The Microbiome and Neurotoxicity

1st Edition, Volume 11 - April 30, 2024
Imprint: Academic Press
Editors: Michael Aschner, Lucio G. Costa, Alexey Tinkov
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 2 1 5 6 0 - 5
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 1 5 6 1 - 2

Advances in Neurotoxicology, Volume 11 presents interesting chapters written by an international board of authors. Chapters in this new release include Gut microbiota as a mediat… Read more

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Advances in Neurotoxicology, Volume 11 presents interesting chapters written by an international board of authors. Chapters in this new release include Gut microbiota as a mediator on the neurotoxicity of mercury, Relationships between lead-induced learning and memory impairments and gut microbiota disturbance in mice, Utility of zebrafish-based models in understanding molecular mechanisms of neurotoxicity mediated by the gut-brain axis, Alterations of gut microbiota linking environmental exposures to neurotoxicity, Iron Toxicity, Ferroptosis and Microbiota in Parkinson’s Disease: Implications for Novel Targets, and Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Environmental chemical-induced adverse effects on gut microbiota and their implications for the etiopathogenesis of chronic neurological diseases
Abstract
1 Introduction
2 The conduits and mechanisms of microbiota-gut-brain dysfunction
3 Environmental chemical exposures and gut microbiome
4 Gut microbiome alterations by environmental exposures contributing to neurotoxicity
5 General conclusion
Acknowledgments
References
Chapter Two: Gut microbiota as a mediator of the neurotoxicity of mercury
Abstract
1 Introduction
2 The neurotoxicity of different mercury species
3 Gut microbiota as a mediator of the neurotoxicity of Hg
4 Conclusion and perspectives
Acknowledgements
References
Chapter Three: Iron toxicity, ferroptosis and microbiota in Parkinson’s disease: Implications for novel targets
Abstract
Abbreviations
1 Introduction
2 Parkinson’s disease
3 Glial cells
4 Iron (Fe)
5 Ferroptosis—diseases
6 Ferroptosis—neurodegenerative diseases
7 Ferroptosis—PD
8 Gut microbiota (GM)
9 GM—ferroptosis—PD
10 Ferroptosis as drug target
11 GM-ferroptosis as targets for PD
12 Conclusion
Acknowledgments
References
Chapter Four: Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity
Abstract
Abbreviations
1 Gut-brain axis and its role in neurotoxicity (Introduction)
2 Exogenous neurotoxic agents
3 Endogenous neurotoxicants
4 Conclusions
Acknowledgments
References
Chapter Five: Utility of zebrafish-based models in understanding molecular mechanisms of neurotoxicity mediated by the gut–brain axis
Abstract
1 Introduction
2 The gut microbiota–brain axis
3 Neurotransmitter modulation by the gut microbiota
4 Zebrafish as an emerging model to investigate gut microbiota–brain axis
5 Neurotoxic mechanisms of xenobiotics via the gut microbiota–brain axis in zebrafish
6 Anthropogenic chemicals and the gut microbiota–brain axis
7 Pharmaceuticals and the gut microbiota–brain axis
8 Bacteria exposure and the gut microbiota–brain axis
9 Conclusion
Acknowledgments
References

Michael Aschner

Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control), and is a member of the Neurotoxicology and Alcohol study section (NIH). Research in our lab focuses on the following topics: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of MeHg uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg’s neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. Our studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.

Affiliations and expertise

Professor, Department of Molecular Pharmacology, Albert Einstein College of Medicine, NY, USA

Lucio G. Costa

Dr. Lucio G. Costa is Professor of Toxicology at the University of Washington in Seattle, and of Pharmacology/Toxicology at the University of Parma Medical School. He received a doctorate in Pharmacology from the University of Milano in 1977, and was a postdoctoral fellow at the University of Texas at Houston. He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various award for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. He serves in various editorial capacities for several toxicology journals, and is an active manuscript and grant reviewer. Dr. Costa has been the member of dozens of panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has chaired and/or organized symposia at scientific meetings in the United States and internationally. He has been teaching classes in the area of toxicology, neurotoxicology and pharmacology to graduate and medical students for 30 years. He keeps an active research program in the area of neurotoxicology.

Affiliations and expertise

Professor of Toxicology, University of Washington, Seattle, WA, USA

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