Biocatalysis in Asymmetric Synthesis

1st Edition - May 4, 2024
Editors: Gonzalo De Gonzalo, Andrés R. Alcántara
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 0 5 7 - 5
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 0 5 8 - 2

Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion on synthesizing biological catalysts usi… Read more

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Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion on synthesizing biological catalysts using asymmetric synthesis for varying applications. Here, global experts in the field analyze a wide variety of biocatalysts and their physical states, process conditions for their asymmetric synthesis, solvents required during synthesis, and even downstream procedures for the recovery of final products. The book adopts an interdisciplinary approach, merging fundamental biology and its synthetic applications across industries with a wide range of practical examples, from directed evolution to biotransformation and production of novel enzymes and non-conventional catalysts. Throughout the book, the impact and application of biocatalysis in sustainable processing is considered in-depth. This book will also help non-experts in biocatalysis to apply this knowledge in their own research, providing a thorough overview of the ways asymmetric biocatalytic approaches may be adapted for different disciplines and downstream products.

Cover image
Title page
Table of Contents
Copyright
List of contributors
About the editors
Preface
Chapter 1. Introduction to asymmetric synthesis employing biocatalysts
Abstract
1.1 Introduction
1.2 Type of enzymatic processes for generating asymmetry
1.3 Biocatalysts preparations
1.4 Novel-to-nature enzymatic processes
1.5 Enzymes in multicatalytic systems
1.6 Outlook
References
Chapter 2. Biocatalysis and Green Chemistry: assessing the greenness of enzymatic processes
Abstract
2.1 Introduction
2.2 Green Chemistry metrics
2.3 Green Chemistry in biocatalysis for practitioners: defining the boundaries of a biocatalytic reaction
2.4 Conclusions
References
Chapter 3. Study of stereocontrol in enzymatic reactions using atomic models and computational methods
Abstract
3.1 Introduction
3.2 Relevant features for stereocontrol in enzymes
3.3 Studying the stereocontrol in enzyme catalysis using atomic models
3.4 Some final considerations for a step-by-step protocol for simulation of enzyme activity
References
Chapter 4. Control of the activity and enantioselectivity in biocatalyzed procedures: immobilization, medium engineering, and protein engineering
Abstract
4.1 Introduction
4.2 Immobilization of enzymes
4.3 Medium engineering
4.4 Protein engineering
4.5 Conclusions and future perspectives
References
Chapter 5. Hydrolases and their application in asymmetric synthesis
Abstract
5.1 Hydrolases
5.2 Low/nonaqueous solvents as media for asymmetric synthesis by hydrolases
5.3 Asymmetric synthesis catalyzed by key lipases
5.4 Proteases (peptidases)
5.5 Other hydrolases in asymmetric synthesis
5.6 Tools to discover and improve hydrolases
5.7 Conclusions
References
Chapter 6. Biocatalysis for the selective reduction of carbonyl groups
Abstract
6.1 Introduction
6.2 Examples of the application of alcohol dehydrogenases in asymmetric synthesis
6.3 Dynamic processes catalyzed by alcohol dehydrogenases
6.4 Alcohol dehydrogenases in deracemization protocols
6.5 Use of alcohol dehydrogenases in multienzymatic systems
6.6 Conclusions
References
Chapter 7. Synthesis of chiral amines employing imine reductases and reductive aminases
Abstract
7.1 Introduction
7.2 Imine reductases: structural and mechanistic aspects
7.3 Cyclic imine reductions
7.4 Imine reductase/RedAm-mediated reductive aminations
7.5 Conclusions and perspectives
References
Chapter 8. Biocatalyzed Carbon–Carbon bond formation in enantioselective synthesis
Abstract
8.1 Introduction
8.2 Enzymatic aldol reactions. Enzymes involved. Classification
8.3 Synthetic applications
8.4 Perspectives and concluding remarks
References
Chapter 9. Synthesis of chiral compounds through biooxidations
Abstract
9.1 Introduction
9.2 Dehydrogenases
9.3 Oxidases
9.4 Peroxidases
9.5 Monooxygenases
9.6 Peroxygenases
9.7 Conclusion and perspectives
References
Chapter 10. Asymmetric biocatalysis in nonconventional media: neat conditions, eutectic solvents, and supercritical conditions
Abstract
10.1 Introduction
10.2 Neat conditions
10.3 Eutectic solvents
10.4 Supercritical conditions
10.5 Summary and perspectives
References
Chapter 11. Multienzyme-catalyzed processes in asymmetric synthesis: state of the art and future trends
Abstract
11.1 Introduction
11.2 Process design and optimization
11.3 Recent developments and future trends
11.4 Summary
References
Chapter 12. Development of asymmetric biotransformations: flow biocatalysis, photobiocatalysis, and microwave biocatalysis
Abstract
12.1 Introduction
12.2 Flow biocatalysis
12.3 Photobiocatalysis
12.4 Microwave biocatalysis
12.5 Conclusions
References
Chapter 13. Industrial asymmetric biocatalysis
Abstract
13.1 Introduction
13.2 Asymmetric biocatalysis in manufacturing chiral intermediates and building blocks
13.3 Asymmetric biocatalysis in manufacturing chiral pharmaceutical intermediates and active pharmaceutical ingredients
13.4 Biocatalytic synthesis of chiral metabolites
13.5 Biocatalytic synthesis of chiral flavor ingredients
13.6 Biocatalytic synthesis of chiral fragrance ingredients
13.7 Biocatalytic synthesis of chiral cosmetic ingredients
13.8 Biocatalytic synthesis of chiral agrochemicals
13.9 Asymmetric biocatalysis in manufacturing chiral monomers
13.10 Biocatalytic synthesis of chiral oligomers and polymers
13.11 Conclusions
References
Chapter 14. Patents based on biocatalytic methods for the synthesis of valuable chiral compounds
Abstract
14.1 Motivation for the biocatalytic synthesis of chiral compounds
14.2 Methodologies for the synthesis of chiral compound employing wild-type enzymes
14.3 Patented methodologies for the synthesis of chiral compounds employing modified enzymes
14.4 Concluding remarks
References
Index

Gonzalo De Gonzalo

Prof. Gonzalo de Gonzalo is an Associate Professor at the Organic Chemistry Department of the Chemistry Faculty at the University of Seville, Spain. He obtained his Degree and his Ph.D. in Chemistry at the University of Oviedo, Spain. He spent his postdoctoral stage at Consiglio Nazionale delle Ricerche, Milan, Italy, moving back to University of Oviedo with a Juan de la Cierva Fellowship. In 2010, he spent one year at the University of Groningen, The Netherlands, working in the research of novel oxidative enzymes. He worked two years for the pharmaceutical company Antibióticos S.A.U. León, Spain, moving to Seville in 2014 as a Ramón y Cajal Researcher, getting his present position in 2019. His research is focused on asymmetric synthesis by using different approaches, including biocatalytic and organocatalytic procedures, as well as the development of concurrent chemo- and biocatalytic reactions. He has published more than 90 scientific papers, including two books focused on biocatalysis applied to the synthesis of valuable compounds.

Affiliations and expertise

Associate Professor, Organic Chemistry Department, Chemistry Faculty, University of Seville, Spain

Andrés R. Alcántara

Prof. Andrés R. Alcántara is a Full Professor at the Department of Chemistry in Pharmaceutical Sciences of the Pharmacy Faculty at the Complutense University of Madrid, Spain. He obtained his Degree and his Ph. D. in Chemistry at the University of Córdoba (Spain). He spent his postdoctoral stage at the University of Kent Canterbury (UK), returning to the Complutense University where he was Associate Professor from 1993 until 2018, when he gained Full Professorship. His research has been focused on Biotransformations and Applied Biocatalysis in Organic Chemistry, more specifically, in the preparation of enantiomerically pure compounds as chemical drug precursors, using mainly proteases, lipases and alcohol dehydrogenases, either native or immobilized. On the other hand, his work fits perfectly within Sustainable Chemistry, since he has applied these biocatalysts mainly in sustainable bio-solvents, which generates a very beneficial synergy from the point of view of the sustainability of the processes. All this has led him to publish more than 130 scientific papers, reviews, monographs, book chapters, and more than 100 communications to national and international Congresses. He is a member of the Board of ESAB (European Society of Applied Biocatalysis) and ESAB delegate inside the Board of SusChem, the European Platform of Sustainable Chemistry.

Affiliations and expertise

Full Professor at the Department of Chemistry in Pharmaceutical Sciences, Pharmacy Faculty Complutense University of Madrid, Spain

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