
Biocatalysis in Asymmetric Synthesis
- 1st Edition - May 4, 2024
- Editors: Gonzalo De Gonzalo, Andrés R. Alcántara
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 0 5 7 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 0 5 8 - 2
Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion on synthesizing biological catalysts usi… Read more

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Request a sales quote- Explores biocatalysts as exquisite catalysts for fine chiral compound synthesis in different reaction media
- Features both foundational overviews and applied, practical examples across research and industry
- Includes chapter contributions from international leaders in the field
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- About the editors
- Preface
- Chapter 1. Introduction to asymmetric synthesis employing biocatalysts
- Abstract
- 1.1 Introduction
- 1.2 Type of enzymatic processes for generating asymmetry
- 1.3 Biocatalysts preparations
- 1.4 Novel-to-nature enzymatic processes
- 1.5 Enzymes in multicatalytic systems
- 1.6 Outlook
- References
- Chapter 2. Biocatalysis and Green Chemistry: assessing the greenness of enzymatic processes
- Abstract
- 2.1 Introduction
- 2.2 Green Chemistry metrics
- 2.3 Green Chemistry in biocatalysis for practitioners: defining the boundaries of a biocatalytic reaction
- 2.4 Conclusions
- References
- Chapter 3. Study of stereocontrol in enzymatic reactions using atomic models and computational methods
- Abstract
- 3.1 Introduction
- 3.2 Relevant features for stereocontrol in enzymes
- 3.3 Studying the stereocontrol in enzyme catalysis using atomic models
- 3.4 Some final considerations for a step-by-step protocol for simulation of enzyme activity
- References
- Chapter 4. Control of the activity and enantioselectivity in biocatalyzed procedures: immobilization, medium engineering, and protein engineering
- Abstract
- 4.1 Introduction
- 4.2 Immobilization of enzymes
- 4.3 Medium engineering
- 4.4 Protein engineering
- 4.5 Conclusions and future perspectives
- References
- Chapter 5. Hydrolases and their application in asymmetric synthesis
- Abstract
- 5.1 Hydrolases
- 5.2 Low/nonaqueous solvents as media for asymmetric synthesis by hydrolases
- 5.3 Asymmetric synthesis catalyzed by key lipases
- 5.4 Proteases (peptidases)
- 5.5 Other hydrolases in asymmetric synthesis
- 5.6 Tools to discover and improve hydrolases
- 5.7 Conclusions
- References
- Chapter 6. Biocatalysis for the selective reduction of carbonyl groups
- Abstract
- 6.1 Introduction
- 6.2 Examples of the application of alcohol dehydrogenases in asymmetric synthesis
- 6.3 Dynamic processes catalyzed by alcohol dehydrogenases
- 6.4 Alcohol dehydrogenases in deracemization protocols
- 6.5 Use of alcohol dehydrogenases in multienzymatic systems
- 6.6 Conclusions
- References
- Chapter 7. Synthesis of chiral amines employing imine reductases and reductive aminases
- Abstract
- 7.1 Introduction
- 7.2 Imine reductases: structural and mechanistic aspects
- 7.3 Cyclic imine reductions
- 7.4 Imine reductase/RedAm-mediated reductive aminations
- 7.5 Conclusions and perspectives
- References
- Chapter 8. Biocatalyzed Carbon–Carbon bond formation in enantioselective synthesis
- Abstract
- 8.1 Introduction
- 8.2 Enzymatic aldol reactions. Enzymes involved. Classification
- 8.3 Synthetic applications
- 8.4 Perspectives and concluding remarks
- References
- Chapter 9. Synthesis of chiral compounds through biooxidations
- Abstract
- 9.1 Introduction
- 9.2 Dehydrogenases
- 9.3 Oxidases
- 9.4 Peroxidases
- 9.5 Monooxygenases
- 9.6 Peroxygenases
- 9.7 Conclusion and perspectives
- References
- Chapter 10. Asymmetric biocatalysis in nonconventional media: neat conditions, eutectic solvents, and supercritical conditions
- Abstract
- 10.1 Introduction
- 10.2 Neat conditions
- 10.3 Eutectic solvents
- 10.4 Supercritical conditions
- 10.5 Summary and perspectives
- References
- Chapter 11. Multienzyme-catalyzed processes in asymmetric synthesis: state of the art and future trends
- Abstract
- 11.1 Introduction
- 11.2 Process design and optimization
- 11.3 Recent developments and future trends
- 11.4 Summary
- References
- Chapter 12. Development of asymmetric biotransformations: flow biocatalysis, photobiocatalysis, and microwave biocatalysis
- Abstract
- 12.1 Introduction
- 12.2 Flow biocatalysis
- 12.3 Photobiocatalysis
- 12.4 Microwave biocatalysis
- 12.5 Conclusions
- References
- Chapter 13. Industrial asymmetric biocatalysis
- Abstract
- 13.1 Introduction
- 13.2 Asymmetric biocatalysis in manufacturing chiral intermediates and building blocks
- 13.3 Asymmetric biocatalysis in manufacturing chiral pharmaceutical intermediates and active pharmaceutical ingredients
- 13.4 Biocatalytic synthesis of chiral metabolites
- 13.5 Biocatalytic synthesis of chiral flavor ingredients
- 13.6 Biocatalytic synthesis of chiral fragrance ingredients
- 13.7 Biocatalytic synthesis of chiral cosmetic ingredients
- 13.8 Biocatalytic synthesis of chiral agrochemicals
- 13.9 Asymmetric biocatalysis in manufacturing chiral monomers
- 13.10 Biocatalytic synthesis of chiral oligomers and polymers
- 13.11 Conclusions
- References
- Chapter 14. Patents based on biocatalytic methods for the synthesis of valuable chiral compounds
- Abstract
- 14.1 Motivation for the biocatalytic synthesis of chiral compounds
- 14.2 Methodologies for the synthesis of chiral compound employing wild-type enzymes
- 14.3 Patented methodologies for the synthesis of chiral compounds employing modified enzymes
- 14.4 Concluding remarks
- References
- Index
- No. of pages: 520
- Language: English
- Edition: 1
- Published: May 4, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443190575
- eBook ISBN: 9780443190582
GG
Gonzalo De Gonzalo
Prof. Gonzalo de Gonzalo is an Associate Professor at the Organic Chemistry Department of the Chemistry Faculty at the University of Seville, Spain. He obtained his Degree and his Ph.D. in Chemistry at the University of Oviedo, Spain. He spent his postdoctoral stage at Consiglio Nazionale delle Ricerche, Milan, Italy, moving back to University of Oviedo with a Juan de la Cierva Fellowship. In 2010, he spent one year at the University of Groningen, The Netherlands, working in the research of novel oxidative enzymes. He worked two years for the pharmaceutical company Antibióticos S.A.U. León, Spain, moving to Seville in 2014 as a Ramón y Cajal Researcher, getting his present position in 2019. His research is focused on asymmetric synthesis by using different approaches, including biocatalytic and organocatalytic procedures, as well as the development of concurrent chemo- and biocatalytic reactions. He has published more than 90 scientific papers, including two books focused on biocatalysis applied to the synthesis of valuable compounds.
AA
Andrés R. Alcántara
Prof. Andrés R. Alcántara is a Full Professor at the Department of Chemistry in Pharmaceutical Sciences of the Pharmacy Faculty at the Complutense University of Madrid, Spain. He obtained his Degree and his Ph. D. in Chemistry at the University of Córdoba (Spain). He spent his postdoctoral stage at the University of Kent Canterbury (UK), returning to the Complutense University where he was Associate Professor from 1993 until 2018, when he gained Full Professorship. His research has been focused on Biotransformations and Applied Biocatalysis in Organic Chemistry, more specifically, in the preparation of enantiomerically pure compounds as chemical drug precursors, using mainly proteases, lipases and alcohol dehydrogenases, either native or immobilized. On the other hand, his work fits perfectly within Sustainable Chemistry, since he has applied these biocatalysts mainly in sustainable bio-solvents, which generates a very beneficial synergy from the point of view of the sustainability of the processes. All this has led him to publish more than 130 scientific papers, reviews, monographs, book chapters, and more than 100 communications to national and international Congresses. He is a member of the Board of ESAB (European Society of Applied Biocatalysis) and ESAB delegate inside the Board of SusChem, the European Platform of Sustainable Chemistry.