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Books in Life sciences

  • Animal Models of Disease Part E

    • 1st Edition
    • Volume 203
    • English
    Animal Models of Disease, Part E, Volume 203 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

  • The Resistance of Cervical Cancer to Chemotherapy and its Reversal

    • 1st Edition
    • Volume 9
    • S. Muthusami
    • English
    The Resistance of Cervical Cancer to Chemotherapy and its Reversal provides a holistic understanding of cervical cancer development, immune-evading mechanisms of HPV, immunotherapies available, methods to study cervical cancer and the development of newer drugs. Content shows the involvement of signaling pathways during chemoresistance in cervical cancer, the involvement of genes in drug resistance, and introduces long noncoding RNAs as novel biomarkers.In 10 chapters, this book first provides an introduction and history of cervical cancer; next, it discusses the influence of viruses on cervical cancer and finally, it describes therapies to overcome chemotherapy resistance in cervical cancer. This is the perfect reference to provide the fundamental base of knowledge needed for oncologists, pharmacologists, translational investigators, immunotherapists, scientists, and clinicians interested in building a comprehensive understanding of the field.

  • Fundamentals of Biologicals Regulation

    Vaccines and Biotechnology Medicines
    • 2nd Edition
    • Rebecca Sheets + 6 more
    • English
    Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines, Second Edition serves as an introduction to the international regulatory arena in which biologicals are developed, offering an overview of processes and insights into the scientific concepts underpinning global regulations. This edition provides in-depth coverage of Quality by Design, Combination Products, Risk Management Plans, REMS, and switching from reliance on in vivo to in vitro analytical methods. It reflects new developments and processes accelerated by the COVID-19 vaccine experience, including emergency use authorizations and conditional marking authorizations. New pedagogic elements and case studies have been added to improve learning outcomes.This book provides multiple levels of readership, with guidance on basic concepts, a detailed look at regulatory challenges, and practical insights into how regulators consider regulatory science and regulatory process issues across various regions, with an emphasis on the European Medicines Agency and the U.S. Food and Drug Administration.

  • Lateral Flow Assays for Rapid Point-of-care Testing

    Recent Advances, Emerging Trends, and Future Direction
    • 1st Edition
    • Seema Nara + 2 more
    • English
    The emergence and re-emergence of new infectious diseases places emphasis on the need for greater investment in rapid healthcare diagnostic solutions. As a result, lateral flow immunoassay technology is quickly evolving with new inventions. Lateral Flow Assay for Rapid Point-of-Care Testing covers today’s most significant advancements, emerging trends, and future directions linked with this technology. The book begins with a review of the format, flow, and design of old-generation lateral flow assays and the challenges impeding performance before moving into innovation in materials for rapid test strips, advances in manipulating sample flow, and the latest developments in molecular imprinting and bioconjugation techniques. Subsequent sections cover various biorecognition elements and review signal amplification as well as quantification trends. Final chapters delve into recent applications for infectious diseases detection, monitoring antibiotic resistance, multiplex detection of analytes, as well as future directions leading to the next generation of healthcare. Academicians, researchers, industrialists, and device manufacturers linked to the development of rapid and affordable point-of-care immunodiagnostics will find value in this resource.

  • Basic Microbiology

    History, Fundamentals and Insights
    • 1st Edition
    • Saurabh Bhatia + 2 more
    • English
    Basic Microbiology: History, Fundamentals and Insights offers an exploration of the microbiology, providing a foundation in the study of microorganisms and their impact on health and disease. Beginning with an introduction to microbiology, the book covers the metabolism of microorganisms, revealing the biochemical processes that sustain microbial life. It then examines microbial genetics, uncovering the mechanisms of genetic variation and inheritance in microbes. Detailed chapters on bacteria, fungi, viruses, and protozoa provide thorough insights into the structure, function, and classification of these diverse organisms. The book also covers the principles of immunity, explaining the body’s defense mechanisms against microbial invasion. Finally, it addresses infection and diseases, highlighting the relationship between pathogens and human health. Ideal for students, educators, and professionals in microbiology and related field, Basic Microbiology: History, Fundamentals and Insights serves as an essential resource for understanding the microscopic world and its relevance to medicine and biology.

  • Vaccinology and Immunizations

    • 1st Edition
    • Jahangir Moini + 2 more
    • English
    Vaccinology and Immunizations is a thorough resource on the immune system, the history of vaccines, vaccine preparation, the process of vaccine approval, and the prevention and eradication of diseases. It also includes chapters on vaccine safety and errors, and complete information on pediatric and adult immunizations. There is also discussion on elderly immunology and immunization for people who are seeking to travel abroad, as well as timely information about COVID-19.Its focus on the innate and adaptive defense systems of the body will ensure understanding of human immunity and how immunizations are effective. There is a variety of available titles related to vaccinology and immunizations, but many are now outdated. Vaccinology and Immunizations provides a new, updated resource that is widely needed, and will be welcomed by students of undergraduate, graduate and master level in vaccinology or immunology, and would also be of interest to nurses, researchers, and pharmacists.

  • Applied Microbiology

    Microbes, Pharmaceutical Techniques and Procedures
    • 1st Edition
    • Saurabh Bhatia + 1 more
    • English
    Recently, molecular technologies have positively affected the field of applied microbiology, providing rapid quantitative as well as qualitative information on microorganisms present in a given sample. The development of microbiology-based inventions suggests a worthwhile but challenging prospect to create pharmaceutical products and harvest the superior potential therein. Some of the challenges while patenting the microorganisms can be overcome by updating aspirants related with ethical and regulatory issues, especially guidelines established in microbiology to explore its more clinical applications. Applied Microbiology: Microbes, Pharmaceutical Techniques and Procedures includes diverse applications of microorganisms in 21st century like emerging infections and their futuristic impact over the society. Applied Microbiology: Microbes, Pharmaceutical Techniques and Procedures carries outcomes of present research to reach those whose aspiration allows using this information and know-how in both the basic as the applied settings.

  • Basic Principles of Drug Discovery and Development

    • 3rd Edition
    • Benjamin E. Blass
    • English
    Basic Principles of Drug Discovery and Development, Third Edition presents a unique overview of the drug discovery and development program not available elsewhere. Each chapter provides sufficient technical details on the topics covered so that non-experts will have the tools and information necessary to interact and exchange information with colleagues across the entire spectrum of the drug discovery and development process. The drug discovery and development process involves individuals and teams with a wide array of expertise ranging from basic sciences (medicinal chemistry, biology) to applied science (pharmacology, pharmacokinetics, clinical sciences) to business driven fields (regulatory affairs, intellectual property experts, marketing specialists).The success or failure of a program focused on bringing a new medication to market often depends on clear communication between individuals and teams with vastly different expertise. As a result, it is critical that experts in one aspect of drug discovery and development (e.g., medicinal chemists) have a working understanding of the wide range of disciplines that take part in the overall process.

  • Cutting-Edge Nanocarrier-Based Strategies in the Management of Leukaemia

    • 1st Edition
    • Devesh U. Kapoor + 2 more
    • English
    Cutting-edge Nanocarrier-Based Strategies in the Management of Leukaemia addresses the importance of nanocarriers in leukemia treatment. The book explores advancements in nanotechnology, highlighting therapies like siRNA, miRNA, and gene therapy that improve patient outcomes. Sections provide an introduction to leukemia, covering its epidemiology and risk factors, discuss innovative therapies and the use of various nanocarriers, such as polymeric nanoparticles, liposomes, dendrimers, and hydrogels, and discuss precision medicine, AI in leukemia care, and strategies to overcome treatment resistance. The book is enriched with tables, figures, and images, giving healthcare providers, including physicians, immunologists, oncologists, and pharmacists an invaluable resource on cutting-edge therapies.

  • Stress: Psychopathology and Psychiatry

    • 1st Edition
    • George Fink
    • English

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