE
- 5: Apoptosis and SLE
- 6: The complement system and SLE
- 7: Toll-like receptors and SLE
- 8: Innate and adaptive immunity
- 9: Tissue inflammation and clinical manifestations (organ-specific disease features)
- 10: Treatment
- 11: Conclusion
- References
- Chapter 15: Challenges in systemic lupus erythematosus: From bench to bedside
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Pathogenesis
- 3: Diagnosis
- 4: Classification criteria
- 5: SLE phenotypes and key disease biomarkers
- 6: Management
- 7: Management of cardiovascular disease risk
- 8: Management of lupus nephritis (LN)
- 9: Management of refractory SLE with a focus on phase 2/3 clinical trials
- 10: Conclusion
- References
- Chapter 16: Therapeutic potential of the current options in treating systemic lupus erythematosus: Challenges and prospective
- Abstract
- 1: Introduction
- 2: SLE progression and factors affecting it
- 3: Therapeutic options for SLE
- 4: Current strategies to combat ADS
- 5: Conclusion
- References
- Chapter 17: The pathology and potential clinical applicability of interfering T cells in systemic lupus erythematosus
- Abstract
- 1: Introduction
- 2: Pivotal immunologic players in SLE pathophysiology
- 3: Physiology and anatomy of T cells
- 4: Current and evaluated therapies of SLE that manipulate T-cell physiology
- 5: Phenotypic and functional change of T-cell subsets after B-cell depletion
- 6: Conclusion
- References
- Chapter 18: Rheumatic chorea
- Abstract
- 1: Introduction
- 2: Pathophysiology
- 3: Clinical features
- 4: Treatment options
- 5: Conclusion
- References
- Chapter 19: Evaluation and surgical management of the rheumatoid foot and ankle
- Abstract
- 1: Introduction
- 2: History and physical exam
- 3: Preoperative considerations
- 4: Vascular evaluation in the rheumatoid patient
- 5: Preoperative testing
- 6: Preoperative medication considerations
- 7: Venous thromboembolism prophylaxis
- 8: Foot and ankle manifestations of rheumatoid arthritis
- 9: Extraarticular and soft-tissue disorders
- 10: Pathomechanics
- 11: Forefoot reconstruction
- 12: Midfoot
- 13: Rearfoot
- 14: Ankle
- 15: Conclusion
- References
- Further reading
- Chapter 20: Immunopathogenesis and treatment of scleroderma
- Abstract
- Acknowledgment
- 1: Introduction
- 2: Pathogenesis
- 3: Treatment
- 4: Conclusion
- References
- Chapter 21: Skin manifestations and autoimmune disturbances in dermatomyositis
- Abstract
- 1: Introduction
- 2: Cutaneous manifestations of DM correlate with specific autoantibodies
- 3: Myositis-specific autoantibodies in a new classification system
- 4: Conclusion
- References
- Chapter 22: T cells in the pathogenesis of systemic sclerosis
- Abstract
- 1: Introduction
- 2: Pathogenesis of systemic sclerosis
- 3: T cells: A brief overview
- 4: T cells in systemic sclerosis
- 5: Th2/Th1 balance in systemic sclerosis
- 6: Th17 cells
- 7: Regulatory T cells (Tregs) and Tregs/Th17 balance
- 8: Tfh cells
- 9: Other Th subsets
- 10: Unconventional T cells
- 11: Angiogenic T cells
- 12: T cells and vasculopathy
- 13: Lessons from animal models of scleroderma
- 14: Immunotherapy and future prospects
- 15: Conclusion
- References
- Chapter 23: Etiopathogenesis of Behçet’s syndrome: The role of infectious, genetic, and immunological environmental factors
- Abstract
- 1: Introduction
- 2: Microbial etiology
- 3: Genetic etiology
- 4: Epigenetic contribution
- 5: Immunological etiology
- 6: Additional triggering factors
- 7: Conclusion
- References
- Chapter 24: Interleukin-1 family in Behçet’s disease: Inflammatory and antiinflammatory mediators
- Abstract
- 1: Introduction
- 2: The biological characteristics of IL-1 family cytokines
- 3: The association of IL-1 family genes and BD
- 4: Expression and function of IL-1 family cytokines in BD
- 5: Clinical application and participation of IL-1 family cytokines in BD
- 6: Conclusion
- References
- Chapter 25: Salivary gland regeneration and repair in Sjögren’s syndrome
- Abstract
- 1: Introduction
- 2: Salivary glands in Sjögren’s syndrome
- 3: Regenerative medicine
- 4: Regeneration of salivary glands
- 5: Conclusion
- References
- Chapter 26: Regulation of bone and joint inflammation by type 2 innate lymphoid cells
- Abstract
- 1: Introduction
- 2: Rheumatoid arthritis and T cell
- 3: Rheumatoid arthritis and ILC
- 4: Spondyloarthritis and ILCs
- 5: Role of ILC2 on the initiation phase of arthritis
- 6: Bone homeostasis and cytokines mediated by T cell
- 7: Bone homeostasis and ILC
- 8: Conclusion
- References
- Chapter 27: Arboviruses (Alphavirus) related to autoimmune rheumatic diseases: Triggers and possible therapeutic interventions
- Abstract
- 1: Introduction
- 2: Chikungunya virus (CHIKV)
- 3: O’nyong-nyong virus (ONNV)
- 4: Ross River virus (RRV)
- 5: Barmah Forest virus (BFV)
- 6: Mayaro virus (MAYV)
- 7: Sindbis virus (SINV)
- 8: Interface of possible treatments for alphaviruses in rheumatoid arthritis
- 9: Conclusion
- References
- Chapter 28: Rheumatologic manifestations of autoinflammatory diseases
- Abstract
- 1: Introduction
- 2: Familial Mediterranean fever (FMF)
- 3: Mevalonate kinase deficiency (MKD)
- 4: Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS)
- 5: Cryopyrin-associated periodic syndromes (CAPS)
- 6: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome
- 7: Conclusion
- References
- Index
- No. of pages: 628
- Language: English
- Edition: 1
- Published: February 20, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323858311
- eBook ISBN: 9780323984546
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