Standardizing Pharmacology: Assays and Hormones

Discoveries in Pharmacology, Volume 2

2nd Edition - February 23, 2023
Editors: Michael J. Parnham, Clive Page, Jacques Bruinvels
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 5 1 7 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 5 1 8 - 1

Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced wit… Read more

Purchase options

Institutional subscription on ScienceDirect

Request a sales quote

Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries.

Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hökfelt and V.C. Jordan.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Preface
Chapter 1A Commentary on the development of receptor theory by John Parascandola
References
Chapter 1B The development of receptor theory
1.1 Background
1.2 Ehrlich and the receptor theory in immunology
1.3 Ehrlich changes his mind about drug receptors
1.4 Langley and receptive substances
1.5 Ehrlich’s chemoreceptor theory
1.6 Impact of Ehrlich-Langley receptor theory
1.7 A.J. Clark and receptor theory
Acknowledgements
References
Chapter 2A Commentary on Making visible the invisible by Annica Dahlström and Arvid Carlsson
2.1 Background
2.2 Chemical neuroanatomy
2.3 The formaldehyde fluorescence method for monoamines (FAM), a.k.a. the Falck-Hillarp technique
2.4 Nils-Åke Hillarp
2.5 What came after FAM?
2.6 Concluding remarks
Acknowledgements
References
Chapter 2B Making visible the invisible. Recollections of the first experiences with the histochemical fluorescence method for visualization of tissue monoamines
2.1 Introduction
2.2 In search of a histochemical method; prelude I
2.3 The histochemical fluorescence method; prelude II
2.4 Exploring the unknown; fugue
Acknowledgements
Addendum
References
Chapter 3A Radioimmunoassay: Insulin and beyond. Commentary on A probe for the fine structures of the body by Rosalyn S. Yalow
References
Chapter 3B A probe for the fine structures of the body
3.1 Diverse applications of radioisotopes
3.2 The discovery of insulin-binding antibodies
3.3 Development of the insulin RIA
3.4 The glucagon RIA
3.5 The acceptance of RIA
3.6 Heterogeneity introduces complications
3.7 Diverse applications of RIA
3.8 Future prospects
References
Chapter 4A Commentary on The guts of the matter: Contribution of studies on smooth muscle to discoveries in pharmacology by Michael J. Rand and Frederick Mitchelson
References
Chapter 4B The guts of the matter: Contribution of studies on smooth muscle to discoveries in pharmacology
4.1 The gastrointestinal tract
4.2 The vasa deferentia
4.3 The anococcygeus muscle
4.4 Retractor penis
4.5 The urinary bladder
4.6 Conclusion
References
Chapter 5A Commentary on Bioassay: a pharmacological endeavour by Jacques M. van Rossum and J.Th.A. Hurkmans
References
Chapter 5B Bioassay: a pharmacological endeavour
5.1 Introduction
5.2 Early excursions in bioassay
5.3 A personal introduction to pharmacology through bioassay
5.4 Bioassay in pharmacology
5.5 Typical responses of various isolated organs
5.6 Cumulative dose-response curves
5.7 The isolated neurone system of the snail
5.8 Multiple organ assay
5.9 Responses in the intact animal
5.10 Responses of individual cells
5.11 Conclusion
References
Chapter 6A Commentary on The emergence of endocrinology by Marius Tausk
References
Chapter 6B The emergence of endocrinology
6.1 Introduction
6.2 Hormonal effects of the testes
6.3 The thyroid and parathyroids
6.4 Endocrine functions of the ovary
6.5 The pituitary
6.6 Endocrinology in retrospect
References
Chapter 7A Commentary on Androgens and anabolic steroids by Marius Tausk
7.1 Introduction
7.2 Evolution of testosterone therapy
7.3 Testosterone misuse
7.4 Current AUA guidelines
7.5 Conclusion
References
Chapter 7B Androgens and anabolic steroids
7.1 The discovery of the male hormone
7.2 The apparent dissociation of androgenic and anabolic properties
7.3 On the mechanism of action of androgenic/anabolic steroids
References
Chapter 8A Changes in oral contraceptive design since the original release. Commentary on The biological history of the Pill by Roy O. Greep
References
Chapter 8B The biological history of the Pill
8.1 Introduction
8.2 Historical background
8.3 In retrospect
Acknowledgement
References
Chapter 9A Progress in the chemistry of agents to modulate reproduction. Commentary on The chemical history of the Pill by Carl Djerassi
References
Chapter 9B The chemical history of the Pill*
9.1 Introduction
9.2 Steroid chemistry: a brief primer
9.3 Mexico: a steroid chemist’s paradise
9.4 The chemical origin of the Pill
9.5 Other steroid oral contraceptives
References
Index

Michael J. Parnham

Professor Michael J. Parnham, Ph.D., C.Biol.MRSB, FBPhS studied Pharmacology at Chelsea (now King's) College, gaining practical experience in the department of the subsequent Nobel Prize winner, John R. Vane, at the Royal College of Surgeons. With a PhD from Bristol University (1976), he carried out postdoctoral research on prostaglandins and chronic inflammation with Ivan Bonta at Erasmus University Rotterdam, The Netherlands. He established laboratories in pharmacology and toxicology and was Director of Preclinical Discovery working on novel anti-inflammatory macrolides at GSK from 2006. From 2012 to 2019, Prof. Parnham built up preclinical research in the Fraunhofer Institute of Molecular Biology & Applied Ecology IME. Dr. Parnham has published and lectured extensively and organised symposia on various aspects of immunopharmacology and anti-inflammatory therapy and in 2015, received a Lifetime Achievement Award from the International Association of Inflammatory Societies (IAIS). He is a scientific advisor to several companies.

Affiliations and expertise

Professor, Faculty of Biochemistry, Chemistry and Pharmacy, Goethe University Frankfurt, Frankfurt am Main, Germany

Clive Page

Professor Clive P. Page, BSc PhD OBE HonFBPhS is a Professor of Pharmacology, King’s College London and Director of the Sackler Institute of Pulmonary Pharmacology, King’s College London. Clive’s main research interests are in the pharmacology of inflammation and respiratory disease and he has published over 250 scientific papers. Clive was the co-founder and previous Chairman of the Board of Verona Pharma plc, an AIM listed Company developing new drugs for the treatment of Respiratory Diseases. He is a Non Executive Director of and on boards of several companies. He was awarded the Society of Biology President’s Medal in 2012 for an outstanding contribution to the life sciences over the previous year. He is a Fellow of the Royal Society of Biology and an Honorary Fellow and President Elect of the British Pharmacological Society. In 2017, Clive was awarded an OBE for Services to Pharmacology.

Affiliations and expertise

Professor of Pharmacology, King’s College London and Director of the Sackler Institute of Pulmonary Pharmacology, King’s College London, UK

Jacques Bruinvels

Professor Jacques Bruinvels, Ph.D. is Professor Emeritus of Pharmacology, Department of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands. Full biography to follow

Affiliations and expertise

Professor Emeritus of Pharmacology, Department of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Standardizing Pharmacology: Assays and Hormones

Discoveries in Pharmacology, Volume 2

Purchase options

Institutional subscription on ScienceDirect

Michael J. Parnham

Clive Page

Jacques Bruinvels